臺灣博碩士論文加值系統

多年來，乳酸菌早已被視為擁有多種功效之益生菌，其中主要有維持腸道菌相、降低乳糖不耐症、降血壓、降血脂、抗癌、抗發炎及調節免疫力等，是廣受人們喜愛的保健食品。比菲德氏菌為乳酸菌家族之一，為剛出生之幼兒腸道中的最大菌群，在各項研究中發現，其在腸道中的菌量與人們壽命成正比的關係，越長壽者，其比菲德氏菌比例越高。比菲德氏菌作為益生菌，主要功能在於治療腹瀉、維持腸道菌相和對抗有害菌等。在免疫方面雖已有實驗證實其功效，但普遍研究發現其調節免疫之能力並不特別彰顯，故本實驗目的為選用已在體外試驗中，篩出調節免疫能力較佳之比菲德氏菌，進一步以動物試驗測試其在體內之反應，以開發有強力調節免疫能力之菌株。本實驗是探討以高、中、低三種劑量之比菲德氏菌，餵食Der p致敏之BALB/c小鼠，對脾臟細胞之增生、分泌之細胞激素以及血清中特異性免疫球蛋白含量之影響。結果發現，只有以ConA刺激之Medium dose組的脾臟細胞有顯著性的增生；High及Mediumn dose組皆可刺激IFN-γ顯著的上升，且降低IL-4之分泌，對IL-10、IL17則沒有影響，IFN-γ/IL-4之比值亦明顯的提升，使免疫反應導向Th1；特異性免疫球蛋白的試驗中，三種劑量皆顯著降低特異性IgE，High dose組可顯著降低特異性IgG1。由以上結果顯示，Bifidobacterium longum subsp. infants GB-1640 有調節塵蟎致敏小鼠免疫反應之能力。

Over the years, lactic acid bacteria have long been regarded as the effectiveness of probiotics, which can maintain of intestinal microflora, reduce lactose intolerance, blood pressure, blood fats, anti-cancer, anti-inflammation and regulate the immune system. It is kind of functional food is widely liked by people. Bifidobacterium, is belong to lacitic acid bacteria family and the greatest microflora in the infant gut. In the studies found that the population of Bifidobacterium in the gut is associated with the life span of the host, and the more longevity, the higher proportion of this bacteria.The main function of Bifidobacterium is to treat diarrhea, maintain intestinal microbial homeostasis and protect against harmful intestinal bacteria colonizing. Although there have confirmed their effectiveness in the immune experiments , but generally found that their ability to regulate immunity is not particularly powerful.The previous experiments has been shown that Bifidobacterium longum supsp. infants. GB-1496 had best capacity to modulate immunity in vitro. Therefore, further investigations on regulation of immune responses in murine model in vivo. In the present studies, we fed the Der p-sensitized BALB/c mice on high (3.0*107 cfu/per mice) , medium (9*107 cfu/per mice) and low (3.0*106 cfu/per mice) dose. The proliferation of splenocyte, cytokines secreted by splenocyte (IFN-γ, IL-4, IL-10 and IL-17) , and specific immunoglobulin in serum were measured. The results showed that only medium dose group stimulated by ConA had significant enhance proliferation of splenocyte; high and mediumn dose group can significantly increase the production of IFN-γ, reduced the secretion of IL-4 and no effect of IL-10 and IL-17; IFN-γ/IL-4 ratio is also significantly improved, so that the immune response directed Th1; specific immunoglobulin trial, three doses were significantly lower specific IgE, and High dose can down regular specific IgG1. These results showed that Bifidobacterium longum subsp. infants GB-1640. had ability to modulate in mite allergen-sensitize mice.

