Dunne TE. Alzheimer’s Disease: An Overview. Encyclopedia of mental health (Second edition). 2016. P58-63.
Martinez-Cayuela M. Oxygen free radicals and human disease. Biochimie. 1995; 77(3): 147-161.
Praticò D. Alzheimer’s disease and oxygen radicals: new insights. Biochemical pharmacology. 2002; 63(4): 563-567.
Wojtunik-Kulesza KA, Oniszczuk A, Oniszczuk T and Waksmundzka-Hajnos M. The influence of common free radicals and antioxidants on development of Alzheimer’s Disease. Biomedicine & pharmacotherapy. 2016; 78: 39-49.
Alscher RG, Donahue JL and Cramer CL. Reactive oxygen species and antioxidants: relationships in green cells. Physiologia plantarum. 1997; 100(2): 224-233.
Smith MA and Perry G. Free radical damage, iron, and Alzheimer's disease. Journal of the neurological sciences. 1995; 134: 92-94.
Kumar GP, Navya K, Ramya E, Venkataramana M, Anand T and Anilakumar K. DNA damage protecting and free radical scavenging properties of Terminalia arjuna bark in PC-12 cells and plasmid DNA. Free radicals and antioxidants. 2013; 3(1): 35-39.
Venigalla M, Sonego S, Gyengesi E, Sharman MJ and Münch G. Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease. Neurochemistry international. 2016; 95: 63-74.
詹幼如。金錢薄荷萃取物之安全性、抗致突變性及抗氧化活性探討。 2008。靜宜大學食品營養學系碩士論文。詹菀菁。金錢薄荷熱水萃取物對氧化傷害下PC12細胞之保護作用及其機制探討。2014。靜宜大學食品營養學系碩士論文。李學勇。基礎植物學-下冊。1987。國立編譯館出版。P1422-1424。
中山大學生物系、南京大學生物系。植物學之系統與分類。1990。地景企業股份有限公司出版部。P332-335。
李誠祐。藥用植物學。1975。文光圖書有限公司出版。P446-447。
Trivellini A, Lucchesini M, Maggini R, Mosadegh H, Villamarin TSS, Vernieri P, Mensuali-Sodi A and Pardossi A. Lamiaceae phenols as multifaceted compounds: bioactivity, industrial prospects and role of “positive-stress”. Industrial crops and products. 2016; 83: 241-254.
Khaled-Khodja N, Boulekbache-Makhlouf L and Madani K. Phytochemical screening of antioxidant and antibacterial activities of methanolic extracts of some Lamiaceae. Industrial crops and products. 2014; 61: 41-48.
Stagos D, Portesis N, Spanou C, Mossialos D, Aligiannis N, Chaita E, Panagoulis C, Reri E, Skaltsounis L and Tsatsakis AM. Correlation of total polyphenolic content with antioxidant and antibacterial activity of 24 extracts from Greek domestic Lamiaceae species. Food and chemical toxicology. 2012; 50(11): 4115-4124.
Lee CJ, Chen LG, Chang TL, Ke WM, Lo YF and Wang CC. The correlation between skin-care effects and phytochemical contents in Lamiaceae plants. Food chemistry. 2011; 124(3): 833-841.
De Lima V, Vieira M, Kassuya C, Cardoso C, Alves J, Foglio M, de Carvalho J and Formagio A. Chemical composition and free radical-scavenging, anticancer and anti-inflammatory activities of the essential oil from Ocimum kilimandscharicum. Phytomedicine. 2014; 21(11): 1298-1302.
鄭武燦。台灣植物圖鑑(下冊)。2000。茂昌圖書有限公司出版。P1375。
邱年永、張光雄。原色台灣藥用植物圖鑑(3)。1995。南天出版。
https://www.minnesotawildflowers.info/flower/ground-ivy.
李幸祥。台灣藥草事典(二)。1999。旺文社股份有限公司出版。P114-115。
田中孝治。藥用植物大事典。2003。晨星有限公司出版。P67。
姚巧梅、劉克襄、台灣植物同好會。台灣野生食用植物圖錄。2009。玉山社出版公司。
劉新裕、林俊儀、張成國。藥用植物專輯。2001。行政院農業委員會農業試驗所出版。P248-250。
潘瑞熾。植物生理學。2006。藝軒圖書出版社。P149-162。
Shan Q, Cao G, Cai H and Cai B. Simultaneous determination of four bioactive compounds in Glechoma longituba extracts by high performance liquid chromatography. Pharmacognosy magazine. 2013; 9(35): 216.
林俊樺。金錢薄荷熱水萃取物之化學成分分離與鑑定。2014。國立中興大學化學系所碩士論文。Xie Z, Liang Z, Xie C, Zhao M, Yu X, Yang M, Huang J and Xu X. Separation and Purification of Rosmarinic Acid and Rutin from Glechoma hederacea L. using High-Speed Counter-Current Chromatography. Separation science and technology. 2014; 49(4): 588-593.
Döring AS and Petersen M. Production of caffeic, chlorogenic and rosmarinic acids in plants and suspension cultures of Glechoma hederacea. Phytochemistry letters. 2014; 10: 111-117.
Shi H, Shi A, Dong L, Lu X, Wang Y, Zhao J, Dai F and Guo X. Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress. Clinical nutrition. 2016. DOI：10.1016 / j.clnu.2016.03.002
Bagdas D, Etoz BC, Gul Z, Ziyanok S, Inan S, Turacozen O, Gul NY, Topal A, Cinkilic N and Tas S. In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile. Food and chemical toxicology. 2015; 81: 54-61.
