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研究生:陳郁旻
研究生(外文):Yu-Wen Chen
論文名稱:4-苯胺基呋喃[2,3-b]喹啉衍生物之合成與抗癌活性評估
論文名稱(外文):Synthesis and anticancer evaluation of 4-anilinofuro[2,3-b]quinoline derivatives
指導教授:陳義龍
指導教授(外文):Yeh-Long Chen
學位類別:博士
校院名稱:高雄醫學大學
系所名稱:醫藥暨應用化學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2011
畢業學年度:100
語文別:中文
論文頁數:267
中文關鍵詞:
外文關鍵詞:4-anilinofuro[23-b]quinoline derivatives
相關次數:
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本實驗室合成一系列的4-苯胺呋喃[2,3-b]喹啉(4-anilinofuro[2,3-b]quinoline)衍生物並測試其抗增生活性,雖然有良好的活性,但這些化合物共同的缺點有:抗增生活性的選擇性(selective cytotoxicity)差、水溶解度(water solubility)低、口服生體可利用率(oral bioavailability)差等。因此,在4-苯胺呋喃[2,3-b]喹啉的衍生物中,我們發現(E)-1-(4-(呋喃[2,3-b]喹啉-4-基胺基)苯基)乙酮O-2-胺基乙基((E)-1-(4-(furo[2,3-b]quinolin-4-ylamino) phenyl)ethanone O-2-aminoethyloxime)(17g)對於非小細胞肺癌細胞NCI-H460是具有明顯選擇性的抗增生活性及良好的水溶度(63 μg/mL)。化合物 17g.3 HCl 不僅具有高度的水溶度 (1049 μg/mL) 、良好的生體可利用率BA=57.1%(口服投藥)。化合物17g可藉由結合微管蛋白(tubulin)並且抑制微管蛋白聚合(tubulin polymerization)來誘發有絲分裂停滯(mitotic arrest)以及細胞凋亡(apoptosis)。因此,化合物17g非常有潛力成為高選擇性的非小細胞肺癌抑制劑。


We have reported the preparation and anticancer evaluation of certain 4-anilinofuro-[2,3-b]quinolines. However, drawbacks such as lack of selective cytotoxicity, poor oral bioavailability, and poor water solubility exhibited by these compounds prompted us to search for newer derivatives. Among them, (E)-1-(4-(furo[2,3-b]quinolin-4-ylamino) phenyl)ethanone O-2-aminoethyloxime (17g) is selectively active against the growth of NCI-H460 and is highly water-soluble (63 μg/mL). Its hydrochloride salt, 17g.3 HCl exhibited not only excellent water solubility (1049 μg/mL) but also a high oral bioavailability (57.1%). Compound 17g may cause cancer cell apoptosis through inducing mitotic arrest and mitotic catastrophe mechanism. Xenographic studies indicated the tumor size with 17g.3 HCl treated nude mice was significantly lower than control. Further evaluation in an orthotopic lung cancer model indicated that 17g.3HCl can be absorbed readily through oral administration, distributed to lung tissue, and exhibited significant efficacy in inhibiting the growth of lung cancers.

中文摘要………………………………………………………1
英文摘要………………………………………………………2
壹、緒論………………………………………………………3
貳、研究背景及目的…………………………………………7
一、 針對呋喃[2,3-b]喹啉(furo[2,3-b]quinoline)
進行結構修飾……………………………………16
二、 針對CIL-378進行結構修飾……………………19
三、 針對CIL-102進行結構修飾……………………21
参、合成方法、結果與討論…………………………………26
一、 逆合成分析………………………………………26
二、 實驗結果與討論…………………………………29
三、 圖譜分析與討論…………………………………38
肆、藥理活性結果與討論……………………………………41
一、 furo[2,3-b]quinoline衍生物之體外活性試
驗…………………………………………………41
二、 CIL-378衍生物之體外活性試驗………………44
三、 CIL-102衍生物之體外活性試驗………………47
四、 CIL-102衍生物(化合物15g及17g)之體內活性
試驗………………………………………………59
伍、結論………………………………………………………68
一、 furo[2,3-b]quinoline之衍生物………………68
二、 CIL-378之衍生物………………………………69
三、 CIL-102之衍生物………………………………70
陸、合成實驗部份……………………………………………72
一、 溶劑及處理過程……………………………72
二、 儀器…………………………………………73
三、 試藥…………………………………………75
四、 各化合物製備………………………………77
柒、參考文獻………………………………………………250
捌、研究成果目錄…………………………………………259
一、 投稿論文………………………………………259
二、 學會口頭論文發表……………………………260
三、 學會壁報論文發表……………………………261

1.
