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研究生:廖晏瑩
研究生(外文):Liao, Yen-Ying
論文名稱:甘藷萃取物對於調節免疫功能之評估
論文名稱(外文):Assessment of Sweet Potato Extract on Immunomodulatory Effect
指導教授:陳巧明陳巧明引用關係
指導教授(外文):Chen, Qiao-Ming
口試委員:徐麗芬李信昌
口試委員(外文):Shyur, Li-FangLi, Sing-Chung
口試日期:2013-11-13
學位類別:碩士
校院名稱:實踐大學
系所名稱:食品營養與保健生技學系碩士班
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2013
畢業學年度:102
語文別:中文
論文頁數:97
中文關鍵詞:甘藷乙酸乙酯萃取物免疫功能OVA 致敏氣喘
外文關鍵詞:sweet potatoetheyl acetateimmune functionOVA-induced asthma
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  • 被引用被引用:1
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西蒙 1 號 (Simon No.1) 是一種原產自巴西山區的白皮甘藷,坊間相傳它具有治療白血病及免疫調節的功能。本實驗室先前的體外實驗發現,西蒙 1 號萃取物具有增加小鼠脾臟細胞 NK cell 的活性。因此本研究擬以健康小鼠模式及卵白蛋白 (OVA) 致敏小鼠模式,來探討西蒙 1 號乙酸乙酯萃取物 (Simon No.1 ethyl acetate, SEA) 及台灣常食用的甘藷─台農 66 號乙酸乙酯萃取物 (Tainong No.66 ethyl acetate, TEA) 對於全身免疫功能及特異性過敏反應之調節作用。在健康小鼠模式中,分別給予低劑量 (50 mg/kg BW) 或 高劑量 (200 mg/kg BW) 之甘藷萃取物,每兩日管餵一次,持續四週,以評估小鼠全身性免疫功能。而在 OVA 致敏小鼠模式中,每日給予低劑量 (100 mg/kg BW) 或高劑量 (400 mg/kg BW) 之甘藷萃取物持續 16 天,以評估萃取物對於特異性免疫及非特異性免疫的影響。研究結果發現,在健康小鼠模式當中,餵食 SEA 的組別,能隨著劑量顯著增加脾臟淋巴細胞增殖率,在 ConA 的刺激之下會減少脾臟淋巴細胞分泌 IL-4 的濃度,在 LPS 的刺激之下會增加 IL-4 的分泌、減少 IL-5 的分泌。SEA 的介入對於小鼠體重、組織重量、淋巴亞群分佈、NK cell 活性及腸道沖出液 IgA 分泌量沒有顯著差異。餵食 TEA 的組別,其脾臟淋巴細胞在添加 LPS 的培養液中會增加 IL-4分泌量,而對於小鼠體重、組織重量、淋巴亞群分佈、NK cell 活性、脾臟淋巴細胞增殖率及腸道沖出液 IgA 分泌量沒有顯著差異。在致敏小鼠模式中,給予 SEA 的組別,在 Con A 的刺激之下能顯著增加脾臟淋巴細胞增殖率、IL-4 及 IFN-γ分泌量,在 LPS 的刺激之下顯著增加脾臟淋巴細胞增殖率及 IFN-γ分泌量,減少血清中 total IgE、OVA-IgE 及 OVA-IgG1 的濃度而增加 OVA-IgG2a 的濃度,並且顯著改善肺臟支氣管管壁的增生情形。SEA 對於致敏小鼠體重、總體重變化量、器官重量、淋巴亞群分佈、NK cell 活性及白血球吞噬能力沒有影響。給予 TEA 的組別,會使脾臟重量顯著下降,而在 Con A 的刺激之下能顯著增加脾臟淋巴細胞 IL-4 及 IL-10 分泌量,在 LPS 的刺激之下低劑量 TEA 組會減少 IL-2 並增加 IFN-γ 分泌量,而在 OVA 的刺激之下會增加 IL-2分泌量,減少抗原特異性抗體的濃度,TL 組有顯著增加肺部沖洗液中 IFN-γ 的分泌量。TEA 對於致敏小鼠體重、總體重變化量、淋巴亞群分佈、NK cell 活性、白血球吞噬能力、脾臟淋巴細胞增殖率、血清 total IgE 和輕微改善肺臟支氣管管壁增生。由以上結果可得知,在健康小鼠模式之下,SEA 萃取物可能抑制脾臟淋巴細胞 Th2 路徑的表現,TEA 萃取物則可能促進脾臟淋巴細胞 Th2 路徑。而在致敏小鼠模式之下,SEA 及 TEA 皆能藉由調控血清中抗體、細胞激素的分泌,有效減緩小鼠過敏反應及呼吸道發炎反應,具有發展為改善過敏體質的保健食品之潛力
Simon No.1 is one of the white-skinned sweet potato (Ipomoea batatas) that is used as an immunomodulation food and leukemia therapy in the aboriginal tribe. In our previous study, we found sweet potato extract can increase cytotoxic activity of splenocyte NK cell in vitro. Therefore, we investigated the immuneregulatory effect of ethely acetate fraction of Simon No.1 sweet potato (SEA) and Tainong