Shimoyama AT, Santin JR, Machado ID, e Silva AMdO, de Melo ILP, Mancini-Filho J and Farsky SH. Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer. Naunyn-schmiedeberg's archives of pharmacology. 2013; 386(1): 5-14.
Yun N, Kang JW and Lee SM. Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties. The journal of nutritional biochemistry. 2012; 23(10): 1249-1255.
Bagdas D, Cinkilic N, Ozboluk HY, Ozyigit MO and Gurun MS. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain. Journal of natural medicines. 2013; 67(4): 698-704.
Bagdas D, Ozboluk HY, Cinkilic N and Gurun MS. Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy. Journal of medicinal food. 2014; 17(6): 730-732.
Liang N and Kitts DD. Role of chlorogenic acids in controlling oxidative and inflammatory stress conditions. Nutrients. 2015; 8(1): 16.
Dos Santos MD, Almeida MC, Lopes NP and De Souza GEP. Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biological and pharmaceutical bulletin. 2006; 29(11): 2236-2240.
Karthikesan K, Pari L and Menon V. Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agents. Chemico-biological interactions. 2010; 188(3): 643-650.
Cinkilic N, Cetintas SK, Zorlu T, Vatan O, Yilmaz D, Cavas T, Tunc S, Ozkan L and Bilaloglu R. Radioprotection by two phenolic compounds: chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro. Food and chemical toxicology. 2013; 53: 359-363.
Ji L, Jiang P, Lu B, Sheng Y, Wang X and Wang Z. Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism. The journal of nutritional biochemistry. 2013; 24(11): 1911-1919.
Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, Sugawara M and Iseki K. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. International journal of pharmaceutics. 2011; 403(1): 136-138.
Khan FA, Maalik A and Murtaza G. Inhibitory mechanism against oxidative stress of caffeic acid. Journal of food and drug analysis. 2016.
Pradhananga S and Shim WS. Caffeic acid exhibits anti-pruritic effects by inhibition of multiple itch transmission pathways in mice. European journal of pharmacology. 2015; 762: 313-321.
Pang C, Zheng Z, Shi L, Sheng Y, Wei H, Wang Z and Ji L. Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system. Free radical biology and medicine. 2016; 91: 236-246.
Tsai SJ, Chao CY and Yin MC. Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice. European journal of pharmacology. 2011; 670(2): 441-447.
Huang Y, Jin M, Pi R, Zhang J, Chen M, Ouyang Y, Liu A, Chao X, Liu P and Liu J. Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neuroscience letters. 2013; 535: 146-151.
Masuda T, Shingai Y, Takahashi C, Inai M, Miura Y, Honda S and Masuda A. Identification of a potent xanthine oxidase inhibitor from oxidation of caffeic acid. Free radical biology and medicine. 2014; 69: 300-307.
Saija A, Tomaino A, Trombetta D, De Pasquale A, Uccella N, Barbuzzi T, Paolino D and Bonina F. In vitro and in vivo evaluation of caffeic and ferulic acids as topical photoprotective agents. International journal of pharmaceutics. 2000; 199(1): 39-47.
Li W, Li N, Tang Y, Li B, Liu L, Zhang X, Fu H and Duan J-a. Biological activity evaluation and structure–activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer. Bioorganic & medicinal chemistry letters. 2012; 22(19): 6085-6088.
MUÑOZ‐MUÑOZ J, GARCIA‐MOLINA F, Ros E, Tudela J, GARCÍA‐CANOVAS F, and RODRIGUEZ‐LOPEZ J, Prooxidant and antioxidant activities of rosmarinic acid. Journal of food biochemistry. 2013; 37(4): 396-408.
Boonyarikpunchai W, Sukrong S and Towiwat P. Antinociceptive and anti-inflammatory effects of rosmarinic acid isolated from Thunbergia laurifolia Lindl. Pharmacology biochemistry and behavior. 2014; 124: 67-73.
Domitrović R, Potočnjak I, Crnčević-Orlić Ž and Škoda M. Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice. Food and chemical toxicology. 2014; 66: 321-328.
Karthikkumar V, Sivagami G, Vinothkumar R, Rajkumar D and Nalini N. Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1, 2-dimethylhydrazine induced rat colon carcinogenesis. Environmental toxicology and pharmacology. 2012; 34(3): 949-958.
Domitrović R, Škoda M, Marchesi VV, Cvijanović O, Pugel EP and Štefan MB. Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice. Food and chemical toxicology. 2013; 51: 370-378.
Yang SY, Hong CO, Lee GP, Kim CT and Lee KW. The hepatoprotection of caffeic acid and rosmarinic acid, major compounds of Perilla frutescens, against t-BHP-induced oxidative liver damage. Food and chemical toxicology. 2013; 55: 92-99.
Liu J. Pharmacology of oleanolic acid and ursolic acid. Journal of ethnopharmacology. 1995; 49(2): 57-68.
Somova L, Shode F, Ramnanan P and Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. Journal of ethnopharmacology. 2003; 84(2): 299-305.
夏國豪、章永紅、王瑞平。熊果酸抗腫瘤作用研究進展。2002。國外醫學腫瘤。
熊斌、雷志勇、陳虹。熊果酸藥理學的研究進展。2004。國外醫學腫瘤分冊。31(3)卷。P133-135。
Barros L, Heleno SA, Carvalho AM and Ferreira IC. Lamiaceae often used in Portuguese folk medicine as a source of powerful antioxidants: Vitamins and phenolics. LWT-Food Science and Technology. 2010; 43(3): 544-550.
