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研究生:趙威凱
研究生(外文):Wei-Kai Chao
論文名稱:中國菟絲子對小鼠鎮痛及抗發炎作用機轉之研究
論文名稱(外文):Studies on the analgesic and anti-inflammatory mechanisms of Cuscuta chinensis Lam. in mice
指導教授:林民昆
指導教授(外文):Ming-Kuem Lin
學位類別:碩士
校院名稱:中國醫藥大學
系所名稱:中國藥學暨中藥資源學系碩士班
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:88
中文關鍵詞:鎮痛抗發炎中國菟絲子醋酸扭體試驗福馬林舔足實驗λ-角叉菜膠誘發小鼠足蹠浮腫試驗
外文關鍵詞:analgesicanti-inflammatoryCuscuta chinensis Lam.acetic acid-induced writhing responseformalin testsλ-carrageenan- induced paw edema in mice
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中國菟絲子是台灣傳統中醫常用滋補中藥之一,其基原為旋花科植物中國菟絲子 [Cuscuta chinensis (Lam.)]的種子。常被用來治療胎動不安、大小便失禁、高血壓、腎虛等症狀。有關中國菟絲子的研究文獻指出具有抗氧化能力和增強人體免疫力,但對抗發炎與鎮痛能力的探討深入未盡完全。此研究以醋酸扭體試驗以及福馬林舔足實驗做為探討其中國菟絲子之鎮痛作用,並以λ-角叉菜膠誘發小鼠足蹠浮腫試驗來探討其中國菟絲子之抗發炎作用。並檢測其腳組織內MDA、NO、COX-2、NF-κB、TNF-α、IL-1β、IL-6,藉以探討抗發炎分子的機轉;檢測其肝組織內SOD、GPx、GRd抗氧化酵素的活性。上述結果顯示,中國菟絲子甲醇萃取物能有效抑制醋酸扭體次數、福馬林前期中樞性與後期發炎性疼痛作用以及λ-角叉菜膠誘發小鼠足蹠浮腫的反應,並有效減少發炎因子 (MDA、NF-κB、TNF-α、IL-1β、IL-6、NO、COX-2)的含量,並提昇肝臟抗氧化酵素 (SOD、GPx、GRd)的活性。

A member of the Convolvulaceae family, seeds of Cuscuta chinensis (Lam.) called Chinese Dodder are commonly used as a tonic medicinal material and used for treating tocolysis, incontinence, high blood pressure and kidney deficiency by traditional Chinese physicians in Taiwan. In previous studies, the extracts of C. chinensis exhibit efficient antioxidative and human immunity enhancement activities. However, those researches of the anti-inflammatory and analgesic effects of Cuscutae Semen are still not enough thorough. In this study, the anti- inflammatory and analgesic effects of the methanolic extract of C. chinensis (CCMeOH) were examined by acetic acid-induced writhing response and formalin tests. The anti-inflammatory effect of the CCMeOH was examined by λ-carrageenan- induced paw edema in mice, and the indomethacin was used as a positive control among these animal experiments. To understand the mechanism of anti- inflammatory effect of the CCMeOH, the superoxide dismutase (SOD), glutahoine reductase (GSH-Rx), glutahoine peroxidase (GSH-Px) activities in livers and malondialdehyde (MDA), nitric oxide (NO), cyclooxygenase 2 (COX-2), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1-beta (IL-1β), and interleukin-6 (IL-6) levels in paws were evaluated by ELISA kit. The result showed that CCMeOH inhibited the acetic acid-induced writhing response, the early phase and late phase of formalin- induced licking times and Carrageenan-induced rat paw oedema. CCMeOH decreased those inflammatory factors (MDA、NF-κB、TNF-α、IL-1β、IL-6、NO、COX-2) and increased the ability of those antioxidant enzymes (SOD、GPx、GRd).