行政院衛生署台灣地區99年主要死因分析,2011。
2.
Parkin, D.M.; Bray, F.; Ferlay, J.; Pisani, P. Global cancer statistics. Ca Cancer J Clin. 2005, 55, 74-108.
3.
國家衛生研究院(NHRI)癌症研究組 臺灣癌症臨床研究合作組織 (TCOG)(2004)。非小細胞肺癌臨床指引。肺癌臨床指引(39-72頁)。台北市:國家衛生研究院 (NHRI)。
4.
何明霖醫師(民99年)。非小細胞肺癌治療。民100年12月19日,取自:http://www2.cch.org.tw/lungcancer/NSCLC_tx.htm
5.
陳育民醫師(民99年)。非小細胞肺癌的化學治療—還能再突破嗎?。民100年12月19日,取自:http://cisc.twbbs.org/lifetype/index.php?op=ViewArticle&articleId=1993&blogId=1
6.
何明霖醫師(民99年)。Taxol汰癌勝。民100年12月19日,取自:http://www2.cch.org.tw/lungcancer/taxol.htm
7.
何明霖醫師(民99年)。Taxotere剋癌易。民100年12月19日,取自:http://www2.cch.org.tw/lungcancer/taxotere.htm
8.
何明霖醫師(民99年)。Gemzar健擇。民100年12月19日,取自:http://www2.cch.org.tw/lungcancer/gemzar.htm
9.
何明霖醫師(民99年)。Navelbin溫諾平針劑。民100年12月19日,取自:http://www2.cch.org.tw/lungcancer/navelbin.htm
252
10.
何明霖醫師(民99年)。NSCLC化療的療程。民100年12月19日,取自:http://www2.cch.org.tw/lungcancer/LC_regimen.htm
11.
Atwell, G. J.; Cain, B. F.; Seelye, R. N. Potential antitumor agents. 12. 9-Anilinoacridine. J. Med. Chem. 1972, 15, 611-615.
12.
Cain, B. F.; Wilson, W. R.; Baguley, B. C. Structure-activity relationships for thiolytic cleavage rates of antitumor drugs in the 4’-(9-acridinylamino)methanesulfonanilide series. Mol. Pharmacol. 1976, 12, 1027-1035.
13.
Denny, W. A.; Atwell, G. J.; Cain, B. F. Potential antitumor agents. 26. Anionic congeners of the 9-anilinoacridines. J. Med. Chem. 1978, 21, 5-10.
14.
Baguley, B. C.; Denny, W. A.; Atwell, G. J.; Cain, B. F. Potential antitumor agents. Part 35. Quantitative relationships between antitumor (L1210) potency and DNA binding for 4’-(9-acridinylamino)methanesulfon-m-anisidide analogues. J. Med. Chem. 1981, 24, 520-525.
15.
Denny, W. A.; Cain, B. F.; Atwell, G. J.; Hansch, C.; Panthananickal, A.; Leo, A. Potential antitumor agents. 36. Quantitative relationships between experimental antitumor activity, toxicity, and structure for the general class of 9-anilinoacridine antitumor agents. J. Med. Chem. 1982, 25, 276-315.
16.
Rewcastle, G. W.; Atwell, G. J.; Chambers, D.; Baguley, B. C.; Denny, W. A. Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent
253
N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide. J. Med. Chem. 1986, 29, 472-477.
17.
Denny, W. A.; Atwell, G. J.; Rewcastle, G. W.; Baguley, B. C. Potential antitumor agents. 49. 5-Substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity. J. Med. Chem. 1987, 30, 658-663.
18.
Gamage, S. A.; Tepsiri, N.; Wilairat, P.; Wojcik, S. J.; Figgitt, D. P.; Ralph, R. K.; Denny, W. A. Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum. J. Med. Chem. 1994, 37, 1486-1494.
19.
