臺灣博碩士論文加值系統

磁性材料應用於生物組織之熱療已有數十年之研究，其中磁奈米粒熱療加熱系統主要是利用直徑10到50奈米的氧化鐵（Fe3O4），將其放置於交變磁場下加熱至42 ℃以上，藉此達到殺死癌細胞，治療癌症的目的。磁奈米粒的加熱效果會受到顆粒大小、磁場大小與頻率的影響，在系統的設計上必須設計一套效率高、磁場輻射集中且可變頻的電磁加熱系統。本研究使用高速數位微控制器(TI TMS320F28235)做為數位控制系統的核心，以脈波寬度調變技術控制全橋串聯諧振電路，精確地控制交變磁場的輸出頻率與功率，並經由磁奈米加熱實驗，發現顆粒大小10 nm磁奈米粒對於295 kHz附近的感應頻率有較佳的升溫反應，升溫可達13 ℃。

The application of magnetic materials for hyperthermia of biological tissue has been studied for decades. The underlying notion of magnetic nanoparticle (MNP) thermotherapy is to utilize 10- to 50-nm diameter of ferric oxide (Fe3O4) which are heated up to 42 ℃ under AC magnetic field for cancer therapy applications. The size of nanoparticles and the strength and frequency of magnetic field all have influence to the heating efficiency of MNP. In order to achieve the goal of killing cancer cells using the AC magnetic field, we designed a digital controlled heating system to generate magnetic field that is frequency adjustable. The core of the system is based on a high speed microcontroller（TI TMS320F28235）and a full-bridge series resonant circuit for the high frequency induction heater. The heating results show that the system can produce fast and accurate outputs. The experiments show that the MNP produces thermal loss and has maximum temperature increase up to 13 ℃ under a AC magnetic field. Finally, we discuss the heating effect of different density of magnetic nanoparticles under different operating frequency.

摘 要 I
ABSTRACT II
誌謝 III
圖目錄 VII
表目錄 IX
第一章 緒論 1
1-1研究背景 1
1-2 國內外文獻回顧 2
1-3 研究動機與目的 4
1-4全文概述 4
第二章 感應加熱系統原理 5
2-1 感應加熱之基本原理 5
2-2 感應加熱基本特性 5
2-2-1 磁滯損失（Hysteresis Loss） 5
2-2-2 渦流損失（Eddy Current Loss） 6
2-2-3 集膚效應（Skin effect） 8
2-3 磁奈米加熱原理 9
第三章 系統設計 11
3-1 數位控制系統 11
3-1-1 系統架構 12
3-2控制核心TMS320F28235簡介 13
3-3 降壓型電路 15
3-3-1 導通模式 15
3-3-2 動作原理 16
3-3-3 降壓型閘極驅動電路 19
3-4 全橋串聯諧振電路架構與分析 20
3-4-1 全橋串聯諧振電路架構 20
3-4-2 全橋串聯諧振電路元件設計 21
3-4-3 全橋串聯諧振式電路操作模式 25
3-4-4 全橋驅動與隔離電路 30
3-5 系統軟體主程式架構 31
3-5-1 系統初始化 32
3-5-2 外部周邊模組 35
3-5-1 系統中斷服務副程式 42
第四章 實驗結果與討論 43
4-1前言 43
4-2系統電路測試 44
4-2-1 PWM控制訊號 44
4-2-2 全橋驅動訊號 45
4-3 諧振電路?數設定 46
4-4-1 加熱頻率與電流量測 47
4-4磁奈米粒感應加熱實驗 49
4-4-2 第一部份相同濃度不同頻率升溫實驗 49
4-4-3第二部分不同濃度與不同頻率加熱實驗 53
4-5 實驗結果與討論 54
第五章 結論與未來展望 56
5-1 結論 56
5-2 未來展望 57
參考文獻 58
自述 62

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