目錄 i
略字表 iv
圖目錄 vi
表目錄 viii
中文摘要 1
Abstract 2
第一章 緒論 3
第二章 總論 6
第一節 中國菟絲子文獻考察 6
一、 中國菟絲子之歷代本草考察 6
二、 中國菟絲子之植物考察 6
三、 中國菟絲子之化學成分考察 8
四、 中國菟絲子之藥理考察 9
第二節 鎮痛與抗發炎實驗相關文獻 11
一、 鎮痛實驗 11
二、 抗發炎實驗 13
第三節 抗氧化相關文獻 18
一、 自由基 18
二、 自由基的種類 18
三、 自由基與疾病 21
四、 生物體內的抗氧化防禦系統 21
五、 抗氧化酵素 22
第三章 材料與方法 26
第一節 實驗架構與流程 26
第二節 藥材萃取 26
第三節 實驗動物 27
第四節 中國菟絲子甲醇萃取物急性毒性試驗 27
第五節 中國菟絲子甲醇萃取物動物實驗 28
一、 試劑 28
二、 儀器 29
三、 實驗方法 30
第六節 統計分析 54
第四章 結果 55
第一節 中國菟絲子甲醇萃取物急性毒性試驗 55
第二節 動物實驗 56
一、 醋酸扭體反應試驗 56
二、 福馬林舔足實驗 57
三、 λ-角叉菜膠誘導足蹠腫脹實驗 59
第三節 抗氧化酵素測定實驗 60
一、 SOD活性測定 60
二、 GSH-Px活性測定 61
三、 GSH-Rd活性測定 62
第四節 足蹠組織中發炎介質含量測定 63
一、 足蹠組織中脂質過氧化物MDA濃度測定 63
二、 足蹠組織中NO含量測定 64
三、 足蹠組織中COX-2活性測定 65
四、 足蹠組織中NF-κB濃度測定 66
五、 足蹠組織中TNF-α濃度測定 67
六、 足蹠組織中IL-1β濃度測定 68
七、 足蹠組織中IL-6濃度測定 69
第五章 討論 70
第六章 結論 76
第七章 參考文獻 77


1.王曉良:應用分子藥理學,北京,中國協和醫科大學出版社,2005: pp.296-297。
2.Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacological Reviews 2004; 56(3): 387-437.
3.Vodovotz Y, Kim PK, Bagci EZ, Rementrout GB, Chow CC, Bahar I, Billiar TR. Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. Current Molecular Medicine 2004. 4(7):753-762.
4.Ferreira SH, Moncada S, Vane JR. Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs. British Journal of Pharmacology 1997; 120(S1): 401-412.
5.Holthusen H, Arndt JO. itric oxide evokes pain in humans on intracutaneous injection. Neuroscience letters 1994. 165(1-2): 71-74.
6.Bogdan C. Nitric oxide and the immune response. Nature Immunolody, 2001; 2: 907-916.
7.Kroncke KD, Fehsel K, Kolb-Bachofen K. Inducible nitric oxide synthase in human diseases. Clinical and Experimental Immunology 1998; 113(2):147-156.
8.Cuzzocrea S, Zingarelli B, Calapai G, Nava F, Caputi AP. Zymosan-activated plasma induces paw oedema by nitric oxide and prostaglandin production. Life sciences 1997; 60(3): 215-220.
9.Maxwell SR. Prospects for the use of antioxidant therapies. Drugs 1995; 49(3): 345-361.
10.行政院衛生署中華藥典中藥集編修小組編纂:中華中藥典. 1992:pp.161。
11.南京中醫藥大學:中藥大辭典,2006,下冊:pp. 2894。
12.Lee MS, Chen CJ, Wan L, Ayano K, Chan WT, Yang MJ, Lin WH, Tsai FJ, Lin MK. Quercetin is increased in heat-processed Cuscuta campestris seeds, which enhances the seed''s anti-inflammatory and anti-proliferative activities. Process Biochemistry 2011; 46(12): 2248-2254.
13.Lin MK, Yu YL, Chen KC, Chang WT, Lee MS, Yang MJ, Cheng HC, Liu CH, Chen DC, Chu CL. Kaempferol from Semen cuscutae attenuates the immune function of dendritic cells. Immunobiology 2011; 216(10): 1103-9.