目次
中文摘要 i
Abstract iii
目次 v
圖目次 ix
表目次 xi
符號縮寫表 xii
第一章 前言 1
第二章 文獻整理 3
一、乳酸菌 3
(一) 乳酸菌之概述 3
(二) 乳酸菌之功效 4
二、過敏疾病 (allergy) 7
(一) 過敏反應 (hypersensitivity reacion) 7
三、家蟎 (House dust mite; HDM) 過敏原 11
四、比菲德氏菌 11
(一) 比菲德氏菌之概述 12
(二) 比菲德氏菌之免疫功效 13
第三章 實驗目的 17
第四章 材料與方法 19
一、實驗材料 19
(一) 實驗動物 19
(二) 實驗菌株 19
(三) 藥品 19
(四) 儀器 20
(五) 試劑 21
(六) 溶液之配製 21
二、實驗方法 23
(一) 動物實驗 23
(二)Der p粗萃物之製備 23
(三) Der p致敏 23
(四) 小鼠呼吸道阻力測試 25
(五) 支氣管肺沖堤液 (BALF) 25
(六) 脾臟細胞之製備 25
(七) ELISA 測試 IFN-g、IL-4 、IL-10和IL-17 26
(八) ELISA 測試total IgE 27
(九) ELISA 測試特異性 IgE、IgG1、IgG2a 27
(十) 細胞增生測試 28
(十一) 統計分析 29
第五章 結果 30
一、餵食比菲德氏菌粉對於BALB/c小鼠的體重變化 30
二、餵食比菲德氏菌粉對於BALB/c小鼠肺功能之影響。 30
三、肺沖堤液之細胞激素含量分析 30
四、餵食比菲德氏菌對於BALB/c小鼠脾臟增生之影響 31
五、餵食比菲德氏菌對BALB/c小鼠脾臟細胞分泌細胞激素之影響 31
(一) IFN-g 31
(二) IL-4 32
(三) IL-10 32
(四) IL-17 33
六、餵食比菲德氏菌對BALB/c小鼠血清中免疫球蛋白含量之影響 33
(一) Total IgE 33
(二) 特異性免疫球蛋白 34
第六章 討論 35
一、餵食比菲德氏菌對 BALB/c 小鼠脾臟細胞分泌細胞激素之影響 36
二、餵食比菲德氏菌對於BALB/c小鼠血清中特異性抗體產生之影響 42
三、餵食比菲德氏菌對於BALB/c小鼠呼吸道發炎之影響 44
第七章 結論 45
參考文獻 57

圖目次
圖2-1 CD+4 T細胞之功能 ‎ 10
圖2-2 腸道菌相隨者年齡的改變 13
圖6-1、IFN-g 調控輔助型 T 細胞及過敏之反應 41
圖5-1、BALB/c小鼠在餵食期間體重之變化 46
圖5-2、餵食B. logum supsp. infantis GB-1496對於以Der p呼吸道致敏後之BALB/c小鼠，其肺功能對methacholine之敏感度測試 47
圖5-3、餵食B. logum supsp. infantis GB-1496對於小鼠肺沖堤液中細胞激素含量之影響 48
圖5-4、餵食比菲德氏菌對 Der p 致敏 BALB/c 小鼠脾臟細胞增生之影響 49
圖5-5、餵食B. logum supsp. infantis GB-1496對於小鼠脾臟細胞分泌IFN-g之影響 50
圖5-6、餵食B. logum supsp. infantis GB-1496對於小鼠脾臟細胞分泌IL-4之影響 51
圖5-7、餵食B. logum supsp. infantis GB-1496對於小鼠脾臟細胞分泌IL-10之影響 52
圖5-8、餵食B. logum supsp. infantis GB-1496對於小鼠脾臟細胞分泌 IL-17之影響 53
圖5-9、餵食B. logum supsp. infantis GB-1496對於小鼠血清中total IgE含量之影響 54
圖5-10、餵食B. logum supsp. infantis GB-1496對於Der p致敏小鼠血清中特異性免疫球蛋白含量之影響 55
圖5-11、餵食B. logum supsp. infantis GB-1496對於以Der p呼吸道致敏後小鼠血清中特異性免疫球蛋白含量之影響 56

表目次
表6-1、適應性免疫反應相關之細胞激素 40

Ahrne, S., Nobaek, S., Jeppsson, B., Adlerberth, I., Wold, A. E. and Molin, G. . (1998)."The normal Lactobacillus flora of healthy human rectal and oral mucosa." Journal of Applied Microbiology 85:88–94.
