跳到主要內容

臺灣博碩士論文加值系統

(216.73.216.176) 您好!臺灣時間:2025/09/08 08:24
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:陳思伃
研究生(外文):Ssu-Yu Chen
論文名稱:補充黑大蒜與運動對停經後婦女體內氧化 壓力及心血管疾病危險因子之影響
論文名稱(外文):Effects of aged black garlic extract and exercise on oxidativestress factor for cardiovascular disease in postmenopausal women
指導教授:李淑玲李淑玲引用關係
指導教授(外文):Shu-Lin Lee
口試委員:傅正思何應志
口試日期:2014-07-24
學位類別:碩士
校院名稱:中州科技大學
系所名稱:保健食品系
學門:農業科學學門
學類:食品科學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:中文
論文頁數:45
中文關鍵詞:黑大蒜停經後婦女氧化壓力心血管疾病
外文關鍵詞:aged black garlic extractpostmenopausal womenoxidative stresscardiovascular disease
相關次數:
  • 被引用被引用:1
  • 點閱點閱:384
  • 評分評分:
  • 下載下載:13
  • 收藏至我的研究室書目清單書目收藏:2
本研究目的為探討停經後婦女體內氧化壓力及心血管疾病
危險因子的影響。本實驗採雙盲設計進行9 週黑大蒜補充及運
動介入之研究,受試者隨機分為四組:(a)黑大蒜補充組(AGE,
n=11);(b)安慰劑組(PL, n=12);(c)黑大蒜補充+運動組(AGE +EX,
n=14);(d)安慰劑+運動組(PL+EX, n=7),所有受試者於實驗前
第0 週及第9 週進行血液採集,進行分析。研究結果發現(一)
各組間於介入前,在年齡、身高、體重、BMI 並無顯著性差異,
因此可確認實驗前之身體組成的一致性;(二)補充黑大蒜組體脂
肪率雖有下降,但未達顯著差異,而在黑大蒜配合運動組其體
脂肪率及腰圍有顯著下降;(三)安慰劑配合運動組及黑大蒜配合
運動組介入對收縮壓具有顯著下降的效益;(四)血糖濃度變化的
情形;安慰劑組、黑大蒜組及黑大蒜配合運動組皆具有顯著下
降;(五)血脂質濃度改變情形;三酸甘油脂、總膽固醇、高密度
膽固醇等數據,在各組內前後測比較皆無顯著差異。(六)丙二醛
(MDA)濃度與紅血球中SOD 活性之結果各組組內之數據並無顯
著性的差異。由結果發現黑大蒜配合運動介入對停經後婦女體
內降低脂質過氧化物之濃度與提升SOD 抗氧化酵素活性無顯著
影響,但是在身體組成與降低收縮壓上確實有顯著的效益,顯
IV
示:黑大蒜配合運動對降低停經後婦女體內心血管疾病危險因子
將有所幫助。
The purpose of this study is to investigate aged black garlic extract and
exercise on oxidative stress and cardiovascular disease risk factors in
postmenopausal women. Subjects were randomly divided into four
groups : (1) aged black garlic extract supplement group (AGE, n=11);
(2) Placebo group (PL, n=12); (3) aged black garlic extract supplement
and physical activity program group (AGE+Ex, n=14); (4) Placebo and
physical activity program group (PL+Ex, n=7). All subjects were
collected blood sample before and 9 weeks of supplement and exercise
intervention. The results showed that (1) there were no significantly
different in age, height, weight, and body fat prior the trail between
four groups. The results confirmed the body composition consistency
prior experiment ; (2) body fat percentage has tend to decrease in AGE
group after 9 weeks intervention, and body fat and waist circumference
were significantly decreased in AGE+Ex group; (3) systolic blood
pressure has significantly decreased in PL+Ex and AGE+Ex groups ;(4)
blood glucose concentration were significantly decreased after 9 weeks
intervention in AGE, PLA and AGE+Ex groups; (5) the lipid profiled
were no significantly changes between four groups; (6) the
concentrations of malondialdehyde and erythrocyte SOD activity are
not significantly differences before and after 9 weeks interventions.