14.Mahat MY, Kulkarni NM, Vishwakarma SL, Khan FR, Thippeswamy BS, Hebballi V, Adhyapak AA, Benade VS, Ashfaque SM, Tubachi S, Patil BM. Modulation of the cyclooxygenase pathway via inhibition of nitric oxide production contributes to the anti-inflammatory activity of kaempferol. European journal of pharmacology 2010; 642(1–3): 169-176.
15.Kang BY, Kim S, Lee KH, Lee YS, Hong I, Lee MO, Min D, Chang I, Hwang JS, Park JS, Kim DH, Kim BG. Transcriptional profiling in human HaCaT keratinocytes in response to kaempferol and identification of potential transcription factors for regulating differential gene expression. Experimental & molecular medicine 2008; 40(2):208-19.
16.中華民國行政院衛生署中醫藥委員會:中華民國中藥典範,1985:pp.629-630。
17.中華人民共和國衛生部藥政管理局,中國藥品生物製品檢定所:現代實用草本,2000:pp. 366-373。
18.香港賽馬會中藥研究院:當代藥用植物典,2006. 第1冊:pp. 279。
19.Hsu YH, Lo CF, Lin JH, Chang HC. Studies on Adulteration and Misusage of Marketed Cuscutae Semen. Annual Scientific Report of National Laboratories of Foods and Drugs 2002; 20: p. 120-134.
20.葉敏,閰玉凝,喬梁,倪雪梅:中藥菟絲子化學成分研究,2002,27(2): pp. 115-117。
21.金曉,李家實,閰文玫:莬絲子黃酮類成分的研究,中國中藥雜誌,1992, 17(5):pp. 292-294。
22.王展,何直升:菟絲子化學成分的研究,中草藥,1998,29(9):pp. 577-579。
23.Yahara S, Domoto H, Sugimura C, Nohara T, Niiho T, Nakajima T, Ito H. An alkaloid and two lignans from Cuscuta chinensis. Phytochemistry 1994; 37(6): 1755-1757.
24.Xiang SX, He ZS, Ye Y. Furofuran lignans from Cuscuta chinensis. Chinese Journal of Chemistry 2001; 19(3):282-285.
25.許益民,王永珍,郭戎,于漣,姜小平:五子衍宗丸及其組成中藥磷脂成分的分析 1989,20(7):pp. 15-17。
26.王展,方積年:具有抗氧化活性的酸性菟絲子多糖H2的研究,植物學報 2001,43(3):pp. 243-248。
27.王展,方積年:菟絲子多糖H3的研究,藥學學報 2001,36(3):pp.192-195。
28.王展,鮑幸峰,方積年:菟絲子中兩個中性雜多糖的化學結構研究,中草藥 2001,32(8):pp. 675-678。
29.宓鶴鳴,郭澄,宋洪濤,郭良君,喬智勝,張芝玉,蘇中武,鄭漢臣,李承祜:三種菟絲子補腎壯陽作用的比較,中草藥 1991,22(12):pp. 547-550。
30.彭守靜,陸仁康,俞麗華,王福楠:菟絲子、仙茅、巴戟天對人精子體外運動和膜功能影響的研究,中國中西醫結合雜誌 1997,17(3):pp.145-147。
31.秦達念,佘白蓉,佘運初:菟絲子黃酮對實驗動物及人絨毛組織生殖功能的影響,中藥新藥與臨床藥理 2001,11(11):pp. 349-351。
32.王建紅,王敏璋,伍慶華,閔建新,陳曉凡,歐陽棟:菟絲子黃酮對應激大鼠卵巢內分泌的影響,中草藥 2002,33(12):pp.1099-1101。
33.王建紅,王敏璋,歐陽棟,伍慶華:菟絲子黃酮對心理應激雌性大鼠下丘腦β-EP與腺垂體FSH、LH的影響,中藥材 2002,25(12):pp.886-888。
34.顧立剛,葉敏,閰玉凝,賈翎,趙建晴:菟絲子金絲桃苷體內外對小鼠免疫細胞功能的影響,中國中醫藥信息雜誌 2001,11(8):pp. 42-44。
35.王昭,朴金花,張鳳梅,李晶,白大芳,楊晶:菟絲子對D-半乳糖所致衰老模型小鼠紅細胞免疫功能的影響,黑龍江醫藥科學 2003,12(26):pp.16-17。
36.郭澄,蘇中武,李承祜,張芝玉,鄭漢臣:中藥菟絲子保肝活性的研究,時珍國藥研究 1992,3(2):pp.62-64。
37.王本祥:現代中藥藥理學,1997:pp.1248-1250。
38.孫維仁,侯文詠,謝正勇,劉健強,林瑞明:C-fos細胞致癌基因在疼痛訊號傳遞過程中所扮演的角色,疼痛醫學雜誌 1994:pp.75-88。
39.Boyce-Rustay JM, Honore P, Jarvis MF. Animal models of acute and chronic inflammatory and nociceptive pain. Methods in Molecular Biology (Clifton, N.J.) 2010; 617: 41-55.
