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研究生:周政憲
研究生(外文):Cheng Hsien Chou
論文名稱:有氧間隔性及中度持續性運動訓練對於淋巴球表型及功能的影響
論文名稱(外文):Effects of Aerobic Interval Exercise Training and Moderate Continuous Exercise Training on lymphocyte Phenotype and Function
指導教授:王鐘賢王鐘賢引用關係
指導教授(外文):J. S. Wang
學位類別:碩士
校院名稱:長庚大學
系所名稱:物理治療學系
學門:醫藥衛生學門
學類:復健醫學學類
論文種類:學術論文
論文出版年:2015
畢業學年度:103
論文頁數:89
中文關鍵詞:淋巴球免疫衰老歸巢移行增生活化
外文關鍵詞:lymphocyteImmune senescenceproliferationhomingmigrationactivation
相關次數:
  • 被引用被引用:1
  • 點閱點閱:185
  • 評分評分:
  • 下載下載:5
  • 收藏至我的研究室書目清單書目收藏:0
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致謝 - iii -
中文摘要 - iv -
英文摘要 - vi -
目錄 - viii -
第一章 緒論(Introduction) - 1 -
第一節 研究背景及目的 - 1 -
第二節 研究目的 - 2 -
第二章 文獻回顧 (Literature Review) - 3 -
第一節 淋巴球 - 3 -
第二節 運動與免疫 - 4 -
第三節 低氧暴露下之生理變化 - 4 -
第四節 免疫衰老 - 5 -
第五節 淋巴球表面標記CD28、CD57、CD45RA、CD45Ro - 5 -
第六節 淋巴球歸巢 - 7 -
第七節 淋巴球功能 - 8 -
第八節 運動處方的制定 - 8 -
第三章 實驗設計(Experimental Design) - 10 -
第一節 實驗材料(Study equipments) - 10 -
第二節 研究方法 - 15 -
一、 受試者(Subjects) - 15 -
二、 實驗流程 - 16 -
三、 運動測試 - 16 -
四、 運動訓練 - 19 -
五、 血液實驗 : - 19 -
第四章 統計方法 - 23 -
第五章 結果 (Results) - 24 -
第一節 淋巴球表型比例變化情形 - 24 -
一、 淋巴球表面標記CD4、CD8、CD8bright - 24 -
二、 淋巴球表面標記CD28分布百分比 - 24 -
三、 淋巴球表面標記CD57分布百分比 - 24 -
四、 淋巴球表面標記CD11a分布百分比 - 25 -
五、 淋巴球表面標記CD62L分布百分比 - 25 -
六、 淋巴球表面標記CD45Ra分布百分比 - 25 -
七、 淋巴球表面標記CD45Ro分布百分比 - 26 -
第二節 淋巴球活化後氧氣代謝情形 - 26 -
第三節 淋巴球活化後氫離子代謝情形 - 26 -
第四節 淋巴球增生、分裂、遷移的情形 - 27 -
第六章 討論 - 28 -
第一節 兩組訓練對於最大運動表現的影響 - 28 -
第一節 淋巴球數目以及比例變化情形 - 28 -
第二節 淋巴球衰老、歸巢、記憶標記比例變化情形 - 29 -
第三節 淋巴球活化後氧氣消耗、氫離子流產生情形 - 30 -
第四節 淋巴球增生情形 - 32 -
第五節 淋巴球移行情形 - 33 -
第七章 結論 - 34 -
第八章 圖表附錄 - 35 -
表一 人體基本測量數值與運動表現 - 36 -
表二 最大運動前後血液數值 - 37 -
表三 低氧運動前後血液數值 - 39 -
表四 最大運動前後血液中白血球數量 - 42 -
表五 低氧運動前後血液中白血球數量 - 44 -
圖一 淋巴球表面CD4/CD8/CD8bright分布百分比 - 45 -
圖二 淋巴球衰老/歸巢/記憶表面標記分布 - 45 -
圖三 輔助型T淋巴球衰老/歸巢/記憶表面標記分布 - 47 -
圖四 毒殺型T淋巴球衰老/歸巢/記憶表面標記分布 - 48 -
圖五 bright毒殺型T淋巴球衰老/歸巢/記憶表面標記分布 - 49 -
圖六 淋巴球活化實驗:分別加入glucose(10mM)、ionomycin(500ng/ml)、PMA(5ng/ml)、oligomycin(2 µg/ml )、2-Deoxy-D-glucose(10mM) - 50 -
圖七 淋巴球處於高糖環境、加入ionomycin(500ng/ml)、PMA(5ng/ml)以及加入超氧化物歧化酶或NADPH氧化酶抑制劑之氧氣(a.c)、氫離子流(b.d)變化情形 - 51 -
圖八 淋巴球活化後氧氣消耗情形 - 52 -
圖九 淋巴球活化後氫離子流產生情形 - 54 -
圖十 淋巴球遷移情形 - 56 -
圖十一 使用flowJo software (Tree Star, OR).分析運動前後淋巴球增生情形 - 57 -
圖十二 淋巴球增生、分裂情形 - 58 -
參考文獻(Reference) - 59 -
附錄 - 68 -



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