臺灣博碩士論文加值系統

共軛亞麻油酸(Conjugated Linoleic Acid, CLA) 是一群含18個碳分子，具共軛雙烯鍵的脂肪酸。先前動物研究顯示一段時間的CLA補充可以提高脂肪酸的氧化及減少體內脂肪堆積，但是，也有研究顯示CLA長期補充有可能影響葡萄糖利用。然而，少有人體研究對於短期CLA補充是否可改變年輕健康人體胰島素作用，進而影響全身葡萄糖利用。因此，本研究探討八週口服CLA補充是否會影響有運動習慣者全身葡萄糖利用。招募12名男性受試者(年齡 21.58 ± 0.53歲)給予8週CLA(4.0 g/day)補充。補充CLA前，及補充4週與8週後，受試者分別接受口服葡萄糖耐受度測驗(Oral Glucose Tolerance Test, OGTT)。實驗當天，受試者將進行3小時的OGTT。受試者在實驗當天到達實驗室時給予75公克葡萄糖水搭配500毫升純水飲用後開始計時3小時，3小時內每30分鐘採血一次，蒐集後做血液生化值的分析。研究結果顯示補充CLA至第4週後，受試者身體組成並未改變，OGTT 血糖濃度明顯升高，以ISI指數測得之全身胰島素敏感性也顯著變差，且至第8週仍未見改善。本研究顯示補充8週CLA無法改變年輕健康人體身體組成，同時可能無法提升葡萄糖的利用率，對人體全身胰島素敏感性亦可能沒有正面的效果。

關鍵詞：共軛亞麻油酸、口服葡萄糖耐受度測驗(Oral Glucose Tolerance Test, OGTT)、胰島素敏感性

Conjugated linoleic acid (CLA) is a compound that contains eighteen carbons and unsaturated fatty acids with two double bonds. CLA has been shown to enhance the fatty acid oxidation and reduce the body fat in animal studies. However, there were adverse effects on glucose uptake were found in obese human studies. Little study was found regarding to whether short term CLA administration is expected to influence glucose homeostasis and reducing insulin action in health humans. Therefore, the present study was to examined that effect of eight weeks oral CLA supplementation on whole body glucose and insulin response in health human study. Twelve male subjects (21.58 ± 0.53 yrs) completed eight weeks CLA supplementation (4.0 g per day). Before (baseline) and at the 4th week and the 8th week after CLA supplementation, all subject accepted OGTT test (oral glucose tolerance test, OGTT) and calculated AUC of glucose and insulin. Simultaneously, ISI (insulin sensitivity index) was calculated for represented the insulin action. No significant change in body composition was found in the present study. However, the AUC in glucose and insulin level after OGTT test were higher compared to baseline. In addition, ISI value was decreased significantly from 4th week to 8th week CLA supplementation compared to baseline. The results in this study implied that there was no change in body composition after eight weeks CLA supplementation. In addition, the CLA supplementation influenced glucose homeostasis and reduced insulin action in health humans.