Akdis, M., Verhagen, J., Taylor, A., Karamloo, F., Karagiannidis, C.,Crameri, R., Thunberg, S., Deniz, G. et al. . (2004) "Immune responses in healthy and allergic individuals are characterized by a fine balance betweenallergen-specific T regulatory 1 and T helper 2 cells. "The Journal of Experimental Medicine. 199: 567–1575.Andresen, V. and Baumgart, D. C. . (2006) "Role of probiotics in the treatment of irritable bowel syndrome: potential mechanisms and current clinical evidence." International Journal of Probiotics and Prebiotics 1:11-18.
Arboleya, S., Ruas-Madiedo, P., Margolles, A., Solis, G., Salminen, S.,Reyes-Gavilan, C. G. and Gueimonde, M. . (2010)."Characterization and in vitro properties of potentially probiotic Bifidobacterium strains isolated from breast-milk." International Journal of Food Microbiology 9.
Baroutkoub, A., Mehdi, R. Z., Beglarian, R., Hassan, J., Zahra, S., Mohammad, M. S. and Mohammad, M. S. . (2010). "Effects of probiotic yoghurt consumption on the serum cholesterol levels in hypercholestromic cases in Shiraz, Southern Iran." Scientific
Research and Essays 5(16): 206-209.
Barton, G. M. and Kanga, J. C. (2009). "A cell biological view of Toll-like receptor function: 8 regulation through compartmentalization." Nature Reviews Immunology 9: 535-542.
Beasley, R. . (1998). "Worldwide variation in prevalenceof symptoms of asthma, allergic rhinoconjunctivitis,and atopic eczema." ISAAC Lancet. 351: 1225–1232.
Bellinghausen, I., Konig, B., Bottcher, I., Knop, J. and Saloga, J. . (2006). "Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin-10-treated dendritic cells and transforming growth factor-b for their induction." Clinical and Experimental Allergy 36: 1546-1555.
Brandtzaeg, P. (2010). "Food allergy: separating the science from the mythology." Nature Reviews Gastroenterology and Hepatology 7: 380-400.
Brandtzaeg, P., Kiyono, H., Pabst, R. and Russell, M. W. . (2008). "Terminology: nomenclature of mucosa-associated lymphoid tissue." Mucosal Immunology 1(1): 31-37.
Casanova, J. L. and Abel, L. . (2004). "The human model: a genetic dissection of immunity to infection in natural conditions." NatureReviews Immunology 4: 55-66.
Cheona, S., Leeb, K. W., Kima, K. E., Parkc, J. K., Parka, S., Kimc, C., Kimd, D., Leeb, H. J. and Chena, D. C. . (2010). "Heat-killed Lactobacillus acidophilus La205 enhances NK cell cytotoxicity through increased granule exocytosis." Immunology Letters 2(136): 171-176.
Chua, K. Y. and Dilworth, R. J. . (1990). "Expression of Dermatophagoides pteronyssinus allergen, Der p II, in Escherichia coli and the binding studies with human IgE." International Archives of Allergy & Applied Immunology 91(2): 124-129.
Ciprandi, G., Tosca, M. A. and Marseglia, G. L. . (2009). "Sublingual immunotherapy mechanisms of action: the role of Th1 response." International Journal of Immunopathology and Pharmacology 4(22):9-12.
Clements, M. L., Levine, M. M. and Black, R. E. . (1981). "Lactobacillus prophylaxis for diarrhea due to enterotoxigenic Escherichia coli. ." Antimicrob Agents Chemother 20: 104-108.
Coffman, R. L. and Carty, J. (1986) ." A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-g."The Journal of Immunology 36: 949-54.
Corthesy, B., Gaskins, H. R.and Mercenier, A. .(2007). "Cross-Talk between Probiotic Bacteria and the Host Immune System." The journal of nutrition 137: 781-790.
de Jong, E. C., Smits, H. H. and Kapsenberg, M. L. . (2005). "Dendritic cell-mediated T cell polarization." Springer Seminars in Immunopathology 26: 289–307.
de Moreno de Leblanc, A. and P., G. . (2010). "The application of probiotic fermented milks in cancer and intestinal inflammation." Proceedings of the Nutrition Society 69(3): 421-428.