The results showed that AGE supplement with exercise intervention
not improve antioxidant capacity, but that may benefit on change of
body composition and the systolic blood pressures. Therefore, black
garlic combined with exercise will helpful for reducing cardiovascular
risk factors in postmenopausal women.
Keywords: aged black garlic extract, postmenopausal women ,
oxidative stress , cardiovascular disease
目錄
審定書
授權書 I
中文摘要 III
英文摘要 V
誌謝 VI
第一章 緒論_______________________________________________1
第一節 研究背景與動機___________________________________ 1
第二節 研究目的_________________________________________ 3
第三節 研究問題_________________________________________ 4
第四節 名詞解釋_________________________________________ 4
第二章 文獻探討___________________________________________6
第一節 停經婦女之生理變化與疾病問題_____________________ 6
(一) 停經婦女之生理變化________________________________ 6
(二) 停經後婦女對心血管疾病、抗氧化的相關性____________ 8
第二節 自由基的介紹____________________________________ 10
(一) 自由基的定義_____________________________________ 10
(二) 自由基與抗氧化的相關性___________________________ 12
IX
第三節 黑大蒜成份及生理功能____________________________ 14
(一) 黑大蒜的簡介____________________________________ 14
(二) 黑大蒜對心血管疾病、抗氧化的相關性______________ 19
第四節 運動與停經後婦女之健康探討______________________ 20
(一) 運動對停經後婦女的益處__________________________ 20
第三章 研究方法__________________________________________25
第一節 研究對象________________________________________ 25
第二節 實驗設計________________________________________ 25
第三節 研究工具與方法__________________________________ 27
第四節 統計分析________________________________________ 31
第四章 結果與討論________________________________________32
第五章 結論與建議________________________________________45
第一節 結論____________________________________________ 45
第二節 建議____________________________________________ 45
參考文獻
一、中文部分
1. 方進隆(2000)。停經後婦女的運動保健。載於行政院體育委員
會、中華民國體育學會(主編),婦女體育(頁29-41)。台北市:
中華民國體育學會。
2. 王秀華(2003)。中年女性參與不同等及身體活動與其影響因素
之調 查研究。體育學報,35,1-14。
3. 行政院衛生署(2011)。99 年度死因統計【原始數據】。取自
http://www.doh.gov.tw/CHT2006/DM/DM2_2.aspx?now_fod_list
_no=11962&class_no=440&level_no=4
4. 行政院衛生署國民健康局人口與健康調查研究中心(2004) 。人
口、家庭與國民健康政策回顧與展望。
5. 吳德玉(2004)。規律運動訓練對心血管疾病危險群婦女危險因
子及情緒狀態之影響(碩士論文,台北醫學大學,2004)。
6. 沈立言(2004) 。大蒜與健康。科學發展 384:24-29。
7. 林宇旋、張幸真、陳姿伶(2003)。台灣地區婦女更年身心症狀
盛行率及健康相關知識行為-民國91 年國民健康促進知識態度
與行為調查結果。
48
8. 林宛臻、林麗娟、羅詩文、楊宜青、姚維仁。低阻力彈力帶訓
練對停經後婦女身體組成與功能性體適能之影響。(台灣老年
醫學暨老年學雜誌 2010;5(4):266-276)。
9. 洪子涵(2011)探討梅納反應對大蒜生理機能之影響:抗氧化及細
胞減脂活性。(碩士論文,國立宜蘭大學,2011)。
10. 洪志宏(2012)。健康管理學刊10(2) 138-139。
11. 徐錦興 (2007)‧走路有風- 透過健走促進健康‧科學發展,
413 , 72-77 。
12. 張婷方(2010) 。彈力帶運動對退化性膝關節炎女性患者下肢功
能之影響。(碩士論文,國立台北護理學院,2010)
13. 曹榮穎(2006)。淺談更年期症候群的中醫療法與自我保健之
