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研究生:余靜芳
研究生(外文):Ching-Fang Yu
論文名稱:低脂高纖維營養補充品對於第2型糖尿病患血脂質之影響
論文名稱(外文):The Effect of Low Fat and High Fiber Nutrition supplement on the Blood Lipid of Type 2 Diabetes
指導教授:楊淑惠楊淑惠引用關係
指導教授(外文):Shwu-Huey Yang
學位類別:碩士
校院名稱:臺北醫學大學
系所名稱:保健營養學研究所
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2008
畢業學年度:96
語文別:中文
論文頁數:80
中文關鍵詞:糖尿病血脂質營養補充品飲食脂肪纖維質
外文關鍵詞:diabetes millitus、blood lipid、nutrition supplement、dietary fat、fiber
相關次數:
  • 被引用被引用:1
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  • 收藏至我的研究室書目清單書目收藏:1
研究的目的是在探討低脂高纖維營養補充品介入第2型糖尿病患者飲食後是否可以改善病人血液脂質生化值。
研究分為二部分,第一部分為計算低脂高纖維營養補充品昇糖指數及昇糖負荷。第二部分評估給予第2型糖尿病患3個月低脂高纖維營養補充品對於血糖、血脂質影響。第一部分招募條件為19~30歲健康者,結果以葡萄糖水溶液當作參考標準試驗食品時昇糖指數14.7 (昇糖負荷5.8),以白吐司當作參考標準試驗食品時昇糖指數23.6 (昇糖負荷9.2)。
第二部分受試者招募條件為30~70歲,經臨床醫師判斷確認為第2型糖尿病患者且已穩定接受糖尿病治療患者。研究為期5個月之臨床研究,於介入期間給予85公克低脂高纖維營養補充品,結果患者之低密度脂蛋白膽固醇濃度顯著降低( p<0.05),白蛋白顯著增加( p<0.05),其餘飯前血糖、三酸甘油酯、膽固醇、高密度脂蛋白膽固醇、肌酸酐、尿素氮、天門冬胺酸轉胺酶、丙胺酸轉胺酶則無顯著差異。結論低脂高纖維營養配方為低昇糖負荷及低昇糖指數食品,且對第2型糖尿病患者有降低低密度脂蛋白膽固醇值。
This study purpose was to evaluate the effect of low fat high fiber nutrition supplement on blood lipids in Type 2 DM patients. Study was divided as two phase. Phase one was to evalutate glycemic index (GI) and glycemic load (GL) of low fat, high fiber nutrition supplement. Phase two was to evaluate the effect of low fat, high fiber nutrition supplement on the blood glucose and blood lipid of Type 2 Diabetes after they had nutrition supplement 3 months.
The result as following, fat, high fiber nutrition supplement ‘s GI: 14.7, GL: 5.8.
46 Type 2 Diabetic subjects was recruited aged from 30 to 70 years old. This is a 5-month clinical study, observation period (month 0 to month 1), intervention period (month 1~4th), and the follow-up period. The study subjects were given 85g of low fat high fiber nutrition supplement in theintervention period. The LDL-C concentration of the subjects has dropped significantly (p<0.05) after took the low fat high fiber nutrition supplement for 3 months. Albumin increased significantly ( p<0.05). Fasting blood glucose, triglyceride, total cholesterol, high density lipoprotein cholesterol creatinine , blood urea nitrogen , aspartate aminotransferase, and alanine aminotransferase no significant difference exist.
This low fat high fiber nutrition supplement was low GL and GL food and it had a positive effect on the blood lipid of Type 2 Diabetic patients.
頁數
摘 要 Ⅰ
英文摘要 II
致 謝 IV
目 錄 V
圖目錄 VII
表目錄 VIII
附錄目錄 IX
第一章 緒論 1
第二章 文獻回顧 3
第一節 糖尿病的流行病學 3
第二節 糖尿病之診斷標準及分類 4
第三節 糖尿病併發症 6
第四節 第2型糖尿病患血脂異常特點及治療目標 7
第五節 糖尿病的飲食建議 8
第六節 膳食纖維定義及果寡糖特性 10
第七節 膳食纖維對於血脂的影響 11
第八節 低脂飲食對於血脂的影響 12
第三章 材料與方法 14
第一節 研究目的 14
第二節 低脂高纖營養補充品成份說明 15
第三節 研究流程 15
第四節 第一部份研究設計 17
第五節 第一部份研究對象及試驗材料 17
第六節 第一部份分析項目及方法 18
第七節 第一部份統計分析 18
第八節 第二部份研究設計 18
第九節 第二部份研究對象 20
第十節 第二部份分析項目 20
第十一節 第二部份分析方法 21
第十二節 第二部份飲食紀錄 28
第十三節 第二部份統計方法 29
第四章 結果 30
第一部份計算低脂高纖維營養補充品GI與GL 30
第一節 受試者基本資料 30
第二節 測量參考試驗食品-葡萄糖水溶液、白吐司之GI 30
第三節 低脂高纖營養補充品之GI及GL 31
第二部份低脂高纖維營養補充品對於糖尿病患血脂質之影響 32
第一節 受試者基本資料 32
第二節 低脂高纖營養補充品攝取狀況 32
第三節 飲食攝取量 32
第四節 受試者體位測量 34
第五節 血液生化值 34
第五章 討論 38
第一節 低脂高纖維營養補充品成份探討 38
第二節 受試者的飲食攝取情形 39
第三節 受試者體位之變化 40
第四節 受試者血脂之變化 42
第五節 受試者其他相關之血液指標 42
第六節 探討影響受試者營養狀況因素 44
第六章 結論 45
第七章 參考文獻 46




