Kumarasamy Y, Cox P, Jaspars M, Nahar L and Sarker S. Biological activity of Glechoma hederacea. Fitoterapia. 2002; 73(7): 721-723.
An HJ, Jeong HJ, Um JY, Kim HM and Hong SH. Glechoma hederacea inhibits inflammatory mediator release in IFN-γ and LPS-stimulated mouse peritoneal macrophages. Journal of ethnopharmacology. 2006; 106(3): 418-424.
Qiao Z, Koizumi Y, Zhang M, Natsui M, Flores MJ, Gao L, Yusa K, Koyota S and Sugiyama T, Anti-melanogenesis effect of Glechoma hederacea L. extract on B16 murine melanoma cells. Bioscience, biotechnology, and biochemistry. 2012; 76(10): 1877-1883.
Ohigashi H, Takamura H, Koshimizu K, Tokuda H and Ito Y. Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L. Cancer letters. 1986; 30(2): 143-151.
Hwang J, Erkhembaatar M, Gu D, Lee S, Lee C, Shin D, Lee Y and Kim M. Glechoma hederacea suppresses RANKL-mediated osteoclastogenesis. Journal of dental research. 2014; 93(7): 685-690.
Kim J, Lee I, Ha D, Seo J, Min B, Yoo I and Bae K. New sesquiterpene lactones from Glechoma hederacea L. and their cytotoxic effects on human cancer cell lines. Planta medica. 2011; 77(09): 955-957.
Kim J, Song S, Lee I, Kim Y, Yoo I, Ryoo I and Bae K. Anti-inflammatory activity of constituents from Glechoma hederacea var. longituba. Bioorganic & medicinal chemistry letters. 2011; 21(11): 3483-3487.
Okuyama E, Yamazaki M and Ishii Y. Isolation and identification of ursolic acid-related compounds as the principles of Glechoma hederacea having an antiulcerogenic activity. Shoyakugaku zasshi. 1983; 37: 52-55.
Tokuda H, Ohigashi H, Koshimizu K and Ito Y. Inhibitory effects of ursolic and oleanolic ancid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer letters. 1986; 33(3): 279-285.
Milovanovic M, Zivkovic D and Vucelic-Radovic B. Antioxidant effects of Glechoma hederacea as a food additive. Natural product communications. 2010; 5(1): 61-63.
Masuda A, Takahashi C, Inai M, Miura Y and Masuda T. Chemical evidence for potent xanthine oxidase inhibitory activity of Glechoma hederacea var. grandis leaves (Kakidoushi-Cha). Journal of nutritional science and vitaminology. 2013; 59(6): 570-575.
章偉浩。仙草癒合組織與十種唇形花科植物之迷迭香酸、熊果酸含量、抗氧化力與酪胺酸酶抑制力比較研究。2006。大同大學生物工程研究所。
賴佳珮。探討金錢薄荷與岩蘭草精油抗氧化與抗發炎活性。1999。靜宜大學食品營養學系碩士論文。Chou ST, Chan YR and Chung YC. Studies on the antimutagenicity and antioxidant activity of the hot water extract of Glechoma hederacea. Journal of food & drug analysis. 2012; 20(3).
陳思妤。金錢薄荷50%乙醇萃取物之抗致突變性及抗氧化活性探討。1998。靜宜大學食品營養學系碩士論文。黎國媛。金錢薄荷熱水萃取物之安全性評估及其抗氧化活性探討。2013。靜宜大學食品營養學系碩士論文。林采樺。金錢薄荷熱水萃取物之抗發炎活性及其機制探討。2016。靜宜大學食品營養學系碩士論文。吳紹起、陳小鳴。溶劑萃取化學基本原理與應用。1982。淡江大學出版部出版。
陳煇仁。錫蘭橄欖葉抗氧化成分之研究。2006。國立臺灣大學森林環境暨資源學系碩士論文。蘇惠如。蓮子萃取物抗氧化性之研究。2000。國立中興大學食品科學系碩士論文。曾佳齡。不同萃取方法及乾燥熱處理對苧麻葉和根的抗氧化能力表現之探討。2006。台南女子技術學院生活應用科學系碩士論文。沈宜蓁。龍眼花萃取物抗氧化性之探討。2005。國立臺灣大學食品科技系碩士論文。賴建興。香椿葉萃取物之降低尿酸、抗氧化活性以及安全性毒理評估。2006。國立中興大學農藝學系碩士論文。蕭順安。台灣本土草藥藤紫丹抗氧化活性及安全性評估研究。2010。國立嘉義大學生化科技學系碩士論文。黃詩愉。納紅豆之安全性評估及對腸道菌相的影響。2010。靜宜大學食品營養系碩士論文。趙克然、楊毅軍、曹道俊。氧自由基與臨床。2003。合記圖書出版社。
Fang Y-Z, Yang S and Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002; 18(10): 872-879.
劉伯康。數種傳統食用植物抗氧化性之研究。1997。國立中興大學食品科學系碩士論文。Jacob R. Nutrition, health and antioxidants. INFORM. 1994; 5: 1271-1275.
Ahsan H, Ali A and Ali R. Oxygen free radicals and systemic autoimmunity. Clinical & experimental immunology. 2003; 131(3): 398-404.
