臺灣博碩士論文加值系統

現代人生活過於忙碌，因此常常造成超時晚睡、長期熬夜…等現象。而這些往往就是造成一般人的生理時鐘失調的主因，也就是所謂的生物節律失調，而這種現象會引起嚴重的睡眠障礙。相關研究指出，靜坐練習在生理、心理各方面皆有顯著的放鬆效果。本研究設計了一套可用以評估生物節律狀況的系統，讓使用者了解自我生物節律的失調情況及評估改善生物節律失調的方法。
本研究採用心電圖(ECG)、體表溫度(temperature)、心率(HR)、心率變異度(HRV)等多個生理參數，來評估與比較熬夜和靜坐對於生物節律影響的程度。實驗結果顯示，經常熬夜不僅對自律神經產生影響，對於生物節律的失調亦有一定程度的影響。靜坐練習能改善生物節律失調的現象，讓失調的現象能有一定程度的恢復。

In the modern time, because of the life is too busy, many people have the problems such as sleep too late and long-term stay up all night. These may cause the disorder of people’s biological clock, also known as circadian rhythm disorders, which may in turn cause serious sleep disorder. Related researches indicate that meditation practice may have apparent relaxation effects in physical and mental aspects. In this research, we designed an evaluation system for people’s circadian rhythm to provide the users to understand their self-circadian rhythm disorder and to evaluate the effects of the manners adopted to improve this situation.
In this research, we adopt multiple physiological parameters such as electrocardiogram (ECG), body temperature, heart rate (HR), heart rate variability (HRV), to evaluate the effects of meditation practice and sleep deprivation on circadian rhythm. The experimental results show that the sleep deprivation could not only affect the autonomic nervous system, but also may cause the disorder of circadian rhythm. Meditation practice can effectively
cause the recovery of the circadian rhythm disorder.

中文摘要...........................I
英文摘要...........................II
致謝...............................III
目?...............................IV
表目錄.............................VII
圖目錄.............................VIII
第一章 緒論
1.1研究動機與目的..........................................1
1.2文獻探討...............................................2
1.2.1生物節律失調之相關研究.................................2
1.2.2 靜坐數息之相關研究…..................................4
1.2.3 心律變易度之相關研究..................................5
1.2.4 加速度計與體溫之相關研究...............................7
1.3 論文架構...............................................9
第二章 生理訊號處理與分析
2.1 心電圖(ECG)訊號處理與分析..............................10
2.1.1心率變異度(Heart Rate Variability,HRV)...............11
2.1.2時域分析(Time domain analysis).......................12
2.1.3頻域分析(Frequency domain analysis)..................14
2.1.3.1 短時間訊號頻譜分析.................................15
2.1.3.2 長時間訊號頻譜分析.................................16
2.2 生物節律的判斷與分析...................................17
第三章 系統設計與測試
3.1系統架構...............................................19
3.2 硬體系統設計與測試.....................................20
3.2.1 硬體系統量測模組.....................................20
3.3 軟體系統設計...........................................22
3.3.1 系統取樣頻率.........................................22
3.3.2 訊號擷取程式.........................................23
3.3.3 訊號分析程式.........................................24
3.3.3.1 心電訊號分析程式....................................24
第四章 實驗流程與結果
4.1 實驗目的...............................................28
4.2 實驗流程架構...........................................28
4.3 受測者................................................29
4.3.1 睡眠型態偏好量表......................................29
4.3.2 靜坐數息法...........................................30
4.4 生理訊號量測位置........................................31
4.5 實驗流程與方法.........................................33
4.6 實驗結果與分析.........................................35
4.6.1 心電圖量測結果與分析..................................35
4.6.2 體溫量測結果與分析....................................43
4.6.3生物節律結果與分析.....................................45
第五章 討論
5.1 實驗結果討論...........................................51
5.2 實驗問題討論...........................................53
第六章 結論與未來展望
6.1 結論..................................................55
6.2 研究貢獻...............................................55
6.3 未來展望...............................................56
參考文獻...................................................57
附錄A 系統實體圖...........................................60
附錄B 中文版睡眠型態偏好量表.................................61
自述......................................................64