No.66 sweet potato (TEA) in healthy murine model and ovalbumin (OVA)-induced mice model. In healthy mice model, mice were treated with control, low-dose (50 mg/kg BW) or high-dose (200 mg/kg BW) of sweet potato extract every two days for 4 weeks. In OVA-induced mice model, mice were sensitized with OVA (ovalbumin), and then administered with different dosages of control, low-dose (100 mg/kg BW), high-dose (400 mg/kg BW) or dexamethasone (5 mg/kg BW, as a positive control for this study) for 16 days. Our result showed high dose extract of SEA increased interleukin-2, interferon-γ secretion with Con A stimulation; it also increased interleukin-4 and decreased interleukin-5 secretion with LPS stimulation. It seems trend to exhibit increased Th1 and decreased Th2 responses. High dose extract of TEA only significant increased interleukin-4 secretion with LPS stimulation and no different changes in other parameters. It might trend to promoted T helper 2 cell pathway in mice splenocyte. In OVA-induced mice model, SEA treatment significant decreased serum total IgE, OVA-IgE, and increased OVA-IgG2a level with dose manner, it also decreased interleukin-5 level in bronchoalveolar lavage fluid (BALF). TEA treatment significant decreased serum OVA-IgE, OVA-IgG1, OVA-IgG2a level with dose manner and increased interleukin-10 and interferon-γ level in BALF. The pathologic histopathological assay of lung section revealed that high dose of SEA and TEA had less inflammatory cells infiltrated in peribrochial and peribronchiolar regions as compared to the control group. Through the immune response might be different, but SEA and TEA could ameliorate allergic response and airway inflammation. Thus, SEA and TEA have potential to develop as a nutraceutical food.
中文摘要 II
Abstract III
縮寫對照表 IV
第一章 前言 2
第二章 文獻回顧 3
第一節 甘藷之功效 3
(一) 甘藷的介紹 3
(二) 甘藷的功效 4
(三) 白皮甘藷的介紹 5
(四) 白皮甘藷的功效 6
第二節 免疫系統 9
(一) 先天性免疫 9
(二) 後天性免疫 9
(三) 過敏 13
(四) 過敏性氣喘 13
第三節 甘藷之免疫功效 17
第三章 研究目的 19
第四章 材料與方法 20
第一節 實驗材料 20
第二節 動物實驗材料及儀器 23
第三節 甘藷萃取物在健康小鼠模式中對全身免疫之影響 30
(一) 研究架構 30
(二) 實驗方法 31
第四節 甘藷萃取物在 OVA 致敏小鼠中對特異性免疫之影響 33
(一) 研究架構 33
(二) 實驗方法 35
第五節 分析方法 38
(一) Phagocytosis test 38
(二) Lymphocyte subpopulation analysis 38
(三) NK cell cytotoxic activity assay 38
(四) Cell proliferation assay 40
(五) Cytokines secretion analysis 40
(六) Total IgE and OVA-IgE production analysis 41
(七) OVA-IgG1 and OVA-IgG2a production analysis 41
