臺灣博碩士論文加值系統

光學同調斷層掃描發展至今，已有各種功能性影像，在各領域受重視與研究，臨床上也廣泛運用。而微循環在人體中佔有要角，光學同調斷層掃描血管造影觀察微血管結構，對疾病的診斷與治療有所助益。
本論文中描述瓊斯矩陣光學同調斷層掃描儀器的架設，而後著重於皮膚血管造影方法的研究。利用相關映射與瓊斯矩陣運算的結合，試圖最佳化影像。OCT訊號包含振幅與相位，取振幅相關性與相位解析的相關性做比較，並且比較了有無加上同調修正後的結果。在本系統相位不穩的狀況下，導致相位解析的結果雜訊大，使用同調複合修正後有效的改善訊雜比，但總體而言振幅相關性的結果好上許多，所以雖然犧牲掉相位的資訊，但此系統目前狀況下用振幅相關映射血管造影的效果最清楚，加上同調複合修正後訊雜比些微上升，改善程度不大。

After more than ten years of development, many functional images of optical coherence tomography (OCT) has been invented. It’s valuable and being studied in various fields as well widely applied in clinical diagnosis. Microcirculation is an essential part of the human body. OCT angiography can observe the structure of capillaries. It can be a powerful tool for disease diagnosis and treatment when collaborating with other functional OCT images.
In this thesis, first, we introduce Jones matrix OCT system setup. Then we focus on angiography of human skin and attempt to optimize the result by using the combination of correlation mapping and Jones matrix calculation. OCT signal contains amplitude and phase. We compare intensity correlation and complex correlation and use coherence composite to improve sensitivity. Due to the phase instability of our system, the noise on the result of the complex correlation is large. Although its sensitivity increase after the coherence composite, the result of intensity correlation is much better. So I use intensity correlation angiography in this circumstances.

中文摘要 i
Abstract ii
誌謝 iii
目錄 iv
圖目錄 v
表目錄 vi
第一章 緒論 1
1-1光學同調斷層掃描背景 1
1-2瓊斯矩陣偏振敏感OCT 1
1-3 OCT血管造影 2
1-4 cmOCT與JM-OCT的應用 3
1-5研究動機及目的 5
第二章 瓊斯矩陣三維光學同調斷層掃描 7
2-1 JM-OCT系統架構 7
2-2系統配置 9
2-3基於強度影像相關性的血管造影演算法 11
2-4相位解析相關係數映射血管造影 12
2-5標準與同調複合方法之比較 12
第三章 In vivo cmOCT血管造影 16
3-1強度影像及基於強度影像相關性的活體皮膚血管造影 16
3-2不同時間間距的OCTA影像 20
3-3同調複合方法的OCTA影像 23
3-4相位解析相關係數映射的OCTA影像 24
3-5結果討論 25
第四章 結論與未來展望 30
4-1結論 30
4-2未來展望 30
參考文獻 31

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