Aruoma O. Nutrition and health aspects of free radicals and antioxidants. Food and chemical toxicology. 1994; 32(7): 671-683.
林天送。氫基自由基：毒性極高的破壞分子。1995。健康世界。112卷P6-10。Nordberg J and Arner ES. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free radical biology and medicine. 2001; 31(11): 1287-1312.
Beckman JS, Beckman TW, Chen J, Marshall PA and Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proceedings of the national academy of sciences. 1990; 87(4): 1620-1624.
Blair IA. Lipid hydroperoxide-mediated DNA damage. Experimental gerontology. 2001; 36(9): 1473-1481.
Sareen S, Gropper JLS, James LG, 邱琬淳。營養生化學。2006。華騰文化。
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M and Telser J. Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology. 2007; 39(1): 44-84.
Biewenga GP, Haenen GR and Bast A. The pharmacology of the antioxidant lipoic acid. General pharmacology: the vascular system. 1997; 29(3): 315-331.
劉湘梅、關尚勇。基礎神經病理學。1993。合記圖書出版社。
吳進安。基礎神經學。1996。合記圖書出版社。
張寓智、林口長庚醫院神經內科一科。臨床神經學。2002。合記圖書出版社。
Mesquita SD, Ferreira AC, Sousa JC, Correia-Neves M, Sousa N and Marques F. Insights on the pathophysiology of Alzheimer's disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system. Neuroscience & biobehavioral reviews. 2016; 68: 547-562.
Yin F, Sancheti H, Patil I and Cadenas E. Energy metabolism and inflammation in brain aging and Alzheimer’s disease. Free radical biology and medicine. 2016.
何康隆。神經系統疾病-病理變化和臨床症狀。1976。合記圖書出版社。
Harman D. Aging: a theory based on free radical and radiation chemistry. Science's SAGE KE. 2002(37): 14.
Mehlhorn RJ and Cole G. The free radical theory of aging: a critical review. Advances in free radical biology & medicine. 1985; 1(1): 165-223.
Newton RK, Ducore JM and Sohal R. Relationship between life expectancy and endogenous DNA single-strand breakage, strand break induction and DNA repair capacity in the adult housefly, Musca domestica. Mechanisms of ageing and development. 1989; 49(3): 259-270.
Aruoma OI. Free radicals, oxidative stress, and antioxidants in human health and disease. Journal of the american oil chemists' society. 1998; 75(2): 199-212.
Ames BN, Shigenaga MK and Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the national academy of sciences. 1993; 90(17): 7915-7922.
Pryor WA. Free radical biology: xenobiotics, cancer, and aging. Annals of the new york academy of sciences. 1982; 393(1): 1-22.
Hwang E, Park S-Y, Yin CS, Kim H-T, Kim YM and Yi TH. Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin. Journal of ginseng research. 2016.
Blache D, Devaux S, Joubert O, Loreau N, Schneider M, Durand P, Prost M, Gaume V, Adrian M and Laurant P. Long-term moderate magnesium-deficient diet shows relationships between blood pressure, inflammation and oxidant stress defense in aging rats. Free radical biology and medicine. 2006; 41(2): 277-284.
林惠瑩。天麻水萃物對皮質固酮誘導PC12細胞損傷之神經保護功效。2010。台灣大學食品科技研究所碩士論文。Burke SL, Maramaldi P, Cadet T and Kukull W. Neuropsychiatric symptoms and Apolipoprotein E: Associations with eventual Alzheimer’s disease development. Archives of gerontology and geriatrics. 2016; 65: 231-238.
Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM and Crystal RG. Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models. Neurobiology of aging. 2016; 44: 159-172.
Ferret P-J, Soum E, Negre O and Fradelizi D. Auto-protective redox buffering systems in stimulated macrophages. BMC immunology. 2002; 3(1): 1.
Cui S, Reichner JS, Mateo RB and Albina JE. Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or-independent mechanisms. Cancer research. 1994; 54(9): 2462-2467.
Zhao X-C, Zhang L, Yu H-X, Sun Z, Lin X-F, Tan C and Lu R-R. Curcumin protects mouse neuroblastoma Neuro-2A cells against hydrogen-peroxide-induced oxidative stress. Food chemistry. 2011; 129(2): 387-394.
Cole GM, Teter B and Frautschy SA. Neuroprotective effects of curcumin, in the molecular targets and therapeutic uses of curcumin in health and disease. Springer. 2007; P197-212.
Francis PT, Palmer AM, Snape M and Wilcock GK. The cholinergic hypothesis of Alzheimer’s disease: a review of progress. Journal of neurology, neurosurgery & psychiatry. 1999; 66(2): 137-147.
黃詠銘。阿茲海默氏症之藥物治療概論。花蓮慈濟醫院藥劑科。
Tariot P. Current status and new developments with galantamine in the treatment of Alzheimer’s disease. Expert opinion on pharmacotherapy. 2001; 2(12): 2027-2049.
Albuquerque E, Santos M, Alkondon M, Pereira E and Maelicke A. Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease. Alzheimer disease & associated disorders. 2001; 15: 19-25.
Pinto T, Lanctôt KL and Herrmann N. Revisiting the cholinergic hypothesis of behavioral and psychological symptoms in dementia of the Alzheimer's type. Ageing research reviews. 2011; 10(4): 404-412.
