Adhami VM, Ahmad N and Mukhtar H (2003) Molecular targets for green tea in prostate cancer prevention. J Nutr 133:2417S-2424S.
Agarwal R, Katiyar SK, Zaidi SI and Mukhtar H (1992) Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives. Cancer Res 52:3582-8.
Annaert W and De Strooper B (2002) A cell biological perspective on Alzheimer''s disease. Ann Rev Cell Dev Biol 18:25-51.
Artese L, Rubini C, Ferrero G, Fioroni M, Santinelli A and Piattelli A (2001) Microvessel density (MVD) and vascular endothelial growth factor expression (VEGF) in human oral squamous cell carcinoma. Anticancer Res 21:689-95.
Asthana S, Greig NH, Holloway HW, Raffaele KC, Berardi A, Schapiro MB, Rapoport SI and Soncrant TT (1996) Clinical pharmacokinetics of arecoline in subjects with Alzheimer''s disease. Clin Pharmacol Ther 60:276-82.
Avramovich Y, Amit T and Youdim MB (2002) Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. J Biol Chem 277:31466-73.
Baldus CD, Liyanarachchi S, Mrozek K, Auer H, Tanner SM, Guimond M, Ruppert AS, Mohamed N, Davuluri RV, Caligiuri MA, Bloomfield CD and de la Chapelle A (2004) Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes. Proc Natl Acad Sci U S A 101:3915-20.
Barker JN, Mitra RS, Griffiths CE, Dixit VM and Nickoloff BJ (1991) Keratinocytes as initiators of inflammation. Lancet 337:211-4.
Baskin F, Rosenberg RN, Fang X, Hynan LS, Moore CB, Weiner M and Vega GL (2003) Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients. Neurology 60:2006-2007.
Beck M, Bigl V and Rossner S (2003) Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo. Neurochem Res 28:637-44.
Beck M, Muller D and Bigl V (1997) Amyloid precursor protein in guinea pigs--complete cDNA sequence and alternative splicing. Biochim Biophys Acta 1351:17-21.
Blasko I, Apochal A, Boeck G, Hartmann T, Grubeck-Loebenstein B and Ransmayr G (2001) Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells. Neurobiol Dis 8:1094-101.
Bundgaard T, Wildt J, Frydenberg M, Elbrond O and Nielsen JE (1995) Case-control study of squamous cell cancer of the oral cavity in Denmark. Cancer Causes Control 6:57-67.
Burke WJ, McLaughlin JR, Chung HD, Gillespie KN, Grossberg GT, Luque FA and Zimmerman J (1994) Occurrence of cancer in Alzheimer and elderly control patients: an epidemiologic necropsy study. Alzheimer Dis Assoc Disord 8:22-8.
Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon JJ, Johnson RS, Castner BJ, Cerretti DP and Black RA (1998) Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem 273:27765-7.
Cai XD, Golde TE and Younkin SG (1993) Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science 259:514-6.
Canet-Aviles RM, Anderton M, Hooper NM, Turner AJ and Vaughan PF (2002) Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C. Brain Res Mol Brain Res 102:62-72.
Cao J, Xu Y, Chen J and Klaunig JE (1996) Chemopreventive effects of green and black tea on pulmonary and hepatic carcinogenesis. Fundam Appl Toxicol 29:244-50.
Caswell MD, Mok SS, Henry A, Cappai R, Klug G, Beyreuther K, Masters CL and Small DH (1999) The amyloid beta-protein precursor of Alzheimer''s disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons. Eur J Biochem 266:509-16.
Chan G, Boyle JO, Yang EK, Zhang F, Sacks PG, Shah JP, Edelstein D, Soslow RA, Koki AT, Woerner BM, Masferrer JL and Dannenberg AJ (1999) Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. Cancer Res 59:991-4.
Chang MC, Ho YS, Lee PH, Chan CP, Lee JJ, Hahn LJ, Wang YJ and Jeng JH (2001a) Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 22:1527-35.
Chang MC, Kuo MY, Hahn LJ, Hsieh CC, Lin SK and Jeng JH (1998a) Areca nut extract inhibits the growth, attachment, and matrix protein synthesis of cultured human gingival fibroblasts. J Periodontol 69:1092-7.
Chang YC, Lii CK, Tai KW and Chou MY (2001b) Adverse effects of arecoline and nicotine on human periodontal ligament fibroblasts in vitro. J Clin Periodontol 28:277-82.
