臺灣博碩士論文加值系統

本研究探討體外組織內圓柱型發熱源附近溫度分佈及熱損傷區域隨熱療時間之變化。研究工作包括：1.改良本研究室已有的壓克力載具，以改進熱電偶的定位，並增加溫度量測點；2.修改學長之數學模式，以考量發熱源所發出之熱部份被導線帶走之效應；3.進行體外組織加熱實驗並利用實驗數據迴歸數學模式中之參數；4.將組織內溫度分佈隨時間之變化轉換成組織熱損傷區域隨時間之增加。
先前使用之數學模式中有兩個參數，即導熱度及熱傳係數。本研究增加功率因子作為參數，而導熱度則引用前人之實驗值。因此，參數仍維持二個。非線性數據迴歸的結果顯示，引進功率因子使實驗數據與模式計算值相當吻合，而且大幅降低兩者之間的平均誤差。
本研究以電腦模擬繪出不同時間之溫度分佈，以靜態方式顯示二維溫度分佈隨時間之變化，同時計算並繪出熱損傷區域之增加。此電腦模擬結果可作為以熱療法治療腫瘤時之參考。

Time variation of temperature profile and thermal lesion region around a cylindrical heat source in an in vitro tissue has been studied. The search works include: 1. Modifying an existing acrylic loader to improve the precision of the location of thermocouple and to increase the number of temperature monitoring points; 2. Modifying an existing mathematical model for considering that part of heat from the heat source is taken away by the conducting wire; 3. Conducting experiments in an in vitro tissue (pork liver) and performing nonlinear data regression to obtain the parameters in the model; 4. Using time-variable temperature profiles to calculate the expansion of thermal lesion region.
The existing mathematical model has two parameters, thermal conductivity and heat transfer coefficient. Another parameter, the power factor, was introduced in this study. However, the thermal conductivity was adopted from the literature, making the modified model still a two-parameter one. Results from nonlinear regression show that introducing the power factor makes the model calculations agree well with experimental data, and decreases significantly the average error.
The simulation results were used to show the time-variation of temperature profiles that were further used to calculate the expansion of thermal legion region during thermal therapy. The results of computer simulation could be a good reference for tumor-treating by thermal therapy.

誌謝i
英文摘要ii
中文摘要iv
目錄v
圖目錄vii
表目錄x
標記符號xi
第一章 前言
1.1 熱療法1
1.2 組織中之熱傳導5
1.3 本研究目的7
第二章 數學模式
2.1 圓柱型發熱源附近之熱傳遞及二維溫度分佈9
2.2 熱損傷區域13
第三章 實驗
3.1 實驗裝置與介面16
3.2 實驗步驟18
第四章 結果與討論27
第五章 結論55
參考文獻57

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