|
參考文獻 顏焜熒, “原色常用中藥圖鑑”, 台北市, 南天出版社, 第一版, p25-28 (1980). 邱永年, 張光雄, “原色台灣藥用植物圖鑑 (3)”, 台北市, 南天出版社, 第一版, p149-151(1992). Abraham E (2003) Neutrophils and acute lung injury. Critical Care Medicine 31(4 Suppl):S195-199. Abrahamsen H, Baillie G, Ngai J, Vang T, Nika K, Ruppelt A, Mustelin T, Zaccolo M, Houslay M, and Tasken K (2004) TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling. Journal of Immunology 173(8):4847-4858. Amatruda TT, 3rd, Dragas-Graonic S, Holmes R, and Perez HD (1995) Signal transduction by the formyl peptide receptor. Studies using chimeric receptors and site-directed mutagenesis define a novel domain for interaction with G-proteins. The Journal of Biological Chemistry 270(47): 28010-28013. Anderson R, Goolam Mahomed A, Theron AJ, Ramafi G, and Feldman C (1998) Effect of rolipram and dibutyryl cyclic AMP on resequestration of cytosolic calcium in FMLP-activated human neutrophils. British Journal of Pharmacology 124(3):547-555. Andrews S, Stephens LR, and Hawkins PT (2007) PI3K class IB pathway in neutrophils. Science's STKE 2007(407):cm3. Ariga M, Neitzert B, Nakae S, Mottin G, Bertrand C, Pruniaux MP, Jin SL, and Conti M (2004) Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. The Journal of Immunology 173(12):7531-8. Arruda MA and Barja-Fidalgo C (2009) NADPH oxidase activity: In the crossroad of neutrophil life and death. Frontiers in bioscience 1(14):4546-4556. Au BT, Teixeira MM, Collins PD, and Williams TJ (1998) Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol. British Journal of Pharmacology 123(6):1260–1266. Baggiolini M, Boulay F, Badwey JA, and Curnutte JT (1993) Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst. FASEB Journal 7(11):1004-1010. Barnes PJ (2007) New molecular targets for the treatment of neutrophilic diseases. The Journal of Allergy and Clinical Immunology 119(5):1055-1062. Barnes PJ, Shapiro SD, and Pauwels RA (2003) Chronic obstructive pulmonary disease: molecular and cellular mechanisms. European Respiratory Journal 22(4):672-688. Barnes PJ (2008) Immunology of asthma and chronic obstructive pulmonary disease. Nature Reviews Immunology 8:183-192. Basnet P, Yasuda I, Kumagai N, Tohda C, Nojima H, Kuraishi yasushi, and Komatsu K (2001) Inhibition of itch-scratch response by fuits of Cnidium monnier in mice. Biological and Pharmaceutical Bulletin 24(9):1012-1015. Beavo JA (1995) Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiological Reviews 75(4):725-748. Bender AT and Beavo JA (2006) Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacological Reviews 58(3):488-520. Bengis-Garber C and Gruener N (1996) Protein kinase A downregulates the phosphorylation of p47 phox in human neutrophils: a possible pathway for inhibition of the respiratory burst. Cellular Signalling 8(4):291-296. Bertocchi F, Breviario F, Proserpio P, Wang JM, Ghezzi P, Travagli RA, Prosdocimi M, and Dejana E (1989) In vitro inhibition of human polymorphonuclear cell function by cloricromene. Naunyn-Schmiedeberg's Archives of Pharmacology 339(6):697-703. Bialojan C and Takai A (1988) Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. The Biochemical Journal 256(1):283-290. Bokoch GM and Zhao T (2006) Regulation of the phagocyte NADPH oxidase by Rac GTPase. Antioxidants & Redox Signaling 8(9-10):1533-1548. Bosanac I, Michikawa T, Mikoshiba K, and Ikura M (2004) Structural insights into the regulatory mechanism of IP3 receptor. Biochimica et Biophysica Acta 1742(1-3):89-102. Brechard S and Tschirhart EJ (2008) Regulation of superoxide production in neutrophils: role of calcium influx. Journal of Leukocyte Biology 84(5):1223- 1237. Breitkreutz D, Braiman-Wiksman L, Daum N, Denning MF, and Tennenbaum T (2007) Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium. Journal of Cancer Research and Clinical Oncology 133(11):793-808. Brittsan AG and Kranias EG (2000) Phospholamban and cardiac contractile function. Journal of Molecular and Cellular Cardiology 32(12):2131-2139. Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, and Nurnberg B (2003) Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. The Journal of Cell Biology 160(1):89-99. Brown GE, Stewart MQ, Bissonnette SA, Elia AE, Wilker E, and Yaffe MB (2004) Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. The Journal of Biological Chemistry 279(26):27059-27068. Buck J, Sinclair ML, Schapal L, Cann MJ, and Levin LR (1999) Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proceedings of the National Academy of Sciences of the United States of America 96(1):79-84. Burgos RA, Hidalgo MA, Figueroa CD, Conejeros I, and Hancke JL (2009) New potential targets to modulate neutrophil function in inflammation. Mini-Reviews in Medicinal Chemistry 9(2):153-168. Busse WW and Lee TP (1976) Decreased adrenergic responses in lymphocytes and granulocytes in atopic eczema. The Journal of Allergy and Clinical Immunology 58(5):586-596. Castro A, Jerez MJ, Gil C, and Martinez A (2005) Cyclic nucleotide phosphod- iesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors. Medicinal Research Reviews 25(2):229-244. Cavicchioni G, Fraulini A, Turchetti M, Varani K, Falzarano S, Pavan B, and Spisani S (2005) Biological activity of for-Met-Leu-Phe-OMe analogs: relevant substitutions specifically trigger killing mechanisms in human neutrophils. European Journal of Pharmacology 512(1):1-8. Chang L and Karin M (2001) Mammalian MAP kinase signalling cascades. Nature 410(6824):37-40. Chen J, Chiou WF, Chen CC, and Chen CF (2000) Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro. The Journal of Urology 163(6):1975-1980. Chen Q, Powell DW, Rane MJ, Singh S, Butt W, Klein JB, and McLeish KR (2003) Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. Journal of Immunology 170(10):5302-5308. Chen YF, Tsai HY, and Wu TS (1995) Anti-inflammatory and analgesic activities from roots of Angelica pubescens. Planta Medica 61(1):2-8. Chen ZC, Duan XB, and Liu KR (1988) The anti-allergic activity of osthol extracted from the fruits of Cnidium monnieri (L.) Cusson. Yao Xue Xue Bao. 23(2):96-99. Cheng HP, Wei S, Wei LP, and Verkhratsky A (2006) Calcium signaling in physiology and pathophysiology. Acta Pharmacologica Sinica 27(7):767-772. Chiou WF, Huang YL, Chen CF, and Chen CC (2001) Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum. Planta Medica 67(3):282-284. Chiu PR, Lee WT, Chu YT, Lee MS, Jong YJ, and Hung CH (2008) Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells. Pediatrics and Neonatology 49(4):135-140. Chou SY, Hsu CS, Wang KT, Wang MC, and Wang CC (2007) Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study. Phytotherapy Research 21(3):226-230. Cohen P and Cohen PT (1989) Protein phosphatases come of age. The Journal of Biological Chemistry 264(36):21435-21438. Conese M, Copreni E, Di Gioia S, De Rinaldis P, and Fumarulo R (2003) Neutrophil recruitment and airway epithelial cell involvement in chronic cystic fibrosis lung disease. Journal of Cystic Fibrosis 2(3):129-135. Conti M, Nemoz G, Sette C, and Vicini E (1995) Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocrine Reviews 16(3):370-389. Corbin JD, Turko IV, Beasley A, and Francis SH (2000) Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities. European Journal of Biochemistry 267(9):2760-2767. Cowburn AS, Condliffe AM, Farahi N, Summers C, and Chilvers ER (2008) Advances in neutrophil biology: clinical implications. Chest 134(3):606-612. Cuevas BD, Abell AN, and Johnson GL (2007) Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene 26(22):3159-3171. Curnutte JT, Erickson RW, Ding J, and Badwey JA (1994) Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may regulate superoxide production by neutrophils stimulated with a phorbol ester. The Journal of Biological Chemistry 269(14):10813-10819. Czap AF (2004) Monograph. Angelica sinensis. Alternative Medicine Review 9(4):429-433. Dahlgren C and Karlsson A (1999) Respiratory burst in human neutrophils. Journal of Immunological Methods 232(1-2):3-14. Dale DC, Boxer L, and Liles WC (2008) The phagocytes: neutrophils and monocytes. Blood 112(4):935-945. Dalpiaz A, Spisani S, Biondi C, Fabbri E, Nalli M, and Ferretti ME (2003) Studies on human neutrophil biological functions by means of formyl-peptide receptor agonists and antagonists. Current Drug Targets Immune Endocrine Metabolic Disorders 3(1):33-42. Dang PM, Fontayne A, Hakim J, El Benna J, and Perianin A (2001) Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst. Journal of Immunology 166(2):1206-1213. Dang PM, Hakim J, and Perianin A (1994) Immunochemical identification and translocation of protein kinase C zeta in human neutrophils. FEBS Letters 349(3):338-342. Dang PM, Morel F, Gougerot-Pocidalo MA, and El Benna J (2003) Phosphorylation of the NADPH oxidase component p67(PHOX) by ERK2 and P38MAPK: selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region. Biochemistry 42(15):4520-4526. Dastidar SG, Rajagopal D, and Ray A (2007) Therapeutic benefit of PDE4 inhibitors in inflammatory diseases. Current Opinion in Investigational Drugs 8(5):364-372 Davis RJ (2000) Signal transduction by the JNK group of MAP kinases. Cell 103(2):239-252. Degerman E, Belfrage P, and Manganiello VC (1997) Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3). The Journal of Biological Chemistry 272(11):6823-6826. Dekker LV, Leitges M, Altschuler G, Mistry N, McDermott A, Roes J, and Segal AW (2000) Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils. The Biochemical Journal 347(Pt 1):285-289. DeLeo FR, Allen LA, Apicella M, and Nauseef WM (1999) NADPH oxidase activation and assembly during phagocytosis. Journal of Immunology 163(12):6732-6740. Dewas C, Fay M, Gougerot-Pocidalo MA, and El-Benna J (2000) The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils. Journal of Immunology 165(9):5238-5244. Diebold BA and Bokoch GM (2005) Rho GTPases and the control of the oxidative burst in polymorphonuclear leukocytes. Current Topics in Microbiology and Immunology 291:91-111. Djerdjouri B, Combadiere C, Pedruzzi E, Hakim J, and Perianin A (1995) Contrasting effects of calyculin A and okadaic acid on the respiratory burst of human neutrophils. European Journal of Pharmacology 288(2):193-200. Dumont JE, Jauniaux JC, and Roger PP (1989) The cyclic AMP-mediated stimulation of cell proliferation. Trends in Biochemical Sciences 14(2):67-71. Durstin M, Gao JL, Tiffany HL, McDermott D, and Murphy PM. (1994) Differential Expression of Members of the N-Formylpeptide Receptor Gene Cluster in Human Phagocytes. Biochemical and Biophysical Research Communications 201(1):174-179. El-Benna J, Dang PM, Gougerot-Pocidalo MA, and Elbim C (2005) Phagocyte NADPH oxidase: a multicomponent enzyme essential for host defenses. Archivum Immunologiae et Therapiae Experimentalis 53(3):199-206. El-Benna J, Dang PM, and Gougerot-Pocidalo MA (2008) Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Seminars in Immunopathology 30(3):279-289. El-Benna J, Dang PM, Gougerot-Pocidalo MA, Marie JC, and Braut-Boucher F (2009) p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases. Experimental and Molecular Medicine 41(4):217-225. El Benna J, Han J, Park JW, Schmid E, Ulevitch RJ, and Babior BM (1996) Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Archives of Biochemistry and Biophysics 334(2):395-400. Ellson CD, Gobert-Gosse S, Anderson