臺灣博碩士論文加值系統

本研究使用O/W型乳化添加非溶劑法製備水溶性藥物微膠囊。探討 藥物損
失之過程，並謀求改善藥物損失的方法，同時亦討論所製備 膠囊之特性
。實驗選擇茶葉鹼為核物質，乙基纖維素為殼物質，二氯眚J為溶劑,正己
烷為非溶劑。本實驗首先就藥物損失，發生於製備過程中的那一步驟加以
探討。揤篘蝯痕G顯示，藥物損失的95%發生在當包覆溶液倒入水溶液分散
介隢嶊?分鐘分散時間內。因此，為了改善藥物損失，可由改變包覆溶G
與水溶液分散介質兩者之性質加以著手。本研究嘗試下列6種方法加H探討
，在包覆溶液方面之改良有：(1)改變高分子溶液濃度，(2)包覆輔G中預
先添加非溶劑，(3)使用混合溶劑二氯甲烷及甲苯，在水溶液懂略飭銴霅
惜壯翵}有：(1)分散介質中預先添加非溶劑，(2)分散介質仆K加水溶性高
分子，(3)搭配兩種乳化劑。此外，並討論所製備微膠n之特性。由實驗結
果顯示，提高高分子溶液濃度、包覆溶液中預先添加非遝砥B增加混合溶
劑中甲苯量及分散介質中預先添加非溶劑皆可減少蘆奐l失。而分散介質
中添加水溶性高分子及搭配兩種乳化劑，對藥奐l失之改善則未有明顯效
果。由溶出試驗得知，隨著高分子溶液濃蚺尬W加、包覆溶液中預先添加
非溶劑量之增加、混合溶劑中甲苯量尬W加或分散介質中預先添加非溶劑
量之增加，微膠囊內藥物溶出之t率將隨之增快。而添加不同種類之水溶
性高分子於分散介質中，對騝L膠囊內藥物溶出速率則未有明顯的影響。
而不論由何種條件所製④孚L膠囊，其藥物溶出現象符合一階溶出模式及
Higuchi圓球形間質 溶出模式。

The preparation of ethylcellulose microcapsules
containingheophylline by using o/w emulsion nonsolvent-addition
phaseeparation method was developed. Dichloromethane-n-hexane
werehosen as solvent-nonsolvent system. The first stage of this
workas to determine the process of drug loss. In the second
stage ofhis work, some methods were proposed to reduce drug
loss. Theharacteristics of microcapsules prepared by these
methods werenvestigated. The results indicated that almost drug
loss happened in fiveinutes after coating solution was poured
into dispersion medium.he drug loss was reduced by increasing
the polymer concentration,y adding nonsolvent in coating
solution, by using mixed solventnd by adding nonsolvent in the
dispersion medium in advance. Theorphology of microcapsules
prepared by these methods was alsonfluenced. Dissolution
studies showed that the release rate ofheophylline from
microcapsules increased with the increase ofolymer
concentration, with the increase of the volume of ddition in
coating solution, with the increase of the volume ofoluene in
mixed solvent and with the increase of the volume ofonsolvent
in advance addition in dispersion medium. However, theelease
behavior of various ethylcellulose microcapsules fittedhe first
order release model and Higuchi matrix release model.