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研究生:黃楚雲
研究生(外文):Chu-Yun Huang
論文名稱:台灣初期帕金森病患使用樂伯克速效劑型直接轉換至長效劑型之可行性評估: 開放性、交叉試驗
論文名稱(外文):The Feasibility of Overnight Switching of Pramipexole from Immediate-release to Extended-release Formulation in Early Parkinson''s Disease: An Open-labeled, Crossover Study in Taiwan
指導教授:林本元林本元引用關係
學位類別:碩士
校院名稱:臺北醫學大學
系所名稱:藥學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:英文
論文頁數:103
中文關鍵詞:臨床藥學樂伯克R樂伯克長效劑型第四期臨床研究帕金森氏症狀衡量表
外文關鍵詞:Clinical pharmacyMirapexRpramipexole extended-releasephase IV clinical studyUnified Parkinson’s Disease Rating Scale
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  • 被引用被引用:0
  • 點閱點閱:629
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1. Introduction..................................1
1.1 Justification of the Study...............1
1.1.1 Rationale of the Study...................1
1.1.2 Aims of the Study........................1
1.2 Literature Review........................2
1.2.1 Pathology................................2
1.2.2 Epidemiology.............................2
1.2.3 Symptoms of Parkinson’s Disease..........2
1.2.4 Clinical Stages..........................3
1.2.5 Diagnosis................................3
1.2.6 Treatment Overview.......................5
1.2.7 Clinical Trials of Dopamine Agonists....13
1.2.8 Introduction of Pramipexole Dihydrochloride (Mirapex (R..............................................20
2. Methods......................................28
2.1 Study Subjects..........................28
2.2 Study Materials.........................28
2.2.1 Study Medications.......................28
2.2.2 Evaluation Scales.......................29
2.3 Study Design............................31
2.4 Statistical Analysis....................36
3. Results......................................37
3.1 Study Subjects..........................37
3.2 Primary Endpoints.......................41
3.2.1 Successful Switching Rate...............41
3.2.2 Compliance..............................41
3.3 Secondary Endpoints.....................44
3.3.1 UPDRS part II, III and II plus III......44
3.3.2 CGI-I and PGI-C Scores and Responders...44
3.3.3 TSQM....................................48
3.3.4 Preference of Formulations..............48
3.4 Safety and Tolerability.................51
4. Discussion...................................56
5. References...................................62

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