臺灣博碩士論文加值系統

中文摘要
合成一系列Alkylfurochromone類化合物，並以FMLP 誘導的嗜中性球去顆
粒作用 (Neutrophil degranulation)、 FMLP 誘導的嗜中性球過氧化物
生成作用(Neutrophil superoxide formation)及PMA 誘導的嗜中性球過
氧化物生成作用(Neutrophil superoxide formation)等三種作用的抑制
百分率強度來測量其抗過敏活性。 結果以
Ethyl furo[2,3-b]chromone-2-carboxylate ( 13 ) 對FMLP 誘導的嗜中
性球去顆粒作用 (Neutrophil degranulation)抑制活性較佳、而以
Ethyl 6-Methylfuro [2,3-b]chromone-2-carboxylate ( 16 )對FMLP 誘
導的嗜中性球過氧化物生成作用(Neutrophil superoxide formation)抑
制活性較佳、而對PMA 誘導的嗜中性球過氧化物生成作用(Neutrophil
superoxide formation)則都不具明顯活性。

SUMMARY A series of alkylfurochromones
have been synthesized.Their antiallergic activity are measured
by inhibiting percentage-strength of three actionswhich are
FMLP-induced neutrophil degranulation , FMLP-induced neutrophil
superoxide formation , and PMA-induced neutrophil superoxide
formation . The inhibitory
activity of Ethyl furo[2,3-b]chromone-2-carboxylate( 13 ) is
significant to FMLP-induced neutrophil degranulation , and the
inhibitory activity
of Ethyl 6- methylfuro[2,3-b]chromone-2-carboxylate ( 16 ) is
significant to FMLP-induced neutrophil superoxide formation
.However, all these compounds have no significant effect to PMA-
induced neutrophilsuperoxide formation .