Keywords: CLA, OGTT, insulin sensitivity

目 次
國科會授權書
國家圖書館授權書
謝誌
中文摘要 I
英文摘要 II
目 次 III
表 次 V
圖 次 V
附 錄 V
第一章 緒論 1
第一節 研究背景 1
第二節 研究問題 3
第三節 研究目的 4
第四節 研究假設 5
第五節 研究範圍與限制 5
第六節 名詞操作型定義 5
第二章 文獻探討 7
第一節 共軛亞麻油酸 7
第二節 胰島素敏感性 19
第三節 本章總結 25

第三章 研究方法與步驟 26
第一節 研究對象 26
第二節 實驗設計與流程 26
第三節 資料處理與統計分析 30
第四章 結果 31
第一節 研究對象基本資料 31
第二節 血液生化值反應 32
第五章 討論與結論 37
第一節 主要發現 37
第二節 身體組成 37
第三節 血液生化值 38
第四節 結論 39

參考文獻 40
中文部份 40
英文部分 41


表 次
表2-1 食物中共軛亞麻油酸的含量 8
表4-1 受試者基本資料 31

圖 次
圖2-1 共軛亞麻油酸結構 7
圖2-2 胰島素降血糖機轉路徑圖 24
圖3-1 實驗流程圖 27
圖3-2口服葡萄糖耐受度測驗流程圖 28
圖4-1第零週、第四週、第八週血液葡萄糖濃度之變化圖 32
圖4-2第零週、第四週、第八週葡萄糖反應曲線下面積圖 33
圖4-3第零週、第四週、第八週胰島素濃度之變化圖 34
圖4-4第零週、第四週、第八週胰島素曲線下面積圖 35
圖4-5第零週、第四週、第八週胰島素敏感性指數圖 36

附 錄
附錄一 人體試驗委員會審查意見表 54
附錄二 受測者同意書 55
附錄三 口服葡萄糖耐受度測驗步驟 56
附錄四 總實驗原始數據 57

參考文獻
【中文部分】
行政院衛生署國民健康局 (2011)。衛生統計系列(一)死因統計。行政院衛生署網站，資料引自http://www.doh.gov.tw/CHT2006/DM/DM2_2.aspx?now_fod_list_no=9510&class_no=440&level_no=1
沈秋宏(2008)。非肥胖者不等程度減重對提昇胰島素敏感性的影響。未出版碩士論文，國立台中教育大學體育學系，台中市。
唐正乾、陳滄山、徐維信與許世元（2006）。胰島素、脂肪與癌症：藥理學觀點。內科學誌，17，169-176。
陳金柱、李思遠與郭宗正（2006）。胰島素阻抗之病理生理學。台灣醫界，49（9），28-34。
陳科良(2009)。BMI正常及過重之兒童與成人胰島素敏感性及代謝症候群組成因子之比較。未出版碩士論文，國立台中教育大學體育學系，台中市。
陳嬿如、黃麗卿（2005）。胰島素敏感性及抗性之測定方法。基層醫學，20（10），253-259。
郭家驊、邱麗玲、張振崗、流珍、劉珍芳、劉昉青、祁業榮、郭婕（2010）。運動營養學（三版）。臺中市：華格。
蔡櫻蘭、邱思慈(2006)。10-11歲女童20公尺漸速來回跑測驗的信度和效度。大專體育學刊，8(1)，125-131。
潘恆嘉、黃國晉與陳慶餘（2006）。胰島素阻抗與代謝症候群。基層醫學，21（10），273－277。
簡盟月、吳英黛（2006）。胰島素阻抗與運動訓練的效果－細胞與分子層面之探討。物理治療，31（2），130-141。

【英文部分】
Albers, R., van der Wielen, R. P. J., Brink, E. J., Hendriks, H. F. J., Dorovska-Taran, V. N., & Mohede, I. C. M. (2003). Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. European Journal of Clinical Nutrition, 57,595–603.
Aro, A., Männistö, S., Salminen, I., Ovaskainen, M. L., Kataja, V., & Uusitupa, M. (2000). Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. Nutrition and Cancer, 38(2), 151-157.
Azain, M. J. (2003). Conjugated linoleic acid and its effects on animal products and health in single-stomached animals. Proceedings of the Nutrition Society, 62, 319-328.
Banting, F. G., & Best, C. H. (1922). The internal secretion of the Pancreas. Journal of Laboratory and Clinical Medicine, 7(5), 251-266.
Bassaganya-Riera, J., Hontecillas-Margarzo, R., Bregendahl, K., Wannemuehler, M. J., & Zimmerman, D. R. (2001). Effect of dietary conjugated linoleic acid in nursey pigs of dirty and clean environments on growth, empty body composition and immune competence. Journal of Animal Science, 79(3), 714-721.
Basu, S., Risérus, U., Turpeinen, A., & Vessby, B. (2000). Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clinical Science, 99, 511-516.