[1] 李宇宙(2005),失眠症的臨床評估與處置,台灣醫學,9(3),346-353。
[2] 張素珠(2002)。不同身體活動量與靜坐者睡眠品質之比較研究。臺灣師範大學體育學系在職進修碩士班，台北市。
[3] Zaguskina, S.S., Zaguskin, S.L.,and Gurov, Y.V. (2008). Circahoralian rhythms in assessment of heart rate variability. Bullrtin of Experimental Biology and Medicine, 146(2), 196-199.
[4] 蕭永薰、黃元中、何廷俊(1999),日夜節律與輪班工作,中華職業醫學雜誌6(2):63-72。
[5] Mari Y., Ken A., Yoshihiro S., Koichi I. and Tetsuo K.(2006). Exposure to Bright Light Modifies HRV Responses to Mental Tasks during Nocturnal Sleep Deprivation. J Physiol Anthropol, 25(2), 153–161.
[6] Janet M.M., Monika H., Maria T., Jorge M.S. and Hans K.M.(2009), Cardiovascular, Inflammatory, and Metabolic Consequences of Sleep Deprivation. Progress in Cardiovascular Diseases, 51(4), 294-302.
[7] Wallace, R.K.(1976). Physiological effects of transcendental meditation . Science 27 , 167(3926), 1751 – 1754.
[8] Tetsuya T.T.M., Toshihiko H., Masao O., Hirotaka K., Mitsuru K., Haruyoshi Y., et al.(2005). Changes in EEG and autonomic nervous activity during meditation and their association with personality traits. International Journal of Psychophysiology, 55(2), 199– 207.
[9] Sukanya P., Yongyuth P., Pakorn C., Chidchanok L.(2008). Changes in heart rate variability during concentration meditation. International Journal of Cardiology, 130(3), 481–484.
[10] Hendrik B., Wiegand K.H., Axel B., Nina K., Hugo A. Katus, Gert R. and Jurgen P.(2003). Circadian Profile of Cardiac Autonomic Nervous Modulation in Healthy Subject: Differing Effects of Aging and Gender on Heart Rate Variability. J Cardiovasc Electrophysiol, 14(8), 791-799.
[11] F. European Society Of Cardiology Task, P. North American Society Of,and Electrophysiology(1996), Heart rate variability: Standards of measurement, physiological interpretation, and clinical use, Circulation, 93(5), 1043-1065.
[12] Burger, A. J., Charlamb, M. and Sherman, H. B. (1999). Circadian patterns of heart rate variability in normals, chronic stable angina and diabetes mellitus. International Journal of Cardiology 71(4), 41–48.
[13] Hiroyuki I., Masahiko N., Toru M., Yoshikazu K. and Yasuo T.(2001). Shift work modifies the circadian patterns of heart rate variability in nurses. International Journal of Cardiology, 79, 231–236.
[14] Andrzej B. et al. (2005). Circadian rhythm of spectral indices of heart rate variability in healthy subjects. Journal of Electrocardiology, 38 (3), 239– 243.
[15] Kripke D.F. et al. (1978). Wrist actigraph measures of sleep and rhythms. Electroencephalogr Clin Neurophysiol , 44(5), 674-676.
[16] Bjorn B., Staile P.(2009). A practical approach to circadian rhythm sleep disorders A candidate of new index of the circadian system. Sleep Medicine Reviews, 13(1), 47-60.
[17] Makoto U., Masako O., Kayo S., Keiko K., Hirokuni T., Yoshihisa K., et al.(2000). Altered phase relation between sleep timing and core body temperature rhythm in delayed sleep phase syndrome and non-24-hour sleep-wake syndrome in humans. Neuroscience Letters, 294 (2) 101-104.
[18] J.A. Sarabia, M.A. Rol, P. Mendiola, J.A. Madrid.(2008). Circadian rhythm of wrist temperature in normal-living subjects. Physiology ＆ Behavior 95, 570–580.
[19] Lack, L.C., Gradisar, M., Eus J.W., Van S., Wright, H.R. and Kurt L.(2008). The relationship between insomnia and body temperatures. Sleep Medicine Reviews 12(4), 307–317.
[20] Horne, J.A. and Ostberg, O.(1976). A self-assessment questionnaire to determine morningness-eveningness in humam circadian rhythms. Int. J. Chronobiol, 4, 97-110.
[21] Horne, J.A. and Ostberg, O.(1978). Indifferences in human circadian rhythms. Biol Psychol 7, 29-35.
[22] Kerkhof G.(1985). Inter-individual differences in the human circadian system: A review. Biol Psychol 20(2), 83-112.
[23] Smith C.S., Reilly C. and Midkiff K.(1989). Ecaluation of three circadian rhythm questionnaires with suggestions for an improved measure of morningness. J Applied Psychology 74(5), 728-738.
[24] 惠汝生(2006) : LabVIEW 8.X圖控程式應用。台北市 : 全華科技圖書股份有限公司
[25] 劉建昇、游睿、張信豪(2006) : 數位訊號處理-LabVIEW ＆ 生醫訊號。台北縣 : 宏友圖書開發股份有限公司