Chang YC, Tai KW, Cheng MH, Chou LS and Chou MY (1998b) Cytotoxic and non-genotoxic effects of arecoline on human buccal fibroblasts in vitro. J Oral Pathol Med 27:68-71.
Chang YC, Tai KW, Lii CK, Chou LS and Chou MY (1999) Cytopathologic effects of arecoline on human gingival fibroblasts in vitro. Clin Oral Investig 3:25-9.
Checler F (1995) Processing of the beta-amyloid precursor protein and its regulation in Alzheimer''s disease. J Neurochem 65:1431-44.
Chen C, Shen G, Hebbar V, Hu R, Owuor ED and Kong AN (2003) Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Carcinogenesis 24:1369-78.
Chen C, Yu R, Owuor ED and Kong AN (2000) Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch Pharm Res 23:605-12.
Chu NS (1993) Cardiovascular responses to betel chewing. J Formos Med Assoc 92:835-7.
Chu NS (1995) Effect of betel chewing on RR interval variation. J Formos Med Assoc 94:106-10.
Chu NS (2001) Effects of betel chewing on the central and autonomic nervous systems. J Biomed Sci 8:229-36.
Chung FL, Schwartz J, Herzog CR and Yang YM (2003) Tea and cancer prevention: studies in animals and humans. J Nutr 133:3268S-3274S.
Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I and Selkoe DJ (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer''s disease increases beta-protein production. Nature 360:672-4.
Colciaghi F, Borroni B, Pastorino L, Marcello E, Zimmermann M, Cattabeni F, Padovani A and Di Luca M (2002) [alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients. Mol Med 8:67-74.
Cox JM, Clayton CL, Tomita T, Wallace DM, Robinson PA and Crabtree JE (2001) cDNA array analysis of cag pathogenicity island-associated Helicobacter pylori epithelial cell response genes. Infect Immun 69:6970-80.
De Strooper B and Annaert W (2000) Proteolytic processing and cell biological functions of the amyloid precursor protein. J Cell Sci 113 ( Pt 11):1857-70.
De Strooper B and Konig G (2001) An inflammatory drug prospect. Nature 414:159-60.
Elattar TM and Virji AS (2000) Effect of tea polyphenols on growth of oral squamous carcinoma cells in vitro. Anticancer Res 20:3459-65.
Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, Oltersdorf T, McClure D and Ward PJ (1990) Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 248:1122-4.
Fahrenholz F, Gilbert S, Kojro E, Lammich S and Postina R (2000) Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure. Ann N Y Acad Sci 920:215-22.
Farlow M, Gracon SI, Hershey LA, Lewis KW, Sadowsky CH and Dolan-Ureno J (1992) A controlled trial of tacrine in Alzheimer''s disease. The Tacrine Study Group. JAMA 268:2523-9.
Fassbender K, Simons M, Bergmann C, Stroick M, Lutjohann D, Keller P, Runz H, Kuhl S, Bertsch T, von Bergmann K, Hennerici M, Beyreuther K and Hartmann T (2001) Simvastatin strongly reduces levels of Alzheimer''s disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A 98:5856-61.
Fischer OM, Hart S, Gschwind A and Ullrich A (2003) EGFR signal transactivation in cancer cells. Biochem Soc Trans 31:1203-8.
Fisher A (2000) Therapeutic strategies in Alzheimer''s disease: M1 muscarinic agonists. Jpn J Pharmacol 84:101-12.
Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27-31.
Frei B and Higdon JV (2003) Antioxidant activity of tea polyphenols in vivo: evidence from animal studies. J Nutr 133:3275S-84S.
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F and et al. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373:523-7.
Glenner GG and Wong CW (1984) Alzheimer''s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885-90.
Gooch MD and Stennett DJ (1996) Molecular basis of Alzheimer''s disease. Am J Health Syst Pharm 53:1545-57; quiz 1603-4.
Graham HN (1992) Green tea composition, consumption, and polyphenol chemistry. Prev Med 21:334-50.
Gupta S, Hastak K, Afaq F, Ahmad N and Mukhtar H (2004) Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. Oncogene 23:2507-22.
Haass C, Hung AY, Selkoe DJ and Teplow DB (1994) Mutations associated with a locus for familial Alzheimer''s disease result in alternative processing of amyloid beta-protein precursor. J Biol Chem 269:17741-8.
Hansel DE, Rahman A, Wehner S, Herzog V, Yeo CJ and Maitra A (2003) Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation. Cancer Res 63:7032-7.
Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lubke T, Lena Illert A, von Figura K and Saftig P (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet 11:2615-24.
Hastak K, Gupta S, Ahmad N, Agarwal MK, Agarwal ML and Mukhtar H (2003) Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells. Oncogene 22:4851-9.
Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L and De Strooper B (2000) Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. Nat Cell Biol 2:461-2.
Hoffmann J, Twiesselmann C, Kummer MP, Romagnoli P and Herzog V (2000) A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation. Eur J Cell Biol 79:905-14.
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F and Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99-102.
IARC (1985) Betel-quid and areca-nut chewing. IARC Monogr Eval Carcinog Risk Chem Hum 37:137-202.
Jeng JH, Hahn LJ, Lin BR, Hsieh CC, Chan CP and Chang MC (1999) Effects of areca nut, inflorescence piper betle extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes. J Oral Pathol Med 28:64-71.
Jeng JH, Ho YS, Chan CP, Wang YJ, Hahn LJ, Lei D, Hsu CC and Chang MC (2000) Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes. Carcinogenesis 21:1365-70.
Jeng JH, Kuo ML, Hahn LJ and Kuo MY (1994) Genotoxic and non-genotoxic effects of betel quid ingredients on oral mucosal fibroblasts in vitro. J Dent Res 73:1043-9.
Jeng JH, Lan WH, Hahn LJ, Hsieh CC and Kuo MY (1996) Inhibition of the migration, attachment, spreading, growth and collagen synthesis of human gingival fibroblasts by arecoline, a major areca alkaloid, in vitro. J Oral Pathol Med 25:371-5.
Jeong JH, Kim HJ, Lee TJ, Kim MK, Park ES and Choi BS (2004) Epigallocatechin 3-gallate attenuates neuronal damage induced by 3-hydroxykynurenine. Toxicology 195:53-60.
Johnstone EM, Chaney MO, Norris FH, Pascual R and Little SP (1991) Conservation of the sequence of the Alzheimer''s disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Brain Res Mol Brain Res 10:299-305.
Kammesheidt A, Boyce FM, Spanoyannis AF, Cummings BJ, Ortegon M, Cotman C, Vaught JL and Neve RL (1992) Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci U S A 89:10857-61.
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K and Muller-Hill B (1987) The precursor of Alzheimer''s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-6.
Kataoka H, Seguchi K, Iwamura T, Moriyama T, Nabeshima K and Koono M (1995) Reverse-zymographic analysis of protease nexin-II/amyloid beta protein precursor of human carcinoma cell lines, with special reference to the grade of differentiation and metastatic phenotype. Int J Cancer 60:123-8.
Katiyar SK (2003) Skin photoprotection by green tea: antioxidant and immunomodulatory effects. Curr Drug Targets Immune Endocr Metabol Disord 3:234-42.
Katiyar SK, Matsui MS, Elmets CA and Mukhtar H (1999) Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Photochem Photobiol 69:148-53.
Khafif A, Schantz SP, Al-Rawi M, Edelstein D and Sacks PG (1998) Green tea regulates cell cycle progression in oral leukoplakia. Head Neck 20:528-34.
Kirsch C, Eckert GP, Koudinov AR and Muller WE (2003) Brain cholesterol, statins and Alzheimer''s Disease. Pharmacopsychiatry 36 Suppl 2:S113-9.
Kishimoto K, Sasaki A, Yoshihama Y, Mese H, Tsukamoto G and Matsumura T (2003) Expression of vascular endothelial growth factor-C predicts regional lymph node metastasis in early oral squamous cell carcinoma. Oral Oncol 39:391-6.
Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S and Ito H (1988) Novel precursor of Alzheimer''s disease amyloid protein shows protease inhibitory activity. Nature 331:530-2.
Ko SY, Lin SC, Chang KW, Liu CJ, Chang SS, Lu SY and Liu TY (2003) Modulation of KGF-1 gene expression in oral fibroblasts by ripe areca nut extract. J Oral Pathol Med 32:399-407.
Kostrzewa RM and Segura-Aguilar J (2003) Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review. Neurotox Res 5:375-83.
Kuttan NA and Bhakthan NM (1997) Epidermal growth factor receptor (EGFR) in oral squamous cell carcinomas: overexpression, localization and therapeutic implications. Indian J Dent Res 8:9-18.
Lahiri DK, Farlow MR, Nurnberger JI, Jr. and Greig NH (1997a) Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures. Ann N Y Acad Sci 826:416-21.