道。中國醫訊,134。
14. 許朝欽、黃國恩 (1997) 。比較停經後婦女接受中藥治療或雌激
素治療其更年期症狀血脂肪及骨質密度之研究。
15. 黃國晉、林瑞雄、陳慶餘、宋丕錕、周松男(2000)。停經前後
體脂肪組成與血清瘦素值的研究。台灣醫學,4(1) ,8-13。
16. 黃彩玉、王榮全、郭彥呈(2011)。台南科技大學通識教育學刊 (10)
185-202 。
49
17. 楊再興(2000)。更年期荷爾蒙補充治療新貌。北市衛生雙月刊,
51,7-8。
18. 趙文婉、張珍田、周淑姿(2002)。淺談植物類化學物質對抗自
由基機制。食品工業月刊34(2):49-59。
19. 趙克然、楊毅軍、曹道俊、胡淼琳(2002)。氧自由基與臨床。
合記出版社。
20. 劉紹毅(2012)自由基、動脈粥樣硬化、高血壓和血管疾病的預
防與治療。中華民國血液淨化醫學會雜誌,16 (1),74-97。
21. 簡辰霖、簡盟月、吳英黛(2008) 。雌激素在血管與心肌的作用。
22. 簡辰霖、簡盟月、吳英黛 (2008)。 停經後女性身體活動與心
血管 疾病的相關性。物理治療,33(4),254-264。
50
二、英文部分
1. Amagase, H., Petesch, B. L., Matsuura, H., Kasuga, S., & Itakura, Y.
(2001). Intake of garlic and its bioactive components. Journal of
Nutrition, 131(3s), 955S-962S.
2. Amagase,H.(2006).Clarifying the real bioactive constituents of
garlic.Journal of Nutrition,136,716-725.
3. Alwan, A. (2011). Global status report on noncommunicable
diseases 2010. World Health Organization, Geneva: WHO Press.
Retrieved from
http://whqlibdoc.who.int/publications/2011/9789240686458_eng.pdf
4. Al-Qattan KK, Khan I, Alnaqeeb MA and Ali M
(2001).Thromboxane-B2, prostaglandin-E2 and hypertension in the
rat 2-kidney 1-clip model: a possible mechanism of the garlic
induced hypotension. Prostaglandins Leukot Essent Fatty Acids.,
64:Ter.Arkh.,
5. Asikainen, T. M., Kukkonen-Harjula, K., & Miilunpalo, S. (2004).
Exercise for health for early postmenopausal women: A systematic
review of randomized controlled trials. Sports Medicine, 34(11),
753-778.
6. Antioxidant effect of garlic and aged black garlic in animal model
of type 2diabetes mellitus Nutrition Research and Practice (2009),
3(2), 156-161 DOI: 10.4162/nrp.2009.3.2.156 2009 The Korean
Nutrition Society and the Korean Society of Community Nutrition
7. Avci, A., Atli, T., Erguder, I. B., Varli, M., Devrim, E., Aras, S., &
Durak, I. (2008). Effects of garlic consumption on plasma and
erythrocyte antioxidant parameters in elderly subjects. Gerontology,
54(3), 173-176.
8. Banerjee SK, Mukherjee PK, Maulik SK (2003) Garlic as an
antioxidant: the good, the bad and the ugly. Phytother
Res.17:97-106.
9. Colin-Gonzalez, A. L., Santana, R. A., Silva-Islas, C. A.,
Chanez-Cardenas, M. E., Santamaria, A., & Maldonado, P. D.
(2012). The antioxidant mechanisms underlying the aged garlic
extract- and S-allylcysteine-induced protection. Oxidative Medicine
and Cellular Longevity, 2012, 907162.
10. Dae Yun Seo et al. (2012) Independent beneficial effects of aged
garlic extract intake with regular exercise on cardiovascular risk in
postmenopausal women, 6(3), 226-231.
