臺灣博碩士論文加值系統

近十幾年以來7AI的雙氫鍵雙體以及其受光激發後的雙質子轉移在分子階層上經常被用來當作DNA的基質(Purines)之簡單模型。其主要目標是用來研究DNA中可能因激發態的雙質子轉移機構而?生的基因突變。在本實驗室已經利用分子設計的方式陸續的研究出一系列的相關性衍生物的光譜性質；例如：4-Azabenzaimidazole (4ABI)、7-Azaindoline (7AZD)、3-Formyl-7-Azaindole、3-Cyano-7-Azainodole 等類比物。但是這些類比物，包含7AI分子並不能真正模擬DNA中的基質分子；所以，我的研究就是合成類比於DNA基質分子Purine和Adenine的衍生物來做光譜動力學研究，在經過分子設計修飾後進行一系列的激發態雙質子轉移研究。

Self - dimerization of 7-Azaindole has long been recognized for undergoing the excited - state double proton transfer (ESDPT) resulting in a large Stokes shifted emission. Such a simple ESDPT process, at molecular level, provides one possible mechanism for the mutation due to a "misprint " of a specific DNA base pair. Through the molecular design we have already explored the spectra and dynamics of proton-transfer propriety among 4-azabenzaimidazole (4ABI), 7-azaindoline (7AZD), 3-Formyl-7-Azaindole and 3-Cyano-7-Azainodole, etc. Unfortunately such 7AI analogues cannot really simulate the base pair molecule such as adenine in DNA. The goal of my research is to design and synthesize various derivatives of which are analogous to the base pair molecules of DNA such as purine and adenine; and to precede a series of spectroscopy and dynamics studies based on their corresponding absorption and fluorescence properties.

中文摘要
英文摘要
第一章 緒論……………………………………. 1
第一節 引言…………………………………….. 1
第二節 研究動機………………………………... 4
第三節 相關理論及名詞解釋……………………. 5
壹、相關之光物理現象……………………….. 5
貳、名詞解釋：…………..……………….… 9
第二章 研究內容………………………………. 14
第一節 引言…………………………………….. 14
第二節 Observation of Molecular-Based Tuning Proton-Transfer Tautomrism……………… 16
壹、簡介：………………………………….. 16
貳、實驗步驟：……………………………… 17
參、結果與討論：…………………………… 20
第三節 Excited-State Amino-Imino Double Proton Tautomerism in Adenine Nucleotide Analogues Catalyzed by Carboxylic Acids……………………………………. 26
壹、簡介：………………..………………… 26
貳、實驗步驟：………..……………….…… 27
參、結果與討論：…………………………… 31
第四節 結論…………………………………. 34
參考文獻…….…………………………………….. 35

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