Donkora, O. H., Henrikssonb, A., Singhc, T. K.,Vasiljevica, T. and Shaha, N. T. . (2007). "ACE-inhibitory activity of probiotic yoghurt." International Dairy Journal 17: 1321–1331.
Elias, J. A., Lee, C. G., Zheng, T., Ma, B., Homer, R. J. and Zhu, Z. . (2003)."New insights into the pathogenesis of asthma." The jouranl of clinical investigation 3(111): 291–297.
Fan, Y. J., Chen, S. J., Yu, Y. C., Si, J. M. and Liu, B. . (2006). "A probiotic treatment containing Lactobacillus, Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial." Journal of Zhejiang University science 12(7): 987-991.
Fantuzzi, L., Puddu, P., Varano, B., del Corno, M., Belardelli, F. and Gessani, S. . (2000). "IFN-α and IL-18 exert opposite regulatory effects on the IL-12 receptor expression and IL-12-induced IFN-γ production in mouse macrophages: novel pathways in the regulation of the inflammatory response of macrophages " Journal of Leukocyte Biology 68: 707-714.
Frank, O. N. and Curdin, C. . (2004). "The IL-12 Family Member p40 Chain as a Master Switch and Novel Therapeutic Target in Psoriasis." Journal of Investigative Dermatology 123: 1037-1038.
Gagnon, M., Kheadr, E. E., Dabour, N., Richard, D. and Fliss, I. . (2006). "Effect of Bifidobacterium thermacidophilum probiotic feeding on enterohemorrhagic Escherichia coli O157:H7 infection in BALB/c mice." International Journal of Food Microbiology 1(111): 26-33.
Gajewski, T. F. and Fitch., F. W. . (1988). "Anti-proliferative effect ofIFN-g in immune regulation I. IFN-g inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones." The Journal of immunology 140: 4245-4252.
Ghadimi, D., de Vrese, M., Heller, K. J. and Schrezenmeir, J. . (2010). "Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-gamma) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen." International Immunopharmacology 10(6): 694-706
Goncharova, G. I., Semenova, L. P., Liannaia, A. M., Kozlova, E. P and Donskikh, E. E. . (1987). "Human Bifidobacterium flora, its normalizing and protective functions." Antibiot Med Biotekhnol 32(3): 179-183.
Gronlund, M. M., Arvilommi, H., Kero, P., Lehtonen, O. P and Isolauri, E. . (2000). "Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0-6 months." British Medical Journal 3(83): 186-192.
Hasbold, J., J. S. Hong, et al. (1999). "Integrating signals from IFN-gamma and IL-4 by B cells: positive and negative effects on CD40 ligand-induced proliferation, survival, and division-linked isotype switching to IgG1, IgE, and IgG2a." The Journal of Immunology 163(8): 4175-4181.
He, F., Ouwehand, A. C., Isolauri, E., Hosoda, M., Benno, Y. and Salminen, S. . (2001). "Differences in composition and mucosal adhesion of bifidobacteria isolated from healthy adults and healthy seniors." Current Microbiology 43(5): 351-354.
Herias, M. V., Midtvedt, T., Hanson, L. A. and Wold, A. E. . (1998). "Increased antibody production against gut-colonizing Escherichia coli in the presence of the anaerobic bacterium Peptostreptococcus." Scandinavian Journal of Immunology 48: 277-282.
Hirata, H., Arima, M. and Yukawa, T. . (2000). "Effect of rush immunotherapy (RIT) on cytokine production in hymenoptera allergy." Dokkyo journal of medical sciences 1(27): 27–40.
Hoarau, C., Lagaraine, C., Martin, L., Velge-Roussel, F. and Lebranchu, Y. . (2006). "Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway." Journal of Allergy and Clinical Immunology 117(3): 696-702.
Holgate, S. T. and Polosa., R. . (2008). "Treatment strategies for allergy and asthma." Nature Reviews Immunology 8: 218-230.