Bauman, D. E., Baumgard, L. H., Corl, B. A., & Griinari J. M. (1999).Biosynthesis of conjugated linoleic acid in ruminants. Proceedings of the American Society of Animal Science, 1-5.
Belury, M. A., Mahon, A., & Banni, S. (2003). The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. The Journal of Nutrition, 133(1), 257S-260S.
Belury, M. A., Nickelb, K. P., Birdc, C. E., & Wuc, Y. (1996). Dietary conjugated Linoleic acid modulation of phorbol ester skin tumor promotion. Nutrition and Cancer, 26(2), 149-157.Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., Wadstein, J., & Gudmundsen, O. (2000). Conjugated linoleic acid reduces body fat mass in overweight and obese humans. The Journal of Nutrition, 130(12), 2943-2948.
Blury, M. A. (2002). Dietary conjugated linoleic acid in health: Physiological effects and mechanisms of action. Annual Review of Nutrition, 22(1), 505-531.
Brown, J. M., & McIntosh, M. K. (2003). Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity. The Journal of Nutrition, 133(10), 3041-3046.
Bulgarella, J. A., Patton, D., & Bull, A. W. (2001). Modulation of prostaglandin H synthase activity by conjugated linoleic acid (CLA) and specific CLA isomers. Lipids, 36(4), 407-412.
Carlos, T. M., Schwartz, B. R., Kovach, N. L., Yee, E., Rosso, M., Osborn, L., Chi-Rosso, G., Newman, B., Lobb, R., & M. Harlan, J. (1990). Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood, 76(5), 965-970.
Cartee, G. D., Young, D. A., Sleeper, M. D., Zierath, J., Wallberg-Henriksson, H., & Holloszy, J. O. (1989). Prolonged increase in insulin-stimulated glucose transport in muscle after exercise. American Journal of Physiology. Endocrinology and Metabolism, 256(4), 494-499.
Cesano, A., Visonneau, S., Scimeca, J. A., Kritchevsky, D., & Santoli, D. (1998). Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Research, 18(3A), 1429-1434.
Chajès, V., Lavillonnière, F., Ferrari, P. (2002). Conjugated linoleic acid content in breast adipose tissue is not associated with the relative risk of breast cancer in a population of French patients. Cancer Epidemiol, Biomarkers & Prevention, 11, 672-673.
Choi, J. S., Jung, M. H., Park, H. S., & Song, J. (2004). Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition, 20(11), 1008-1017.
Clément, L., Poirier, H., Niot, I., Bocher, V., Guerre-Millo, M., Krief, S., Staels, B., & Besnard, P. (2002). Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. The Journal of Lipid Research, 43, 1400-1409.
DeFronzo, R. A. (1988). Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes, 37(6), 667-687.
DeLany, J. P., Blohm, F., Truett, A. A., Scimeca, J. A., & West, D. (1999). Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. American Journal of Physiology, 276(4), R1172-R1179.
Du, M., Ahn, D., & Sell, J. L. (1999). Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. Poultry Science, 78(11), 1639-1645.
Eyjolfson, V., Spriet, L. L., Dyck, D. J. (2004). Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Medicine & Science in Sports & Exercise, 36(5), 814-820.
Evans, M. E., Brown, J. M., & McIntosh, M. K. (2002). Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. The Journal of Nutritional Biochemistry, 13(9), 508-516.
Farese, R. V., Sajan, M. P., & Standaert, M. L. (2005). Insulin-sensitive protein kinases (a typical protein kinase C and protein kinase B/Akt): actions and defects in obesity and Type II diabetes. Experimental Biology and Medicine, 230(9), 593-605.
Gaullier, J. M., Berven, G., Blankson, H., & Gudmundsen, O. (2002). Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies. Lipids, 37(11), 1019-1025.
Gaullier, J. M., Halse, J., Hoye, K., Kristiansen, K., Fagertun, H., Vik, H., & Gudmundsen, O. (2004). Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. American Journal of Clinical Nutrition, 79(6), 1118-1125.
