臺灣博碩士論文加值系統

本論文主要以泡沫銅來當作工作電極，再利用氫氧化鎳(水熱法)、奈米鑽石(NUNCD)來做非酵素型葡萄糖感測器的修飾，在氫氧化鎳和奈米鑽石介面形成鍵結來維持穩定度，並改善泡沫銅隨時間氧化產生靈敏度衰減的現象，根據不同參數來實驗出最佳的非酵素型葡萄糖感測器條件。水熱法氫氧化鎳有最好的靈敏度為 8257.6μAmM-1cm-2 (0.5~2 mM)、LOD為 2.492 μM。低濃度下水熱法氫氧化鎳靈敏度為18964 (5~40μm)、LOD為 2.141 μM。

退火奈米鑽石的添加降低試片整體衰減性，對於水熱法氫氧化鎳靈敏度在大氣環境下放置7天後衰減程度減少為 6.6~9.7%。，添加退火奈米鑽石的水熱法氫氧化鎳有最好的靈敏度為 4753.6μAmM-1cm-2 (0.5~2 mM)、LOD為2.179μM。

In this study, we report nickel hydroxide (Ni(OH)2) and nitrogen incorporated ultrananocrystalline diamond (N-UNCD)/(Ni(OH)2) on copper foam for non-enzyme glucose sensor. Initially, the hydrothermal growth condition of (Ni(OH)2) was optimized to study their glucose sensing properties. It was revealed that the best sensitivity of hydrothermal Ni(OH)2 is 8257.6 µAmM-1cm-2 (0.5~2 mM), LOD is 2.492 μM. On the other hand, the Ni(OH)2/copper foam exhibits the low concentration glucose sensitivity of 18964 µAmM-1cm-2 (5~40μm), LOD is 2.141 μM, respectively. This result is 10 times better than the sensitivity of high glucose concentration measurements. The stability of the Ni(OH)2/copper foam was then measured after 7 days, which shows the decay of 28.5%. To overcome the decay of Ni(OH)2/copper foam electrode, N-UNCD was grown on copper foam with and without anneal. Thus, the highest sensitivity of Ni(OH)2 /N-UNCD/copper foam is 4753.6 µAmM-1cm-2 (0.5~2 mM), LOD is 2.179μM. However, despite the sensitivity of Ni(OH)2 /N-UNCD/copper foam is not as high as compared with the Ni(OH)2/copper foam electrode, still the stability of the annealed N-UNCD exhibits only 6 to 9% of decay after 7 days. This is because the chemical stability of N-UNCD in electrolyte solution and the electrocatalytic behavior of Ni(OH)2/copper foam. Furthermore, the synergistic effect between N-UNCD and Ni(OH)2/copper foam enhances the stability of Ni(OH)2/N-UNCD/copper foam electrode based glucose sensor.

目錄
中文摘要 I
英文摘要 II
目錄 III
圖目錄 VII
表目錄 XII
第一章 緒論 1
1.1 前言 1
1.2 研究動機 3
第二章 文獻回顧 4
2.1 氫氧化鎳 4
2.1.1 氫氧化鎳的特性 4
2.1.2 氫氧化鎳水熱法成長機制 …5
2.1.3 氫氧化鎳水熱法成長機制 6
2.1.4 超奈米鑽石成長機制 6

