臺灣博碩士論文加值系統

本研究旨在探討三週肉鹼增補搭配高強度間歇訓練對有氧能力與氧化壓力之影響。研究以10名無規律運動習慣的健康男性為對象，將實驗參與者隨機分為肉鹼組 (25.0±4.4歲、80.3±8.5公斤、170.2±4.3公分) 及安慰劑組 (22.4±3.3歲、69.1±11.2公斤、172.2±6.3公分)，每組5人。實驗參與者接受每日2克的肉鹼或安慰劑增補，持續3週；增補期間並以腳踏車進行每週3次、每次10回合、運動強度為90% VO2max、運動期2分鐘、恢復期1分鐘的高強度間歇訓練。在補充前、後各進行1次漸增強度運動測試至力竭以測量VO2max及運動至力竭時間；48小時後進行高強度間歇運動測試，於測試前、測試後立即、測試後1小時、3小時採血以測量肌酸激酶 (creatine kinase, CK) 及尿酸、硫化巴比妥酸反應物 (thiobarbituric acid reactive substances, TBARS)、前列腺素烷族 (F2-isoprostanes)。結果顯示，肉鹼組3週訓練後之最大攝氧量與運動至力竭時間分別為 (43.0±2.4 vs. 37.6±5.0 mL/min/kg) 及 (1563.0±221.0 vs. 1496.0±207.6 秒，p < .05) 均有顯著增加，安慰劑組則無差異。此外，肉鹼組在補充前的高強度間歇測試後之尿酸值、TBARS、F2-isoprostanes在運動後3小時仍顯著高於運動前，分別為 (7.8±2.0 vs. 8.8±2.1 mg/dL，p < .05) 及 (5.7±0.8 vs. 4.2±0.7 µmol/L，p < .05) 及 (1328.4±67.5 vs. 1135.5±156.4 pg/mL，p < .05)，但經3週的補充後高強度間歇測試後1、3小時的尿酸都顯著低於補充前 (p < .05)。本研究發現在安慰劑組有氧能力未提升的狀況下，肉鹼增補有提升有氧能力的效益，但氧化壓力指標有個別差異，結果並無改善的效益。

The purpose of this study was to investigate the effects of three weeks of carnitine supplementation and HIT combination on aerobic capacity and oxidative stress. Ten untrained healthy males were recruited and randomly assigned into carnitine group (25.0±4.4 yr, 80.3±8.5 kg, 170.2±4.3 cm) or placebo group (22.4±3.3 yr, 69.1±11.2 kg, 172.2±6.3 cm). Subjects received carnitine or placebo supplementation 2 g per day for 3 weeks. All subjects also performed the HIT three day per week. The HIT protocol contains 10 bouts of cycling trail at 90%VO2max, with each bout lasting 2 min and separated by 1 min of rest. The increment cycling tests were conducted before and after supplementation. The VO2max and time to fatigue were measured by the increment cycling test. High-intensity interval exercise tests were also performed 48 hours after the increment cycling test. Blood samples were drawn before the test, immediately after test, 1 h and 3 h after test to determine the activities or concentrations of creatine kinase (CK) and uric acid, TBARS,F2-isoprostanes. The result showed that after 3 week of supplementation, VO2max (43.0±2.4 vs. 37.6±5.0 mL/min/kg) and time to fatigue (1563.0±221.0 vs. 1496.0±207.6 sec) significantly increased (p < .05) in carnitine group. However, there were no differences in placebo group. In carnitine group, the values of blood uric acid in high-intensity interval exercise test before supplementation still elevated at 3 h after test (7.8±2.0 vs. 8.8±2.1 mg/dL, p < .05). However, the values returned to baseline after 3 weeks of supplementation (7.8±1.9 vs. 7.7±1.9 mg/dL, p >.05) and uric acid at 1 and 3 hr after test were significantly lower than pre- supplementation (p <.05). In carnitine group, the values of blood TBARS after high-intensity interval exercise test before supplementation significantly elevated as compared to baseline (5.7±0.8 vs. 4.2±0.7 µmol/L，p < .05). However, there were no significant differences after 3 weeks of supplementation (4.6±1.7 vs. 4.3±0.9 mg/dL，p > .05) and TBARS concentrations at post 3 hr after exercise were significantly lower than pre- supplementation (p <.05). In carnitine group, the values of blood F2-isoprostanes in high-intensity interval exercise test before supplementation significantly increased immediately after test, (1328.4±67.5 vs. 1135.5±156.4 pg/ml，p < .05). However, the values returned to baseline after 3 weeks of supplementation (1217.5±235.0 vs. 1179.4±174.2 pg/mL，p > .05) and F2-isoprostanes concentrations immediately after test, at 1 and 3 hr after test were significantly lower than pre- supplementation (p <.05). It is concluded that carnitine supplementation during HIT is benefit to aerobic capacity and reduce the oxidative stress after high-intensity interval exercise.

目 錄

中文摘要 I
英文摘要 II
謝 誌 IV
表 目 錄 VII
圖 目 錄 VIII
第壹章 緒論 1
第一節 研究背景 1
第二節 研究目的 3
第貳章 文獻探討 4
第一節 肉鹼 4
第二節 高強度間歇訓練的效果與氧化壓力 10
第三節 文獻小結 12
第參章 研究方法與步驟 13
第一節 研究對象 13
第二節 實驗設計與步驟 14
第三節 資料處理 20
第肆章 結果 21
第一節 肉鹼增補對高強度間歇訓練後有氧能力的變化 22
第二節 肉鹼增補對高強度間歇訓練後氧化壓力的變化 23
第伍章 討論 25
第一節 有氧能力 25
第二節 氧化壓力 26
第陸章 結論與建議 27
參考文獻 28
中文部分 28
外文部分 28

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