臺灣博碩士論文加值系統

?阻斷劑這類抗高血壓藥有一共同中間體quinazoline，此中間體可與各種不同amide中間體製備各種不同?阻斷劑如Prazosin、Doxazosin、Terazosin等，從文獻與輝瑞公司的專利可得到2-amino-4-chloro-6,7-
dimethoxyquinazoline的製程，以此製程加以研究改善，使2-amino-4-chloro-6,7-dimethoxyquinazoline能量化生產，攻國內各藥廠開發?阻斷劑各項抗高血壓藥。

2-Amino-4-chloro-6,7-dimethoxyquinazoline is a common key intermediate of some a-blocker anti-hypertension drugs including Prazosin, Doxazosin, and Terazosin. The preparation of 2-amino-4-chloro-6,7-dimethoxyquinazoline was first reported by Pfizer pharmaceutical company. Some modifications have been done in order to achieve economic scale-up and mass production towards those anti-hypertension drugs.