臺灣博碩士論文加值系統

　　本實驗目的是為瞭解廣東住血線蟲（Angiostrongylus cantonensis）在大的感染情形。實驗犬共分為兩組；第一組的實驗犬每隻感染500隻廣東住血線蟲的第三組幼蟲，而第二組的實驗犬在感染前先每週注射ivermectin（0.05ml/kg），共給藥四周。之後停藥兩週，再和第一組之實驗犬同時進行感染（感染劑量同第一組）。兩組的實驗犬定期採血，測定其血清中之Lactic dehydroginase (LDH)、Creatine phosphokinase (CK)、Total protein (TP)及抗體的變化。
　　第一組實驗犬在感染後第三週時其血清中之LDH開始上昇，在第五週及第六周時達到最高，之後便逐漸下降至九週後和對照組不再有明顯之差異。CK則無明顯的變化，顯示在病程中肌肉組織並沒有受到明顯的傷害。TP在感染後即開始上昇，並在第四、五、六週時達到高峰，之後開始下降至第八週時回復至感染前之水平。血中抗體在感染後第三週開始上昇，至感染後第四週∼第六週達到最高峰。白血球數則在感染後即開始增加，至感染後第三週時達到最高值。第二組實驗犬因其體內仍有殘留之ivermectin ，所以感染並未成立，其各實驗值和對照組之犬沒有明顯的差異。

　　In order to understand the condition of dogs after the infection of Angiostrongylus cantonensis, this experiment was performed. In this experiment dogs were divided into two groups , dogs of the first group were infected with 500 3rd stage larvae of Angiostrongylus cantonensis each. And the dogs of the second group were given ivermectin (0.05mg/kg, IM)every week for four weeks, rested for two weeks, then were infected with the same amount of 3rd stage larvae as the first group simultaneously with the first group. Blood was obtained from dogs of both group. and various tests were carried out to moniter the changes of blood CK, LDH, TP level and the antibody titer during the infection.
　　Tests results of the first gruop were as followed ; the LDH level began to increase during the 3rd week postinfection (pi) and reach the top during the 5th and 6th week pi, then started to decrease, There were no notable changed of blood CK level . Total protein started to increase right after the infection, reached the hightest level during the 4th, 5th and 6th week, and dropped to the level.before the infection during the 8th week pi. number of WBC also started to increase right after the infection adn were the hightest during the 3rd week pi. Antibody titer were raised during the 3rd week pi, reached the top during the 4-6th week, then gradually started to decrease. Dogs of the second group were still protected by ivermectin which were not completely metablized and were not infected. The test results of these dogs showed no significant differences as compared with the test results of the control group.