臺灣博碩士論文加值系統

背景：唾液腺腫瘤是頭頸部一罕見疾病，且其病因及風險尚不確定。肥胖已證實會增加許多不同器官組織罹患腫瘤的風險。唾液腺腫瘤是否會被肥胖風險影響仍具爭議性，故本研究的目的在探討並確立肥胖是否會增加罹患唾液腺腫瘤的風險。
方法：本研究以病例對照研究方法探討2005-2014年在三軍總醫院就診且年齡在35-65歲之間的病人，總個案數共有1845人，包含239個經由病理診斷為唾液腺腫瘤之住院病人為病例組，以及1606個於健檢中心作健康檢查的對象為對照組，病例組與對照組比例為1:7；並以危險對比值及95%信賴區間分析此資料中肥胖與罹患唾液腺腫瘤之相關性。
結果：在排除糖尿病病史後，針對唾液腺腫瘤病例組病人及對照組間分析比較中，校正性別、年齡、抽菸、喝酒及嚼檳榔變項後，與正常體重(BMI<25 kg/m2)相比，肥胖(BMI≥ 30 kg/m2)在女性唾液腺腫瘤病人(OR=4.76，95% CI:1.90- 11.92)、良性唾液腺腫瘤病人(OR=2.15，95% CI: 1.11- 4.18)，以及大唾液腺腫瘤病人(OR=2.07，95% CI:1.11- 3.85) 中發現肥胖之危險因子與罹患唾液腺腫瘤有顯著的正相關。
結論：本研究提出了肥胖危險因子可能與罹患唾液腺腫瘤有顯著的正相關證據，且此危險因子在女性，良性以及大唾液腺腫瘤病人中有統計之顯著意義。

關鍵字：唾液腺腫瘤、肥胖、身體質量指數。

Background: Salivary gland tumor (SGT) is a rare disease with a largely unknown etiology. High body-mass index (BMI) or obesity predispose to several site-specific tumor, but detailed characteristics of risk of salivary gland tumor has not previously been explored. We aimed to investigate the association between BMI and salivary gland tumor.
Methods: We conducted a case-control study of totally 1845 patients aged 35–65 years, including 239 patients with pathologcally proven salivary gland tumor and 1606 controls from health management center during 2005–2014 to examine the association between obesity and the risks of salivary gland tumors. The ratio of cases and controls is about 1:7. Odds ratios (OR) and their 95% confidence interval (CI) for the association of risk factors to salivary gland tumor were calculated.
RESULTS: In cases and controls with no diabetes group, compared with people with normal weight (BMI<25 kg/m2), obese (BMI ≥30 kg/m2) had an increased risk of women salivary gland tumor (adjusted OR =4.76, 95% CI: 1.90- 11.92), benign salivary gland tumor subgroup (OR=2.15, 95% CI: 1.11- 4.18), and major salivary gland rumor subgroup (OR=2.07, 95% CI: 1.11- 3.85).
CONCLUSION: This study provides evidence that obesity is positively associated with the risk of salivary gland tumor, especially in female, benign, and major salivary gland tumor subgroup.

KEY WORDS: obesity, salivary gland tumor, body mass index.

表目錄 I
圖目錄 II
摘要 III
第一章 緒論 1
第一節 研究背景 1
第二節 研究動機 6
第三節 研究目的 7
第二章 文獻探討 8
第一節 唾液腺腫瘤 8
第二節 肥胖 12
第三節 肥胖之相關疾病及腫瘤 18
第四節 肥胖與唾液腺癌症之關係 26
第三章 研究方法 29
第一節 研究對象與研究假設 29
第二節 人口基本資料及危險因子收集 31
第三節 研究變項與定義 33
第四節 研究材料與方法 34
第四章 研究結果 35
第一節 唾液腺腫瘤病例組與對照組之描述性統計 35
第二節 男性與女性唾液腺腫瘤病例組之描述性統計 41
第三節 唾液腺腫瘤在有無糖尿病中之風險 54
第五章 討論 64
第一節 資料特性 64
第二節 唾液腺腫瘤與肥胖之關係 67
第三節 唾液腺腫瘤與糖尿病之關係 73
第四節 研究限制 74
第六章 結論及建議 77
參考文獻 78

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