51
11. Dallongeville J, Marecaux N, Isorez D, Zylbergberg G, Fruchart
JC, Amouyel P.(1995). Multiplecoronary heart disease risk factors
are associated with menopause and influenced by
substitutivehormonal therapy in a cohort of French women.
Atherosclerosis 1995; 118(1): 123
12. Dalle-Donne, I., Rossi, R., Colombo, R., Giustarini, D., & Milzani,
A. (2006). Biomarkers of oxidative damage in human disease.
Clinical Chemistry, 52(4), 601-623.
13. Davison, S. & Davis, S. R. (2003). New markers for cardiovascular
disease risk in women: impact of endogenous estrogen status and
exogenous postmenopausal hormone therapy. Journal of Clinical
Endocrinology and Metabolism, 88(6), 2470-2478.
14. Edmunds, E. & Lip, G. Y. H. (2000).Cardiovascular risk in women:
The cardiologist’s perspective. QJM.93(3),135-145.
15. Foody, J. M.(2001). Prevent cardiology: Strategies for the
prevention and treatment of coronary artery disease. New Jersey:
Humana press.
16. Gohlke-Barwolf C. (2000).Coronary artery disease—is menopause
a risk factor? Basic Res Cardiol 2000;95(Suppl 1): I77-I83.
17. Gregg EW,Cauley JA,Stone K,Thompson TJ,Bauer
DC,Cum-mings SR.(2003). Relationship of changes in physical
activity and mortality among Older women .JAMA 2003 ;
289:2379-86.
18. Gurevitz, O., Jonas, M., Boyko, V., Rabinowitz, B., &
Reicher-Resis H. (2000). Clinical profile and long-term prognosis
of women ≤50 years of age referred for Coronary angiography for
evaluation of chest pain. American Journal Cardiology, 85,
806-809.
19. Hagberg, J. M., Park, J. J., & Brown, M. D. (2000). The role of
exercise training in the treatment of hypertension: an update. Sports
Medicine, 30(3), 193-206.
20. Harauma A, Moriguchi T.(2006). Aged garlic extract improves
blood pressure in spontaneously hypertensive rats more safely than
raw garlic. J Nutr 2006;136:769S-773S.
21. Hennekens, C. H.(1997). Coronary disease: Risk intervention.
Women and heartdisease. London: Nosby.
52
22. Hiroshi Azumi, Nobutaka Inoue, Yoshitaka Ohashi, Mitsuyasu
Terashima, Takao Mori, Hideki Fujita, Kojiro Awano, Katsuya
Kobayashi, Kazumi Maeda, Katsuya Hata,Toshiro Shinke, Seiichi
Kobayashi, Ken-ichi Hirata, Seinosuke Kawashima, Hiroyuki
Itabe, Yoshitake Hayashi, Shinobu Imajoh-Ohmi, Hiroshi
Itoh, and Mitsuhiro Yokoyama,(2002).Superoxide Generation in
Directional Coronary Atherectomy Specimens of Patients With
Angina Pectoris Arteriosclerosis, Thrombosis, and Vascular
Biology.2002; 22: 1838-1844
23. Hoshino T, Kashimoto N, Kasuga S. Effects of garlic preparations
on the gastrointestinal mucosa. J Nutr 2001;131:1109S- 1113S
24. Ide, N., & Lau, B. H. (2001). Garlic compounds minimize
intracellular oxidative stress and inhibit nuclear factor-kappa b
activation. Journal of Nutrition, 131(3s), 1020S-1026S.
25. Imai J Ide N and Itakura Y.(1994) Antioxidant and radical
scavenging Effects of aged garlic extract and its constituents .Planta
Med.60:417-420.
26. Ishikawa, K., Ohta, T., Zhang, J., Hashimoto, S. & Tanaka, H.
(1999).Influence of age and gender on exercise training-induced
blood pressure reduction in systemic hypertension. The American
Journal of Cardiology, 84, 192-196.
