臺灣博碩士論文加值系統

合成一系列 1-substituted 5-methyl-3-phenylfuro[3,2-c]
pyrazoles 類化合物(III1-11)及其中間體(II1-13)提供抗血小板活性
試驗。大部份的化合物對於膠原蛋白及花生四烯酸所引發的血小板凝集
反應具有顯著的活性。其中以 5-methyl-2-furyl phenyl keetone
3',4'-dichlorophenylhydrazone(II6)之活性最強,因而將此化合物提供
作藥理活性機轉之研究。在5-methyl-2-furyl phenyl ketone 4-
chlorophenylhydrazone 以 lead tetraacetate,boron trifluoride
etherate 氧化環化過程中發現副產物 p-chlorobiphenyl,故以 subs-
tituted phenyl hydrazine 與 benzene or toluene 在 lead tetra-
acetate 催化下可得到高產率之 biphenyl deratives,其應用性及確
實之反應機轉值得進一步的探討。

A series of 1-substituted 5-methyl-3-phenylfuro[3,2-c]
pyrazoles(III1-11) and its intermediates (II1-13) have been
synthesized,and evaluated for antipletelet activities.Most of
them showed significant effect on the inhibition of platelet
aggregation that induced by collagen and arachidonic acid.
Among them 5-methyl-2-furyl phenyl ketone 3',4'-dichlorophenyl
hydrazone (II6) was the most promising and therefore the action
mechanism of this compound was further studied.When 5-methyl-2
-furyl phenyl ketone 4-chlorophenylhydrazone treat with lead
tetraacetate,boron trifluoride etherate to carry out oxidative
cyclization,side product p-chlorobiphenyl also obtained.
Therefore we react substituted pphenylhydrazine with benzene
or toluene in the present of lead tetraacetate,we can obtain
high yield of biphenyl deratives.The application and the
really mechanism were worthy of further studied.