Lahiri DK, Farlow MR and Sambamurti K (1998) The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Brain Res Mol Brain Res 62:131-40.
Lahiri DK, Farlow MR, Sambamurti K and Nall C (1997b) The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells. Life Sci 61:1985-92.
Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C and Fahrenholz F (1999) Constitutive and regulated alpha-secretase cleavage of Alzheimer''s amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A 96:3922-7.
Lee CH, Lin RH, Liu SH and Lin-Shiau SY (1996) Mutual interactions among ingredients of betel quid in inducing genotoxicity on Chinese hamster ovary cells. Mutat Res 367:99-104.
Lee MJ, Lambert JD, Prabhu S, Meng X, Lu H, Maliakal P, Ho CT and Yang CS (2004a) Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extract. Cancer Epidemiol Biomarkers Prev 13:132-7.
Lendon CL, Ashall F and Goate AM (1997) Exploring the etiology of Alzheimer disease using molecular genetics. JAMA 277:825-31.
Levites Y, Amit T, Mandel S and Youdim MB (2003) Neuroprotection and neurorescue against A beta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB J 17:952-4.
Li N, Han C and Chen J (1999a) Tea preparations protect against DMBA-induced oral carcinogenesis in hamsters. Nutr Cancer 35:73-9.
Li N, Sun Z, Han C and Chen J (1999b) The chemopreventive effects of tea on human oral precancerous mucosa lesions. Proc Soc Exp Biol Med 220:218-24.
Lin JK and Liang YC (2000) Cancer chemoprevention by tea polyphenols. Proc Natl Sci Counc Repub China B 24:1-13.
Lin SC, Chang KW, Chang CS, Liu TY, Tzeng YS, Yang FS and Wong YK (2000) Alterations of p16/MTS1 gene in oral squamous cell carcinomas from Taiwanese. J Oral Pathol Med 29:159-66.
Lin SC, Liu CJ, Chiu CP, Chang SM, Lu SY and Chen YJ (2004) Establishment of OC3 oral carcinoma cell line and identification of NF-kappa B activation responses to areca nut extract. J Oral Pathol Med 33:79-86.
Lin SC, Wang CP, Chen YM, Lu SY, Fann MJ, Liu CJ, Kao SY and Chang KW (2002) Regulation of IGFBP-5 expression during tumourigenesis and differentiation of oral keratinocytes. J Pathol 198:317-25.
Liu TY, Chen CL and Chi CW (1996) Oxidative damage to DNA induced by areca nut extract. Mutat Res 367:25-31.
Lopez-Perez E, Seidah NG and Checler F (1999) Proprotein convertase activity contributes to the processing of the Alzheimer''s beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway. J Neurochem 73:2056-62.
Lopez-Perez E, Zhang Y, Frank SJ, Creemers J, Seidah N and Checler F (2001) Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10. J Neurochem 76:1532-9.
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL and Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 82:4245-9.
Masuda M, Suzui M and Weinstein IB (2001) Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin Cancer Res 7:4220-9.
Mattei MG, Borg JP, Rosnet O, Marme D and Birnbaum D (1996) Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively. Genomics 32:168-9.
Maurice T, Lockhart BP and Privat A (1996) Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction. Brain Res 706:181-93.
Maurice T, Su TP and Privat A (1998) Sigma1 (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism. Neuroscience 83:413-28.
McCulloch DR, Akl P, Samaratunga H, Herington AC and Odorico DM (2004) Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP. Clin Cancer Res 10:314-23.
McCulloch DR, Harvey M and Herington AC (2000) The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone. Mol Cell Endocrinol 167:11-21.
Meng JY, Kataoka H, Itoh H and Koono M (2001) Amyloid beta protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivo. Int J Cancer 92:31-9.
Michaelis ML (2003) Drugs targeting Alzheimer''s disease: some things old and some things new. J Pharmacol Exp Ther 304:897-904.
Millauer B, Longhi MP, Plate KH, Shawver LK, Risau W, Ullrich A and Strawn LM (1996) Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo. Cancer Res 56:1615-20.
Millauer B, Shawver LK, Plate KH, Risau W and Ullrich A (1994) Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367:576-9.
Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W and Ullrich A (1993) High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72:835-46.
Millichip MI, Dallas DJ, Wu E, Dale S and McKie N (1998) The metallo-disintegrin ADAM10 (MADM) from bovine kidney has type IV collagenase activity in vitro. Biochem Biophys Res Commun 245:594-8.