Su, T. L.; Chou, T. C.; Kim, J. Y.; Huang, J. T.; Ciszewska, G.; Ren, W. Y.; Otter, G. M.; Sirotnak, F. M.; Watanabe, K. A. 9-Substituted acridine derivatives with long half-life and potent antitumor activity: Synthesis and structure-activity relationships. J. Med. Chem. 1995, 38, 3226-3235.
20.
Gamage, S. A.; Figgitt, D. P.; Wojcik, S. J.; Ralph, R. K.; Ransijn, A.; Mauel, J.; Yardley, V.; Snowdon, D.; Croft, S. L.; Denny, W. A. Structure-activity relationships for the antileishmanial and antitrypanosomal activities of 1’-substituted 9-anilinoacridines. J. Med. Chem. 1997, 40, 2634-2642.
21.
Stanslas, J.; Hagan, D. J.; Ellis, M. J.; Turner, C.; Carmichael, J.; Ward, W.; Hammonds, T. R.; Stevens, M. F. G. Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines. J. Med. Chem. 2000, 43, 1563-1572.
22.
Shoemaker, D. D., Cysyk, R. L.; Gormley, P. E.; DeSouza, J. J. V.;
254
Malspeis, L. Metabolism of 4’-(9-acridinylamino)methanesulfon-m
-anisidide by rat liver microsomes. Cancer Res. 1984, 44, 1939-1945.
23.
Fang, K. C.; Chen, Y. L.; Sheu, J. Y.; Wang, T. C.; Tzeng, C. C. Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives. J. Med. Chem. 2000, 43, 3809-3812.
24.
Hsu, S. L.; Chen, Y. L.; Tzeng, C. C. Synthesis and cytotoxic activities of  -methylidene- -butyrolatones bearing a quinolin-4(1H)-one moiety. Helv. Chim. Acta. 2001, 84, 874-879.
25.
Chen, I. S.; Wu, S. J.; Lin, Y. C.; Tsai, I. L.; Seki, H.; Ko, F. N.; Teng, C. M. Dimeric 2-quinolone alkaloid and antiplatelet aggregation constituents of Zanthoxylum simulans. Phytochemistry 1994, 36, 237-239.
26.
Chen, I. L.; Chen, Y. L.; Tzeng, C. C.; Chen, I. S. Synthesis and cytotoxic evaluation of certain 4-aniline[2,3-b]quinoline derivatives. Helv. Chim. Acta. 2002, 85, 2214-2221.
27.
Tuppy, H.; Bohm, F. Synthesis of Dictamnine. Monatash. Chem. 1956, 87, 720-734.
28.
Zhao, Y. L.; Chen, Y. L.; Tzeng, C. C.; Chen, I. L. ; Wang, T. C. ; Han, C. H. Synthesis and cytotoxic evaluation of certain 4-(phenylamino) furo[2,3-b]quinoline and 2-(furan-2-yl)-4-(phenyl-
amino)quinoline derivatives. Chem. Biodiver. 2005, 2, 205-214.
29.
Huang, Y. T.; Huang, D. M.; Guh, J. H.; Chen, I. L.; Tzeng, C. C.; Teng, C. M. CIL-102 Interacts with Microtubule Polymerization and Causes Mitotic Arrest following Apoptosis in the Human Prostate
255
Cancer PC-3 Cell Line. J. Biol. Chem. 2005, 280, 2771-2779.
30.
Chen Y. L.; Chen I. L.; Wang T. C.; Han C. H.; Tzeng C. C. Synthesis and anticancer evaluation of certain 4-anilinofuro[2,3-b]
quinoline and 4-anilinofuro[3,2-c]quinoline derivatives. Eur. J. Med. Chem. 2005, 40, 928–934.
31.
Chen, Y. L.; Lin, H. C.; Yang, C. N.; Lu, P. J.; Tzeng, C. C. Synthesis and Antiproliferative Evaluation of Certain 4-Anilino-7-
methoxyfuro-[2,3-b]quinoline and 4-Anilino-6-methoxy-furo[2,3-b]
quinoline Derivatives. Part 5. Chem. Biodiv. 2008, 4, 267-278.
32.
Rupp, C.; Steckel, H.; Mueller, B. W. Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine. Int. J. Pharm. 2010, 395, 272-280;
33.
Mueller, C. E. Prodrug Approaches for Enhancing the Bioavailability of Drugs with Low Solubility. Chem. Biodiver. 2009, 6, 2071-2083.
34.
