臺灣博碩士論文加值系統

本論文研究使用真空凍結乾燥機組分別為典型壓縮系統凍乾機組，與多段壓縮系統凍乾機組，探討其適用性，將所得數據進行迴歸分析做交叉比對，並以四物湯做為實驗品，先量測出其共晶點以兩個系統的最大極限來將物料凍結至共晶點以下-10℃。因在一次的凍乾製程裡時間相當的稍長藉由本次的研究來探討兩個製程時間上的差異性，並找出如何縮短整個製程的工作時間，及會造成凍乾物料在凍乾製程裡有哪些不良的後遺症。
本論文的研究結果可提供工程師在設計凍乾機時重要的參考，及製程上所需注意的幾項要點以期減少設計上失敗手段避免浪費的過多的時間及精神。

In this study, vacuum freeze drying units were separated into the typical compression system freeze dryer group, and the multi-segment compression system freeze dryer group, to discuss its applicability, and then doing Regression Analysis with the statistic. Using Siwu medication as an experimental, we measure the maxmum of eutectic point from two groups to freeze materials below -10℃. Due to the long process, the study present the investigation between two groups to find the way to abbreviate the process, and avoid some adverse effects during the freezing process.
The consequence will be an important reference while engineers design a freezing machines, and it also could avoid some failures.

中文摘要 i
英文摘要 ii
致謝 iii
目錄 iv
表目錄 vi
圖目錄 vii
符號說明 ix
一、 序論 1
1.1 前言 1
1.2 研究動機 4
1.3 文獻回顧 5
二、 真空冷凍乾燥基礎理論 8
2.1 物理真空技術 8
2.2 水分在真空下之特性 12
2.3 冷阱特性 14
2.4 典型冷凍循環系統 16
2.5 冰昇華的條件 19
2.6 真空凍結乾燥原理 21
2.6.1 預凍前處理階段 22
2.6.2 預凍階段 22
2.6.3 初級乾燥階段 24
2.6.4 解析乾燥 27
2.6.5 乾燥後處理 29
三、 凍乾設備系統組成分析 30
3.1 壓縮機特性 30
3.2 真空腔體 31
3.3 凍乾機冷阱 35
3.4 真空系統 37
3.5 控制系統 38
四、 凍乾實驗差異性分析 41
4.1 真空凍結乾燥前共晶點量測 41
4.2 典型蒸汽壓縮系統凍乾機流程 43
4.3 雙段蒸汽壓縮系統凍乾機流程 48
4.4 實驗後數據差異分析 53
五、 結論與展望 57
5.1 結論 57
5.2 展望 58

參考文獻 59
附錄一 62

1.經濟部工業局,2003,11月┌乾燥技術效率提升手冊」，.
2.李良梧,2001,8月, 空氣調節與空氣污染工程學,全華科技圖書出版社
3.蘇清森,1990,真空技術,東華書局
4.趙鶴皋，鄭效東，黃良瑾，季樹廣，2005,冷凍乾燥技術與設備,華中科技 大學出版社
5.許敦復,鄭效東,2005,冷凍乾燥技術與凍乾機,化學工業出版社
6.Kobayashi,M,1991:Vial variance of the sublimation rate in shelf freeze-drying.Paper 312.International Institute of Refrigeration(IIR),Montreal.
7.Bardat,A.,Biguet,J.,Chatenet,E.,Courteille,F,1993:Moisture measurement:a new method for monitoring freeze-drying cycles.PDA j.Parenteral Sci.Technol.47,293-299.
8.Thijssen,H.A.C.,Rulkens,W.H,1969:Effect of freezing rate on rate of sublimation and flavour retention in freeze-drying,pp.99-114. Thijssen,H.A.C.,Rulkens,W.H.1968:Retention on aromas in drying food liquids.De Ingenieur,Chemische Techniek (Niederlande)80,45-56.
9.H.-P. Cheng, C.-T. Lin 78 (2007).The morphological visualization of the water in vacuum cooling and freezing process, Journal of Food Engineering .569–576.
10.Wu, Takahiro Orikasa , 83 (2007)Journal of Food Engineering 422–429.
11.V. Ferna´ndez-Pe´reza, J. Tapiadorb, A. Martı´nc, M.D. Luque de Castro, 2004.Optimization of the drying step for preparing a new commercial powdered soup,Innvative Food&Emerging Technologies.
12.Hsu,C.C.,Ward,C.A,Pearlman,R.,Nguyen,H.M.,Yeung;D.A,Curley,G,1992:Determining the optimum residual moisture in lyophilized protein pharmaceuticals.In Developments in Biological Standardization,Vol.74,pp.255-271.
13.F. Nastaj, K. Witkiewicz, B. Wilczyska 2008.Experimental and simulation studies of primary vacuum freeze-drying process of random solids at microwave heating
,International Communications in Heat and Mass Transfer Vol.35 430–438.
14.Katrin Heinzelmann, Knut Franke .1999 “Using freezing and drying techniques of emulsions for the microencapsulation of fish oil to improve qxidation stability” Colloids and Surfaces B: Biointerfaces Vol.12. 223-229.
15.Spiess,W,1974:Verfahrensgrundlagen der trocknung bei niedrigen Temperraturen.VDI-Bildungswerk Vol.2229,p5.
16.Willem F. Wolkers , Fern Tablin , John H. Crowe.2002 “From anhydrobiosis to freeze-drying of eukaryotic cells” Comparative Biochemistry and Physiology Part A 131 .535–543.
17.Heldner,M.,Steinkamp,H.,Spreckelmeyer,J.2000:Einsatz von neuen Kaltemiteln und der LN-Technik bei Lyophili-sationsanlagen.APV-Symposium,Bonn,September.
18.Kapsalis,J.G.,Wolf,M.,Driser,M.,Walker,J.E,1971:The effect of moisture on the flavor content and texture stability of dehydrated foods.ASHRAE j.13,93-99.
19.Medas,M.,Simatose,D,1971:Freeze-drying and reconstitution of raspberries,influence of the chemical content and variety.International Institute of Refrigeration,pp.605-610,Washington,DC.
20.Gegov,Y.P,1998:Changes in freeze-dried vegetables during their production and storage.III.Carrots.Nauchni Tr.Vissh.Inst.Khranit.Vkusova Promst.,Plovdiv43,213-221.
21.Merryman,H.T,1968:The minimum cell volume modes of freezing injury.Nature 218,333.
22.Girlich,D,1991:Multikernresonanzunter suchungen zur molekularen Dynamik wasseriger Saccharidlosungen.Dissertation .Naturwissenschaftliche FakultatIII,Biologie and vorklinische Medizinder Universitat Regensburg.
23.Karel,M.:Basic principles of moisture equilibria.6th International Course of Freeze-Drying and Advanced Food Technology ,Burgenstock,1973.
24.KONA .1996Powder and Patricle .Published by Hosokawa Powder Technology Foundation.