謝坪螢。秦皮及其香豆素成分改善記憶障礙及神經保護作用機轉之探討。2007。中國醫藥大學中國藥學系碩士論文。楊舒涵。靈芝萃取物複方對老化促進小鼠抗老化及學習記憶能力之探討。2010。靜宜大學食品營養學系碩士論文。吳建興。桑各藥用部位抗氧化活性比較及其成分Scopoletin改善記憶障礙機轉之研究。2009。中國醫藥大學中國藥學系碩士論文。Greene LA and Tischler AS. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proceedings of the national academy of sciences. 1976; 73(7): 2424-2428.
林怡。由細胞黏著力探討川芎秦對氧糖剝奪損傷的PC12細胞之保護作用。2007。成功大學醫學工程系碩士論文。Dawson VL and Dawson TM. Nitric oxide neurotoxicity. Journal of chemical neuroanatomy. 1996; 10(3): 179-190.
Andersen JK. Oxidative stress in neurodegeneration: cause or consequence? 2004; 10: 18-25.
Gloire G, Legrand-Poels S and Piette J. NF-κB activation by reactive oxygen species: fifteen years later. Biochemical pharmacology. 2006; 72(11): 1493-1505.
Vimard F, Nouvelot A and Duval D. Cytotoxic effects of an oxidative stress on neuronal-like pheochromocytoma cells (PC12). Biochemical pharmacology. 1996; 51(10): 1389-1395.
Li P-F, Dietz R and Von Harsdorf R. Reactive oxygen species induce apoptosis of vascular smooth muscle cell. FEBS letters. 1997; 404(2-3): 249-252.
Manton KG, Volovik S and Kulminski A. ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiation. Current alzheimer research. 2004; 1(4): 277-293.
邱泓智。巴西洋菇萃取物與數種純化合物在PC-12細胞模式中抗阿茲海默症之潛力。2009。台灣大學食品科技系碩士論文。黃玟瑄。紅肉李萃取物對於以H2O2誘發PC-12神經細胞氧化壓力之影響。2010。台北醫學大學保健營養學系碩士論文。林嘉偉。木犀草素對PC12細胞氧化壓力傷害下神經保護機制之探討。2009。慈濟大學分子生物暨人類遺傳學系碩士論文。McCullough KD, Martindale JL, Klotz L-O, Aw T-Y and Holbrook NJ Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Molecular and cellular biology. 2001; 21(4): 1249-1259.
Goldshmit Y, Erlich S and Pinkas-Kramarski R. Neuregulin rescues PC12-ErbB4 cells from cell death induced by H2O2 regulation of reactive oxygen species levels by phosphatidylinositol 3-kinase. Journal of biological chemistry. 2001; 276(49): 46379-46385.
Yamakawa H, Ito Y, Naganawa T, Banno Y, Nakashima S, Yoshimura S-i, Sawada M, Nishimura Y, Nozawa Y and Sakai N. Activation of caspase-9 and-3 during H2O2-induced apoptosis of PC12 cells independent of ceramide formation. Neurological research. 2000; 22(6): 556-564.
李佳蒨。水黃皮果莢部分抗氧化活性成分之研究。2014。靜宜大學應用化學系碩士論文。吳偉華。柑橘果皮中 naringin 與 hesperidin 之定量分析及其抗氧化能力之探討。2012。國立臺灣海洋大學食品科學系碩士論文。Ellman GL, Courtney KD, Andres V and Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical pharmacology. 1961; 7(2): 88-95.
Yang ZD, Duan DZ, Xue WW, Yao XJ and Li S. Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure–activity relationships. Life sciences. 2012; 90(23): 929-933.
呂鋒洲、林仁混。基礎酵素學。1991。聯經出版社。
呂鋒洲。酵素學精義。1989。藝軒圖書出版社。
Nicholas C. Price LS, Fundamentals of enzymology. 1989: Oxford university science publications.
Mary K, Campbell SOF. 生物化學。2007。偉明圖書有限公司。
張珍田。酵素學特論。靜宜大學食品營養學系。P23-37。
Brand-Williams W, Cuvelier ME and Berset C. Use of a free radical method to evaluate antioxidant activity. LWT-Food science and technology. 1995; 28(1): 25-30.
Re R, Pellegrini N, Proteggente A, Pannala A, Yang M and Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free radical biology and medicine. 1999; 26(9): 1231-1237.
Oyaizu M. Studies on products of browning reaction antioxidative activities of products of browning reaction prepared from glucosamine. Jpn J Nutri. 1986; 44: 307-315.
Liao KL and Yin MC. Individual and combined antioxidant effects of seven phenolic agents in human erythrocyte membrane ghosts and phosphatidylcholine liposome systems: importance of the partition coefficient. Journal of agricultural and food chemistry. 2000; 48(6): 2266-2270.
Taga MS, Miller E and Pratt D. Chia seeds as a source of natural lipid antioxidants. Journal of the American Oil Chemists’ Society. 1984; 61(5): 928-931.
Julkunen-Tiitto R. Phenolic constituents in the leaves of northern willows: methods for the analysis of certain phenolics. Journal of Agricultural and Food Chemistry. 1985; 33(2): 213-217.
Sultana B, Anwar F and Ashraf M. Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plant extracts. Molecules. 2009; 14(6): 2167-2180.
Strober W. Trypan blue exclusion test of cell viability. Current protocols in immunology. 2001.
Schneider-Stock R, Mawrin C, Motsch C, Boltze C, Peters B, Hartig R, Buhtz P, Giers A, Rohrbeck A and Freigang B. Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer. The American journal of pathology. 2004; 164(4): 1233-1241.