Wall, M. E.; Wani, M. C.; Cook, C. E.; Palmer, K. H.; McPhail, A. T.; Sim, G. A. J. Am. Chem. Soc. 1966, 88, 3888-3890.
35.
Werbovetz, K. A.; Bhattacharjee, A. K.; Brendle, J. J.; Scovill, J. P. Bioorg. Med. Chem. 2000, 8, 1741-1747.
36.
Bedeschi, A.; Zarini, F.; Cabri, W.; Candiani, I.; Penco, S.; Capolongo, L.; Ciomei, M.; Farao, M.; Grandi, M. Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives. Bioorg. Med. Chem. Lett. 1996, 6, 671-674.
37.
Schmid Bjorn; Chung Da-Eun; Warnecke Andre; Fichtner Iduna; Kratz Felix Albumin-binding prodrugs of camptothecin and
256
doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy. Bioconjugate Chem. 2007, 18, 702-716.
38.
Ishii M; Iwahana M; Mitsui I; Minami M; Imagawa S; Tohgo A; Ejima A Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6. Anti-cancer drugs 2000, 11, 353-362.
39.
Kim Y. Y.; Park C. K.; Kim S. K.; Phi J. H.; Kim J. H.; Kim C. Y.; Wang K. C.; Cho B. K. CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines. Oncolo. Rep. 2009, 21, 1413-1419.
40.
Pettit, G. R.; Cragg, G.. M.; Herald, D. L.; Schmidt, J. M.; Lobavanijaya, P. Anti-neoplastic Agents. 84. Isolation and Structure of Combretastatin. Can. J. Chem. 1982, 60, 1347-1376.
41.
Nam, N. H. Combretastatin A-4 Analogues as Antimitotic Antitumor Agents. Curr. Med. Chem. 2003, 10, 1697-1722.
42.
Xia, Y.; Yang, Z.-Y.; Xia, P.; Bastow, K. F.; Tachibana, Y.; Kuo, S.-C.; Hamel, E.; Hackl, T.; Lee, K.-H. Antitumor Agents. 181. Synthesis and Biological Evaluation of 6,7,2’,3’,4’-Substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents. J. Med. Chem. 1998, 41, 1155-1162.
43.
McGown, A. T.; Fox, B. W. Differential Cytotoxicity of Combretastatin-A1 and Combretastatin-A4 in 2
257
Daunorubicin-Resistant P388 Cell lines. Cancer Chemother. Pharmacol. 1990, 26, 79-81.
44.
El-Zayat, A. A. E.; Degen, D.; Drabek, S.; Clark, G. M.; Pettit, G. R.; Von Hoff, D. D. In Vitro Evaluation of the Antineoplastic Activity of Combretastatin-A-4, a Natural Product from Combretum-caffrum (acid shrub). Anti-Cancer Drugs 1993, 4, 19-25.
45.
Ohsumi, K.; Nakagava, R.; Fukuda, Y.; Hatanaka, T.; Morinaga, Y.; Nihei, U.; Ohishi, K.; Suga, Y.; Akiyama, Y.; Tsuji, T. J. Med. Chem. 1998, 41, 3022-3032.
46.
Bedford, S. B.; Quarterman, C. P.; Rathbone, D. L.; Slack, J. A.; Griffin, R. J.; Stevens, M. F. G. Synthesis of Water-soluble Prodrugs of the Cytotoxic Agent Combretastatin A4. Bioorg. Med. Chem. Lett. 1996, 6, 157-160.
47.
Yang, C. L.; Tseng, C. H.; Chen Y. L.; Lu, C. M.; Kao, C. L.; Wu, M. H.; Tzeng C. C. Identification of benzofuro[2,3-b]quinoline derivatives as a new class of antituberculosis agnets. Eur. J. Med. Chem. 2010, 45, 602–607.
48.
Ple, P. A.; Green, T. P.; Hennequin, L. F.; Gurwen, J.; Fennell, M.; Allen, J.; Brempt, C. L.; Costello, G. Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src. J. Med. Chem. 2004, 47, 871-887.
49.
Tseng, C. H.; Chen, Y. L.; Lu, P. J.; Yang, C. N.; Tzeng, C. C. Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Bioorg. Med. Chem. 2008, 16, 3151-3162.
258
50.