Ha, Y. L., Grimm, N. K., & Pariza, M. W. (1987). Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis, 8(12),1881-1887.
Ha, Y. L., Grimm, N. K., & Pariza, M. W. (1989). Newly recognized anticarcinogenic fatty acids: Identification and quantification in natural and processed cheeses. Journal of Agricultural and Food Chemistry, 37(1), 75-81.
Ha, Y. L., Storkson, J., & Pariza, M. W., (1990). Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Research, 50, 1097-1101.
Hayek, M. G., Han, S. N., Wu, D., Watkins, B. A., Meydani, M., Dorsey, J. L., Smith, D. E., & Meydani, S. N. (1999). Dietary conjugated linoleic acid influences the immune response of young and old C57BL/bNCrlBR mice. The Journal of Nutrition, 129(1), 32-38.
Henriksen, E. J., Teachey, M. K., Taylor, Z. C., Jacob, S., Ptock, A., Krämer, K., & Hasselwander, O. (2003). Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. American Journal of Physiology Endocrinology and Metabolism, 285(1), E98-E105.
Hotamisligil, G. S., & Spiegelman, B. M. (1994). TNFα: a key component of obesity-diabetes link. Diabetes, 43(11), 1271-1278.
Houseknechta, K. L., Heuvelb, J. P. V, Moya-Camarenac, S. Y., Portocarreroa, C. P., Peckc, L. W., Nickelc, K. P., & Belury, M. A. (1998). Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker Diabetic Fattyfa/faRat. Biochemical and Biophysical Research Communications, 244(3), 678-682.
Hubbard, N. E., Lim, D., & Erickson, K. L. (2003). Effect of separate conjugated linoleic acid isomers on murine mammary tumorigenesis. Cancer Letters, 190(1), 13-19.
Ip, C., Chin, S. F., Scimecab, J. A., & Pariza, M. W. (1991). Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Research, 51, 6118-6124.
Ip, C., Singh, M., Thompson, H. J., & Scimeca, J. A. (1994). Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of mammary gland in the rat. Cancer Research, 54, 1212-1215.
Ip, C., Scimecab, J. A., & Thompsonc, H. (1995). Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. Nutrition and Cancer, 24(3), 241-247.
Iwata, T., Kamegai, T., Yamauchi-Sato, Y., Ogawa, A., Kasai, M., Aoyama, T. & Kondo, K. (2007). Safety of dietary conjugated linoleic acid (CLA) in a 12-weeks trial in healthy overweight Japanese male volunteers. Journal of Oleo Science, 56(10), 517-525.
Javadi, M., Beynen, A. C., Hovenier, R., Lankhorst, A., Lemmens, A. G., Terpstra, A. H. M., & Geelen, M. J. H. (2004). Prolonged feeding of mice with conjugated linoleic acid increases hepatic fatty acid synthesis relative to oxidation. The Journal of Nutritional Biochemistry, 15(11), 680-687.
Jeukendrup, A. E., & Randell, R. (2011). Fat burners: nutrition supplements that increase fat metabolism. Obesity reviews, 12, 841-851.
Jiang, J., Björck, L., & Fondén, R. (1998). Production of conjugated linoleic acid by dairy starter cultures. Journal of Applied Microbiology, 85(1), 95-102.
Kamphuis, M. M. J. W., Lejeune, M. P. G. M., Saris, W. H. M., Westerterp-Plantenga, M. S. (2003). Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. European Journal of Clinical Nutrition, 57,1268-1274.
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000). Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans. The Journal of Clinical Endocrinology & Metabolism, 85(7), 2402-2410.
Kendall, D. M., & Harmel, A. P. (2002). The metabolic syndrome, type 2 diabetes, and cardiovascular disease: Understanding the role of insulin resistance. American Journal of Managed Care, 8(20), S635-S653.