27. Jung, E. S., Park, S. H., Choi, E. K., Ryu, B. H., Park, B. H., Kim,
D. S., . . . Chae, S. W. (2014). Reduction of blood lipid parameters
by a 12-wk supplementation of aged black garlic: A randomized
controlled trial. Nutrition, [Epub ahead of print]. doi:
10.1016/j.nut.2014.02.014
28. Jung, Y. M., Lee, S. H., Lee, D. S., You, M. J., Chung, I. K.,
Cheon, W. H., . . . Ku, S. K. (2011). Fermented garlic protects
diabetic, obese mice when fed a high-fat diet by antioxidant effects.
Nutrition Research, 31(5), 387-396.
29. Kim, K. M., Chun, S. B., Koo, M. S., Choi, W. J., Kim, T. W.,
Kwon, Y. G., . . . Kim, Y. M. (2001). Differential regulation of NO
availability from macrophages and endothelial cells by the garlic
component S-allyl cysteine. Free Radical Biology & Medicine,
30(7), 747-756.
30. Kodera, Y., Suzuki, A., Imada, O., Kasuga, S., Sumioka, I.,
Kanezawa, A., . . . Ono, K. (2002). Physical, chemical, and
biological properties of s-allylcysteine, an amino acid derived from
53
garlic. [J Agric Food Chem]. Journal of Agricultural and Food
Chemistry, 50(3), 622-632.
31. Knopp, R. H.(2002). Risk factors for coronary artery disease in
women. TheAmerican Journal of Cardiology, 89(12A),28E-35E.
32. Morihara, N., Hayama, M., & Fujii, H. (2011). Aged garlic extract
scavenges superoxide radicals. [Plant Foods Hum Nutr]. Plant
Foods for Human Nutrition, 66(1), 17-21
33. Mosca.L..Banka.C.L..Benjamin.E.J.Berra.K..Bushnell,C..Dolor.R.
J..et al.(2007).Evidence-based guidelines for cardiovascular disease
prevention in.
34. Na, H. K., Kim, E. H., Choi, M. A., Park, J. M., Kim, D. H., &
Surh, Y. J. (2012). Diallyl trisulfide induces apoptosis in human
breast cancer cells through ROS-mediated activation of JNK and
AP-1. Biochemical Pharmacology, 84(10), 1241-1250.
35. Numagami, Y., & Ohnishi, S. T. (2001). S-allylcysteine inhibits
free radical production, lipid peroxidation and neuronal damage in
rat brain ischemia. [J Nutr]. Journal of Nutrition, 131(3s),
1100S-1105S.
36. Oztasan, N., Taysi, S., Gumustekin, K., Altinkaynak, K., Aktas, O.,
Timur, Siktar, H.E., Keles, S., Akar, S., Akcay, F., Dane, S &Gul,
M.(2004). Endurance training attenuates exercise-induced oxidative
stress in erythrocytes in rat. European Journal of Applied
Physiology, 91(5), 622 – 627.
37. Park, J. H., Park, Y. K.and Park, E. (2009).Antioxidative and
antigenotoxic effects of garlic(Allium sativam L.) prepared by
different processing methods.Plant Food Hum.Nutr.64:244-249
38. Pines, A., & Berry, E. M. (2007). Exercise in the menopause-an
update. Climacteric,10(Suppl 2), 42-46.
39. Reuter, H. D., Koch, H. P., & Lawson, L. D. (1996). Therapeutic
effects of garlic and its preparations in Garlic: The Science and
Therapeutic Application of Allium Sativum L and Related Species.
Williams & Wilkins, London, UK.
40. Rosamond W,Flegal K,Friday G,Furie K,Go A ,Greenlund
K.(2007).Heart disease and strok statistics—2007 update:A report
from the American Heart Association Statistics Committee and
Stroke StatisticsSubcommittee.Circulation 2007;115:e69-171.
