臺灣博碩士論文加值系統

心血管疾病是常見嚴重威脅全人類生命的疾病之一，然而血管支架置入術是常用治療血管阻塞的方式之一，支架尺寸微小和結構複雜若直接採用樣品設計與功能測試則成本高，因此有限元素結合電腦技術應用成為支架設計與研究過程不可或缺的重要手段。針對平面式支架的設計與模擬並沒有一套完整有效的方式，因此本文將文獻中實驗數值，採用有限元素法模擬平面式支架擴張，結果表明，本文先將平面式支架展開後再進行模擬的方式，支架擴張至目標尺寸的最大等效應力是小於最大抗拉強度，由von Mises理論其仍在安全範圍之內，不論模擬是低估還是高估可擴張能力，皆可以利用較優異材料性質來輔助設計。為提升文獻平面式支架的功能，本文重新設計一款平面式支架，而新型平面式支架以提升徑向強度與擴張能力為設計考量，結果表明，擴張率由38%提升至60%，更能適應不同管徑的血管；金屬覆蓋率由18.7%提升至31.1%，其金屬覆蓋率是影響徑向強度重要因子，由金屬覆蓋率的提升也可視為徑向強度提升。

Cardiovascular disease is one of common sickness and a serious threat to all mankind life. However, the Vascular stent surgery is one of common ways to use the treatment for vascular obstruction. Therefore, the application of computer technology combined with the finite element method to the stent design and study process are indispensable tools. There is no comprehensive and effective way to the planar stent design and simulation so far. Therefore, deformation simulations of the planar stent are investigated in the thesis. It has been shown that stent expansion to the target size of the maximum equivalent stress is less than the maximum tensile strength. It is still within the safe range based on von Mises theory. In order to enhance the function of plane stent, this study designs a new plane stent in order to enhance radial strength and the ability of expansion. The results show that, the expansion rate improved from 38 % to 60%. Metal coverage rate is improved from 18.7% to 31.1%. The metal coverage ratio is a key factor of radial strength.

摘要 .................................................................................................................................. I
Abstract ............................................................................................................................. II
誌謝 ............................................................................................................................... III
目錄 ............................................................................................................................... IV
表目錄 ............................................................................................................................ VI
圖目錄 ........................................................................................................................... VII
第一章 緒論 .................................................................................................................... 1
1-1前言 .................................................................................................................... 1
1-1-1治療方式 ................................................................................................ 5
1-1-1-1 藥物治療 .................................................................................... 5
1-1-1-2 外科手術 .................................................................................... 5
1-1-1-3 侵入式治療 ................................................................................ 6
1-2研究動機與目的 ................................................................................................ 9
1-3文獻回顧 .......................................................................................................... 10
1-4論文架構 .......................................................................................................... 12
第二章 支架介紹 .......................................................................................................... 14
2-1支架分類 .......................................................................................................... 14
2-1-1支架特性 .............................................................................................. 14
2-1-2生醫材料 .............................................................................................. 15
2-1-3擴張方式 .............................................................................................. 17
2-1-4表面披覆 .............................................................................................. 18
2-2血管支架未來趨勢 .......................................................................................... 19
2-3支架製程 .......................................................................................................... 20
2-3-1材料選用 .............................................................................................. 20
2-3-2結構設計與分析 .................................................................................. 20
2-3-3雷射加工 .............................................................................................. 22
2-3-4超音波洗淨與酸洗處理 ...................................................................... 24
2-3-5真空熱處理 .......................................................................................... 25
2-3-6電化學拋光 .......................................................................................... 25
2-3-7支架檢測 .............................................................................................. 25
V
第三章 模擬與分析 ...................................................................................................... 26
3-1 支架設計中軟體應用 ..................................................................................... 26
3-2 相關理論說明 ................................................................................................. 28
3-2-1板材塑性變形 ...................................................................................... 28
3-3-2降伏準則 .............................................................................................. 29
3-2-2隱式解法與顯式解法 .......................................................................... 29
3-3模擬架構規劃 .................................................................................................. 31
3-3-1模型 ...................................................................................................... 31
3-3-1-1新型平面式支架 ....................................................................... 31
3-3-1-2球囊 ........................................................................................... 32
3-3-1-3支架、球囊耦合模型 ............................................................... 32
3-3-2材料選用 .............................................................................................. 33
3-3-3網格劃分 .............................................................................................. 34
3-3-4負荷定義 .............................................................................................. 36
3-3-5接觸和邊界條件 .................................................................................. 36
3-3-6求解控制方法 ...................................................................................... 37
3-3-6-1球囊加壓速度設定 ................................................................... 37
3-3-6-2系統沙漏能 ............................................................................... 38
第四章 結果與討論 ...................................................................................................... 39
4-1假設與驗證結果 .............................................................................................. 39
4-2支架壓握 .......................................................................................................... 44
4-2-1支架應力應變 ...................................................................................... 44
4-2-2支架軸向變化 ...................................................................................... 46
4-3支架擴張 .......................................................................................................... 48
4-3-1支架應力應變 ...................................................................................... 48
4-3-2支架徑向變化 ...................................................................................... 50
4-3-3支架軸向變化 ...................................................................................... 51
4-4金屬覆蓋率 ...................................................................................................... 52
第五章 結果與未來展望 .............................................................................................. 55
5-1結論 .................................................................................................................. 55
5-2未來展望 .......................................................................................................... 56
參考文獻 ........................................................................................................................ 57
作者簡介 ........................................................................................................................ 60

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