40.徐淑云:藥理實驗方法學,1991:pp.693-701。
41.Dubner R. Methods of assessing pain in animals. Edinburgh London Melbourne and New York: Churchill Livingstone 1989; Textbook of pain Vol. I Second Ed. (Wall PD and Melzack R): 247-250.
42.Collier HO, Dinneen LC, Johnson CA, Schneider C. The abdominal constrction response and its suppression by analgesic drugs in the mouse. British Journal of Pharmacology Chemother 1968; 32: 295-310.
43.Berkenkopf JW, Weichman BM, Production of prostacyclin in mice following intraperitoneal injection of actic acid, phenylbenzoquinone and zymosan: its role in the writhing response. Prostaglandins 1988; 36(5): 693-709.
44.Rosland JH, Tjolsen A, Maehle B, Hole K. The formalin test in mice: effect of formalin concentration. Pain 1990; 42(2): 235-242.
45.Siegmund E, Cadmus R, Lu G. A method for evaluating both non-narcotic and narcotic analgesics. Proceedings of the Society for Experimental Biology and Medicine. 1957; 95(4): 729-31.
46.Taber RI, Greenhouse DD, Rendell JK, Irwin S. Agonist and antagonist interactions of opioids on acetic acid-induced abdominal stretching in mice. The Journal of Pharmacology and Experimental Therapeutics 1969; 169(1): 29-38.
47.Ribeiro RA, Vale ML, Thomazzi SM, Paschoalato AB, Poole S, Ferreira SH, Cunha FQ. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. European Journal of Pharmacology 2000; 387(1): 111-118.
48.Andrade SF, Cardoso LG, Carvalho JC, Bastos JK. Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea. Journal of Ethnopharmacology 2007; 109(3): 464-471.
49.Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 1977; 4(2): 161-174.
50.Shibata M, Ohkubo T, Takahashi H, Inoki R. Modified formalin test: characteristic biphasic pain response. Pain 1989; 38(3): 347-352.
51.Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain 1992; 51(1): 5-17.
52.O''Callaghan JP, Holtzman SG. Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. The Journal of Pharmacology and Experimental Therapeutics 1975; 192:497-505.
53.McCarson KE, Goldstein BD. Naloxone blocks the formalin-induced increase of substance P in the dorsal horn. Pain 1989; 38(3):339-345.
54.Hong YG, Abbott FV. Peripheral opioid modulation of pain and inflammation in the formalin test. European journal of pharmacology 1995; 277(1):21-28.
55.Vaccarino AL, Marek P, Liebeskind JC. Stress-induced analgesia prevents the development of the tonic, late phase of pain produced by subcutaneous formalin. Brain Research 1992; 572(1-2): 250-252.
56.Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 1987; 30(1): 103-114.
57.楊光華:病理學,北京,人民衛生出版社 2002;第五版:pp. 572。
58.Ohshima H, Tazawa H, Sylla BS, Sawa T. Prevention of human cancer by modulation of chronic inflammatory processes. Mutation Research 2005; 591(1-2): 110-122.
59.McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). The Journal of Biological Chemistry 1969; 244(22): 6049-6055.
