臺灣博碩士論文加值系統

本文主要探討多組成反應的設計、合成及結構鑑定，一系列吡咯里西啶及氮呯/香豆素稠合之衍生物，並探討其潛在抗菌活性。第一部份，由微波輔助三組成反應，以脯氨酸、苯甲醛和1,3-茚二酮作為起始物，合成吡咯里西啶衍生物。第二部份，以假三組成反應縮合3-氨基-4-羥基香豆素與苯乙酮，製備氮呯/香豆素稠合之七員環雜環衍生物。探討合成方法範圍與限制並推測其反應機構，也發現部份氮呯/香豆素稠合的化合物具有對大腸桿菌的中等抗菌活性。

In this thesis, we report the design, synthesis, and characterization of pyrrolizidine and azepine/coumarin-fused compounds via multicomponent reactions and subsequent evaluation of their potential antibacterial activities. In the first part, microwave-assisted three-component reactions of L-proline, benzaldehyde and 1,3-indandione obtained the pyrrolizidine derivatives. In the second part, the azepine/coumarin-fused seven-membered heterocyclic derivatives were prepared by condensation of 3-amino-4-hydroxycoumarin with acetophenone in a pseudo three-component reaction manner. The scope and limitation of these synthetic methods along with the plausible mechanisms are discussed. Some azepine/coumarin-fused compounds were found to possess moderate antibacterial activity against E. coli.

謝誌 I
中文摘要 II
英文摘要 III
目錄 IV
圖表目錄 VI
第一章、緒論 1
1.1多組成反應 1
1.2微波促進反應 4
1.3香豆素 9
1.4吡咯里西啶 11
1.5氮呯 13
第二章、研究動機 15
2.1設計微波輔助三組成反應合成吡咯里西啶衍生物 15
2.2設計假三組成反應合成氮呯/香豆素稠合衍生物 17
第三章、結果與討論 19
3.1設計微波輔助三組成反應合成吡咯里西啶衍生物 19
3.2設計假三組成反應合成氮呯/香豆素稠合衍生物 27
第四章、結論 35
第五章、實驗部份 36
5.1儀器部份及試藥來源 36
5.2化合物的合成 38
第六章、參考文獻 66
附錄一、圖譜目錄 69
附錄二、圖譜資料 74

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