Kassie F, Parzefall W and Knasmüller S. Single cell gel electrophoresis assay: a new technique for human biomonitoring studies. Mutation research/reviews in mutation research. 2000; 463(1): 13-31.
Tatum VL, Changchit C and Chow CK. Measurement of malondialdehyde by high performance liquid chromatography with fluorescence detection. Lipids. 1990; 25(4): 226-229.
Sedlak J and Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical biochemistry. 1968; 25: 192-205.
Paglia DE and Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The journal of laboratory and clinical medicine. 1967; 70(1): 158-169.
Marklund S and Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European journal of biochemistry. 1974; 47(3): 469-474.
HE A. Catalase In: Methods of enzymatic analysis. Verlag Chemie. 1983; 3: 273-286.
Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ and Klenk DC. Measurement of protein using bicinchomic acid. Anal Biochem. 1985; 15: 76-85.
World Alzheimer's Report. The Global Impact of Dementia (2015).
Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiological reviews. 2001; 81(2): 741-766.
Imbimbo BP, Lombard J and Pomara N. Pathophysiology of Alzheimer's disease. Neuroimaging Clinics of North America. 2005; 15(4): 727-753.
LaFerla FM, Green KN and Oddo S. Intracellular amyloid-β in Alzheimer's disease. Nature reviews neuroscience. 2007; 8(7): 499-509.
Reddy PH, Manczak M, Mao P, Calkins MJ, Reddy AP and Shirendeb U. Amyloid-β and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline. Journal of Alzheimer's disease. 2010; 20(S2): 499-512.
Kumar S and Reddy PH. Are circulating microRNAs peripheral biomarkers for Alzheimer's disease? Biochimica et biophysica acta (BBA)-molecular basis of disease. 2016; 1862(9): 1617-1627.
Jayathilake C, Rizliya V and Liyanage R. Antioxidant and free radical scavenging capacity of extensively used medicinal plants in Sri Lanka. Procedia food science. 2016; 6: 123-126.
Yılmaz BS, Altun ML, Orhan IE, Ergene B and Citoglu GS. Enzyme inhibitory and antioxidant activities of Viburnum tinus L. relevant to its neuroprotective potential. Food chemistry. 2013; 141(1): 582-588.
Lv R, Mao N, Wu J, Lu C, Ding M, Gu X, Wu Y and Shi Z. Neuroprotective effect of allicin in a rat model of acute spinal cord injury. Life sciences. 2015; 143: 114-123.
Tal Y, Anavi S, Reisman M, Samach A, Tirosh O and Troen AM. The neuroprotective properties of a novel variety of passion fruit. Journal of functional foods. 2016; 23: 359-369.
Asadbegy M, Karamian R, Ranjbar M, Malmir H and Pakzad R. Antioxidant, antibacterial activity, phenol and flavonoid contents of the methanolic extracts of five Salvia species in Iran. Clinical biochemistry. 2011; 44(13): S350.
Moghaddam M and Mehdizadeh L. Variability of total phenolic, flavonoid and rosmarinic acid content among Iranian basil accessions. LWT-food science and technology. 2015; 63(1): 535-540.
Lushchak VI. Free radicals, reactive oxygen species, oxidative stress and its classification. Chemico-biological interactions. 2014; 224: 164-175.
Lim Y and Quah E. Antioxidant properties of different cultivars of Portulaca oleracea. Food chemistry. 2007; 103(3): 734-740.
Dastmalchi K, Dorman HD, Oinonen PP, Darwis Y, Laakso I and Hiltunen R. Chemical composition and in vitro antioxidative activity of a lemon balm (Melissa officinalis L.) extract. LWT-food science and technology. 2008; 41(3): 391-400.
Bhoopat L, Srichairatanakool S, Kanjanapothi D, Taesotikul T, Thananchai H and Bhoopat T. Hepatoprotective effects of lychee (Litchi chinensis Sonn.): a combination of antioxidant and anti-apoptotic activities. Journal of ethnopharmacology. 2011; 136(1): 55-66.
Shirwaikar A, Patel B, Kamariya Y, Parmar V and Khan S. In vitro Free Radical Scavenging Potential of Defatted Ethanolic Extract of the Seeds of Lepidium sativum Linn. Chinese journal of natural medicines. 2011; 9(6): 435-440.
Yao L, Zhao Q, Xiao J, Sun J, Yuan X, Zhao B, Su H and Niu S. Composition and antioxidant activity of the polysaccharides from cultivated Saussurea involucrata. International journal of biological macromolecules. 2012; 50(3): 849-853.
Zhang CW, Wang CZ, Tao R and Fang C. Enzymolysis-based ultrasound extraction and antioxidant activities of polyprenol lipids from Ginkgo biloba leaves. Process biochemistry. 2016; 51(3): 444-451.
Liu Y, Du YQ, Wang JH, Zha XQ and Zhang JB. Structural analysis and antioxidant activities of polysaccharide isolated from Jinqian mushroom. International journal of biological macromolecules. 2014; 64: 63-68.
El Euch SK, Bouajila J and Bouzouita N. Chemical composition, biological and cytotoxic activities of Cistus salviifolius flower buds and leaves extracts. Industrial crops and products. 2015; 76: 1100-1105.
Wootton-Beard PC, Moran A and Ryan L. Stability of the total antioxidant capacity and total polyphenol content of 23 commercially available vegetable juices before and after in vitro digestion measured by FRAP, DPPH, ABTS and Folin–Ciocalteu methods. Food research international. 2011; 44(1): 217-224.