圖目錄
頁數
圖一、2007年全球地區第2型糖尿病20~39歲、40~59歲、60~79歲人口總數之比較 58
圖二、台灣地區各區域之第2型糖尿病盛行率(2002年) 59
圖三、研究目的 14
圖四、每90克低脂高纖營養補充品提供礦物質及維生素量符合營養素參考建議量(dietary reference intakes,DRIs)百分比 60
圖五、第一部份研究流程 16
圖六、第二部份研究流程 16
圖七、攝食葡萄糖水溶液內含50公克碳水化合物0~150分鐘內之血糖變化與引起血糖升高之區線下面積 61
圖八、攝食內含50公克碳水化合物之白吐司飯後0~150分鐘內血糖上升面積 62
圖九、攝食內含50公克碳水化合物之低脂高纖營養補充品,飯後0 ~120分鐘內血糖上升面積 63






















表目錄
頁數
表一、不同區域20~79歲之糖尿病預估 64
表二、GI及GL定義及參考值 65
表三、每90克低脂高纖營養補充品之營養組成 66
表四、受試者基本資料 67
表五、攝食50公克葡萄糖,飯後0~150分鐘內血糖上升面積 68
表六、攝食內含50公克碳水化合物之白吐司飯後0~120分鐘內血糖上升面積 69
表七、攝食內含50公克碳水化合物之低脂高纖營養補充品,飯後0~120分鐘內血糖上升面積 70
表八、受試者基本資料 71
表九、低脂高纖營養補充品與受試者實際攝取量之比較 72
表十、受試者三大營養素及占總熱量比率、膳食纖維、膽固醇攝取量 73
表十一、受試者體位測量 74
表十二、受試者血液生化值 75
表十三、男性受試者血液生化值 76
表十四、女性受試者血液生化值 77

附錄目錄
頁數
附錄一、受試者每日飲食攝取量記錄表 ……………………….. 78
附錄二、台北醫學大學人體臨床試驗計畫核可函 ……………………….. 79
附錄三、行政院衛生署基隆醫院人體臨床試驗計畫核可函…………………….. 80
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中文部分
中華民國糖尿病衛教學會衛教核心教材,2007。
王曉霖( 1991 )食物模型之建立及其應用於飲食回顧之效度研究。國防醫 學院公共衛生研究所公衛營養組碩士論文。
行政院衛生署 ( 2003 ) 國人膳食營養素參考攝取量及其說明。
行政院衛生署 ( 2006 ) 衛生統計資料網,民國95年衛生統計資料。
行政院衛生署( 1998 ) ,臺灣地區食品營養成份資料庫。
行政院衛生署國民健康局 ( 2003 ) 台灣地區高血壓、高血糖及高血脂之盛行率調查。
吳佩瑜( 2005 ) 完整營養補充劑對於血液透析患者營養及生理狀況之影響。臺北醫學大學保健營養學系碩士論文。
林興中 糖尿病併血脂異常的處理 臺灣醫界 2004;47: 10-11
林宏達(1999)論述血糖控制與糖尿病合併症,中華民國內分泌暨糖尿病學會會訊。12:1-4。
高文惠、陳志朗、陳麗華、崔道華、沈茂庭、黃瓊華、洪美玟等,行政院衛生署(2005).台灣地區2010年衛生指標白皮書。
基隆市政府全球資訊網http://210.69.46.154/web/history/his03_01.asp
基隆市鄉土資源教育網http://linux.syjh.kl.edu.tw/klhometown/03-04.php
張尚宏編譯(1999)當代心臟學診斷與治療 Michael H. Crawford原著
賴明宏(2001)飲食中補充米麩或三價鉻對第2型糖尿病患或STZ誘導糖尿病大白鼠碳水化合物及脂質代謝之影響 臺北醫學院藥學研究所博士。
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