臺灣博碩士論文加值系統

本研究以中藥材茜草根（Rubia cordifolia L.）為實驗材料，主要探討其抗氧化性及活性成分。實驗分為五部分，（一）篩選具抗氧化性之中藥材：將具抗發炎藥理作用之生蒲黃（Typha angustifolia）、石菖蒲（Acorus gramineus）、金銀花（Lonicera japonica）、密蒙花（Buddleia officinalis）、番紅花（Crocus sativus）及茜草根（R. cordifolia）等六種材料分別以三種不同極性溶劑萃取，利用硫氰酸鐵法檢測其抗氧化性，結果顯示出茜草根的正己烷及乙酸乙酯萃取物的抗氧化力較佳於其他樣品的各種溶劑萃取物及對照抗氧化劑α-生育醇，故選取茜草根的正己烷及乙酸乙酯萃取物進行分離純化實驗；（二）茜草根的一般組成分析：茜草根之ㄧ般成分組成為碳水化合物含量70.47％為最高，其次依序為灰分12.44％，粗蛋白質7.19％，粗脂肪1.09％，水分含量8.81％；（三）茜草根之生育醇含量分析：結果顯示茜草根中不含生育醇；（四）茜草根正己烷萃取物抗氧化成分之分離、純化及結構鑑定：分別利用矽膠液相管柱層析及高效能液相層析儀進行分離純化，純化出P1及P2；（五）茜草根乙酸乙酯萃取物抗氧化成分之分離、純化及結構鑑定：分別利用矽膠、XAD-7液相管柱層析及高效能液相層析儀進行分離純化，純化出P3、P4及P5；各純化物質分別利用可見光-紫外線吸光光譜儀、液相層析質譜儀及核磁共振儀進行結構鑑定，其化學成分鑑定為furomollugin（P1）, mollugin（P2）, 2-methyl-1,3,6-trihydroxy-9,10- anthraquinone 3-O-（6’-O-acetyl）-α-rhamnosyl（1→2）-β-glucoside（P3）, 2-methyl-1,3,6- trihydroxy-9,10-anthraquinone-3’-O-α-rhamnosyl（1→2）-β-glucoside（P4）及2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3’-O-α- rhamnosyl（1→3）-β-glucoside（P5）。P1, P2及P3亦利用TEAC法分析，得知其抗氧化性依序為2.91、16.07及0.72mM trolox當量，其中P2的抗氧化性強於BHA及α-生育醇；P2因純化量較多，亦以硫氰酸鐵法比較相對活性，抗氧化性同樣與BHA相當。

The proximate composition and active components in extract of root of Rubia cordifolia were investigated in this study. Compositional analysis of dry root showed that the root contains carbohydrate 70.47%, ash 12.44%, crude protein 7.19%, crude fat 1.09% and moisture 8.81%. The antioxidative activities of n-hexane, ethyl acetate and methanol extract from six species of Chinese crude drugs were measured with ferricthiocyanate assay and compared to those of α-tocopherol and BHA. The results indicated the presence of remarkable antioxidative substance in n-hexane and ethyl acetate extract from R. cordifolia root. Almost no α-tocopherol was found in the unsaponified fraction from the crude drug of R. cordifolia root. By using silica gel, XAD-7 and HPLC, two components (P1 and P2) and three components (P3, P4 and P5) with strong antioxidative activity were isolated from hexane extract of R. cordifolia and from ethyl acetate extract, respectively. The structures of the isolated components were identified by UV-visible spectrometry, liquid chromatography-mass spectra, 1H and 13C-NMR. Five isolated components were identified to be furomollugin (P1), mollugin (P2), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6’-O-acetyl)-α- rhamnosyl (1→2)–β-glucoside(P3), 2-methyl-1,3,6-trihydroxy-9,10- anthraquinone-3’-O-α-rhamnosyl (1→2)–β-glucoside(P4) and 2-methyl- 1,3,6-trihydroxy-9,10-anthraquinone-3’-O-α-rhamnosyl(1→3)-β-glucoside (P5). The antioxidative activity of component P1, P2 and P3 isolated from R. cordifolia root were 2.91, 16.07 and 0.72 mM trolox equivalent and the activity of P2 was stronger than that of BHA and α-tocophenol determined by the TEAC assay. P2 also showed the same activity strong as BHA determined by the ferric thiocyanate analysis.

中文摘要--------------------------------------------------------------------------Ⅱ
英文摘要--------------------------------------------------------------------------Ⅲ
表次--------------------------------------------------------------------------------Ⅳ
圖次--------------------------------------------------------------------------------Ⅴ
第一章、前言-----------------------------------------------------------------------1
第二章、文獻整理-----------------------------------------------------------------3
一、自由基與活性氧--------------------------------------------------------3
二、脂質氧化作用-----------------------------------------------------------8
三、抗氧化機制與抗氧化物質------------------------------------------16
四、抗氧化分析法---------------------------------------------------------42
五、天然抗氧化成分相關生理活性之ㄧ、二--------------------------59
六、茜草根文獻回顧------------------------------------------------------64
第三章、研究目的與實驗架構------------------------------------------------65
ㄧ、研究目的---------------------------------------------------------------65
二、實驗架構---------------------------------------------------------------66
第四章、材料與方法------------------------------------------------------------67
一、實驗材料---------------------------------------------------------------67
二、實驗藥品與儀器------------------------------------------------------67
三、實驗方法---------------------------------------------------------------71
四、統計分析---------------------------------------------------------------86
第五章、結果與討論------------------------------------------------------------87
ㄧ、數種中藥材抗氧化性之比較---------------------------------------87
二、茜草根的一般組成分析---------------------------------------------87
三、茜草根的生育醇含量分析------------------------------------------87
四、茜草根抗氧化成分之萃取、分離及純化--------------------------92
五、茜草根純化物質之結構鑑定---------------------------------------112
六、茜草根純化物質之抗氧化力測定--------------------------------138
第六章、結論--------------------------------------------------------------------140
第七章、參考文獻--------------------------------------------------------------141
第八章、附錄--------------------------------------------------------------------161

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