Batista ÂG, da Silva JK, Cazarin CBB, Biasoto ACT, Sawaya ACHF, Prado MA and Júnior MRM, Red-jambo (Syzygium malaccense): Bioactive compounds in fruits and leaves. LWT-food science and technology. 2016.
Wong CC, Li HB, Cheng KW and Chen F. A systematic survey of antioxidant activity of 30 Chinese medicinal plants using the ferric reducing antioxidant power assay. Food chemistry. 2006; 97(4): 705-711.
Xu Y, Fan M, Ran J, Zhang T, Sun H, Dong M, Zhang Z and Zheng H. Variation in phenolic compounds and antioxidant activity in apple seeds of seven cultivars. Saudi journal of biological sciences. 2016; 23(3): 379-388.
Caillet S, Yu H, Lessard S, Lamoureux G, Ajdukovic D and Lacroix M. Fenton reaction applied for screening natural antioxidants. Food chemistry. 2007; 100(2): 542-552.
Pesakhov S, Benisty R, Sikron N, Cohen Z, Gomelsky P, Khozin-Goldberg I, Dagan R and Porat N. Effect of hydrogen peroxide production and the Fenton reaction on membrane composition of Streptococcus pneumoniae. Biochimica et biophysica acta (BBA)-biomembranes. 2007; 1768(3): 590-597.
Lin ZR, Zhao L and Dong YH. Quantitative characterization of hydroxyl radical generation in a goethite-catalyzed Fenton-like reaction. Chemosphere. 2015; 141: 7-12.
Li Y, Sun J and Sun S-P. Mn2+-mediated homogeneous Fenton-like reaction of Fe (III)-NTA complex for efficient degradation of organic contaminants under neutral conditions. Journal of hazardous materials. 2016; 313: 193-200.
莊梅鈺。探討小葉蕨藻萃取物之抗氧化性及其對血癌細胞生長之影響。2012。靜宜大學食品營養學系碩士論文。Gomathi R and Manian S. Analgesic and acetylcholinesterase inhibition potential of polyphenols from Scolopia crenata (Flacourtiaceae): An endemic medicinal plant of India. Industrial crops and products. 2015; 73: 134-143.
Omena CMB, Valentim IB, Guedes GdS, Rabelo LA, Mano CM, Bechara EJH, Sawaya AC, Trevisan MTS, da Costa JG and Ferreira RCS. Antioxidant, anti-acetylcholinesterase and cytotoxic activities of ethanol extracts of peel, pulp and seeds of exotic Brazilian fruits: antioxidant, anti-acetylcholinesterase and cytotoxic activities in fruits. Food research international. 2012; 49(1): 334-344.
Khan MTH, Orhan I, Şenol F, Kartal M, Şener B, Dvorská M, Šmejkal K and Šlapetová T. Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. Chemico-biological interactions. 2009; 181(3): 383-389.
Zeraik ML, Queiroz EF, Marcourt L, Ciclet O, Castro-Gamboa I, Silva DHS, Cuendet M, da Silva Bolzani V and Wolfender J-L. Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits. Journal of functional foods. 2016; 21: 396-405.
Ali S, Hamed A, Soltan M, El-Halawany A, Hegazy U and Hussein A, Kinetics and molecular docking of vasicine from Adhatoda vasica: An acetylcholinesterase inhibitor for Alzheimer's disease. South african journal of botany. 2016; 104: 118-124.
Ghosh S, Banerjee S and Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food and chemical toxicology. 2015; 83: 111-124.
Vladimir-Knežević S, Blažeković B, Kindl M, Vladić J, Lower-Nedza AD and Brantner AH. Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family. Molecules. 2014; 19(1): 767-782.
Kennedy DO, Pace S, Haskell C, Okello EJ, Milne A and Scholey AB. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery. Neuropsychopharmacology. 2006; 31(4): 845-852.
Pereira RP, Boligon AA, Appel AS, Fachinetto R, Ceron CS, Tanus-Santos JE, Athayde ML and Rocha JBT. Chemical composition, antioxidant and anticholinesterase activity of Melissa officinalis. Industrial crops and products. 2014; 53: 34-45.
Dastmalchi K, Ollilainen V, Lackman P, af Gennäs GB, Dorman HD, Järvinen PP, Yli-Kauhaluoma J and Hiltunen R. Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L. Bioorganic & medicinal chemistry. 2009; 17(2): 867-871.
Loizzo MR, Tundis R, Conforti F, Menichini F, Bonesi M, Nadjafi F, Frega NG and Menichini F. Salvia leriifolia Benth (Lamiaceae) extract demonstrates in vitro antioxidant properties and cholinesterase inhibitory activity. Nutrition research. 2010; 30(12): 823-830.
Kivrak İ, Duru ME, Öztürk M, Mercan N, Harmandar M and Topçu G. Antioxidant, anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia. Food Chemistry. 2009; 116(2): 470-479.
Hu Q, Yu J, Yang W, Kimatu BM, Fang Y, Ma N and Pei F. Identification of flavonoids from Flammulina velutipes and its neuroprotective effect on pheochromocytoma-12 cells. Food chemistry. 2016; 204: 274-282.
Wang F, Liu Q, Wang W, Li X and Zhang J. A polysaccharide isolated from Cynomorium songaricum Rupr. protects PC12 cells against H2O2-induced injury. International journal of biological macromolecules. 2016; 87: 222-228.