Tseng, C. H.; Chen, Y. L.; Chung, K. Y.; Cheng, C. M.; Wang, C. H.; Tzeng, C. C. Synthesis and antiproliferative evaluation of 6-arylindeno[1,2-c]quinoline derivatives. Bioorg. Med. Chem. 2009, 17, 7465-7476.
51.
Tseng, C. H.; Tzeng, C. C.; Yang, C. L.; Lu, P. J.; Chen, H. L.; Li, H. Y.; Chuang, Y. C.; Yang, C. N.; Chen, Y. L. Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2. J. Med. Chem. 2010, 53, 6164–6179.
52.
Cerri, A.; Almirante, N.; Barassi, P.; Benicchio, A.; Fedrizzi, G.; Ferrari, P.; Micheletti, R.; Quadri, L.; Ragg, E.; Rossi, R.; Santagostino, M.; Schiavone, A.; Serra, F.; Zappavigna, M. P.; Mellomi, P. 17-O-Aminoalkyloximes of 5-Androstane-3, 14-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na+, K+-ATPase receptor. J. Med. Chem. 2000, 43, 2332-2349.
53.
Silverstein, R. M.; Webster, F. X. 13C NMR Spectrometry. In Spectrometric Identification of Organic Compounds, 6th ed.; Rose, N., Ed.; John Wiley and Sons. New York, 1998; pp 217-249.
54.
Vougogiannopoulou, K.; Ferandin, Y.; Bettayeb, K.; Myrianthopoulos, V.; Lozach, O.; Fan, Y.; Johnson, C. H.; Magiatis, P.; Skaltsounis, A.-L.; Mikros, E.; Meijer, L. Soluble 30,6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase-3 alter circadian period. J. Med. Chem. 2008, 51, 6421–6431.
55.
Morris, G. M.; Goodsell, D. S.; Halliday, R. S.; Huey, R.; Hart, W. E.; Belew, R. K.; Olson, A. J. Automated docking using a
259
Lamarckian genetic algorithm and empirical binding free energy function. J. Comput. Chem. 1998, 19, 1639–1662.
260
捌、研究成果目錄
一、投稿論文
2011
1.
Chen YW, Chen YL, Tseng CH, Liang CC, Yang CN, Yao YC, Lu PJ*, Tzeng CC * “Discovery of 4-Anilinofuro[2,3-b]quinoline Derivatives as Selectiveand Orally Active Compounds against Non-Small-Cell Lung Cancers” J. Med. Chem., 2011, 54, 4446–4461. (SCI, IF2010 = 5.207, 3/54)
2009
2.
Chen YL, Chen YW, Lo WF, Kao CL, Liu YS, Yao CW, Tzeng CC* “Synthesis and antimycobacterial evaluation on arylsulfonyl and arylcarbonyl derivatives of ofloxacin” J. Chin. Chem. Soc., 2009, 55, 374-380. (SCI, IF2008 = 0.770, 80/125)
2005
3.
Chen YL*, Huang HY, Chen YW, Huang ZY, Tzeng CC, Liu CL, Yao CW “Synthesis and Antimycobacterial Evaluation of Metal-chelator Bearing Fluoroquinolones” Chin. Pharm. J. 2005, 57, 57-70.
261
二、學會口頭論文發表
2010
1.
Chen YW (March 22-26, 2010). “Synthesis and antiproliferative evaluation of 4-anilinofuro[2,3-b]quinoline derivatives” Annual Meeting of College of Life Science of Kaohsiung Medical University, Kaohsiung, Taiwan.
2008
2.
Chen YW, Chen YL, Tzeng CC (April 25-27, 2008). “ Synthesis and anticancer evaluation of 4-anilinofuro[2,3-b]quinoline derivatives” 2008 PSCT Medicinal Chemistry Symposium, Nantou, Taiwan.
262
三、學會壁報論文發表
2010
1.
Shiu YH, Chen YW, Lo WF, Chen YL, Tzeng CC (December 11, 2010). “Synthesis and antiproliferative evaluation of 4-anilinofuro[2,3-b]quinoline derivatives” Annual Meeting of Pharmaceutical Society, Taipei, Taiwan.
2.
Chen YW (May 17-21, 2010). “Synthesis and antiproliferative evaluation of 4-anilinofuro[2,3-b]quinoline derivatives” Annual Graduate Student Paper Competition of Kaohsiung Medical University, Kaohsiung, Taiwan.
3.