Kepler, C. R., Hirons, K. P., McNeill, J. J., & Tove, S. B. (1966). Intermediates and products of the biohydrogenation of linoleic acid by butyrivibrio fibrisolvens. The Journal of Biological Chemistry, 241(6), 1350-1354.
King, H., & Aubert, R. E. (1998). Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes care, 21(9), 1414-1431.
Kramer, J. K. G., Sehat, N., Dugan, M. E. R., Mossoba, M. M., Yurawecz, M. P., Roach, J. A. G., Eulitz, K., Aalhus, J. L., Schaefer, A. L., & Ku, Y. (1998). Distributions of conjugated linoleic acid (CLA) isomers in tissue lipid classes of pigs fed a commercial CLA mixture determined by gas chromatography and silver ion-high-performance liquid chromatography. Lipids, 33(6), 549-558
Krook, A., Wallberg-Henriksson, H., & Zierath, J. (2004). Sending the signal: Molecular mechanisms regulating glucose uptake. Medicine and Science in Sports and Exercise, 36(7), 1212-1217.
Kuniyasu, H., Yoshida, K., Sasaki, T., Sasahira, T., Fujii, K., & Ohmori, H. (2006). Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. International Journal of Cancer, 118(3), 571-576.
Larsen, T. M., Toubro, S., Gudmundsen, O., & Astrup, A. (2006). Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain. American Journal of Clinical Nutrition, 83(3), 606-612.
Larsson, S. C., Bergkvist, L., & Wolk, A. (2005). High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish Mammography Cohort. American Journal of Clinical Nutrition, 82(4), 894-900.
Li, Y., & Watkins, B. A. (1998). Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids, 33(4), 417-425.
Liew, C., Schut, H. A. J., Chin, S.F., Pariza, M. W. & Dashwood, R. H. (1995). Protection of conjugated linoleic acids against 2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis, 16(12), 3037-3043.
Lewis, G. P. (1983). Immunoregulatory activity of metabolites of arachidonic acid and their role in inflammation. British Medical Bulletin, 39(3), 243-248.
Lin, H., Boylston, T. D., Luedecke, L. O., & Shultz, T. D. (1995). Conjugated linoleic acid content of cheddar-type cheeses as affected by processing. Journal of Food Science, 64(5), 874-878.
Malpuech-Brugère, C., Venne, W. V., Mensink, R. P., Arnal, M. A., Morio, B., Brandolini, M., Saebo, A., Lassel, T. S., Chardigny, J. M., Sébédio, J. L., & Beaufrère, B. (2004). Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obesity Research, 12, 591-598.
Matsuda, M., & DeFronzo, R. A. (1999). Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care, 22(9), 1462-1470.
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985). Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7), 412-419.
McAuley, K. A., Williams, S. M., Mann, J. I., Walker, R. J., Lewis-Barned, N. J., Temple, L.A., et al. (2001). Diagnosing insulin resistance in the general population. Diabetes Care, 24(3), 460-464.
McFarlane, S. I., Banerji, M., & Sowers, J. R. (2001). Insulin resistance and cardiovascular disease. The Journal of Clinical Endocrinology and Metabolism, 86(2), 713-718.
McLeod, R. S., LeBlanc, A. M., Langille, M. A., Mitchell, P. L., & Currie, D. L. (2004). Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolism. American Journal of Clinical Nutrition, 79(6), 1169S-1174S.
Mirand, P. P., Arnal-Bagnard, M. A., Mosoni, L., Faulconnier, Y., Chardigny J. M., & Chilliard, Y. (2004). Cis-9, Trans-11 and Trans-10, Cis-12 Conjugated Linoleic Acid Isomers Do Not Modify Body Composition in Adult Sedentary or Exercised Rats. The Journal of Nutrition, 134(9), 2263-2269.
Mizunoya, W., Haramizu, S., Shibakusa, T., Okabe, Y., & Fushiki, T. (2005). Dietary conjugated linoleic acid increases endurance capacity and fat oxidation in mice during exercise. Lipids, 40(3), 265-271.