Mao QQ, Xian YF, Ip SP, Tsai SH and Che CT. Protective effects of peony glycosides against corticosterone-induced cell death in PC12 cells through antioxidant action. Journal of ethnopharmacology. 2011; 133(3): 1121-1125.
Hung WL, Hsu BY, Tung Y-C, Ho C-T and Hwang LS. Inhibitory effects of antioxidant vitamins against thiyl radical-induced trans fatty acid formation in PC-12 cells. Journal of functional foods. 2016; 21: 212-222.
Kubista M, Aakerman B and Norden B. Characterization of interaction between DNA and 4', 6-diamidino-2-phenylindole by optical spectroscopy. Biochemistry. 1987; 26(14): 4545-4553.
Fairbairn DW, Olive PL and O'Neill KL. The comet assay: a comprehensive review. Mutation research/reviews in genetic toxicology. 1995; 339(1): 37-59.
Silva JP, Gomes AC and Coutinho OP. Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 cells. European journal of pharmacology. 2008; 601(1): 50-60.
Yuan L, Liu J, Zhen J, Cai C, Wang S and Xiao R. Serum collected from fruit and vegetable juice treated rats antagonizing H2O2-induced oxidative damage in PC12 cells. Journal of functional foods. 2016; 20: 496-505.
Chen W, Hu T and Liu Y. Protective effects of Ginkgo biloba leaves extract on peroxide-induced oxidative stress damage in PC12 cells. Neural regeneration research. 2007; 2(6): 369-371.
Shaerzadeh F, Ahmadiani A, Esmaeili MA, Ansari N and Khodagholi F. Protection of neuron-like PC12 cells from hydrogen peroxide-induced cytotoxicity by Salvia sahendica. Alzheimer's & dementia. 2010; 6(4): S390.
Olatunji OJ, Chen H and Zhou Y. Lycium chinensis Mill attenuates glutamate induced oxidative toxicity in PC12 cells by increasing antioxidant defense enzymes and down regulating ROS and Ca2+ generation. Neuroscience letters. 2016; 616: 111-118.
Koo BS, Lee WC, Chung KH, Ko JH and Kim CH. A water extract of Curcuma longa L.(Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells. Life sciences. 2004; 75(19): 2363-2375.
Yamada H, Arai T, Endo N, Yamashita K, Fukuda K, Sasada M and Uchiyama T. LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cells. Life sciences. 2006; 78(9): 926-933.
Franco R and Cidlowski J. Apoptosis and glutathione: beyond an antioxidant. Cell death & differentiation. 2009; 16(10): 1303-1314.
Oberley LW. Inhibition of tumor cell growth by overexpression of manganese-containing superoxide dismutase. Age. 1998; 21(2): 95-97.
彭心儀。西洋蓍草精油抗發炎及抗黑色素生成之機制探討。2012。靜宜大學食品營養學系博士論文。
Kovatcheva-Apostolova EG, Georgiev MI, Ilieva MP, Skibsted LH, Rødtjer A and Andersen ML. Extracts of plant cell cultures of Lavandula vera and Rosa damascena as sources of phenolic antioxidants for use in foods. European food research and technology. 2008; 227(4): 1243-1249.
Orhan I, Aslan S, Kartal M, Şener B and Başer KHC. Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food chemistry. 2008; 108(2): 663-668.
Fujimoto A, Shingai Y, Nakamura M, Maekawa T, Sone Y and Masuda T. A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol. Bioorganic & medicinal chemistry letters. 2010; 20(24): 7393-7396.
Oboh G, Agunloye OM, Akinyemi AJ, Ademiluyi AO and Adefegha SA. Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer’s disease and some pro-oxidant induced oxidative stress in rats’ brain-in vitro. Neurochemical research. 2013; 38(2): 413-419.
Falé PL, Borges C, Madeira PJA, Ascensão L, Araújo MEM, Florêncio MH and Serralheiro MLM. Rosmarinic acid, scutellarein 4′-methyl ether 7-O-glucuronide and (16S)-coleon E are the main compounds responsible for the antiacetylcholinesterase and antioxidant activity in herbal tea of Plectranthus barbatus (“falso boldo”). Food chemistry. 2009; 114(3): 798-805.
Costa P, Sarmento B, Gonçalves S and Romano A, Protective effects of Lavandula viridis L’Hér extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line. Industrial crops and products. 2013; 50: 361-365.
Ghaffari H, Venkataramana M, Ghassam BJ, Nayaka SC, Nataraju A, Geetha N and Prakash H. Rosmarinic acid mediated neuroprotective effects against H2O2-induced neuronal cell damage in N2A cells. Life sciences. 2014; 113(1): 7-13.
Crispo JA, Piché M, Ansell DR, Eibl JK, Tai IT, Kumar A, Ross GM and Tai T. Protective effects of methyl gallate on H2O2-induced apoptosis in PC12 cells. Biochemical and biophysical research communications. 2010; 393(4): 773-778.
Shokoohinia Y, Rashidi M, Hosseinzadeh L and Jelodarian Z. Quercetin-3-O-β-d-glucopyranoside, a dietary flavonoid, protects PC12 cells from H2O2-induced cytotoxicity through inhibition of reactive oxygen species. Food chemistry. 2015; 167: 162-167.
El Omri A, Han J, Yamada P, Kawada K, Abdrabbah MB and Isoda H, Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2. Journal of ethnopharmacology. 2010; 131(2): 451-458.