Chen YW (March 22-26, 2010). “Synthesis and antiproliferative evaluation of 4-anilinofuro[2,3-b]quinoline derivatives” Annual Meeting of College of Life Science of Kaohsiung Medical University, Kaohsiung, Taiwan.
2009
4.
Yang CL, Tseng CH, Chen YW, Lo WF, Chen YL, Tzeng CC (November 28, 2009). “Identification of benzofuro[2,3-b] quinoline derivatives as a new class of antituberculosis agents” Annual Meeting of Pharmaceutical Society, Taipei, Taiwan.
5.
Chen YW, Lo WF, Chen YR, Lee JY, Shiu YH, Chen YL, Tzeng CC (June 28-30, 2009) “Indentification of Benzofuro[2,3-b]quinoline Derivatives as a New Class of Antituberculosis Agents” 2009 PSCT Medicinal Chemistry Symposium, Nantou, Taiwan.
6.
Chen YW (March 16-20, 2009). “Synthesis and antimycobacterial
263
evaluation on arylsulfonyl and arylcarbonyl derivatives of ofloxacin” Annual Meeting of College of Life Science of Kaohsiung Medical University, Kaohsiung, Taiwan.
2008
7.
Chen YW, Lo WF, Chen YR, Hsieh HY, Yao CW, Chen YL, Tzeng CC (December 6-7, 2008). “Synthesis and antimycobacterial evaluation on arylsulfonyl and arylcarbonyl derivatives of ofloxacin” Annual Meeting of Chinese Chemical Society, Changhua, Taiwan.
8.
Yang CL, Chen YW, Chen YL, Lo WF, Tzeng CC (November 22, 2008). “Synthesis and antimycobacterial evaluation of ofloxacin derivatives” Annual Meeting of Pharmaceutical Society of Taiwan, Taipei, Taiwan.
9.
Chen YW, Chen YL, Tzeng CC (July 28-August 2, 2008). “Synthesis and antimycobacterial evaluation of ofloxacin derivatives” The 6th International Symposium for Chinese Medicinal Chemists (ISCMC 2008), Shanghai, China.
10.
Chen YW, Chen YL, Tzeng CC (April 25-27, 2008). “ Synthesis and anticancer evaluation of 4-anilinofuro[2,3-b]quinoline derivatives” 2008 PSCT Medicinal Chemistry Symposium, Nantou, Taiwan.
11.
Lo YC, Tseng CH, Chen YW, Chen CT, Lin MN, Chen YL, Tzeng CC (April 25-27, 2008). “Synthesis of Aminoalkoxy Substituted 4,5-Diphenylisoxazole Derivatives As Potential Anti-osteoporotic Agents” 2008 PSCT Medicinal Chemistry Symposium, Nantou, Taiwan.
264
2007
12.
Chen YW, Lin HC, Chen YL, Tzeng CC (December 14-16, 2007). “Synthesis and Antiproliferative Evaluation of Certain 4-Anilino-7- and 4-Anilino-6-methoxyfuro[2,3-b]quinoline Derivatives” Annual Chinese Chemical Society & ICCT 2007 Joint Conference, Hsinchu, Taiwan.
13.
Chen YW, Chang FS, Tseng CH, Yang CL, Chen YL, Tzeng CC (December 8, 2007). “Synthesis and Biological Evaluation of 4-Anilino-7-methoxy and 4-Anilino-6-methoxyfuro[2,3-b]quinoline Derivatives” Annual Meeting of Pharmaceutical Society of Taiwan, Kaohsiung, Taiwan.
14.
Lo WF, Chen YW, Chen YL, Tzeng CC, Yao CW (May 18-20, 2007). “Synthesis and antimycobacterial evaluation of benzoyl- and benzenesulfonyl- Containing fluoroquinolone derivatives” 2007 PSCT Medicinal Chemistry Symposium, Nantou, Taiwan.
2006
15.
Tsneg CH, Yang CL, Chen YW, Peng HK, Lin RW, Ho ML, Wang, GJ, Tzeng CC, Chen YL (December 23, 2006). “Synthesis and anti-osteoporotic evaluation of novel 6H-dibenzo[b,d]pyran-6-one derivatives” Annual Meeting of Pharmaceutical Society, Taichung, Taiwan.
16.