Horinaka, M., Yoshida, T., Kish,i A., Akatani, K., Yasuda, T., Kouhara, J., Wakada, M. and Sakai, T. . (2010). "Lactobacillus strains induce TRAIL production and facilitate natural killer activity against cancer cells." FEBS Letters 584(3): 577-582
Hougee, S., Vriesema, A. J., Wijering, S. C., Knippels, L. M., Folkerts, G., Nijkamp, F. P., Knol, J. and Garssen, J. . (2010). "Oral Treatment with Probiotics Reduces Allergic Symptoms in Ovalbumi-Sensitized Mice: A Bacterial Strain Comparative Study."
International Archives of Allergy and Immunology 151: 107-117.
Ibrahim, S. A., Dharmavaram, S. R., Seo, C. W and Shahbazi, G. . (2001). "Antimicrobial Activity of Bifidobacterium longum (NCFB 2259) as Influenced by Spices." Internet Journal of Food Safety 2: 6-8.
Imaoka, A., Shima, T., Kato, K., Mizuno, S., Uehara, T., Matsumoto, S.,Setoyama, H., Hara, T., Umesaki, Y. . (2008). "Anti-inflammatory activity of probiotic Bifidobacterium: 50 enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis 51 patients and inhibition of IL-8 secretion in HT-29 cells." World Journal Gastroenterol 14: 2511-2516.
Inoue, Y., Iwabuchi, N., Xiao, J. Z., Yaeshima, T. and Iwatsuki, K. . (2009). "Suppressive Effects of Bifidobacterium breve Strain M-16V on T-Helper Type 2 Immune Responses in a Murine Model." Biological and Pharmaceutical Bulletin 4(32): 760—763.
Ishibashi, N., Yaeshima, T. and Hayasawa, H. . (1997). "Bifidobacteria: their significance in human intestinal health." Malaysian Journal of Nutrition 3: 149-159.
James, S. W., Anastasia, S., Nilanjana, S., Mohammed, S. S., Rafeul, A., Masashi, K. and Sanjiv, S. . (2000). "IFN-γ-Inducing Factor (IL-18) Increases Allergic Sensitization, Serum IgE, Th2 Cytokines, and Airway Eosinophilia in a Mouse Model of Allergic Asthma." The Journal of Immunology 164: 2701-2710.
Johnson, A. C., B. Greenwood-Van Meerveld, et al. (2011). "Effects of Bifidobacterium infantis 35624 on Post-Inflammatory Visceral Hypersensitivity in the Rat." Digestive Diseases and Sciences.
Jones, S. E. and Versalovic., J. . (2009). "Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors." BMC Microbiology 9(35): 1471-2180.
Jutel, M., Akdis, M., Blaser, K. and Akdis, C. A. . (2006). "Mechanisms of allergen specific immunotherapy -T-cell tolerance and more." European Journal of Allergy and Clinical Immunology 61: 96–807.
Kawano, Y., Noma, T. and Yata, J. . (1999). "Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2 " The Journal of Immunology 163: 4175-4181.
Kindt, S., and Tack, J. (2006). Impaired gastric accommodation and its role in dyspepsia. Gut 55, 1685-1691.
Kim, D. W., Cho, S. B., Lee, H. J., Chung, W. T., Kim, K. H., Hwangbo, J., Nam, I. S., Cho, Y. I., Yang, M. P. and Chung, I. B. . (2007). "Comparison of cytokine and nitric oxide induction in murine macrophages between whole cell and enzymatically digested Bifidobacterium sp. obtained from monogastric animals." The Journal of microbiology 4(45): 305-310.
Kim, H., Lee, S. Y. and Ji, G. E. . (2005). "Timing of Bifidobacterium administration influences the development of allergy to ovalbumin in mice." Biotechnology Letters(27): 1361–1367.
Kim, J. Y., Young, O. C. and Geun, E. J. . (2008). "Effect of Oral Probiotics (Bifidobacterium lactis AD011 and Lactobacillus acidophilus AD031) Administration on Ovalbumin-Induced Food Allergy Mouse Model." Journal of Microbiology and Biotechnology 8(18): 1393–1400.
