臺灣博碩士論文加值系統

本論文主要針對居家照護之應用場合，發展推估連續動脈血壓之功能。為能達到此能，我們自行製作一非侵入式血壓模組與一光體積描繪圖訊號模組，並透過自行設計上述各模組之軟硬體介面來推估連續動脈血壓。首先，在非侵入式血壓量測部分，本論文利用常見的振盪法取出血壓特徵參數，以建立每個人特有之生理參數。其次，利用光體積描繪圖訊號結合本論文所提出之「推估連續動脈血壓」之技術，主要是光體積描繪圖訊號所量測之血壓波，不僅可以計算血氧飽和濃度，亦可提供推估連續血壓數值。本量測模組，其優點為操作簡單，不需使用者繁複地記錄血壓值、血氧值及心率，即時量測並顯示數值，並可利用電腦將各數值資訊儲存，提供醫生作為診斷的參考依據。為驗證上述技術之效能，我們尋找多位受測者進行推估連續動脈血壓之實驗。而經由實驗結果驗證本論文所研製的推估連續動脈血壓技術，皆能有效達成推估連續動脈血壓之功能。

In this thesis we present the development of a pulse oximeter to estimate continuous blood pressure based on photoplethysmograph and consider its application in home care scenario. In order to accomplish our goal, we combined a sphygmomanometer and a photoplethysmograph module to design a non-invasive blood pressure module which can estimate the continuous blood pressure. First, the Oscillometric Method was used to obtain the diastolic pressure and the systolic pressure of a person. The two parameters are further applied to calibration of the voltage-to-pressure ratio in a photoplethysmograph, which establishes the physiological parameter specific to each person. Second, not only to calculate the SPO2, our pulse oximeter can also measure the value of the continuous blood pressure and the heart rate in a non-invasive way. The pulse oximeter can display real-time results and store the information into a computer, allowing diagnostic reference for doctors. To verify the performance, numerous patients are tested. According to the results of the experiment, the procedure presented in this thesis for estimation of continuous blood pressure was able to effectively achieve the required functions.

論 文 摘 要 I
Abstract II
誌謝 III
目錄 IV
圖目錄 VI
表目錄 IX
第一章序論 1
1.1 簡介 1
1.2 文獻回顧 3
1.3 論文研究貢獻 8
1.4 論文章節組織 9
第二章 血壓生理量測之原理與方法 10
2.1 非侵入式血壓量測原理 10
2.1.1聽診法 (Auscultation Method) 10
2.1.2振盪法 (Oscillometric Method) 12
2.2 光體積描繪圖訊號與量測原理 15
2.2.1光體積描繪圖訊號(Photoplethysmograph, PPG) 15
2.2.2PPG量測原理 17
2.2.3PPG於血氧飽和濃度定義 18
2.2.4比爾藍伯特定律 (Beer-Lambert Law) 20
2.2.5PPG的重要特徵 24
2.3 PPG與連續性血壓生理之相關性 26
2.4 推估連續血壓之特徵值擷取 27
2.4.1脈波訊號波峰波谷偵測 28
2.4.2心率計算及心跳 30
第三章 量測模組設計與實現 31
3.1 血壓量測模組功能設計 34
3.2 血氧量測模組功能設計 38
3.3 數位訊號處理單元 45
第四章 推估連續血壓方法 47
4.1 階段一量測流程 48
4.2 連續取樣量測流程 51
4.3 階段二量測流程 52
第五章 實驗結果 55
5.1 血壓模組實驗 56
5.2 血氧模組實驗 59
5.3 推估連續血壓實驗 67
第六章 結論與未來工作 71
6.1 結論 71
6.2 未來工作 72
參考文獻 73

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