60.Sawatzky DA, Megson IL, Rossi AG. Sildenafil offers protection against NSAID-induced gastric injury. British Journal of Pharmacology 2005; 146(4): 477-478.
61.Beutler B, Cerami A. The biology of cachectin/TNF--a primary mediator of the host response. Annual Review of Immunology 1989; 7: 625-655.
62.Spector WG, Willoughby DA. The inflammatory response. Bacteriol Rev 1963; 27: 117-154.
63.Dawson J, Sedgwick AD, Edwards JC, Lees P. A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse. International Journal of Tissue Reactions 1991. 13(4): 171-185.
64.Lu TC, Ko YZ, Huang HW, Hung YC, Lin YC, Peng WH. Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. Journal of Ethnopharmacology 2007; 113(1): 142-148.
65.Tousoulis D, Davies G, Stefanadis C, Toutouzas P, Ambrose JA. Inflammatory and thrombotic mechanisms in coronary atherosclerosis. Heart (British Cardiac Society) 2003; 89(9): 993-997.
66.陳奇:中藥藥理研究方法學,北京,人民衛生出版社 1993:pp.356-361。
67.Di Rosa M, Giroud JP, Willoughby DA. Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. The Journal of Pathology 1971; 104(1): 15-29.
68.Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine. 1962; 111: 544-547.
69.Kirkova M, Kassabova T, Russanov E. In vivo effects of indomethacin on the activity of metal-containing enzymes. General Pharmacology: The Vascular System 1992; 23(5): 811-814.
70.Di Rosa M, Willoughby DA. Screens for anti-inflammatory drugs. The Journal of Pharmacy and Pharmacology 1971. 23(4): 297-298.
71.Benard C, Cultrone A, Michel C, Rosales C, Segain JP, Lahaye M, Galmiche JP, Cherbut C, Blottiere HM. Degraded Carrageenan Causing Colitis in Rats Induces TNF Secretion and ICAM-1 Upregulation in Monocytes through NF-κB Activation. Public Library of Science One 2010; 5(1): e8666.
72.Borthakur A, Bhattacharyya S, Dudeja PK, Tobacman JK. Carrageenan induces interlukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells. American Journal of Physiology Gastrointestinal and Liver Physiology 2007; 292: 829-838.
73.Bhattacharyya S, Dudeja PK, Tobacman JK. Carrageenan-induced NF-kB activation depends on distinct pathways mediated by reactive oxygen species and Hsp27 or by Bcl10. Biochimica et Biophysica Acta 2008; 1780: 973-982.
74.Mamelak M. Alzheimer'' s disease, oxidative stress and gammahydroxybutyrate. Neurobiology of Aging 2007; 28(9): 1340-1360.
75.Kanter M. Free radicals, exercise and antioxidant supplementation. The Proceedings of the Nutrition Society 1998; 57(1): 9-13.
76.Halliwell B. Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. Free Radical Research 1996; 25(1): 57-74.
77.Zima T, Kalousova M. Oxidative stress and signal transduction pathways in alcoholic liver disease. Alcoholism, Clinical and Experimental Research 2005; 29: 110-115.
78.Petersen RB, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA, Zhu X. Signal transduction cascades associated with oxidative stress in Alzheimer''s disease. Journal of Alzheimer''s Disease : JAD 2007; 11(2): 143-152.
79.Ostalowska A, Birkner E, Wiecha M, Kasperczyk S, Kasperczyk A, Kapolka D, Zon-Giebel A. Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint. Osteoarthritis and Cartilage 2006; 14(2): 139-145.
80.Kwiecien S, Brzozowski T, Konturek PCh, Konturek SJ. The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions. Journal of Physiology and Pharmacology 2002; 53: 761-773.
81.Bosch-Morell F, Sanz A, Diaz-Llopis M, Romero FJ. Lipid peroxidation products in human subretinal fluid. Free Radical Biology and Medicine 1996; 20(7): 899-903.
82.Gaetke LM, Chow CK. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology 2003; 189(1-2): 147-163.
