臺灣博碩士論文加值系統

將對碘苯甲酸(4-iodobenzoic acid)或對碘苯醯氯(4-iodobenzoyl
chloride)和正醇類(n-alkyl alcohol)合成為對碘苯甲酸正烷基酯(n-
alkyl-4-iodobenzoate),其產率在83-92%之間. 再將對碘苯甲酸正烷
基酯製成混合鋅銅親核試劑與N-碳醯基比啶鹽反應得到中間產物二氫比啶
化合物(dihydropyridine),經由硫粉氧化而得正烷基-4-(4'-比啶基)-苯
甲酸酯[n-alkyl-4-(4'-pyridyl)-benzoate],其產在42-56%之間.本篇主
要是以其合成為主.

Reaction of 4-iodobenzoic acid or 4-iodobenzoyl chloride with
n-alkylalcohol gave n-alkyl-4-iodobenzoate compounds in 83-92%
yields. Mixed copper,znic benylic nucleophiles were prepared
by n-alkyl-4-iodobenzoateswith znic metal insertion,followed by
transmetalization with copper.Additionof these nucleophiles to
N-acylpyridinium salts gave the intermediates,1,4-
dihydropyridines.These intermediates which were temporarily
stable underair at room temperature,could be oxidized by sulfur
to produce n-alkyl-4-(4'-pryidyl)-benzoayes in 42-56% yields.