Mills J and Reiner PB (1999) Regulation of amyloid precursor protein cleavage. J Neurochem 72:443-60.
Miyata S, Koshikawa N, Higashi S, Miyagi Y, Nagashima Y, Yanoma S, Kato Y, Yasumitsu H and Miyazaki K (1999) Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture. J Biochem (Tokyo) 125:1067-76.
Molinengo L, Fundaro AM and Cassone MC (1988) Action of a chronic arecoline administration on mouse motility and on acetylcholine concentrations in the CNS. J Pharm Pharmacol 40:821-2.
Mondadori C, Hengerer B, Ducret T and Borkowski J (1994) Delayed emergence of effects of memory-enhancing drugs: implications for the dynamics of long-term memory. Proc Natl Acad Sci U S A 91:2041-5.
Muller DM, Mendla K, Farber SA and Nitsch RM (1997) Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain. Life Sci 60:985-91.
Murti PR, Bhonsle RB, Gupta PC, Daftary DK, Pindborg JJ and Mehta FS (1995) Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing. J Oral Pathol Med 24:145-52.
Myoung H, Hong SD, Kim YY, Hong SP and Kim MJ (2001) Evaluation of the anti-tumor and anti-angiogenic effect of paclitaxel and thalidomide on the xenotransplanted oral squamous cell carcinoma. Cancer Lett 163:191-200.
Myoung H, Hong SP, Yun PY, Lee JH and Kim MJ (2003) Anti-cancer effect of genistein in oral squamous cell carcinoma with respect to angiogenesis and in vitro invasion. Cancer Sci 94:215-20.
Naslund J, Schierhorn A, Hellman U, Lannfelt L, Roses AD, Tjernberg LO, Silberring J, Gandy SE, Winblad B, Greengard P and et al. (1994) Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging. Proc Natl Acad Sci U S A 91:8378-82.
Netland EE, Newton JL, Majocha RE and Tate BA (1998) Indomethacin reverses the microglial response to amyloid beta-protein. Neurobiol Aging 19:201-4.
Ninomiya H, Roch JM, Sundsmo MP, Otero DA and Saitoh T (1993) Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth. J Cell Biol 121:879-86.
Nishimura M, Yu G and St George-Hyslop PH (1999) Biology of presenilins as causative molecules for Alzheimer disease. Clin Genet 55:219-25.
Nor JE, Christensen J, Liu J, Peters M, Mooney DJ, Strieter RM and Polverini PJ (2001) Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Cancer Res 61:2183-8.
Nouri AM, Thompson C, Cannell H, Symes M, Purkiss S and Amirghofran Z (2000) Profile of epidermal growth factor receptor (EGFr) expression in human malignancies: effects of exposure to EGF and its biological influence on established human tumour cell lines. Int J Mol Med 6:495-500.
Nunan J and Small DH (2000) Regulation of APP cleavage by alpha-, beta- and gamma-secretases. FEBS Lett 483:6-10.
Oster-Granite ML, McPhie DL, Greenan J and Neve RL (1996) Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J Neurosci 16:6732-41.
Palma M and Taylor LT (1999) Extraction of polyphenolic compounds from grape seeds with near critical carbon dioxide. J Chromatogr A 849:117-24.
Palma M, Taylor LT, Varela RM, Cutler SJ and Cutler HG (1999) Fractional extraction of compounds from grape seeds by supercritical fluid extraction and analysis for antimicrobial and agrochemical activities. J Agric Food Chem 47:5044-8.
Pan T, Jankovic J and Le W (2003) Potential therapeutic properties of green tea polyphenols in Parkinson''s disease. Drugs Aging 20:711-21.
Panigrahi GB and Rao AR (1982) Chromosome-breaking ability of arecoline, a major betel-nut alkaloid, in mouse bone-marrow cells in vivo. Mutat Res 103:197-204.
Panigrahi GB and Rao AR (1983) Influence of caffeine on arecoline-induced SCE in mouse bone-marrow cells in vivo. Mutat Res 122:347-53.
Panigrahi GB and Rao AR (1986) Study of the genotoxicity of the total aqueous extract of betel nut and its tannin. Carcinogenesis 7:37-9.
Parsonnet J (1997) Molecular mechanisms for inflammation-promoted pathogenesis of cancer--The Sixteenth International Symposium of the Sapporo Cancer Seminar. Cancer Res 57:3620-4.
