臺灣博碩士論文加值系統

隨著科技進步，生醫感測在21世紀逐漸受到重視，而表面電漿感測元件更是適合應用在生醫感測上，但是由於傳統生醫感測元件有著體積較大，量測所耗費樣品數量較多，較不適合運用在較稀少昂貴的樣品，以及製程昂貴這些缺點，使得表面電漿感測元件在使用上有著諸多制肘。
本論文提出了一種新穎的表面電漿感測元件，不同於傳統元件，我們發展出一種嶄新且更便利的製程，利用奈米光學探針，產生表面電漿共振，再利用產生此表面電漿波來對樣品量測，與傳統元件相比，奈米光學探針有著體積較小，製程便利，以及少量的樣品即可量測等優點，且利用FDTD軟體模擬出最佳的製程參數，再與實驗結果比較是否相同，最後再實際測量生物樣品(BSA, 小牛血清蛋白)，來證實元件是否可實際運用在生醫感測上。

Recently, the biosensing has attracted much attention in twenty-one century. SPR has drawn extensive attention for application in biosensing, but traditional SPR setup is typically bulky, expensive and requires a large amount of sample solution.
In this thesis, we have performed the new SPR sensing devices which have many advantages such as easily fabrication and high capability. We used nano optical probe to induce surface plasmon resonance and measure the specimen by SPR. The numerical simulations are performed by using FDTD method. The result of FDTD simulations indicate the SPW generated near the probe tip.
Finally, we used BSA binding on nano optical probe, and it was concluded that the biomedical application have verified by measuring the antigen-antibody interactions.

目 錄
摘要 (中文)………………………………………………………………I
摘要 (英文)……………………………………………………………...II
致謝…………………………………………………………………..III
目錄…………………………………………………………………....1
圖目錄………………………………………………………………....3
表目錄……………………………………………………………………7
第1章 緒論 8
1-1 前言 8
1-2 研究動機與目的 8
第2章 表面電漿共振基本性質 10
2-1 電磁波基本理論 10
2-1-1 斯乃爾定律 10
2-1-2 消逝波理論 12
2-2 表面電漿共振基本性質 13
2-2-1 表面電漿波現象 13
2-2-2 表面電漿共振 14
2-2-3 SPR技術回顧 16
2-2-4 奈米光纖探針表面電漿共振原理 21
第3章 有限時域差分模擬 24
3-1 有限時域差分法理論 25
3-2 模擬光學探針在不同角度下之光場強度變化 29
3-3模擬光學探針在不同金膜厚度下之光場強度變化 37
第4章 實驗設備與方法 42
4-1 利用熱拉法製作奈米光學探針 42
4-2 儀器、實驗系統介紹 45
第5章 實驗結果與討論 48
第6章 結論 56
參考文獻………………………………………………………………..57

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