KE, Davidson K, Erdjument-Bromage H, Tempst P, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Gaffney PR, Coadwell J, Chilvers ER, Hawkins PT, and Stephens LR (2001) PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nature Cell Biology 3(7):679-682. Essayan DM (2001) Cyclic nucleotide phosphodiesterases. The Journal of Allergy and Clinical Immunology 108(5):671-680. Ezeamuzie CI. (2001) Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors. European Journal of Pharmacology 417(1-2):11-18. Fagan KA, Graf RA, Tolman S, Schaack J and Cooper DM (2000) Regulation of a Ca2+-sensitive adenylyl cyclase in an excitable cell. Role of voltage-gated versus capacitative Ca2+ entry. The Journal of Biological Chemistry 275(51):40187-40194. Fan Chung K (2006) Phosphodiesterase inhibitors in airways disease. European Journal of Pharmacology 533(1-3):110-117. Faurschou M and Borregaard N (2003) Neutrophil granules and secretory vesicles in inflammation. Microbes and Infection 5(14):1317-1327. Federman AD, Conklin BR, Schrader KA, Reed RR, and Bourne HR (1992) Hormonal stimulation of adenylyl cyclase through Gi-protien βγ subunits. Nature 356:159-161. Ferretti ME, Spisani S, Pareschi MC, Buzzi M, Cavallaro R, Traniello S, Reali E, Torrini I, Paradisi MP, and Zecchini GP (1994) Two new formylated peptides able to activate chemotaxis and respiratory burst selectively as tools for studying human neutrophil responses. Cellular Signalling 6(1):91-101. Fialkow L, Wang Y, and Downey GP (2007) Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radical Biology & Medicine 42(2):153-164. Figueroa M, Rivero-Cruz I, Rivero-Cruz B, Bye R, Navarrete A, and Mata R (2007) Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida. Journal of Ethnopharmacology 113(1):125-131. Fischer TH and White GC, 2nd (1987) Partial purification and characterization of thrombolamban, a 22,000 dalton cAMP-dependent protein kinase substrate in platelets. Biochemical and Biophysical Research Communications 149(2):700-706. Fontayne A, Dang PM, Gougerot-Pocidalo MA, and El-Benna J (2002) Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation. Biochemistry 41(24):7743-7750. Foyouzi-Youssefi R, Petersson F, Lew DP, Krause KH, and Nusse O (1997) Chemoattractant-induced respiratory burst: increases in cytosolic Ca2+ concentrations are essential and synergize with a kinetically distinct second signal. The Biochemical Journal 322 ( Pt 3):709-718. Freichel M, Schweig U, Stauffenberger S, Freise D, Schorb W, and Flockerzi V (1999) Store-operated cation channels in the heart and cells of the cardiovascular system. Cell Physiology Biochemistry 9(4-5):270-283. Fruman DA, Meyers RE, and Cantley LC (1998) Phosphoinositide kinases. Annual Review of Biochemistry 67:481-507. Fujioka T, Furumi K, Fujii H, Okabe H, Mihashi K, Nakano Y, Matsunaga H, Katano M, and Mori M. Antiproliferative constituents from umbelliferae plants. V (1999) A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica. Chemical and Pharmaceutical Bulletin 47(1):96-100. Fylaktakidou KC, Hadjipavlou-Litina DJ, Litinas KE, and Nicolaides DN (2004) Natural and synthetic coumarin derivatives with anti-inflammatory/ antioxidant activities. Current Pharmaceutical Design 10(30):3813-3833. Gay JC, Raddassi K, Truett AP 3rd, and Murray JJ (1997) Phosphatase activity regulates superoxide anion generation and intracellular signaling in human neutrophils. Biochimica et Biophysica Acta 1336(2):243-253. Gresele P, Ribaldi E, Mezzasoma AM, Quero E, Stasi M, Prosdocimi M, Goracci G, and Nenci GG (1993) Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipids. Biochemical Pharmacology 45(1):123-130. Grootendorst DC, Gauw SA, Baan R, Kelly J, Murdoch RD, Sterk PJ, and Rabe KF. (2003) Does a single dose of the phosphodiesterase 4 inhibitor, cilomilast (15 mg), induce bronchodilation in patients with chronic obstructive pulmonary disease? Pulmonary Pharmacology & Therapeutics 16(2):115-120. Guh JH, Yu SM, Ko FN, Wu TS, and Teng CM (1996) Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens. European Journal of Pharmacology 298(2):191-197. Hallett MB, Davies EV, and Campbell AK (1990) Oxidase activation in individual neutrophils is dependent on the onset and magnitude of the Ca2+ signal. Cell Calcium 11(10):655-663. Hamamoto M, Suga M, Nakatani T, Takahashi Y, Sato Y, Inamori S, Yagihara T, and Kitamura S (2004) Phosphodiesterase type 4 inhibitor prevents acute lung injury induced by cardiopulmonary bypass in a rat model. European Journal of Cardio-Thoracic Surgery 25(5):833-838. Han J and Ulevitch RJ (1999) Emerging targets for anti-inflammatory therapy. Nature Cell Biology 1(2):E39-40. Hanoune J and Defer N (2001) Regulation and role of adenylyl cyclase isoforms. Annual review of Pharmacology and Toxicology 41:145-174. Hanoune J, Pouille Y, Tzavara E, Shen T, Lipskaya L, Miyamoto N, Suzuki Y, and Defer N (1997) Adenylyl cyclases: structure, regulation and function in an enzyme superfamily. Molecular and Cellular Endocrinology 128(1-2):179- 194. Harvath L, Robbins JD, Russell AA, and Seamon KB (1991) cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness. Journal of Immunology 146(1):224-232. Hawkins PT, Davidson K, and Stephens LR (2007) The role of PI3Ks in the regulation of the neutrophil NADPH oxidase. Biochemical Society symposium (74):59-67. Heyworth CM, Dexter TM, Nicholls SE, and Whetton AD (1993) Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells. Blood 81(4):894-900. Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, and Wymann MP (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287(5455):1049-1053. Hirsch JG and Cohn ZA (1960) Degranulation of polymorphonuclear leucocytes following phagocytosis of microorganisms. The Journal of Experimental Medicine 112:1005-1014. Hoffmann R, Baillie GS, MacKenzie SJ, Yarwood SJ, and Houslay MD (1999) The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579. The EMBO Journal 18(4):893-903. Hommes DW, Peppelenbosch MP, and van Deventer SJ (2003) Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 52(1):144-151. Houslay MD and Adams DR (2003) PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. The Biochemical Journal 370(Pt 1):1-18. Houslay MD, Schafer P, and Zhang KY (2005) Keynote review: phosphodiesterase- 4 as a therapeutic target. Drug Discovery Today 10(22):1503-1519. Hoyal CR, Gutierrez A, Young BM, Catz SD, Lin JH, Tsichlis PN, and Babior BM (2003) Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase. Proceedings of the National Academy of Sciences of the United States of America 100(9):5130-5135. Huang RL, Chen CC, Huang YL, Hsieh DJ, Hu CP, Chen CF, and Chang C (1996) Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro. Hepatology 24(3):508-515. Hwang TL, Leu YL, Kao SH, Tang MC, and Chang HL (2006a) Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway. Free Radical Biology & Medicine 41(9):1433-1441. Hwang TL, Yeh SH, Leu YL, Chern CY, and Hsu HC (2006b) Inhibition of superoxide anion and elastase release in human neutrophils by 3'-isopropoxychalcone via a cAMP-dependent pathway. British Journal of Pharmacology 148(1):78-87. Iannone MA, Wolberg G, and Zimmerman TP (1989) Chemotactic peptide induces cAMP elevation in human neutrophils by amplification of the adenylate cyclase response to endogenously produced adenosine. The Journal of Biological Chemistry 264:20177-20180. Ivey FD, Wang L, Demirbas D, Allain C, and Hoffman CS (2008) Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases. Journal of Biomolecular Screening 13(1):62-71. Jamwalks, Anand KK, and Chopra IC (1962) Pharmacological properties of a crystalline substance (Osthol) isolated from Prangos pabularia Lindl. Archivea International Pharmacodynamie Therapy 138:400-411. Jiménez B, Grande MC, Anaya J, Torres P, and Grande M (2000) Coumarins from Ferulago capillaris and F. brachyloba. Phytochemistry 53(8):1025-1031. Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, and Yaffe MB (2001) The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nature Cell Biology 3(7):675-678. Kang OH, Chae HS, Oh YC, Choi JG, Lee YS, Jang HJ, Kim JH, Kim YC, Sohn DH, Park H, and Kwon DY. (2008) Anti-nociceptive and anti-inflammatory effects of Angelicae dahuricae radix through inhibition of the expression of inducible nitric oxide synthase and NO production. The American Journal of Chinese Medicine 36(5):913-928. Kannengiesser C, Gérard B, El Benna J, Henri D, Kroviarski Y, Chollet-Martin S, Gougerot-Pocidalo MA, Elbim C, and Grandchamp B (2008). Molecular epidemiology of chronic granulomatous disease in a series of 80 kindreds: identification of 31 novel mutations. Human Mutation 29(9):E132-E149 Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, and Waterfield MD (2001) Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annual Review of Cell and Developmental Biology 17:615-675. Kawaii S, Tomono Y, Ogawa K, Sugiura M, Yano M, Yoshizawa Y, Ito C, and Furukawa H (2001) Antiproliferative effect of isopentenylated coumarins on several cancer cell lines. Anticancer Research 21(3B):1905-1911. Kawakami N, Takemasa H, Okamura N, Hayakawa T, Shimohama S, and Fujimoto S (1999) Participation of cytosolic protein phosphatase in regulation of NADPH oxidase in polymorphonuclear leukocytes. Biological & Pharmaceutical Bulletin 22(6):556-560. Kent JD, Sergeant S, Burns DJ, and McPhail LC (1996) Identification and regulation of protein kinase C-delta in human neutrophils. Journal of Immunology 157(10):4641-4647. Kim C and Dinauer MC (2001) Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways. Journal of Immunology 166(2):1223-1232. Kim SS, Kim JY, Lee NH, Hyun CG. (2008) Antibacterial and anti-inflammatory effects of Jeju medicinal plants against acne-inducing bacteria. The Journal of General and Applied Microbiology 54(2):101-106. Kim YK, Kim YS, and Ryu SY (2007) Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines. Phytotherapy Research 21(3):288-290. Klinker JF, Wenzel-Seifert K, and Seifert R (1996) G-protein-coupled receptors in HL-60 human leukemia cells. General Pharmacology 27(1):33-54. Ko FN, Wu TS, Liou MJ, Huang TF, and Teng CM (1989) Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens. Thrombosis and Haemostasis 62(3):996-999. Ko FN, Wu TS, Liou MJ, Huang TF, and Teng CM (1992) Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens. European journal of Pharmacology 219(1):29-34. Kobayashi SD, Voyich JM, Burlak C, and DeLeo FR (2005) Neutrophils in the innate immune response. Archivum Immunologiae et Therapiae Experimentalis 53(6):505-517. Kontogiorgis CA and Hadjipavlou-Litina DJ (2005) Synthesis and anti- inflammatory activity of coumarin derivatives. Journal of Medicinal Chemistry 48(20):6400-6408. Kontogiorgis CA, Savvoglou K and Hadjipavlou-Litina DJ (2006) Antiinflammatory and antioxidant evaluation of novel coumarin derivatives. Journal of Enzyme Inhibition Medicinal Chemistry 21(1):21-29. Korkmaz B, Moreau T, and Gauthier F (2008) Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions. Biochimie 90(2):227-242. Kouoh F, Gressier B, Dine T, Luyckx M, Brunet C, Ballester L, and Cazin JC (2002) Antioxidant effects and anti-elastase activity of the calcium antagonist nicardipine on activated human and rabbit neutrophils--a potential antiatherosclerotic property of calcium antagonists? Cardiovascular Drugs and