Perez RG, Zheng H, Van der Ploeg LH and Koo EH (1997) The beta-amyloid precursor protein of Alzheimer''s disease enhances neuron viability and modulates neuronal polarity. J Neurosci 17:9407-14.
Pietrzik CU, Hoffmann J, Stober K, Chen CY, Bauer C, Otero DA, Roch JM and Herzog V (1998) From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc Natl Acad Sci U S A 95:1770-5.
Pilorget A, Berthet V, Luis J, Moghrabi A, Annabi B and Beliveau R (2003) Medulloblastoma cell invasion is inhibited by green tea (-)epigallocatechin-3-gallate. J Cell Biochem 90:745-55.
Ponte P, Gonzalez-DeWhitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Lieberburg I and Fuller F (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 331:525-7.
Popp GM, Graebert KS, Pietrzik CU, Rosentreter SM, Lemansky P and Herzog V (1996) Growth regulation of rat thyrocytes (FRTL-5 cells) by the secreted ectodomain of beta-amyloid precursor-like proteins. Endocrinology 137:1975-83.
Raffaele KC, Asthana S, Berardi A, Haxby JV, Morris PP, Schapiro MB and Soncrant TT (1996) Differential response to the cholinergic agonist arecoline among different cognitive modalities in Alzheimer''s disease. Neuropsychopharmacology 15:163-70.
Raffaele KC, Berardi A, Asthana S, Morris P, Haxby JV and Soncrant TT (1991) Effects of long-term continuous infusion of the muscarinic cholinergic agonist arecoline on verbal memory in dementia of the Alzheimer type. Psychopharmacol Bull 27:315-9.
Reaume AG, Howland DS, Trusko SP, Savage MJ, Lang DM, Greenberg BD, Siman R and Scott RW (1996) Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer''s disease mutations and a "humanized" Abeta sequence. J Biol Chem 271:23380-8.
Rich JB, Rasmusson DX, Folstein MF, Carson KA, Kawas C and Brandt J (1995) Nonsteroidal anti-inflammatory drugs in Alzheimer''s disease. Neurology 45:51-5.
Richards MH (1990) Relative potencies of agonists and differential sensitivity to N-ethylmaleimide on muscarinic autoreceptors and postsynaptic receptors in rat hippocampus. J Pharmacol Exp Ther 255:83-9.
Rietveld A and Wiseman S (2003) Antioxidant effects of tea: evidence from human clinical trials. J Nutr 133:3285S-3292S.
Robakis NK, Wisniewski HM, Jenkins EC, Devine-Gage EA, Houck GE, Yao XL, Ramakrishna N, Wolfe G, Silverman WP and Brown WT (1987) Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. Lancet 1:384-5.
Saija A, Princi P, De Pasquale R and Costa G (1990) Arecoline, but not haloperidol, induces changes in the permeability of the blood-brain barrier in the rat. J Pharm Pharmacol 42:135-8.
Saikia JR, Schneeweiss FH and Sharan RN (1999) Arecoline-induced changes of poly-ADP-ribosylation of cellular proteins and its influence on chromatin organization. Cancer Lett 139:59-65.
Saitoh T, Sundsmo M, Roch JM, Kimura N, Cole G, Schubert D, Oltersdorf T and Schenk DB (1989) Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. Cell 58:615-22.
Sandbrink R, Masters CL and Beyreuther K (1994) Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. J Biol Chem 269:1510-7.
Sartippour MR, Shao ZM, Heber D, Beatty P, Zhang L, Liu C, Ellis L, Liu W, Go VL and Brooks MN (2002) Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. J Nutr 132:2307-11.
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D and Younkin S (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer''s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer''s disease. Nat Med 2:864-70.
Schlondorff J and Blobel CP (1999) Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci 112 ( Pt 21):3603-17.
Schmitz A, Tikkanen R, Kirfel G and Herzog V (2002) The biological role of the Alzheimer amyloid precursor protein in epithelial cells. Histochem Cell Biol 117:171-80.
Selkoe DJ (1994) Normal and abnormal biology of the beta-amyloid precursor protein. Annu Rev Neurosci 17:489-517.
Selkoe DJ (2001) Alzheimer''s disease: genes, proteins, and therapy. Physiol Rev 81:741-66.
Selkoe DJ, Podlisny MB, Joachim CL, Vickers EA, Lee G, Fritz LC and Oltersdorf T (1988) Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci U S A 85:7341-5.
Seo H, Ferree AW and Isacson O (2002) Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice. Eur J Neurosci 15:498-506.