54
41. Sato.T and G.Miyata(2000). 〝Thenatraceuticl benefit,part
iv:garlic. 〞Nutrition 16(9):787-8.
42. Senturk, U. K., Gunduz, F., Kuru, O., Kocer, G., Ozkaya, Y.G.,
Yesilkaya, A.,Bor-Kucukatay, M., Uyuklu, M., YalCin, O., & Kurt,
O.B. (2005).Exercise-induced oxidative stress leads hemolysis in
sedentary but not trainedhumans. Journal of Applied Physiology, 99,
1434-1441.
43. Saravanan, G., & Ponmurugan, P. (2011). Ameliorative potential
of S-allyl cysteine on oxidative stress in STZ induced diabetic rats.
Chemico-Biological Interactions, 189(1-2), 100-106.
44. Schmidt, C., Fagerberg, B., Wikstrand, J., & Hulthe, J. (2006).
apoB/apoA-I ratio is related to femoral artery plaques and is
predictive for future cardiovascular events in healthy men.
Atherosclerosis,189(1),178-185.doi:10.1016/j.atherosclerosis.2005.
11.031
45. Senturk, U. K., Gunduz, F., Kuru, O., Kocer, G., Ozkaya, Y.G.,
Yesilkaya, A.,Bor-Kucukatay, M., Uyuklu, M., YalCin, O., &
Kurt,O.B. (2001).Exercise-induced oxidative stress leads hemolysis
in sedentary but not trainedrats. Journal of Applied Physiology, 91,
1999-2004.
46. Seo, D. Y., Lee, S., Figueroa, A., Kwak, Y. S., Kim, N., Rhee, B.
D., Han, J. (2012). Aged garlic extract enhances exercise-mediated
improvement of metabolic parameters in high fat diet-induced obese
rats. Nutrition Research and Practice, 6(6), 513-519.
47. Smith, J. A. (1995). Exercise, training and red blood cell turnover.
Sports medicine,19(1), 9-31.
48. Szygula, Z. (1990). Erytrocytic system under the influence of
physical exercise and training. The American journal of sports
medicine , 10,181-197.
49. The Taiwan WHOQOL Group. Introduction to the development of
the WHOQOL-Taiwan version. Chinese Journal of Public Health
2000;19:315-
50. Tesch, B. J. (2002). Herbs commonly used by women: an
evidence-based review. Dis Mon, 48(10), 671-696.
51. Warburton, D. E., Nicol, C. W., Gatto, S. N. & Bredin, S. S.
(2007). Cardiovascular disease and osteoporosis: balancing risk
management. Vascular Health and Risk Management, 3(5), 673-89.
55
52. Williams, M. J., Sutherland, W. H., McCormick, M. P., Yeoman,
D. J., & de Jong, S. A. (2005). Aged garlic extract improves
endothelial function in men with coronary artery disease.
Phytotherapy Research 19(4), 314-319.
53. Wang,D.,Feng,Y.,Liu,J.,Wang,M.,Sasaki,J.and Lu,
C.(2010).Black Garlic (Allium sativum) Extracts Enhance the
Immune
54. System.Medicinal and Aromatic Plant Science and Biotechnology
4:37-40
55. Weight, L. M., Byrne, M. J., Jacobs, O.K. (1991). Haemolytic
effects of exercise.Clinical science, 81, 147-152.
56. Wu, T. Y., Yeh, H. I., Chen, P., Chiou, Y. F., & Tsai, J. C. (2007).
The effects of simple eight-week regular exercise on cardiovascular
disease risk factors inmiddle-aged women at risk in Taiwan. Acta
Cardiologica Sinica, 23(3), 169-176.
57. Yung, L. M., Leung, F. P., Yao, X., Chen, Z. Y., & Huang, Y.
(2006). Reactive Oxygen species in vascular wall. Cardiovascular &
Haematological Disorders-Drug Targets, 6, 1-19.
58. Borek,C.(2001).Antrioxidant health effects of aged garlic extract.
J.Nutr.131:1010-1015
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top