Chen YW, Chang FS, Lu CM, Chen IJ, Liang CC, Lo WF, Huang LF, Chen YL, Tzeng CC (December 23, 2006). “Synthesis and antiproliferative evaluation of certain 4-anilinofuro[2,3-b]quinoline derivatives” Annual Meeting of Pharmaceutical Society, Taichung,
265
Taiwan.
17.
Chang FS, Chen YW, Lu CM, Chen YL, Tzeng CC (Novenber 24-26, 2006). “Synthesis and antiproliferative evaluation of certain 4-anilinofuro[2,3-b]quinoline derivatives” Annual Meeting of Chinese Chemical Society, Taipei, Taiwan.
18.
Chen YW, Tseng CH, Yang CL, Chen YL, Tzeng CC (Novenber 24-26, 2006). “Synthesis, antiproliferative, and anti-osteoporotic evaluation of novel isoflavone derivatives” Annual Meeting of Chinese Chemical Society, Taipei, Taiwan.
19.
Tzeng CC, Chen YL, Chen YW, Lin RW, Ho ML, Wang GJ (November 2-7, 2006) “Synthesis and anti-osteoporotic evaluation of novel 6H-dibenzo[b,d]pyran-6-one derivatives” The 5th International Symposium for Chinese Medicinal Chemists (ISCMC 2006), Nanjing, China.
20.
Li SY, Chen YW, Chen YL, Wang CH, Tzeng CC (August 23-25, 2006) “Synthesis and Antiproliferative Evaluation of Certain Pyrido[3,2-g]quinoline Derivatives” 2006 PSCT Medicinal Chemistry Symposium, Pintung, Taiwan.
21.
Chen YW, Lo WF Chen YL, Tzeng CC (August 23-25, 2006) “Synthesis and antiproliferative evaluation of certain 4-anilinofuro[2,3-b]quinoline derivatives” 2006 PSCT Medicinal Chemistry Symposium, Pintung, Taiwan.
2005
22.
Lu CM, Chang FS, Chen YW, Zhao YL, Chen YL, Tzeng CC (December 2-6, 2005). “Synthesis and Antiproliferative Evaluation of
266
Certain 4-Anilinofuro[2,3-b]quinoline and 4-Anilino-2-furanylquinoline Derivatives” International Symposium on New Drug Development: From Bench to Clinics, Taipei, Taiwan.
23.
Chen YW, Huang HY, Huang ZY, Lai HH, Chen YL, Tzeng CC (Novenber 19-20, 2005). “Synthesis And Antimycobacterial Evaluation Of Pyranone And Pyridinone Analogus of the Fluoroquinolones” Annual Meeting of Chinese Chemical Society, Kaohsiung, Taiwan.
24.
Chen YW, Huang HY, Huang ZY, Lai HH, Chen YL, Tzeng CC (September 4-6, 2005). “Synthesis and Antimycobacterial Evaluation of Metal-chelator Bearing Fluoroquinolones” 2005 PSCT Medicinal Chemistry Symposium, Nantou, Taiwan.
2004
25.
Chen YW, Hung HM, Lu CM, Li KC, Chen YL, and Tzeng CC (December 18, 2004). “Synthesis and Anticancer Evaluation of Certain Indolo[2,3-b]quinoline Derivatives” Annual Meeting of Pharmaceutical Society, Taipei.
26.
Chen YW, Hung HM, Lu CM, Li KC, Chen YL, and Tzeng CC (Novenber 19-21, 2004). “Synthesis and Anticancer Evaluation of Certain Indolo[2,3-b]quinoline Derivatives” Annual Meeting of Chinese Chemical Society, Taichung, Taiwan.
27.
Li KC, Liou TL, Chen YW, Chen YL, Tzeng CC (March 5-7, 2004). “Synthesis and Anticancer Evaluation of Tetracyclic Benzo[4,5]oxazolo[3,2-b]isoquinolin-11-one Derivatives” 2004 PSCT Medicinal Chemistry Symposium, Kaohsiung, Taiwan.
267
2003
28.
Li KC, Liuo TL, Chen YW, Jeng HY, Chen YL, Tzeng CC (November 28-30, 2003) “Synthesis of Tetracyclic Benzo[4,5]oxazolo-[3,2-b]isoquinolin-11-one Derivatives for Anticancer Evaluation”, Annual Meeting of Chinese Chemical Society, Chung-Li, Taiwan.

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