Therapy 16(6):515-520. Koyasu S (2003) The role of PI3K in immune cells. Nature Immunology 4(4):313-319. Kuo PL, Hsu YL, Chang CH, and Chang JK (2005) Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells. The Journal of Pharmacology and Experimental Therapeutics 314(3):1290-1299. Kyoi T, Noda K, Oka M, and Ukai Y (2004) Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sciences 76(1):71-83. Lacy A and O'Kennedy R (2004) Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer. Current Pharmaceutical Design 10(30):3797-3811. Lad PM, Glovsky MM, Richards JH, Smiley PA, and Backstrom B (1985) Regulation of human neutrophil guanylate cyclase by metal ions, free radicals and the muscarinic cholinergic receptor. Molecular Immunology 22(7):731-739. Lamontagne S, Meadows E, Luk P, Normandin D, Muise E, Boulet L, Pon DJ, Robichaud A, Robertson GS, Metters KM, and Nantel F (2001) Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey. Brain Research 920(1-2):84-96. Lechner D, Stavri M, Oluwatuyi M, Pereda-Miranda R, and Gibbons S (2004) The anti-staphylococcal activity of Angelica dahurica (Bai Zhi). Phytochemistry 65(3):331-335. Lee YY, Lee S, Jin JL, and Yun-Choi HS (2003) Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Archives of Pharmacal Research 26(9):723-726. Leu YL, Chen YW, Yang CY, Huang CF, Lin GH, Tsai KS, Yang RS, and Liu SH (2009) Extract isolated from Angelica hirsutiflora with insulin secretagogue activity. Journal of Ethnopharmacology 123(2):208-212. Liu AY (1982) Differentiation-specific increase of cAMP-dependent protein kinase in the 3T3-L1 cells. The Journal of Biological Chemistry 257(1):298-306. Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, and Bolton JL (2001) Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. Journal Agricultural and Food Chemistry 49(5):2472-2479. Liu J, Zhang W, Zhou L, Wang X, and Lian Q (2005) Anti-inflammatory effect and mechanism of osthole in rats. Journal of Chinese medicinal materials 28(11):1002-1006. Lu DJ, Takai A, Leto TL, and Grinstein S (1992) Modulation of neutrophil activation by okadaic acid, a protein phosphatase inhibitor. The American Journal of Physiology 262(1 Pt 1):C39-C49. Lugnier C (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacology & Therapeutics 109(3):366-398. MacDowell AL and Peters SP (2007) Neutrophils in Asthma. Current Allergy and Asthma Reports 7:464-468. Mackay HJ and Twelves CJ (2007) Targeting the protein kinase C family: are we there yet? Natural Review Cancer 7(7):554-562. Magnier C, Bredoux R, Kovacs T, Quarck R, Papp B, Corvazier E, de Gunzburg J, and Enouf J (1994) Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines. The Biochemical Journal 297 (Pt 2):343-350. Mahadeo DC, Janka-Junttila M, Smoot RL, Roselova P, and Parent CA (2007) A chemoattractant-mediated Gi-coupled pathway activates adenylyl cyclase in human neutrophils. Molecular Biology of the Cell 18(2):512-522. Marasco WA, Phan SH, Krutzsch H, Showell HJ, Feltner DE, Nairn R, Becker EL, and Ward PA (1984) Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. The Journal of Biological Chemistry 259(9):5430-5439. Matsuda H, Ido Y, Hirata A, Ino Y, Naruto S, Amamiya T, and Kubo M (2002a) Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON). Biological & Pharmaceutical Bulletin 25(2):260-263. Matsuda H, Tomohiro N, Ido Y, and Kubo M (2002b) Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biological & Pharmaceutical Bulletin 25(6):809-812. Méhats C, Jin SL, Wahlstrom J, Law E, Umetsu DT, and Conti M. (2004) PDE4D plays a critical role in the control of airway smooth muscle contraction. The FASEB Journal 17(13):1831-1841. Migeotte I, Communi D, and Parmentier M (2006) Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses. Cytokine and Growth Factor Reviews 17(6):501-519. Miro X, Perez-Torres S, Puigdomenech P, Palacios JM, and Mengod G (2002) Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization. Synapse 45(4):259-269. Morel F (2007) Molecular aspects of chronic granulomatous disease. "the NADPH oxidase complex". Bulletin de l'Academie nationale de medecine 191(2):377-390. Morita T, Hussain D, Asahi M, Tsuda T, Kurzydlowski K, Toyoshima C, and Maclennan DH (2008) Interaction sites among phospholamban, sarcolipin, and the sarco(endo)plasmic reticulum Ca(2+)-ATPase. Biochemical and Biophysical Research Communications 369(1):188-194. Nakamura T, Kodama N, Arai Y, Kumamoto T, Higuchi Y, Chaichantipyuth C, Ishikawa T, Ueno K, and Yano S (2009) Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7. The Japanese Society of Pharmacognosy 63(1):21-27. Nauseef WM (2007) How human neutrophils kill and degrade microbes: an integrated view. Immunological Reviews 219:88-102. Niggli V (2003) Signaling to migration in neutrophils: importance of localized pathways. The International Journal of Biochemstry and Cell Biology 35(12):1619-1638. Nishizuka Y (1989) The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction. JAMA 262(13):1826-1833. Nishizuka Y (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258(5082):607-614. Nishizuka Y (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB Journal 9(7):484-496. Ogawa H, Sasai N, Kamisako T, and Baba K (2007) Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats. Journal of Ethnopharmacology 112(1):26-31. Okamoto T, Kawasaki T, and Hino O (2003) Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway. Biochemical Pharmacology 65(4):677-681. Okamoto T, Yoshida S, Kobayashi T, and Okabe S (2001) Inhibition of concanavalin A-induced mice hepatitis by coumarin derivatives. Japanese Journal of Pharmacology 85(1):95-97. Okuyama M, Sakon M, Kambayashi J, Kawasaki T, and Monden M (1996) Involvement of protein phosphatase 2A in PKC-independent pathway of neutrophil superoxide generation by fMLP. Journal of Cellular Biochemistry 60(2):279-288. Omori K and Kotera J (2007) Overview of PDEs and their regulation. Circulation Research 100(3):309-327. Park JC, Park JG, Kim HJ, Hur JM, Lee JH, Sung NJ, Chung SK, and Choi JW (2002) Effects of extract from Angelica keiskei and its component, cynaroside, on the hepatic bromobenzene-metabolizing enzyme system in rats. Phytotherapy Research 16(1):24-27. Parkkonen J, Hasala H, Moilanen E, Giembycz MA, and Kankaanranta H (2008) Phosphodiesterase 4 inhibitors delay human eosinophil and neutrophil apoptosis in the absence and presence of salbutamol. Pulmonary Pharmacology & Therapeutics 21(3):499-506. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, and Cobb MH (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocrine Reviews 22(2):153-183. Pereira LM, Hatanaka E, Martins EF, Oliveira F, Liberti EA, Farsky SH, Curi R, and Pithon-Curi TC (2008) Effect of oleic and linoleic acids on the inflammatory phase of wound healing in rats. Cell Biochemistry and Function 26(2):197-204. Pham CT (2006) Neutrophil serine proteases: specific regulators of inflammation. Nature Reviews 6(7):541-550. Pham CT (2008) Neutrophil serine proteases fine-tune the inflammatory response. The International Journal of Biochemstry and Cell Biology 40(6-7):1317-1333. Poliak NR (1984) Neutrophil chemotaxis in patients with infectious-allergic bronchial asthma. Zhurnal mikrobiologii, epidemiologii, immunobiologii (1):80-82. Popi Lianou, Athanasios Fortis, Nikolaos Papadopoulos, Nikolaos Trakas, and John Papavassiliou (2001) Defective neutrophil function in patients with perennial allergic rhinitis. Allergology International 50:15-20 Porcellati S, Costantini V, Prosdocimi M, Stasi M, Pistolesi R, Nenci GG, and Goracci G (1990) The coumarin derivative AD6 inhibits the release of arachidonic acid by interfering with phospholipase A2 activity in human platelets stimulated with thrombin. Agents and Actions 29(3-4):364-373. Pozuelo Rubio M, Campbell DG, Morrice NA, and Mackintosh C (2005) Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428. The Biochemical Journal 392(Pt 1):163-172. Pryzwansky KB, Wyatt TA, Nichols H, and Lincoln TM (1990) Compartmentalization of cyclic GMP-dependent protein kinase in formyl-peptide stimulated neutrophils. Blood 76(3):612-618. Putney JW Jr. (1999) TRP, inositol 1,4,5-trisphosphate receptors, and capacitative calcium entry. Proceedings of the National Academy of Sciences of the United States of America 96(26):14669-14671. Quinn K, Henriques M, Parker T, Slutsky AS, and Zhang H (2008) Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases. American Journal of Physiology, Heart Circulatory Physiology 295(5):H1817-1824. Rane MJ, Carrithers SL, Arthur JM, Klein JB, and McLeish KR (1997) Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: role in activation of reduced nicotinamide adenine dinucleotide oxidase. Journal of Immunology 159(10):5070-5078. Rao GX, Gao YL, Lin YP, Xiao YL, Li SH, and Sun HD (2006) Chemical constituents of Selinum cryptotaenium. Journal of Asian Natural Products Research 8(3):273-275. Rebecchi MJ and Pentyala SN (2000) Structure, function, and control of phosphoinositide-specific phospholipase C. Physiological Reviews 80(4):1291-1335. Redig AJ and Platanias LC (2007) The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis. Journal of Interferon and Cytokine Research 27(8):623-636. Resch M, Steigel A, Chen ZL, and Bauer R. (1998) 5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea. Journal of Natural Products 61(3):347-350. Rhee SG (2001) Regulation of phosphoinositide-specific phospholipase C. Annual Review of Biochemistry 70:281-312. Ribaldi E, Mezzasoma AM, Francescangeli E, Prosdocimi M, Nenci GG, Goracci G, and Gresele P (1996) Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation. British Journal of Pharmacology 118(6):1351-1358. Ring J and Lutz J (1983) Decreased release of lysosomal enzymes from peripheral leukocytes of patients with atopic dermatitis. Journal of the American Academy of Dermatology 8(3):378-385. Riviere C, Goossens L, Pommery N, Fourneau C, Delelis A, and Henichart JP (2006) Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker. Natural Product Research 20(10):909-916. Roesler WJ, Vandenbark GR, and Hanson RW (1988) Cyclic AMP and the induction of eukaryotic gene transcription. The Journal of Biological Chemistry 263(19):9063-9066. Rollet-Labelle E, Gilbert C, and Naccache PH (2000) Modulation of human neutrophil responses to CD32 cross-linking by serine/threonine phosphatase inhibitors: cross-talk between serine/threonine and tyrosine phosphorylation. Journal of Immunology 164(2):1020-1028. Rosselli S, Maggio A, Bellone G, Formisano C, Basile A, Cicala C, Alfieri A, Mascolo N, and Bruno M (2007) Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa. Planta Medica 73(2):116-120. Ryu SY, Kou NY, Choi HS, Ryu H, Kim TS, and Kim KM (2001) Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells. Planta Medica 67(2):172-174. Sakamoto K, Kuribayashi F, Nakamura M, and Takeshige K (2006) Involvement of p38 MAP kinase in not only activation of the phagocyte NADPH oxidase induced by formyl-methionyl-leucyl-phenylalanine but also determination of the extent of the activity. Journal of Biochemistry 140:739–745. Sande JB, Sjaastad I, Hoen IB, Bokenes J, Tonnessen T, Holt E, Lunde PK and, Christensen G (2002) Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity. Cardiovascular Research 53(2):382-391. Sanz MJ, Cortijo J, and Morcillo EJ (2005) PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression. Pharmacology & Therapeutics 106(3):269-297. Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, and Penninger JM (2000) Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 287(5455):1040-1046. Schaeffer HJ and Weber MJ (1999) Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Molecular and Cellular Biology 19(4):2435-2444. Schudt C, Winder S, forderkunz S, Hatzelmann, and Ullrich V (1991) Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai. Naunyn-Schmiedeberg’s Archives of Pharmacology 344:682-690. Segal AW (2005) How neutrophils kill microbes. Annual Review of Immunology 23:197-223. Seino S and Shibasaki T (2005) PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiological Reviews 85(4):1303-1342. Selvatici R, Falzarano S, Mollica A, and Spisani S (2006) Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils. European Journal of Pharmacology 534(1-3):1-11. Serhan CN and Savill J (2005) Resolution of inflammation: the beginning programs the end. Nature Immunology 6(12):1191-1197. Sette C and Conti M (1996) Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation. The Journal of Biological Chemistry 271(28):16526-16534. Sharma RK, Negi DS, Gibbons S, and Otsuka H (2008) Chemical and antibacterial constituents of Skimmia anquetelia. Planta Medica 74(2):175-177. Shimizu M, Matsuzawa T, Suzuki S, Yoshizaki M, and Morita N (1991) Evaluation of angelicae radix (Touki) by the inhibitory effect on platelet aggregation. Chemical & Pharmaceutical Bulletin 39(8):2046-2048. Simchowitz L, Fischbein LC, Spilberg I, and Atkinson JP (1980) Induction of a transient elevation in intracellular levels of adenosine-3',5'-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation. Journal of Immunology 124(3):1482-1491. Skalhegg BS and Tasken K (2000) Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA. Frontiers in Bioscience 5:D678-693. Smallwood JI and Malawista SE (1992) Protein kinase C isoforms in human neutrophil cytoplasts. Journal of Leukocyte Biology 51(1):84-92. Smith SJ, Brookes-Fazakerley S, Donnelly LE, Barnes PJ, Barnette MS, and Giembycz MA (2003) Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells. American Journal of Physiology 284(2):L279-289. Smith VB and Spina D. (2005) Selective phosphodiesterase 4 inhibitors in the treatment of allergy and inflammation. Current Opinion in Investigational Drugs 6(11):1136-41. Smolen JE, Korchak HM, and Weissmann G (1980) Increased levels of cyclic adenosine-3',5'-monophosphate in human polymorphonuclear leukocytes after surface stimulation. The Journal of Clinical Investigation 65(5):1077-1085. Spina D (2008) PDE4 inhibitors: current status. British Journal of Pharmacology 155(3):308-315. Spisani S, Pareschi MC, Buzzi M, Colamussi ML, Biondi C, Traniello S, Pagani Zecchini G, Paglialunga Paradisi M, Torrini I, and Ferretti ME (1996) Effect of cyclic AMP level reduction on human neutrophil responses to formylated peptides. Cellular Signalling 8(4):269-277. Styrt B, Rocklin RE, and Klempner MS (1988) Characterization of the neutrophil respiratory burst in atopy. The Journal of Allergy and Clinical Immunology 81(1):20-26. Sun F, Xie ML, Zhu LJ, Xue J, and Gu ZL (2009) Inhibitory effect of osthole on alcohol-induced fatty liver in mice. Digestive and Liver Disease 41(2):127-33. Sunahara RK, Dessauer CW, and Gilman AG (1996) Complexity and diversity of mammalian adenylyl cyclases. Annual Review of Pharmacology and Toxicology 36:461-480. Sunahara RK and Taussig R (2002) Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Molecular Interventions 2(3):168-184. Sutliff RL, Hoying JB, Kadambi VJ, Kranias EG, and Paul RJ (1999) Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice. Circulation Research 84(3):360-364. Suzuki T, Hazeki O, Hazeki K, Ui M, and Katada T (1996) Involvement of the beta gamma subunits of inhibitory GTP-binding protein in chemoattractant receptor-mediated potentiation of cyclic AMP formation in guinea pig neutrophils. Biochimica et Biophysica Acta 1313(1):72-78. Takeya R and Sumimoto H (2006) Regulation of novel superoxide-producing NAD(P)H oxidases. Antioxidants & Redox Signaling 8(9-10):1523-1532. Tang WJ and Gilman AG (1991) Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science 254(5037):1500-1503. Tasken K and Aandahl EM (2004) Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiological Reviews 84(1):137-167. Taylor CW and Laude AJ (2002) IP3 receptors and their regulation by calmodulin and cytosolic Ca2+. Cell Calcium 32(5-6):321-334. Taylor SS, Yang J, Wu J, Haste NM, Radzio-Andzelm E, and Anand G (2004) PKA: a portrait of protein kinase dynamics. Biochimica et Biophysica Acta 1697(1-2):259-269. Teng CM, Lin CH, Ko FN, Wu TS, and Huang TF (1994) The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea. Naunyn-Schmiedeberg's Archives of Pharmacology 349(2):202-208. Theilgaard-Monch K, Porse BT, and Borregaard N (2006) Systems biology of neutrophil differentiation and immune response. Current Opinion in Immunology 18(1):54-60. Tilton B, Andjelkovic M, Didichenko SA, Hemmings BA, and Thelen M (1997) G-Protein-coupled receptors and Fcgamma-receptors mediate activation of Akt/protein kinase B in human phagocytes. The Journal of Biological Chemistry 272(44):28096-28101. Tintinger G, Steel HC, and Anderson R (2005) Taming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control. Clinical and Experimental Immunology 141(2):191–200. Traynor-Kaplan AE, Thompson BL, Harris AL, Taylor P, Omann GM, and Sklar LA (1989) Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils. The Journal of Biological Chemistry 264(26):15668-15673. Tsu RC, Allen RA, and Wong YH (1995) Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors. Molecular Pharmacology 47(4):835-841. Tsushima K, King LS, Aggarwal NR, De Gorordo A, D'Alessio FR, and Kubo K. (2009) Acute lung injury review. Internal Medicine 48(9):621-630. Tyagi SR, Tamura M, Burnham DN, and Lambeth JD (1988) Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst. The Journal of Biological Chemistry 263(26):13191-13198. Uhlik MT, Abell AN, Cuevas BD, Nakamura K, and Johnson GL (2004) Wiring diagrams of MAPK regulation by MEKK1, 2, and 3. Biochemistry and Cell Biology 82(6):658-663. Underwood DC, Bochnowicz S, Osborn RR, Kotzer CJ, Luttmann MA, Hay DW, Gorycki PD, Christensen SB, and Torphy TJ (1998) Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig. The Journal of Pharmacology and Experimental Therapeutics 287(3):988-995. Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, and Waterfield MD (2001) Synthesis and function of 3-phosphorylated inositol lipids. Annual Review of Biochemistry 70:535-602. VanUffelen BE, de Koster BM, and Elferink JG (1998) Interaction of cyclic GMP and cyclic AMP during neutrophil migration: involvement of phosphodiesterase type III. Biochemical Pharmacology 56(8):1061-1063. Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, and Grinstein S (2001) Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. The Journal of Cell Biology 155(1):19-25. Vignais PV (2002) The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell Molecullar Life Science 59(9):1428-1459. Vignola AM (2004) PDE4 inhibitors in COPD- a more selective approach to treatment. Respiratory Medicine 98(6):495-503. Villagrasa V, Navarrete C, Sanz C, Berto L, Perpina M, Cortijo J, and Morcillo EJ (1996) Inhibition of phosphodiesterase IV and intracellular calcium levels in human polymorphonuclear leukocytes. Methods and Findings in Experimental and Clinical Pharmacology 18(4):239-245. Wachtel H (1982) Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3', 5'-monophosphate phosphodiesterase inhibitors. Psychopharmacology 77(4):309-316. Wachtel H (1983) Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology 22(3):267-272. Wada K, Kamisaki Y, Kitano M, Kishimoto Y, Nakamoto K, and Itoh T (1996) A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach. Life Sciences 59(19):PL295-301. Walker EH, Perisic O, Ried C, Stephens L, and Williams RL (1999) Structural insights into phosphoinositide 3-kinase catalysis and signalling. Nature 402(6759):313-320. Wang B, Zhang P, and Wei Q (2008) Recent progress on the structure of Ser/Thr protein phosphatases. Science in China Seres C: Life Sciences 51(6):487-494. Wang JP, Raung SL, Huang LJ, and Kuo SC (1998) Involvement of cyclic AMP generation in the inhibition of respiratory burst by 2-phenyl-4-quinolone (YT-1) in rat neutrophils. Biochemical Pharmacology 56(11):1505-1514. Wang P, Wu P, Ohleth KM, Egan RW, and Billah MM (1999) Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils. Molecular Pharmacology 56(1):170-174. Wenzel-Seifert K, Arthur JM, Liu HY, and Seifert R (1999) Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3). The Journal of Biological Chemistry 274(47):33259-33266. Werner E (2004) GTPases and reactive oxygen species: switches for killing and signaling. Journal of Cell Science 117(Pt 2):143-153. Wiedow O and Meyer-Hoffert U (2005) Neutrophil serine proteases: potential key regulators of cell signalling during inflammation. Journal of Internal Medicine 257(4):319-328. Wilasrusmee C, Kittur S, Siddiqui J, Bruch D, Wilasrusmee S, and Kittur DS (2002a) In vitro immunomodulatory effects of ten commonly used herbs on murine lymphocytes. Journal of Alternative and Complement Medicine 8(4):467-475. Wilasrusmee C, Siddiqui J, Bruch D, Wilasrusmee S, Kittur S, and Kittur DS (2002b) In vitro immunomodulatory effects of herbal products. American Surgeon 68(10):860-864. Witko-Sarsat V, Rieu P, Descamps-Latscha B, Lesavre P, and Halbwachs-Mecarelli L (2000) Neutrophils: molecules, functions and pathophysiological aspects. Laboratory Investigation 80(5):617-653. Wu SN, Lo YK, Chen CC, Li HF, and Chiang HT (2002) Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells. Biochemical Pharmacology 63(2):199-206. Wymann MP and Pirola L (1998) Structure and function of phosphoinositide 3-kinases. Biochimica et Biophysica Acta 1436(1-2):127-150. Yang WJ, Li DP, Li JK, Li MH, Chen YL, and Zhang PZ (2009) Synergistic Antioxidant Activities of Eight Traditional Chinese Herb Pairs. Biological & Pharmaceutical Bulletin 32(6):1021-1026. Zangerl AR and Berenbaum MR (2004) Genetic variation in primary metabolites of Pastinaca sativa; can herbivores act as selective agents? Journal of Chemical Ecoloy 30(10):1985-2002. Zhang Q, Qin L, He W, Van Puyvelde L, Mases D, Adams A, Zheng H, and De Kimpe N (2007) Coumarins from Cnidium monnieri and their antiosteoporotic activity. Planta Medica 73(1):13-19. Zhang Y, Xie M, Xue J, and Gu Z (2007) Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression. Planta Medica 73(8):718-724. Zhang Y, Xie ML, Xue J, and Gu ZL (2008) Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats. Journal of Asian Natural Products Research 10(7-8):807-812. Zhao KJ, Dong TT, Tu PF, Song ZH, Lo CK, and Tsim KW (2003) Molecular genetic and chemical assessment of radix Angelica (Danggui) in China. Journal Agriculturaland Food Chemistry 51(9):2576-2583. Zhu DP (1987) Dong quai. The American Journal of Chinese Medicine 15(3-4):117-125. Zimmermann B, Chiorini JA, Ma Y, Kotin RM, and Herberg FW (1999) PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. The Journal of Biological Chemistry 274(9):5370-5378.
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