臺灣博碩士論文加值系統

隱色微胞劑量計(Leuco micelle dosimeter,LMD)為一新穎的凝膠劑量計。本研究目的為添加穩定劑於LMD中，以期改善其穩定性。首先以紫外光A(ultraviolet A, UV-A)進行照射0 - 1200秒，照射後分析取得劑量反應曲線敏感度、線性度和穩定度。選出較佳的穩定劑後，以臨床使用的直線加速器(6 MV)，經照射0-10 Gy後並分析找尋穩定劑最適合應用於LMD劑量計之配方。穩定劑分別為苯并三唑(benzotriazoles)、二甲亞碸 (dimethyl sulfoxide,DMSO)、三氧化鎢(tunsten trioxide, WO3)、抗壞血酸(ascorbic acid)和四溴乙烷(tetrabromoethane)。LMDBrLh為本研究中最佳劑量計配方(明膠6 %、隱色孔雀石綠0.012 %、chloroform 0.64 %、三氯乙酸0.03 %、SDS1.44 %、四溴乙烷0.025 %)，其光吸收度差異百分比於照射前結果顯示差異度為32%，照射後差異度36%，大幅改善34%與40%之穩定性。不同批次間之光吸收度標準誤差值低。不同劑量點之線性度穩定性由0-1 Gy至0-10 Gy於儲放時間2小時至120小時間，量測時間點內保持線性度R2> 0.99。此新配方凝膠劑量計顯示穩定性更佳，且不影響線性度，具臨床上應用發展潛力。

This study aims to improve the stability of Leuco Micelle Dosimeter (LMD), a novel radiochromic leucodye micelle hydrogel dosimeter that is transparent and an ideal water equivalent. LMDs were stabilized separately by benzotriazole, dimethyl sulfoxide, tunsten trioxide(WO3), ascorbic acid, and tetrabromoethane. All samples were irradiated with UV and photon irradiation system using eight 8-W UV lamps (320 nm to 400 nm) with irradiation time of 0 s to 1200 s. LMD was irradiated from 0 Gy to 10 Gy using the 6-MV photon beam. The added stabilizers can slow down the change of the color for five days; especially, the LMDBrLh(gelatin 6 %、Leuco malachitegreen 0.012 %、chloroform 0.64 %、trichloroacetic acid 0.03 %、SDS1.44 %、tetrabromoethane0.025 %) absorbance before irradiation and 10 Gy irradiationpercentage difference (%) was 32% and 36%, respectively. Which improved 34% and 40% of stabily.For different batch standard deviation was less. In different cumulative dose linearity of stability from 0-1 Gy to 0-10 Gy was shows R2> 0.99 at 2 to 120 hours. The new formulation of LMDBrLh shows improved stablility and good linearity, making clinical applications of dose verification method more feasible.

誌謝 I
中文摘要 II
Abstract III
目錄 IV
圖目錄 VII
表目錄 IX
縮寫字 XI
第一章 前言 1
1.1 引言 1
1.2 惡性腫瘤治療方式 2
1.3 理想劑量計 4
1.4 研究目的 6
第二章 文獻回顧 7
2.1 劑量計發展史 7
2.2 染料類凝膠劑量計組成、反應機轉與特性 12
2.2.1 Fricke gel-Xylenol Orange 12
2.2.1.1 組成與反應機轉 12
2.2.1.2 Fricke gel-Xylenol Orange特性 14
2.2.2 油相-PRESAGE™ 15
2.2.2.1 組成與反應機轉 15
2.2.2.2 PRESAGE™特性 18
2.2.3 水相-Leuco Micelle Dosimeter 19
2.2.3.1 組成與反應機轉 19
2.2.3.2 特性 26
2.3 量測工具 28
2.3.1 磁振造影 28
2.3.2 光學電腦斷層掃描儀 29
2.3.3 可見光分光光度計 30
2.3.4 其他量測工具 30
第三章 材料與方法 31
3.1 實驗設計 31
3.2 實驗流程 32
3.2.1 實驗方法 33
3.2.2 凝膠製備 33
3.2.3 設備與材料 36
3.2.4 穩定劑配方比例 39
3.2.5 凝膠劑量計照射 40
3.2.5.1 UV照射 40
3.2.5.2 直線加速器照射 42
3.2.6 劑量計量測 45
3.2.6.1 最大光吸收度波段範圍 45
3.2.6.2 劑量反應線性度與敏感度 45
3.2.6.3 劑量穩定性探討 46
3.2.7 劑量計基本特性分析 46
3.3 資料分析 47
3.4 水等效(water equivalence) 47
第四章 結果 49
4.1 最大光吸收度 49
4.2 前置實驗(UV-A照射) 50
4.2.1 劑量反應線性度與敏感度 50
4.2.2 劑量反應穩定性 52
4.3 直線加速器照射 57
4.3.1 劑量反應線性度與敏感度 57
4.3.2 劑量反應穩定性 60
4.3.3 水等效 76
第五章 討論 77
5.1 穩定劑於劑量反應線性度與敏感度的影響 77
5.2 劑量反應穩定性 78
5.2.1 三氧化鎢(WO3)與還原劑 79
5.2.2 碳溴化合物(Tetrabromoethane) 80
5.3 水等效 81
5.4 綜合討論 83
第六章 結論 85
第七章 未來規劃 86
第八章 參考文獻 87
附錄一；發表著作 93

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