83.Patel RP, McAndrew J, Sellak H, White CR, Jo H, Freeman BA, Darley-Usmar VM. Biological aspects of reactive nitrogen species. Biochimica et Biophysica acta 1999; 1411: 385-400.
84.Rao KM. Molecular mechanisms regulating iNOS expression in various cell types. Journal of Toxicology and Environmental Health. Part B, Critical Reviews 2000; 3(1): 27-58.
85.Machlin LJ, Bendich A. Free radical tissue damage: protective role of antioxidant nutrients. The FASEB Journal 1987; 1(6): 441-445.
86.Figueroa-Romero C, Sadidi M, Feldman EL. Mechanisms of disease: the oxidative stress theory of diabetic neuropathy. Reviews in Endocrine & Metabolic Disorders 2008; 9(4): 301-314.
87.Schoneich C. Reactive oxygen species and biological aging: a mechanistic approach. Experimental Gerontology 1999; 34(1): 19-34.
88.Moskovitz J, Yim MB, Chock PB. Free Radicals and Disease. Archives of Biochemistry and Biophysics 2002; 397(2): 354-359.
89.Hernandez-Saavedra D, McCord JM. Evolution and free radicals. Importance of oxidative stress in human pathology. Revista Medica del Instituto Mexicano del Seguro Social 2007; 45(5): 477-484.
90.Kathy K Griendling, Garret A FitzGareld. Oxidative Stress and Cardiovascular Injury : Part I: Basic Mechanisms and In Vivo. Review: Clinical Cardiology: New Frontiers 2003; 108: 1912-1916.
91.Bannister, W.H. and J.V. Bannister, Factor analysis of the activities of superoxide dismutase, catalase and glutathione peroxidase in normal tissues and neoplastic cell lines. Free Radical Research Communications 1987; 4(1): p. 1-13.
92.Kato M, Minakami H, Kuroiwa M, Kobayashi Y, Oshima S, Kozawa K, Morikawa A, Kimura H. Superoxide radical generation and Mn- and Cu-Zn superoxide dismutases activities in human leukemic cells. Hematological Oncology 2003; 21(1): 11-16.
93.Power JH, Blumbergs PC. Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson''s disease and dementia with Lewy bodies. Acta Neuropathologica 2009; 117(1): 63-73.
94.Smith JE. Animal model of human disease: inherited erythrocyte glutathione deficiency. The American Journal of Pathology 1976; 82(1): 233-236.
95.Wang X, Ma Y, Huang C, Wan Q, Li N, Bi Y. Glucose-6-phosphate dehydrogenase plays a central role in modulating reduced glutathione levels in reed callus under salt stress. Planta 2008; 227(3): 611-623.
96.Skrzydlewska E, Farbiszewski R. Glutathione consumption and inactivation of glutathione-related enzymes in liver, erythrocytes and serum of rats after methanol intoxication. Archives of Toxicology 1997; 71(12): 741-745.
97.Rosemeyer MA. The biochemistry of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase. Cell Biochemistry and Function 1987; 5(2): 79-95.
98.Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiological Reviews 1979. 59(3): 527-605.
99.Heffner JE, Repine JE. Pulmonary strategies of antioxidant defense. The American Review of Respiratory Disease 1989; 140(2): 531-554.
100.Tsuang YH, Lam SL, Wu LC, Chiang CJ, Chen LT, Chen PY, Sun JS, Wang CC. Isokinetic eccentric exercise can induce skeletal muscle injury within the physiologic excursion of muscle-tendon unit: a rabbit model. Journal of Orthopaedic Surgery and Research 2007; 2(1): p. 13.
101.Hunskaar S, Fasmer OB, Hole K. Formalin test in mice, a useful technique for evaluating mild analgesics. Journal of Neuroscience Methods 1985; 14(1): 69-76.
102.Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L, Cirino G. Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. British Journal of Pharmacology 2004; 142(2): 331-338.
103.Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. The Journal of Biological Chemistry 1972; 247(10): 3170-3175.
104.Woolliams JA, Wiener G, Anderson PH, McMurray CH. Variation in the activities of glutathione peroxidase and superoxide dismutase and in the concentration of copper in the blood in various breed crosses of sheep. Research in Veterinary Science 1983; 34(3): 253-256.
