臺灣博碩士論文加值系統

臨床上很難早期診斷敗血症， 當敗血症已經形成後再給予抗氧化劑
(antioxidants) 和螯合劑 (chelators) 就沒有效了。研究顯示，一氧
化氮 (NO) 與超氧自由基 (O2-) 的結合速率是超氧分解酵素
(Superoxide dismutase ，簡稱 SOD) 的好幾倍。本實驗 就是要瞭解一
氧化氮對於偵測敗血症的過程是否有幫助。採用的動物是雄性重 250 克
的 Wistar 鼠， 以改良過的盲腸結紮穿刺法 (modified cecum
ligation and puncture ，簡稱 modified CLP) 造成輕微敗血症，盲
腸結紮穿刺法 (CLP) 引起嚴重 敗血症， 同時用模擬手術 (Sham
operation) 不結紮和穿刺盲腸當對照組。

The stress of sepsis is difficult to be diagnosed in clinical
practice. The therapies of antioxidants and chelators did not
ameliorate the established septicemia. It has been proved
that the kinetic rate of the reaction between nitric
oxide (NO) and oxygen radical (O2-) is several-fold faster
than that of the scavenging of O2- by superoxide dismutase
(SOD). The purpose of this study was to investigate the
efficiency of NO in serum to detect the development of
septicemia. Male Wistar rats weighing about 250