臺灣博碩士論文加值系統

Amberlyst 15是一種固體酸的催化劑，使用上容易分離移除，不具揮發性，也沒有強的腐蝕性，可回收再利用，不會汙染環境等等優點，相較於金屬性的Lewis acid催化劑更為環保，也較為便宜。
　　Quinoline衍生物有著廣泛的生物活性，例如：抗菌、抗瘧疾、控制糖尿病及抗發炎等等。
　　Imide 衍生物在生物合成及聚合物化學方面，有許多重要的用途。
　　本研究計畫利用Amberlyst 15進行合成Quinoline及 Imide的衍生物。合成方法簡單、反應穩定、不汙染環境符合綠色化學，並且最後能得到不錯的產率。

Amberlyst 15 is a solid acid of catalytic agent, by the advantage it is easy to isolate and remove, and have no volatility and corrosiveness. Amberlyst 15 can be to recycle and used again, and will not pollute the environment. Compared with metal Lewis acid catalyst being the environmental protection even more, and comparatively cheap too.
　Quinoline and its derivatives display a wide spectrum of biological activities such as antimalarial, antibacterial, antidiabetic, and anti-inflammatory.
　Imide derivatives constitute an important class of organic compounds with numerous uses in biology, synthetic and polymer chemistry.
　In this work, Amberlyst 15 catalyzes the synthesis of quinoline and imide derivatives in milder conditions. The advantages of this method such as shorter reaction times, simplicity of the reaction and good product yields.

中文摘要…………… 1
英文摘要…………… 2
第一章 總論……………3
第二章 各論……………8
第一節 利用2-aminobenzophenones與ketones，用Amberlyst 15當路易士酸，在無溶媒下進行Friedländer reaction合成quinoline衍生物……………8
第二節 利用succinic anhydride 與anilines用Amberlyst 15當路易士酸，在離子溶媒下進行合成imide衍生物……………13
第三章 結論……………25
第四章 實驗部分……………27
第一節 儀器……………27
第二節 各化合物的製備……………28
參考文獻……………64

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