Shang ZJ, Li JR and Li ZB (2002) Circulating levels of vascular endothelial growth factor in patients with oral squamous cell carcinoma. Int J Oral Maxillofac Surg 31:495-8.
Sharan RN and Wary KK (1992) Study of unscheduled DNA synthesis following exposure of human cells to arecoline and extracts of betel nut in vitro. Mutat Res 278:271-6.
Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK and Greig NH (2001) Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci U S A 98:7605-10.
Shintani S, Li C, Ishikawa T, Mihara M, Nakashiro K and Hamakawa H (2004) Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma. Oral Oncol 40:13-20.
Simpkins JW, Green PS, Gridley KE, Singh M, de Fiebre NC and Rajakumar G (1997) Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer''s disease. Am J Med 103:19S-25S.
Simpkins JW, Singh M and Bishop J (1994) The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer''s disease. Neurobiol Aging 15 Suppl 2:S195-7.
Sisodia SS, Koo EH, Beyreuther K, Unterbeck A and Price DL (1990) Evidence that beta-amyloid protein in Alzheimer''s disease is not derived by normal processing. Science 248:492-5.
Sjogren M, Gustafsson K, Syversen S, Olsson A, Edman A, Davidsson P, Wallin A and Blennow K (2003) Treatment with simvastatin in patients with Alzheimer''s disease lowers both alpha- and beta-cleaved amyloid precursor protein. Dement Geriatr Cogn Disord 16:25-30.
Slack BE, Breu J, Muchnicki L and Wurtman RJ (1997) Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C. Biochem J 327 ( Pt 1):245-9.
Small DH and McLean CA (1999) Alzheimer''s disease and the amyloid beta protein: What is the role of amyloid? J Neurochem 73:443-9.
Soncrant TT, Raffaele KC, Asthana S, Berardi A, Morris PP and Haxby JV (1993) Memory improvement without toxicity during chronic, low dose intravenous arecoline in Alzheimer''s disease. Psychopharmacology (Berl) 112:421-7.
Souquet JM, Labarbe B, Le Guerneve C, Cheynier V and Moutounet M (2000) Phenolic composition of grape stems. J Agric Food Chem 48:1076-80.
Sprecher CA, Grant FJ, Grimm G, O''Hara PJ, Norris F, Norris K and Foster DC (1993) Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family. Biochemistry 32:4481-6.
Stephenson DT and Clemens JA (1998) Metabotropic glutamate receptor activation in vivo induces intraneuronal amyloid immunoreactivity in guinea pig hippocampus. Neurochem Int 33:83-93.
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M and Sommer B (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A 94:13287-92.
Suh YH and Checler F (2002) Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer''s disease. Pharmacol Rev 54:469-525.
Sundqvist K and Grafstrom RC (1992) Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells. Int J Cancer 52:305-10.
Sundqvist K, Liu Y, Nair J, Bartsch H, Arvidson K and Grafstrom RC (1989) Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Res 49:5294-8.
Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L, Jr., Eckman C, Golde TE and Younkin SG (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 264:1336-40.
Tang DW, Lin SC, Chang KW, Chi CW, Chang CS and Liu TY (2003) Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. J Oral Pathol Med 32:522-9.
Tanzi RE, Gusella JF, Watkins PC, Bruns GA, St George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM and Neve RL (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235:880-4.
Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF and Neve RL (1988) Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer''s disease. Nature 331:528-30.
Tosetti F, Ferrari N, De Flora S and Albini A (2002) Angioprevention'': angiogenesis is a common and key target for cancer chemopreventive agents. FASEB J 16:2-14.
van Wyk CW, Olivier A, Hoal-van Helden EG and Grobler-Rabie AF (1995) Growth of oral and skin fibroblasts from patients with oral submucous fibrosis. J Oral Pathol Med 24:349-53.
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G and Citron M (1999) Beta-secretase cleavage of Alzheimer''s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-41.
Villa A, Latasa MJ and Pascual A (2001) Nerve growth factor modulates the expression and secretion of beta-amyloid precursor protein through different mechanisms in PC12 cells. J Neurochem 77:1077-84.
Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE and Solomon F (1992) Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A 89:10758-62.
Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL and Tanzi RE (1993) Isolation and characterization of APLP2 encoding a homologue of the Alzheimer''s associated amyloid beta protein precursor. Nat Genet 5:95-100.
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE and Koo EH (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414:212-6.
Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT and Delon MR (1982) Alzheimer''s disease and senile dementia: loss of neurons in the basal forebrain. Science 215:1237-9.
