臺灣博碩士論文加值系統

本研究針對離心式左心室輔助器之設計，利用計算流體力學軟體Ansys CFX，模擬開發之模型相關流場與性能分析，模型設計參數包含葉輪轉速、葉輪葉片數量、葉輪葉片高度、葉輪間隙及外殼輪廓設計。模型之外殼曲線輪廓，採用阿基米德螺旋線公式，藉由數值計算軟體Matlab將公式之點資料進行連接，再匯入3D繪圖軟體Solidworks進行模型建構。針對各項參數進行模擬分析，探討參數對心室輔助器性能之影響.。最後綜合各項設計參數，利用田口方法及模糊方法進行實驗規劃及分析設計，找出最佳設計參數組合進行模型修改，進行確認實驗。左心室輔助器之揚程及剪應力應達到設計要求，揚程需高於120mmHg，剪應力需低於150Pa。而本研究之最佳參數組合為m=2.25之外殼、轉速3900rpm、葉片數11片、葉片高度2mm、間隙1mm之組合。經由確認實驗之分析結果，本研究之最佳化左心室輔助器效能揚程為145.7mmHg、最大剪應力為118.3Pa，符合設計需求，也達到本研究之最佳化目的。

This study investigates factors affect performance of centrifugal Left Ventricle Assist Devices (LVAD).The factors include impeller speed, blade number of impeller, impeller height, clearance between impeller and casing, and casing geometry. The casing profiles were generated from Archimedes spiral equation with different parameter m, using Matlab, and then imported to Solidworks to develop 3-dimensional models. The computational fluid dynamic package, Ansys CFX, was utilized to conduct flow analysis and assess performance of the device. The simulation results would provide data for optimization procedure, using Taguchi and Fuzzy methods, to obtain optimal design parameters for the LVAD, that should meet the requirements, including pressure head is over 120 mmHg, and maximum shear stress is less than 150 Pa. The results indicate that set of design parameters consists of m with value of 2.25, speed of 3900rpm, blade height of 2mm, blade number of 11, and clearance of 1mm are optimal parameters for LVAD, that provides pressure head of 145.7 mmHg, and shear stress of 118.3 Pa.

目錄
摘要 I
Abstract II
目錄 III
圖目錄 V
表目錄 VIII
符號表 IX
第一章 緒論 1
1.1 前言 1
1.2 人工心臟簡介 4
1.3 文獻回顧 8
1.3.1 心室輔助器相關文獻 8
1.3.2 血液與剪應力關係與機械破壞 10
1.3.3 血液的功能與特性 11
1.3.4 血液的流體性質 13
1.3.5 牛頓與非牛頓流體之血液黏滯性 15
1.4 研究動機 18
1.5 論文架構 19
第二章 原理與方法 20
2.1. 統御方程式 20
2.2. 紊流模式 22
2.3. 格點系統 25
2.4. 最佳化方法 25
2.4.1. 田口品質工程 25
2.4.2. 模糊理論 29
2.4.2.1. 模糊集合 30
2.4.2.2. 模糊系統 32
2.4.3. 多目標最佳化 34
2.4.3.1. 模糊田口最佳化 34
第三章 結果與討論 36
3.1. 模型建構 36
3.2. 模擬分析及參數設定 38
3.2.1. 邊界條件 38
3.2.2. 網格設定與收斂性 39
3.3. 葉輪模型設計參數分析 41
3.3.1. 葉輪葉片數量 42
3.3.2. 葉輪葉片高度 47
3.3.3. 葉輪葉片與上蓋間隙 53
3.4. 外殼模型分析 61
3.5. 田口方法與模糊方法最佳化 69
第四章 結論與未來展望 79
4.1. 結論 79
4.2. 未來展望 80
參考文獻 81

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