臺灣博碩士論文加值系統

本論文探討螢光碳奈米點(簡稱碳點)的碳源，其碳鏈長度與量子產率(QY)的關聯性。使用環保與簡便之水熱法製備一系列具有高量子產率的碳點。以五種不同碳鏈長度之二羧酸作為碳源，並加入不同比例之表面鈍化劑(乙二胺)與螯合劑(氫氧化鎂)來提升碳點量子產率，研究最適合提升量子產率的合成比例並確認量子產率與碳源碳鏈長度之間的關聯性，量子產率最高達到31.50%。以綠色化學的角度合成碳點，溶劑為二次水，所合成出的碳點水溶性極佳，只需經0.22 μm濾頭過濾不需額外處理即具有高量子產率。該碳點之水溶液在可見光下為淡黃色，在紫外光照射下則發出藍色螢光。實驗所合成之碳點，皆使用紫外線-可見光光譜儀測量其最大吸收波長、螢光光譜儀測量其光致發光的性質與傅立葉紅外線光譜儀鑑定其化學官能基。所有碳點在室溫下儲存近六個月，仍保持良好螢光強度，顯示具有廣大的運用潛力。更進一步，此研究所合成的碳點能做為藥物載體或生物成像的標的物。

This research is to investigate the relation between the length of carbon chain as carbon source and quantum yield (QY), and how to obtain the maximum QY using a green and simple method - hydrothermal synthesis, to produce series of fluorescent carbon dots (CDs). To carry out the experiment, five variations of dicarboxylic acids with different length of carbon chain as carbon source are used. They are then doped with different proportions of ethylenediamine(EDA) which acts as a representative surface passivation agent, and with magnesium hydroxide (Mg(OH)2) as a representative chelation agent to enhance the QY. After the research, the most suitable synthesis proportion to enhance the QY is discovered, and the relation between QY and length of carbon chain as carbon source is also understood. As a result, highest value of QY (31.50%) was achieved. In green chemistry, the solvent used in reactions to synthesize CDs was ultrapure water which makes the CDs totally soluble in water. More than that, CDs need only to be filtered by 0.22 μm filter and no any additional treatment will be needed. The aqueous solution of the CDs was light yellow when observed under visible light and emitted blue fluorescence if irradiated by ultraviolet light. All the CDs in experiments were measured by the UV-Vis spectrometer for their absorbance, fluorescence spectrometer was used to record their properties of photoluminescence and FTIR was used to appraise the chemical functional groups. All the samples are stored at room temperature for almost six months and they still retain their fluorescence intensity. The long duration of fluorescence intensity shows its potential for broad application. Furthermore, we used carbon dots and 5-fluorouracil (5-FU) under ultrasonic oscillation. The CDs produced in this research could be used as a drug carrier or bio-imaging marker.

致謝............................................ I
摘要............................................ II
Abstract....................................... III
目錄............................................ IV
圖目錄.......................................... VI
表目錄.. ........................................IX
第一章 緒論...................................... 1
1.1 前言.................................... 1
1.2 研究背景................................ 2
第二章 簡介及文獻回顧............................. 10
2.1 碳奈米材料介紹........................... 10
2.2 碳點合成方法介紹........................ 10
2.3 本實驗室碳點合成方法介紹.................. 11
2.3.1 水熱法合成碳點............................. 11
2.4 碳點螢光介紹............................. 13
2.5 碳點應用................................ 15
第三章 實驗內容(材料與方法)....................... 25
3.1 實驗藥品................................ 25
3.2 實驗儀器................................ 27
3.3 實驗步驟................................ 28
3.3.1 水熱法合成碳點............................. 28
3.4 實驗流程................................ 35
第四章 結果與討論................................ 36
4.1 碳點之合成............................... 36
4.2 計算量子產率............................ 40
4.2.1 計算測量方法............................... 40
4.2.2 量子產率數據分析討論........................ 43
4.2.3 碳點合成中藥品添加順序與量子產率的關係 ........54
4.3 螢光光譜分析............................ 55
4.3.1碳點螢光光譜分析............................ 55
4.3.2 碳點載藥系統螢光光譜分析.................... 60
4.4 紫外線可見光光譜分析..................... 62
4.4.1 碳點紫外光可見光光譜分析.................... 62
4.4.2 碳點載體系統紫外光可見光光譜分析............. 67
4.5 傅立葉轉換紅外線光譜 (FTIR) 分析..........68
4.5.1 碳點傅立葉轉換紅外線光譜 (FTIR) 分析......... 68
4.5.2 碳點載藥系統傅立葉轉換紅外線光譜 (FTIR) 分析..74
4.6 碳點於室溫下保存對於PL強度的影響.......... 76
第五章 結論...................................... 77
第六章 參考文獻.................................. 79

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