2.2 鑽石薄膜 12
2.2.1 鑽石薄膜的結構與特性 12
2.2.2奈米結晶鑽石 12
2.2.3 超奈米結晶鑽石 13
2.3 電化學分析 13
2.3.1 電化學分析法之簡介 13
2.3.2 電化學分析法之種類 14
2.4 生物感測器 16
2.4.1 生物感測器之簡介 16
2.4.2 生物感測器之種類 17
2.5 葡萄糖感測器 20
2.5.1 葡萄糖感測之發展世代 20
2.5.2 葡萄糖感測器之檢測方式 22
2.5.3 非酵素型葡萄糖感測器之電極與修飾物種類 23
第三章 實驗方法 25
3.1 實驗流程 25
3.2 網狀氫氧化鎳的製備 27
3.2-1 泡沫銅前處理 27
3.2-2 水熱法網狀氫氧化鎳之成長方法 28
3.3 奈米鑽石之製備方法 29
3.3.1 泡沫銅前處理 29
3.3.2 以鑽石粉末及鈦金屬粉末震盪製備種子層 30
3.3.3 以微波電漿化學氣象沉積法(Microwave Plasma Chemical Vapor Deposition System)成長奈米鑽石薄膜 31
3.4 葡萄糖感測器試片封裝及循環伏安法表面改質 32
3.4.1 葡萄糖試片封裝 33
3.4.2 葡萄糖感測器表面改質 34
3.5 實驗分析儀器介紹 34
3.5.1 場發射掃描式電子顯微鏡 (FE-SEM) 35
3.5.2 顯微拉曼光譜儀 (Micro-Raman) 36
3.5.3 D2 PHASER X光繞射儀 37
3.5.4 X射線光電子能譜儀 (XPS) 38
3.5.5 電化學分析儀 (Electrochemical Workstation) 39
第四章 水熱法三維網狀氫氧化鎳之合成及特性分析 40
4.1 水熱法三維網狀氫氧化鎳之表面型態分析 42
4.2 水熱法三維網狀氫氧化鎳之X光繞射儀分析 47
4.3 水熱法三維網狀氫氧化鎳之拉曼光譜儀分析 48
4.4 水熱法三維網狀氫氧化鎳之X射線光電子能譜儀分析 49
4.5 水熱法三維網狀氫氧化鎳之葡萄糖量測電化學分析 50
4.5.1 表面改質 50
4.5.2 循環伏安法分析 51
4.5.3 定電位沉積分析法 (靈敏度分析) 52
4.5.4 定電位沉積分析法 (選擇性分析) 58
4.5.5 定電位沉積分析法 (穩定度分析) 59
第五章 三維網狀氫氧化鎳/奈米鑽石之合成及特性分析 61
5.1 化學氣相沉積法奈米鑽石之表面型態分析 61
5.2 三維網狀氫氧化鎳/奈米鑽石之表面型態分析.......................................62
5.3 三維網狀氫氧化鎳/奈米鑽石之X光繞射儀分析 63
5.4 三維網狀氫氧化鎳/奈米鑽石之拉曼光譜儀分析 64
5.5 三維網狀氫氧化鎳/奈米鑽石之X射線光電子能譜儀分析 65
5.6 三維網狀氫氧化鎳/奈米鑽石之葡萄糖量測電化學分析 66
5.6.1 表面改質 67
5.6.2 循環伏安法分析 68
5.6.3 定電位沉積分析法 (靈敏度分析) 69
5.6.4 定電位沉積分析法 (選擇性分析) 72
5.6.5 定電位沉積分析法 (穩定度分析) 73
第六章 三維網狀氫氧化鎳/退火後奈米鑽石之合成及特性分析 73
6.1 三維網狀氫氧化鎳/退火後奈米鑽石之表面型態分析 73
6.2 三維網狀氫氧化鎳/退火後奈米鑽石之X光繞射儀分析 75
6.3 三維網狀氫氧化鎳/退火後奈米鑽石之拉曼光譜儀分析 76
6.4 三維網狀氫氧化鎳/退火後奈米鑽石之X射線光電子能譜儀分析 79
6.5 三維網狀氫氧化鎳/退火後奈米鑽石之葡萄糖量測電化學分析 80
6.5-1 表面改質 80
6.5-2 循環伏安法分析 82
6.5-3 定電位沉積分析法 (靈敏度分析) 86
6.5-4 定電位沉積分析法 (選擇性分析) 86
6.5-5 定電位沉積分析法 (穩定度分析) 88
第七章 結論與未來展望 89
7.1 結論 90
7.2 未來展望 91
參考文獻 92

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