105.Flohe L, Gunzler WA, Assays of glutathione peroxidase. Methods in Enzymology 1984; 105: 114-121.
106.Murakami K, Shimizu T, Irie K. Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer''s Disease. Journal of Amino Acids 2011; 2011:654207.
107.Prohaska JR, Mowafy M, Ganther HE. Interactions between cadmium, selenium and glutathione peroxidase in rat testis. Chemico-Biological Interactions 1977; 18(3): 253-265.
108.Guntherberg H, Rost J. The true oxidized glutathione content of red blood cells obtained by new enzymic and paper chromatographic methods. Analytical Biochemistry 1966; 15(2): 205-210.
109.Carlberg I, Mannervik B. Glutathione reductase. Methods in Enzymology 1985; 113: 484-490.
110.Nakhai LA, Mohammadirad A, Yasa N, Minaie B, Nikfar S, Ghazanfari G, Zamani MJ, Dehghan G, Jamshidi H, Boushehri VS, Khorasani R, Abdollahi M. Benefits of Zataria multiflora Boiss in Experimental Model of Mouse Inflammatory Bowel Disease. Evidence-Based Complementary and Alternative Medicine 2007; 4(1): 43-50.
111.Kulmacz RJ, Lands WE. Requirements for hydroperoxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase. Prostaglandins 1983; 25(4): 531-540.
112.Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Analytical Biochemistry 1982; 126(1): 131-138.
113.Chun SC, Jee SY, Lee SG. Park SJ, Lee JR, Kim SC. Anti-Inflammatory Activity of the Methanol Extract of Moutan Cortex in LPS-Activated Raw264.7 Cells. Evidence-based Complementary and Alternative Medicine : 2007; 4(3): 327-333.
114.Gepdiremen A, Mshvildadze V, Suleyman H, Elias R. Acute and chronic antiinflammatory effects of Hedera colchica in rats. Journal of Ethnopharmacology 2004; 94(1): 191-195.
115.Lai ZR, Peng WH, Ho YL, Huang SC, Lai SC, Ku YR, Tsai JC, Wang CY, Chang YS. Analgesic and anti-inflammatory activities of the methanol extract of Kalanchoe gracilis (L.) DC stem in mice. The American Journal of Chinese Medicine 2010; 38(3): 529-546.
116.Sawynok J, Reid AR. Reduction of formalin-evoked responses and maintenance of peripheral antinociception by morphine against formalin in the spared nerve injury model. Neuroscience letters 2011; 494(2):99-103.
117.Shannon HE, Lutz EA. Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats. Neuropharmacology 2002; 42(2): 253-261.
118.Millan MJ. The induction of pain: an integrative review. Progress in Neurobiology 1999; 57(1): 1-164.
119.Di Rosa M. Biological properties of carrageenan. The Journal of Pharmacy and Pharmacology 1972; 24(2): 89-102.
120.Vinegar R, Schreiber W, Hugo R. Biphasic development of carrageenin edema in rats. The Journal of Pharmacology and Experimental Therapeutics 1969; 166(1): 96-103.
121.Salvemini D, Wang ZQ, Wyatt PS, Bourdon DM, Maroni MH, Manning PT, Currie MG. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. British Journal of Pharmacology 1996; 118(4): 829-38.
122.Janero DR. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radical Biology and Medicine1990; 9(6):515-540.
123.Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cellular Signalling 2001; 13(2):85-94.
124.Diks SH, van Deventer SJ, Peppelenbosch MP. Lipopolysaccharide recognition, internalisation, signalling and other cellular effects. Journal of Endotoxin Research 2001; 7(5): 335-348.
125.Alexander C, Rietschel ET. Bacterial lipopolysaccharides and innate immunity. Journal of Endotoxin Research 2001; 7(3): 167-202.
126.Reiter RJ, Tan DX, Osuna C, Gitto E. Actions of melatonin in the reduction of oxidative stress. A review. Journal of Biomedical Science 2000; 7(6): 444-458.


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