Kolls, J. K. and Linden, A., (2004) "Interleukin-17 family members and inflammation." Immunity 21: 467-476.Lassila, O. (1989). " Emigration of B cells from chicken bursa of
Fabricius." European Journal of Immunology 19: 955-958.
Lebeer, S., Vanderleyden, J. and de Keersmaecker, S. C. J. . (2010). "Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens." Nature Reviews Microbiology 8:171-184.
Li, Y., Qu, X., Yang, H., Kang, L., Xu, Y., Bai, B. and Song, W. . (2005). "Bifidobacteria DNA Induces Murine Macrophages Activation in vitro." Cellular and Molecular Immunology 6(2): 473-478.
Lighvani, A. A., Frucht, D. M., Jankovic, D., Yamane, H., Aliberti, J., Hissong, B. D., Nguyen, B. V., Gadina, M., Sher, A., Paul, W. E. and O''Shea, J. J. . (2001). "T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells." Proceedings of the National Academy of Sciences 26(98): 15137-15142.
Lim, L.H., Li, H.Y., Huang, C.H., Lee, B.W., Lee, Y.K., and Chua, K.Y. (2009). The effects of heat-killed wild-type Lactobacillus casei Shirota on allergic immune responses in an allergy mouse model. International Archives of Allergy & Applied Immunology.148: 297-304.
Linneberg, A. (2008) . "Increase in allergy: a global challenge. " Drugs Today (Barc) 44:5-10.
Lopez-Moreno, H. S. (2002). "Cestodiasis tisulares: participacion de los linfocitos T cooperadores 1 y 2." Salud Publica de Mexico 44(2): 145-152.
Lyons, A., Mahony, D. O.,Brien, F. O., MacSharry, J., Sheil1, B., Ceddia3, M., Russell, W. M., Forsythe, P. J., Bienenstock, P., Kiely, B., Shanahan, F. and Mahony, L. O. . (2010). "Bacterial strain-specific induction of Foxp3+ T regulatory cells is protective in murine allergy models." Clinical and Experimental Allergy 40: 811–819.
Matsuguchi, T., Takagi, A., Matsuzaki, T., Nagaoka, M., Ishikawa, K., Yokokura, T. and Yoshikai, Y. . (2003). "Lipoteichoic Acids from Lactobacillus Strains Elicit Strong Tumor Necrosis Factor Alpha-Inducing Activities in Macrophages through Toll-Like Receptor 2." Clinical and Diagnostic Laboratory Immunology 2(10): 259–266.
Matsuzaki, T. and Chin, J. . (2000). Modulating immune responses with probiotic bacteria. Immunology and Cell Biology. 78: 67–73.
Miller, L. G. and Finegold, S. M. . (1967). "Antibacterial Sensitivity of BfiJdobacterium (Lactobacillus bifidus)." Journal of Bacteriology 93(1): 125-130.
Mitsuoka, T. (1990). "Bifidobacteria and their role in human health." Journal of Industrial Microbiology and Biotechnology 6(4): 263–267.
Mitsuoka, T. and Kameuchi, C. . (1977). "Ecology of bifidobacteria." The American Journal of Clinical Nutrition 30: 1799–1810.
Mitsuoka, T., Y. Benno, et al. (1978). "Characterization of Propionibacterium acnes isolated from biopsy specimens obtained from patients with sarcoidosis." The Tohoku Journal of Experimental Medicine 48(3): 275-277.
Mombelli, B. and Gismondo, M. R. (2000). “The use of probiotics in medical practice.” International Journal of Antimicrobial Agents 16 (4): 531-536.
Mosmann, T. R. and Coffman, R. L. . (1989). "ThI and Th2 cells: different patterns of lymphokine secretion lead to different functional properties." Annual Review of Immunology 7: 145-173.
Nguyen, T. D., Kang, J. H. and Lee, M. S. . (2007). "Characterization of Lactobacillus plantarum PH04, a potential probiotic bacterium with cholesterol-lowering effects." International Journal of Food Microbiology 113: 358 - 361.