Moloney, F., Yeow, T. P., Mullen, A., Nolan, J. J., & Roche, H. M. (2004). Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. American Journal of Clinical Nutrition, 80(4), 887-895.
Mougios, V., Matsakas, A., Petridou, A., Ring, S., Sagredos, A., Melissopoulou, A., Tsigilis, N., & Nikolaidis, M. (2001). Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. The Journal of Nutritional Biochemistry, 12(10), 585-594.
Nicolosi, R. J., Rogers, E. J., Kritchevsky, D., Scimeca, J. A., & Huth, P. J. (1997). Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery, 22(5), 266-277.
Noone, E. J., Roche, H. M., Nugent, A. P., Gibney, M. J. (2002). The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. British Journal of Nutrition, 88(3), 243-251.
Oku, H., Wongtangtintharn, S., Iwasaki, S., & Toda, T. (2003). Conjugated linoleic acid (CLA) inhibits fatty acid synthetase activity in vitro. Bioscience, Biotechnology, and Biochemistry, 67(7), 1584-1586.
Ostrowska, E., Muralitharan, M., Cross, R. F., Bauman, D. E., & Dunshea, F. R. (1999). Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. The Journal of Nutrition, 129(11), 2037-2042.
Pariza, M. W. (1997). Conjugated linoleic acid, a newly recognized nutrient. Chemistry & Industry, 12(1), 464-466.
Pariza, M. W. (2004). Perspective on the safety and effectiveness of conjugated linoleic acid. American Journal of Clinical Nutrition, 79(6), 1132-1136.
Pariza, M. W., Park, Y., & Cook, M. E. (2000). Mechanisms of action of conjugated linoleic acid: evidence and speculation. Experimental Biology and Medicine, 233(1), 8-13.
Pariza, M. W., Park, Y., & Cook, M. E. (2001). The biologically active isomers of conjugated linoleic acid. Progress in Lipid Research, 40(4), 283-298.
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997). Effect of conjugated linoleic acid on body composition in mice. Lipids, 32(8), 853-858.
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1999). Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids, 34(3), 243-248.
Rahman, S. M., Wang, Y., Yotsumoto, H., Cha, J., Han, S., Inoue, S., & Yanagita, T. (2001). Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. Nutrition, 17(5), 385-390.
Rainer, L. & Heiss, C. J. (2004). Conjugated linoleic acid: health implications and effects on body composition. Journal of the American Dietetic Association, 104(6), 963-968.Reaven, G. M. (1988). Role of insulin resistance in human disease. Diabetes, 37(12), 1595-1607.
Rhodes, C. J., White, M. F. (2002). Molecular insights into insulin action and secretion. European Journal of Clinical Investigation, 32(suppl. 3), 3-13.
Risérus, U., Arner, P., Brismar, K., Vessby, B. (2002). Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care, 25(9), 1516-1521.
Ritzenthaler, K. L., McGuire, M. K., Falen, R., Shultz, T. D., Dasgupta, N., & McGuire, M. A. (2001). Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. The Journal of Nutrition, 131(5), 1548-1554.
Roche, H. M., Noone, E., Sewter, C., Bennett, S. M., Savage, D., Gibney, M. J., O’Rahilly S., & Vidal-Puig, A. J. (2002).Isomer-dependent metabolic effects of conjugated linoleic acid insights from molecular markers sterol regulatory element-binding protein-1c and LXRα. Diabetes, 51(7), 2037-2044.
Ryder, J. W., Portocarrero, C. P., Song, X. M., Cui, L., Yu, M., Combatsiaris, T., Galuska, D., Bauman, D. E., Barbano, D. M., Charron, M. J., Zierath, J. R., & Houseknecht, K. L. (2001).Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes, 50(5), 1149-1157.
Saltiel, A. R. (2000). The molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. J Clin Invest, 106(2), 163-164.
Satory, D. L, & Smith, S. B. (1999). Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3–L1 preadipocytes. The Journal of Nutrition, 129(1), 92-97.
