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Glycyrrhizae (GL), commonly called licorice, has been used
against gastric ulcers and other diseases in Europe and Asia
,and it still occupies an important place in traditional
Oriental medicine. Glycyrrhizic acid (GA), the main component
of GL have been extensively studied in relation to varied
biological activity such as anti-inflammatory activity, direct
and indirect antivival activity and interferon inducibility.
The effects of GL and GA on the survival rate of bone marrow
cells , the synthesis rate of DNA ,RNA and protein of murine
thymus ,testis and bone marrow cells after or before γ-ray
irradiation were investigated in this study. The method of
radioisotope incorporation is used to measure the synthetic
rate of DNA ,RNA and protein in thymus, testis and bone marrow
cells of mice. The present results showed that the relative
thymus and testis weight of irradiated mice decreased
significiently on the fifth day after γ-ray treatment. It
increased obviously on the 19th day with GA and GL treatment
respectively. The DNA synthesis recovered significiently on the
19th day after in GA and GL treatment. The results also showed
that the DNA, RNA and protein synthetic rates were recoveried
rapidly in GA or GL treated andγ-irradiated mice, compared to
the irradiation control.
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