臺灣博碩士論文加值系統

激烈運動會誘發前發炎性與抗炎性細胞激素的增加。目前人蔘有效成份－皂苷（Saponin）僅在動物實驗中發現人蔘皂苷對免疫細胞與細胞激素具有促進與抑制的雙重功效，然未見補充人蔘對運動後人體內細胞激素的影響。本研究採用隨機的雙盲交叉試驗，給予健康男性補充4週的北美人蔘膠囊或安慰劑後，施予80% VO2max強度的運動至力竭，藉以觀察血中細胞激素濃度IL-2, IL-4, IL-6、IL-10、IFN-γ與TNF-β的變化情形。結果發現IL-2、IL-4、IL-10、IFN-γ與TNF-β在組內無任何顯著變化，IL-6則在運動後第7天顯著低於運動前。補充組中的IL-2與TNF-β在運動後第7天顯著低於安慰劑組；IL-4與IFN-γ在運動後2小時與運動後第7天顯著低於安慰劑組；IL-10則在運動後、運動後2小時與運動後第7天顯著低於安慰劑組。本研究結果顯示，北美人蔘的增補可能可抑制細胞激素的增加，以避免在力竭運動所誘發的急性期反應後，進一步的造成全身性的其他組織或器官的二度傷害。

Strenuous exercise induces increased levels in a number of pro-inflammatory and anti-inflammatory cytokines. Data from clinical trials of animal suggest that saponins, which are the active constituents of ginsengs, have dual effects to immune cells and cytokines including promotion and inhibition. However, there is not much information about the effects of ginseng supplement on cytokines after exercise. A randomized, double blind, crossover was designed in this study. Six untrained healthy males were assigned to take either ginseng concentrate (400 mg American ginseng saponin x 4capsules/day) or placebo (hydroxymethylcellulose) for 4 wks. After the intervention, each subject performed treadmill running at 80% of maximal oxygen consumption until exhaustion. IL-2, IL-4, IL-6, IL-10, IFN-γ, and TNF-β levels in plasma were measured. The concentrations of IL-2 and TNF-βon day 7 after exercise in ginseng group were significantly lower than those values in placebo group. The concentrations of IL-4 and IFN-γat 2 hours and day 7 after exercise in ginseng group were significantly lower than those values in placebo group. The concentrations of IL-10 immediately, 2 hours, and day 7 after exercise in ginseng group were significantly lower than that value in placebo group (P<0.05). Ginseng supplementation may inhibit the cytokine production and decrease the degree of secondary damage of systemic tissues or organs.

中文摘要-------------------------------------------------------------------Ⅰ
英文摘要-------------------------------------------------------------------Ⅱ
致謝-----------------------------------------------------------------------Ⅲ
目錄-----------------------------------------------------------------------Ⅳ
表目錄---------------------------------------------------------------------Ⅵ
圖目錄---------------------------------------------------------------------Ⅶ
第一章 緒論
第一節 研究動機----------------------------------------------------------1
第二節 研究目的----------------------------------------------------------1
第二章 文獻探討
第一節 運動與免疫的關係--------------------------------------------------2
第二節 人蔘對免疫的調節與其他功效----------------------------------------7
第三章 材料與方法
第一節 研究對象---------------------------------------------------------11
第二節 方法與步驟-------------------------------------------------------11
第三節 分析方法與步驟---------------------------------------------------12
第四節 統計分析---------------------------------------------------------13
第四章 結果--------------------------------------------------------------14
第五章 討論與結論
第一節 力竭運動對體內細胞激素的影響-------------------------------------19
第二節 北美人蔘對體內細胞激素的影響-------------------------------------20
第三節 結論與建議-------------------------------------------------------22
參考文獻------------------------------------------------------------------22
附錄
一受試者基本資料----------------------------------------------------------31
二運動測試基本資料--------------------------------------------------------32
三血中IL-2原始濃度--------------------------------------------------------33
四血中IFN-γ原始濃度-------------------------------------------------------34
五血中TNF-β原始濃度-------------------------------------------------------35
六血中IL-4原始濃度--------------------------------------------------------36
七血中IL-6原始濃度--------------------------------------------------------37
八血中IL-10原始濃度-------------------------------------------------------38
表 目 錄
表一、受試者基本資料------------------------------------------------------14
表二、IL-2在人蔘組與安慰劑組的血中濃度比較--------------------------------15
表三、IFN-γ在人蔘組與安慰劑組的血中濃度比較-------------------------------15
表四、TNF-β在人蔘組與安慰劑組的血中濃度比較-------------------------------16
表五、IL-4在人蔘組與安慰劑組的血中濃度比較--------------------------------17
表六、IL-6在人蔘組與安慰劑組的血中濃度比較--------------------------------17
表七、IL-10在人蔘組與安慰劑組的血中濃度比較-------------------------------18
圖 目 錄
圖1 IL-2在人蔘組與安慰劑組的血中濃度變化----------------------------------14
圖2 IFN-γ在人蔘組與安慰劑組的血中濃度變化---------------------------------15
圖3 TNF-β在人蔘組與安慰劑組的血中濃度變化---------------------------------16
圖4 IL-4在人蔘組與安慰劑組的血中濃度變化----------------------------------16
圖5 IL-6在人蔘組與安慰劑組的血中濃度變化----------------------------------17
圖6 IL-10在人蔘組與安慰劑組的血中濃度變化---------------------------------18

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