臺灣博碩士論文加值系統

本論文主要探討的是利用離子性高分子-金屬複合材料與PDMS製成之人工括約肌於尿失禁的治療。離子性高分子-金屬複合材料是一種通電時會產生大於40％形變量的材料，而PDMS則為一具彈性之高分子，利用組合而成的人工括約肌進行尿路動力學測試。另外測試了一些離子性高分子-金屬複合材料的性質，例如：擺動角度測試、厚度與擺動高度關係及產生力量的測試。根據實驗結果，本實驗之離子性高分子-金屬複合材料經過85次使用後其擺動角度與初期使用時相近(約90度)，且厚度越薄，擺動高度越高；當離子性高分子-金屬複合材料長度越短時，產生的力量越大。又根據尿路動力學結果顯示，本研究之人工括約肌可提供尿道高達100 cm-H2O的壓力，且當施予電壓為3伏特或4伏特時，壓力下降改變量分別約為10 cm-H2O與20 cm-H2O。

The main point of this thesis is focus on artificial sphincter for urinary incontinence, which uses ionic polymer metal composite (IPMC) and an elastic polymer, polydimethylsiloxane (PDMS) to make this project come true. IPMC is a kind of material which will have more than 40 % shape change under electrical stimulation. Combine IPMC and PDMS to make artificial sphincter in real, surround urinary tract and hold it. We also doing some experiments about characteristics of IPMC, including bending angle, the relationship between thickness and bending displacement, and force generation. According to experiment result, IPMC''s bending angle mostly the same after 85 times uses. As the thickness of IPMC get thinner, the bending displacement will be higher；and the force generation will be larger if the length of IPMC be shorter. According to urodynamic study, our model can offer up to 100 cm-H2O when voltage moved, and decrease about 10 cm-H2O or 20 cm-H2O when voltage was 3 or 4.

中文摘要...............................................I
Abstract..............................................II
目錄.................................................III
圖目錄................................................VI
表目錄.................................................X
英文縮寫與符號說明....................................XI
中英譯名對照表......................................XIII

第一章.................................................1
緒論...................................................1
1.1 研究背景...........................................1
1.2 形狀記憶合金 ( Shape memory alloys )...............4
1.3 電致動高分子 ( Electroactive polymers，EAP)........5
1.4 Nafion 介紹.......................................6
1.5 離子性高分子-金屬複合材料( Ionic Polymer - Metal Composite )............................................7
1.5-1 離子性高分子-金屬複合材料致動原理................9
1.5-2 離子性高分子-金屬複合材料的應用.................10
1.6 電致動高分子於人工括約肌之相關研究................11
1.7 研究動機..........................................12
1.8 研究目的..........................................12
第二章................................................25
實驗藥品、儀器與方法..................................25
2.1 實驗藥品..........................................25
2.2 實驗耗材..........................................26
2.3 實驗儀器..........................................26
2.4 尿路動力學系統 ....................................27
2.5 溶液配置..........................................27
2.6 Nafion膜製作.....................................29
2.7掃描式電子顯微鏡的使用.............................30
2.8 製作離子性高分子-金屬複合材料.....................30
2.8-1 彎曲角度(Bending angle)測試.....................31
2.8-2 離子性高分子-金屬複合材料厚度與擺動高度關係測試.33
2.8-3 離子性高分子-金屬複合材料力的測試...............34
2.9 人工括約肌製作 ....................................34
2.9-1 PDMS製作方法...................................35
2.9-2 量測尿道壓力方法................................36
第三章................................................45
結果與討論............................................45
3.1 製作離子性高分子-金屬複合材料.....................45
3.1-1 彎曲角度測試結果................................46
3.1-2 離子性高分子-金屬複合材料厚度與擺動高度(h)關係測試結果....................................................48
3.1-3離子性高分子-金屬複合材料厚度與擺動高度關係測試結果
......................................................48
3.1-4 離子性高分子-金屬複合材料力的測試結果...........50
3.2 尿路動力學實驗結果................................51
第四章................................................71
結論與建議............................................71
4.1 結論..............................................71
4.2 建議..............................................72
參考文獻..............................................75
附錄..................................................78

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