Orla-Jensen, S. (1924). ”La classification des batterieslactiques.” Lait 4:468-474.
O''Neill, L. A. and Bowie, A. G. . (2007). "The family of five: TIR-domain-containing adaptors in 47 Toll-like receptor signalling." Nature Reviews Immunology 7: 353-364.
Palomares, O., Yaman, G., Azkur, A. K., Akkoc, T., Akdis, M. and Akdis, C. A. . (2010). "Role of Treg in immune regulation of allergic diseases." European Journal of Immunology 40: 1232–1240.
Papadimitrioua, C. G., Vafopoulou-Mastrojiannakia, A., Silvab, S. V., Gomesb, A. M., Malcatab, X. F., and Alichanidis, E. . (2007). "Identification of peptides in traditional and probioticnext term sheep milk previous termyoghurtnext term with angiotensin I-converting enzyme (previous term ACE)-inhibitory activitynext term." Food Chemistry 105(2): 647-656
Parvez, S., Malik, K. A., Ah Kang, S. and Kim, H. Y. . (2006). "Probiotics and their fermented food products are beneficial for health." Journal of Applied Microbiology 100(6): 1171–1185.
Peng, S., Lin, J. Y. and Lin, M. Y. . (2007). "Antiallergic Effect of Milk Fermented with Lactic Acid Bacteria in a Murine Animal Model." Journal of agricultural and food chemistry 55: 5092-5096.
Pestka, J. J. (1993). "Food, diet, and gastrointestinal immune function." Advances in Food and Nutrition Research 37: 1-66.
Platts-Mills, T. A., vervloet, W. R. Thomas, R. C. Aalberse, and M. D. Chpoman. (1997) ."Indllr allergens and asthma : repoert of the Third International Workshop." Journal of Allergy and Clinical Immunology 100:S2-24.
Plantinga, T. S., van Maren, W. W., van Bergenhenegouwen, J., Hameetman, M., Nierkens, S., Jacobs, C., de Jong, D. J., Joosten, L. A., Van''t Land, B., Garssen, J., Adema, G. J. and Netea, M. G. . (2011). "Differential TLR recognition and induction 1 of cytokine profile by 2 Bifidobacterium breve and Lactobacillus strains of probiotics." Clinical and Vaccine Immunology 4(18): 621-628.
Pohjavuori, E., Viljanen, J., Korpela, R., Kuitunen, M., Tiittanen, M., Vaarala, O. and Savilahti, E. . (2005). "Lactobacillus GG effect in increasing IFN-g production in infants with cow''s milk allergy." Food allergy, dermatologic diseases, and anaphylaxis 114(1): 131-136.
Rasic, J. L. and Kurmann, J. A. (1983). "Bifidobacteria and their role. Microbiological, nutritional-physiological, medical and technological aspects and bibliography." Experientia Supplementum 39: 1-295.
Rinne, M., Kalliomaki, M., Arvilommi, H., Salminen, S.and Isolauri, E. . (2005). "Effect of probiotics and breastfeeding on the bifidobacterium and lactobacillus/enterococcus microbiota and humoral immune responses." Journal of Pediatrics 2(147): 186-191.
Saltzman, J. R., Russell, R. M., Golner, B., Barakat, S., Dallal, G. E. and Goldin, B. R. . (1999). "A randomized trial of Lactobacillus acidophilus BG2FO4 to treat lactose intolerance." American Journal of Clinical Nutrition 69(1): 140-146.
Sakata, S., Kitahara, M., Sakamoto, M., Hayashi, H., Fukuyama, M. and Benno, Y. . (2002). Unification of Bifidobacterium infantis and Bifidobacterium suis as Bifidobacterium longum. International Journal of Systematic and Evolutionary Microbiology 52: 1945–1951.
Schabussova, I., Hufnagl, K., Wild, C., Nutten, S., Zuercher, A. W., Mercenier, A. and Wiedermann, U. . (2011). "Distinctive anti-allergy properties of two probiotic bacteria strains in a mouse model of allergic poly-sensitization." Vaccine 10(29): 1981-1990.
