臺灣博碩士論文加值系統

硫酸鈣應用在填補骨骼缺陷之醫療用途可回溯至十九世紀末。硫酸鈣在人體內具有良好的生物相容性而且在植入人體後，不會有血鈣的現象，併發症甚至沒有任何感染，硫酸鈣促進骨再生的性質更大大的增加了硫酸鈣應用在骨取代物可看性，但是缺點就是硫酸鈣在生物體內的生物降解性太快，很快就會被人體吸收。所以本實驗嘗試製造硫酸鈣顆粒，以硫酸鈣粉末比硫酸鈣顆粒為X比Y的比例混和，為本實驗所測試的硫酸鈣骨水泥(X/Y硫酸鈣)。期望藉由硫酸鈣顆粒的添加使硫酸鈣骨水泥的降解速率減緩，進而製造出可控制降解速率又有良好操作性質、崩解性質、注射性質的硫酸鈣骨水泥。

That calcium sulfate used in medical applications to fill bone defects can be traced back to the nineteenth century. In the human body calcium sulfate bone cement has good biocompatibility .When it’s implanted in the human body, there will be not the phenomenon of hypercalcemia syndrome, complications, and even without any infection. Facilitating bone regeneration is a one of the most important features of calcium sulfates, and such importance will make bone substitutes more applicable in the future. However, the drawback is that calcium sulfates degrade rapidly in vivo, in other words, it will soon be absorbed. In this study, calcium sulfate dihydrate as a raw material is tried to fabricate calcium sulfate granules. And then by mixing a certain proportion of calcium sulfate hemihydrate powder and calcium sulfate granule, we can fabricate a calcium sulfate bone cement that has appropriate degradation rate, handleability, and injectability.

中文摘要 I
Abstract II
誌謝 III
總目錄 IV
表目錄 VIII
圖目錄 IX
第一章 總序論 1
1-1 生醫材料的定義與簡介 1
1-2 生醫材料的分類 4
1-2-1金屬材料（metal） 4
1-2-2陶瓷材料（ceramic） 5
1-2-3高分子材料（polymer） 7
1-2-4複合材料（composite） 9
1-3生醫陶瓷種類 12
1-3-1生物惰性陶瓷（Bioinert ceramics） 12
1-3-2生物活性陶瓷(Bioactive ceramics) 13
1-3-3可吸收性生醫陶瓷（Resorbable bioceramics） 13
1-4骨水泥的簡介 17
1-4-1 骨取代材的性質及製程要求 17
1-4-2 骨水泥的定義 18
1-4-3理想骨水泥的要求 18
1-6生醫材料發展簡史 23
第二章 文獻回顧 27
2-1醫用硫酸鈣發展歷史 27
2-2硫酸鈣的相轉換機制 29
2-3硫酸鈣的煆燒特性 33
2-4 α與β半水硫酸鈣特性的比較 35
2-4-1 α與β半水硫酸鈣製造方法 35
2-4-2 α與β半水硫酸鈣的性質差異 35
2-4-3 α與β半水硫酸鈣的水合硬化過程 37
2-5硫酸鈣的作用機制 38
2-5-1脫水機制的分子觀 39
2-5-2硫酸鈣脫水的化學方程式 39
2-5-3結晶結構的影響 40
2-6粉液混合過程對反應的影響 43
2-6-1不同添加劑與硫酸鈣結晶過程的影響 43
2-6-2不同液粉比對硫酸鈣性質的影響 45
2-7磷酸根對二水硫酸鈣生成反應的影響 48
2-8硫酸鈣在生醫材料上的應用 51
2-8-1有添加硫酸鈣的多相複合生醫材料 51
2-8-2硫酸鈣在骨移植術上的應用 54
2-8-3硫酸鈣促進骨再生機制 55
2-9硫酸鈣作為骨水泥的優勢 58
2-10研究目的 60
第三章 實驗原理及步驟 61
3-1 實驗步驟 61
3-1-1製作硫酸鈣顆粒 61
3-1-2硫酸鈣粉末/硫酸鈣顆粒複合材的製作與測試 61
3-2 實驗分析方法 63
3-2-1 崩解性質的測試 63
3-2-2 工作與硬化時間測量 65
3-2-3 抗壓試片製作與強度測試 66
3-2-4 pH值的量測 67
3-2-5 X-Ray diffraction（XRD）分析 68
3-2-6 Scanning Electron Microscopy（SEM）表面觀察 69
3-2-7 孔隙度（Porosity）測試 71
3-2-8 重量損失的量測 72
3-2-9 細胞毒性測試 (Cytotoxicity test) 72
第四章 結果與討論 75
4-1 浸泡人工體液後，X/Y硫酸鈣跟對照組性質比較 75
4-1-1 XRD繞射分析 75
4-1-2 抗壓強度測試 76
4-1-3 孔隙率和重量損失測試 78
4-1-4 pH值量測 81
4-1-5 掃描式電子顯微鏡(SEM)表面型態分析 82
4-2細胞毒性測試 87
第五章 結論 89
參考文獻 90

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經濟部陶瓷技術手冊Chap.31