Williams WM, Hayakawa T, Grange E and Rapoport SI (1998) Arecoline stimulation of radiolabeled arachidonate incorporation from plasma into brain microvessels of awake rat. Neurochem Res 23:551-5.
Wong YK, Liu CJ, Kwan PC and Chao SY (2003) Microvascular density and vascular endothelial growth factor immunoreactivity as predictors of regional lymph node metastasis from betel-associated oral squamous cell carcinoma. J Oral Maxillofac Surg 61:1257-62.
Wu E, Croucher PI and McKie N (1997) Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies. Biochem Biophys Res Commun 235:437-42.
Xu H, Shi XP, Tang WP and Li LX (2002) [Expression and clinical significance of matrix metalloproteinase-9 and vascular endothelial growth factor in oral squamous cell carcinomas]. Ai Zheng 21:983-8.
Yamada K, Ren X and Nabeshima T (1999a) Perspectives of pharmacotherapy in Alzheimer''s disease. Jpn J Pharmacol 80:9-14.
Yamada K, Tanaka T, Han D, Senzaki K, Kameyama T and Nabeshima T (1999b) Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci 11:83-90.
Yamazaki K, Mizui Y and Tanaka I (1997) Radiation hybrid mapping of human ADAM10 gene to chromosome 15. Genomics 45:457-9.
Yan JJ, Tzeng CC and Jin YT (1996) Overexpression of p53 protein in squamous cell carcinomas of buccal mucosa and tongue in Taiwan: an immunohistochemical and clinicopathological study. J Oral Pathol Med 25:55-59.
Yan Y, Shirakabe K and Werb Z (2002) The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol 158:221-6.
Yoshikai S, Sasaki H, Doh-ura K, Furuya H and Sakaki Y (1990) Genomic organization of the human amyloid beta-protein precursor gene. Gene 87:257-63.
Yoshimura T, Tomita T, Dixon MF, Axon AT, Robinson PA and Crabtree JE (2002) ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa. J Infect Dis 185:332-40.
Zen H, Nakashiro K, Shintani S, Sumida T, Aramoto T and Hamakawa H (2003) Detection of circulating cancer cells in human oral squamous cell carcinoma. Int J Oncol 23:605-10.
呂思逸(2002)，檳榔子水萃取物對人類口腔上皮細胞表型及相關抑癌基因活化影響之探討，國立陽明大學口腔生物研究所，碩士論文。林佳賢(2000)，檳榔子水萃取物與綠茶多酚類化合物EGCG併用在口腔癌細胞的研究，國立陽明大學藥理學研究所，碩士論文。吳振鐸(1997)，吳振鐸茶學研究論文選集，科學農業出版社。
洪國富(2004) ， 綠茶多酚類對於人類端粒啟動子活性之探討，國立陽明大學口腔生物研究所，碩士論文。許慧娟(2001)，Sulindac與綠茶抽出物抑制由N-methyl-N-
benzylnitrosamine (MBN)所誘發倉鼠口腔癌之研究，國立陽明大學藥理學研究所，碩士論文。
郭彥彬(2001)，嚼檳榔引發之口腔黏膜纖維化症：流行病學與致病機轉，國家衛生研究院，國家衛生研究院論壇。
張國威(2001)，口腔癌前病變及癌前狀態之診斷、治療、預防與化學預防-以嚼食檳榔相關者為重點，國家衛生研究院，國家衛生研究院論壇。
楊奕馨 (2001)，檳榔相關口腔癌前病變之流行病學研究，國家衛生研究院，國家衛生研究院論壇。
陳秋蘭(2000)，臺灣檳榔塊與口腔癌致癌機轉之研究，國立陽明大學藥理學研究所，博士論文。陳盛鈺(2001)，血管生成抑制劑與腫瘤治療，臨床醫學 47: 27-30。陳國群(1998)，最新簡明癌症學，藝軒圖書出版社。
黃姵綾(2002) ，檳榔成份中多酚類在酸鹼環境下作用探討，國立陽明大學藥理學研究所，碩士論文。蔣文政(2003)，金屬離子催化蛋白水解酵素-13在口腔上皮癌化過程之表現，國立陽明大學口腔生物研究所，碩士論文。
黎萬君(2002)，綠茶多酚類化合物對人類端粒脢調控之探討，國立陽明大學口腔生物研究所，碩士論文。顏焜熒(1986)，檳榔子，原色生藥學，南天書局。