Scheinbach, S. (1998). "Probiotics: funcionality and commercial status." Biotechnology Advances 16(3): 581-608.
Schmidt-Weber, C. B., M. Akdis, et al. (2007). "TH17 cells in the big picture of immunology." Journal of Allergy and Clinical Immunology 120(2): 247-254
Sun, J., Chang, G. F., Le, G. W. and Shi, Y. H. . (2008). "Pathway analysis of modulation on gene expression in murine lymphocytes by Lactobacillus peptidoglycan." Chinese journal of cellular and molecular immunology 6(24): 553-556.
Sun, J., Shi, Y. H., Le, G. W. and Ma, X. Y. . (2005). "Distinct immune response induced by peptidoglycan derived from Lactobacillus sp." World Journal Gastroenterol 40(11): 6330-6337.
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J. L., Kohler, R. H., Chudnovskiy, A., Waterman, P., Aikawa, E., Mempel, T. R., Libby, P., Weissleder, R. and Pittet, M. J. . (2009). "Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites." Science 325: 612-616.
Tannock, G. W. (2004). "A special fondness for lactobacilli." Applied and Environmental Microbiology 70: 3189–3194.
Teixeira, L. K., Fonseca, B. P. F., Barboza, B.A. and Viola, J. P. B. . (2005). "The role of interferon-g on immune and allergic responses." Memorias do Instituto Oswaldo Cruz ."100(1): 137-144.
Whorwell, P. J., L. Altringer, et al. (2006). "Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome." Am J Gastroenterol 101(7): 1581-1590.
Wilson, B. D., J. C. Kucera, et al. (2002). "The role of radiation treatment in the management of eosinophilic pustular folliculitis." American Journal of Medicine 33(1-4): 111-113.
Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T. and Sakaguchi, S. . (2008) "CTLA-4 control overFoxp31regulatory T cell function. Science." 322: 271–275.
Xiao, J. Z., Kondo, S., Yanagisawa, N., Takahashi, N., Odamaki, T., Iwabuchi, N., Iwatsuki, K., Kokubo, S., Togashi, H., Enomoto, K. and Enomoto, T. . (2006). "Effect of Probiotic Bifidobacterium longum BBS36 in relieving clinical symptoms and modulating plasma cytokine levels of japanese cedar pollinosis during the pollen season. A randomized double-blind, placebocontrolled trial." Journal of Investigational Allergology and Clinical Immunology 2(16): 86-93.
Yang, H. Y., Liu, S. L., Ibrahim, S. A., Zhao, L., Jiang, J. L., Sun, W. F. and Ren, F. Z. . (2009). "Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice." Nutrition Research 20: 281-289.
Yoshimura, A., Lien, E., Ingalls, R. R., Tuomanen, E., Dziarski, R. and Golenbock, D. . (1999). "Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2." Journal of Immunology 163(1): 1-5
Yu, J., Jang, S. O., Kim, B. J., Song, Y. H., Kwon, J. W., Kang, M. J., Choi, W. A., Jung, H. D. and Hong, S. J. . (2010). "The Effects of Lactobacillus rhamnosus on the Prevention of Asthma in a Murine Model." Allergy Asthma Immunol Res 2(3): 199-205.
Zhang, C., Zheng, H. T., Du, X. B., Zhang, L., Zhu, T. X. and Chen, J. C. . (1994). "Initial studies between food compositions of Bama''s health macrobian and bifidobacteria in human intestinal tract." Review of Food Science and Technology in China 177: 47-49.
Zhang, L. L., Chen, X., Zheng, P. Y., Luo, Y., Lu, G. F., Liu, Z. Q., Huang, H. and Yang, P. C. . (2010). "Oral Bifidobacterium modulates intestinal immune inflammation in mice with food allergy." Journal of Gastroenterology and Hepatology 25(5): 928-934.
Zhou, W., Zhang, F., Aune, T. M. . (2003). "Either IL-2 or IL-12 is sufficient to direct Th1 differentiation by nonbese diabetic T cell." The Journal of Immunology 170:735-740.