臺灣博碩士論文加值系統

背景：同半胱胺酸(Homocysteine)是動脈粥狀硬化的獨立危險因子。目的：(一)女性銀髮族不同體型在同半胱胺酸之差異；(二)功能性體適能與同半胱胺酸之關聯性；(三)生理數值與同半胱胺酸之關聯性。方法：以32位65歲以上之女性銀髮族為研究對象，以身體質量(BMI)將所有受試者分類為體重正常組(18.5≦BMI＜24)共11人，過重組(24≦BMI＜27)共12人，肥胖組(BMI≧27)共9人。所有受試者隔夜禁食8小時抽血，分析血液中同半胱胺酸、葉酸、維生素B12之濃度，並實施生理數值測量(包括BMI、體脂率、腰圍、腰臀比)；功能性體適能測驗項目，包括：2分鐘原地踏步測驗(心肺耐力測驗)、抓背測試(上肢柔軟度)、椅子坐姿體前彎(下肢柔軟度)、8英呎起身繞行(動態平衡)、30秒單腳站立(靜態平衡)、手臂彎舉(上肢肌耐力)、30秒坐姿起立(下肢肌耐力)。所得結果以單因子變異數分析、獨立樣本t檢定、皮爾森績差相關、多元迴歸分析，進行相關資料分析。結果：(一)體重正常組、過重組和肥胖組之間，在同半胱胺酸、葉酸、維生素B12均沒有顯著差異(p＞.05)；(二)同半胱胺酸與功能性體適能的相關，僅坐姿體前彎測驗(下肢柔軟度)達顯著水準(p＜.05)；(三)以BMI、腰圍、體脂率為自變項，以同半胱胺酸為依變項，進行多元迴歸分析，結果僅體脂率達顯著水準(p＜.05)，R2＝.34。結論：不同體型(以BMI為指標)之間在同半胱胺酸沒有明顯差異；體脂率是血液中同半胱胺酸濃度的預測指標，可解釋34%的變異量。

Background: Homocysteine is an independent risk factor of atherosclerosis. Purpose: (1) Difference of homocysteine in female elderly with different body shapes. (2) Correlation between functional physical fitness and homocysteine. (3) Correlation between physiological values. Methods: The study objects comprised 32 female elderly aged 65 years old, whose body mass index (BMI) was applied to categorize all respondents into 11 respondents in normal weight group (18.5≦BMI＜24), 12 respondents in overweight group (24≦BMI＜27), and 9 respondents in obesity group (BMI≧27). All respondents underwent 8 hours of fasting overnight for blood drawing to analyze the concentration of homocysteine, folic acid, and Vitamin B12 in blood. The respondents also took measurement of physiological values (including BMI, body fat rate, waistline, and waist-hip ratio). Tests of functional physical fitness include: two-minute step test (aerobic endurance test), back scratch test (upper limb flexibility), seated forward bend (lower limb flexibility), eight-foot up-and-go (dynamic balance), 30-second single-leg stand (static balance), arm curls (upper limb muscle strength), and 30-second chair-to-stand (lower limb muscle strength). The results yielded then underwent one-way ANOVA, independent sample t-test, Pearson’s correlation coefficient, and multiple regression analysis. Results: (1) There is no significant difference (p＞.05) among homocysteine, folic acid and Vitamin B12 between the normal weight group, overweight group and obesity group. (2) For correlation between homocysteine and functional physical fitness, only seated forward bend (lower limb flexibility) reached significance (p＜.05). (3) Multiple regression analysis was conducted using BMI, waistline and body fat rate as independent variables while homocysteine was used as dependent variable. The results showed that only the body fat rate reached significance (p＜.05) and R2＝.34. Conclusion: Different body shapes (using BMI as indicator) do not have significant difference in homocysteine and body fat rate is the forecast indicator for the concentration of homocysteine in blood, which explains 34% of variance.

中文摘要……………………………………………………………………………...….i
英文摘要…………………………………………………………………………….…..ii
目 錄………………………………………………………………………………..…iii
表目錄…………………………………………………………………………...………v
圖目錄…………………………………………………………………………….….…vi

第壹章 緒論 1
第一節 研究背景 2
第二節 研究目的 3
第三節 研究範圍與限制 3
第四節 名詞操作型定義 3
第貳章 文獻探討 7
第一節 心血管疾病的新危險指標 7
第二節 同半胱胺酸（homocysteine）與心血管疾病 8
第三節 運動對同半胱胺酸的影響 12
第四節 老年人功能性體適能與身體活動之探討 13
第五節 本章結語 14
第參章 研究方法 15
第一節 研究架構 15
第二節 研究對象 16
第三節 實驗時間和地點 17
第四節 研究過程 18
第五節 實驗步驟 19
第六節 搜集血液檢體及生化分析 20
第七節 基本生理數值測量 22
第八節 功能性體適能測驗 23
第九節 資料處理 26
第肆章 結果 27
第一節 受試者各種變項之描述性統計 27
第二節 不同體型在同半胱胺酸、葉酸、維生素B12的差異 30
第三節 同半胱胺酸與生理數值及功能性體適能之相關 31
第四節 同半胱胺酸與生理數值之統計分析 33
第伍章 討論與結論 37
第一節 討論 37
第二節 結論與建議 39
參考文獻 40
附錄一 受試者須知 43
附錄二 受試者同意書 44
附錄三 運動安全問卷─「PAR-Q and YOU」 45
附錄四 受試者檢測表 46
附錄五 體重正常組生理數值原始資料 47
附錄六 過重組生理數值原始資料 48
附錄七 肥胖組生理數值原始資料 49
附錄八 體重正常組血液分析原始資料 50
附錄九 過重組血液分析原始資料 51
附錄十 肥胖組血液分析原始資料 52









表目錄
表4-1受試者基本資料之描述性統計……………………………………………..….25
表4-2不同體型血液生化分析之描述性統計表……………………………………...26
表4-3不同體型基本生理數值之描述性統計表……………………………………...26
表4-4不同體型功能性體適能之描述性統計表……………………………………...27
表4-5不同組別在各種變項之單因子變異數分析摘要表………………………..….28
表4-6所有受試者(N=32)同半胱胺酸與生理數值之相關摘要表………………..….29
表4-7所有受試者(N=32)同半胱胺酸與功能性體適能測驗成績之相關摘要表..….30
表4-8同半胱胺酸與腰圍獨立樣本t檢定摘要表…………………………………….31
表4-9同半胱胺酸與腰臀比獨立樣本t檢定摘要表………………………………….31
表4-10同半胱胺酸與體脂率獨立樣本t檢定摘要表……………………………….32
表4-11多元迴歸模式變異數分析摘要表………………………....………………….33
表4-12為多元迴規模式係數摘要表………………………………………………….33





圖目錄
圖1 同半胱胺酸(homocysteine)在血液中以四種型式循環存在……………….....4
圖2 研究流程………………………………………………………………………...16
圖3 抽血及基本生理數值測量之功能性體適能測驗流…………………………...17
圖4 搜集血液檢體…………………………………………………………………...19
圖5 基本生理數值測量…………………………………………………………...…20
圖6 功能性體適能測驗海報說明………………………………………………..….21
圖7 實施功能性體適能測驗……………………………………………………..….23

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