Sébédio, J. L., Juaneda, P., Dobson, G., Ramilison, I., Martin, J. C., Chardigny, J. M., & Christie., W. W. (1997). Metabolites of conjugated isomers of linoleic acid (CLA) in the rat. Biochim. Biophys. Acta, 1345(1),5-10.
Smedman, A., & Vessby, B. (2001). Conjugated linoleic acid supplementation in humans - metabolic effects. Lipids, 36(8), 773-781.
Soonthornpun, S., Setasuban, W., Thamprasit, A., Chayanunnukul, W., Rattarasarn, C., & Geater, A. (2003). Novel insulin sensitivity index derived from oral glucose tolerance test. The Journal of Clinical Endocrinology & Metabolism, 88(3), 1019-1023.
Sugano, M., Taujita, A., Yamasaki, M., Noguchi, M., & Yamada, K.(1998). Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids, 33(5), 521-527.
Takahashi, Y., Kushiro, M., Shinohara, K., & Ide, T. (2002). Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice. Comp Biochem Physiol B Biochem Mol Biol;133(3), 395-404.
Terpstra, A. H. (2004). Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. American Journal of Clinical Nutrition, 79(3), 352-361.
Thom, E., Wadstein, J., & Gudmundsen, O. (2001). Conjugated linoleic acid reduces body fat in healthy exercising humans. The Journal of International Medical Research, 29(5), 392-396.
Thrush, A. B., Chabowski, A., Heigenhauser, G. J., McBride, B. W., Or-Rashid, M., & Dyck, D. J. (2007). Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humans. Applied Physiology, Nutrition, and Metabolism, 32(3), 372-382
Tsuboyama-Kasaoka, N., Takahashi, M., Tanemura, K., Kim, H. J., Tange, T., Okuyama, H., Kasai, M., Ikemoto, S., & Ezaki, O. (2000). Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes, 49(9), 1534-1542.
Turband, S., & Hajduch, E. (2011). Protein kinase C isoforms: Mediators of reactive lipid metabolites in the development of insulin resistance. FEBS Letters, 585(2), 269-274.
Turek, J. J., Li, Y., Schoenlein, I. A., Allen, K. G. D., & Watkins., B. A. (1998). Modulation of macrophage cytokine production by conjugated linoleic acids is influenced by the dietary n-6:n-3 fatty acid ratio. The Journal of Nutritional Biochemistry, 9(5), 258-266.
Verhulst, A., Janssen, G., Parmentier, G., & Eyssen, H. (1987). Isomerization of polyunsaturated long chain fatty acids by propionibacteria. Syst. Appl. Microbiol., 9, 12-15.
Voorrips, L. E., Brants, H. A. M., Kardinaal, A. F. M., Hiddink, G. J., van den Brandt, P. A., & Goldbohm, R. A. (2002). Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands cohort study on diet and cancer. American Journal of Clinical Nutrition, 76(4), 873-882.
Weber, T. E., Schinkel, A. P., Houseknecht, K. L., & Richert, B. T. (2001). Evaluation of conjugated linoleic acid and dietary antibiotics as growth promotants in weanling pigs. Journal of Animal Science, 79(10), 2542-2549.
West, D. B., Delany, J. P., Camet, P. M., Blohm, F., Truett, A. A., & Scimeca, J. (1998).Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. American Journal of Physiology, 275(3), R667-R672.
Whigham, L. D., Higbee, A., Bjorling, D. E., Park, Y., Pariza, M. W., & Cook, M. E. (2002). Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. American Journal of Physiology, 282(4), R1104-R1112.
Yamasaki, M., Ikeda, A., Oji, M., Tanaka, Y., Hirao, A., Kasai, M., Iwata, T., Tachibana, H., & Yamada, K. (2003).Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. Nutrition, 19(1), 30-35.
Zambell, K. L., Horn, W. F., & Keim, N. L. (2001). Conjugated linoleic acid supplementation in humans: effects on fatty acid and glycerol kinetics. Lipids, 36(8), 767-772.