(八) Histological examination 42
第六節 統計方法 43
第五章 實驗結果 44
第一節 甘藷萃取回收率 44
第二節 甘藷 EA 萃取物在健康小鼠模式中對全身免疫之影響 45
(一) 甘藷 EA 萃取物對小鼠體重的影響 45
(二) 甘藷 EA 萃取物對小鼠器官的影響 45
(三) 甘藷 EA 萃取物對小鼠淋巴亞群分佈之影響 45
(四) 甘藷 EA 萃取物對小鼠 NK cell 活性之影響 45
(五) 甘藷 EA 萃取物對小鼠脾臟細胞增生之影響 50
(六) 甘藷 EA 萃取物對小鼠脾臟細胞細胞激素分泌之影響 50
(七) 甘藷 EA 萃取物對於小鼠腸道沖出液抗體 IgA 分泌之影響 54
第三節 甘藷 EA 萃取物在致敏小鼠模式中對免疫之影響 55
(一) 甘藷 EA 萃取物對致敏小鼠體重的影響 55
(二) 甘藷 EA 萃取物對致敏小鼠器官的影響 55
(三) 甘藷 EA 萃取物對致敏小鼠淋巴亞群分佈之影響 58
(四) 甘藷 EA 萃取物對 NK cell 活性之影響 58
(五) 甘藷 EA 萃取物對致敏小鼠白血球吞噬能力之影響 58
(六) 甘藷 EA 萃取物對致敏小鼠脾臟細胞增生之影響 62
(七) 甘藷 EA 萃取物對致敏小鼠細胞激素分泌之影響 62
(八) 甘藷 EA 萃取物對致敏小鼠血清中抗體分泌之影響 63
(九) 甘藷 EA 萃取物對致敏小鼠血清中特異性抗體分泌之影響 70
(十) 甘藷 EA 萃取物對致敏小鼠 BALF 中細胞激素分泌之影響 70
(十一) 甘藷 EA 萃取物對致敏小鼠肺臟組織之影響 72
第六章 討論 75
第一節 甘藷 EA 萃取物在健康小鼠模式中對全身免疫之影響 75
(一) 甘藷 EA 萃取物對健康小鼠生長狀況之影響 75
(二) 甘藷 EA 萃取物對健康小鼠全身性免疫之影響 76
第二節 甘藷 EA 萃取物在致敏小鼠模式中對免疫之影響 78
(一) 甘藷 EA 萃取物對致敏小鼠生長狀況之影響 79
(二) 甘藷 EA 萃取物對致敏小鼠全身性免疫之影響 79
(三) 甘藷 EA 萃取物對致敏小鼠抗體分泌之影響 80
(四) 甘藷 EA 萃取物對致敏小鼠肺部之影響 82
第七章 結論 85
第八章 參考文獻 86
一、 英文文獻 86
二、 中文文獻 96

一、 英文文獻
Almazan A. M. and Adeyeye S. O. (1998). "Fat and fatty acid concentrations in some
green vegetables." Journal of Food composition and analysis 11(4): 375-380.
Balaha M. F., et al. (2012). "Oral Nigella sativa oil ameliorates ovalbumin-induced
bronchial asthma in mice." Int Immunopharmacol 14(2): 224-231.
Bernard A. and Boumsell L. (1984). "[Human leukocyte differentiation antigens]."
Presse Med 13(38): 2311-2316.
Bloemen K., et al. (2007). "The allergic cascade: review of the most important molecules
in the asthmatic lung." Immunol Lett 113(1): 6-18.
Bovell-Benjamin A. C. (2007). "Sweet potato: a review of its past, present, and future
role in human nutrition." Adv Food Nutr Res 52: 1-59.
Bradding P. and Holgate S. T. (1999). "Immunopathology and human mast cell
cytokines." Crit Rev Oncol Hematol 31(2): 119-133.
Braun C. M., et al. (1997). "Corticosteroid modulation of human, antigen-specific Th1
and Th2 responses." J Allergy Clin Immunol 100(3): 400-407.
Buelens C., et al. (1997). "Interleukin-10 prevents the generation of dendritic cells from
human peripheral blood mononuclear cells cultured with interleukin-4 and
granulocyte/macrophage-colony-stimulating factor." Eur J Immunol 27(3):
756-762.
Busse W. W. and Lemanske R. F., Jr. (2001). "Asthma." N Engl J Med 344(5): 350-362.
Busse W. W., et al. (2010). "A review of treatment with mepolizumab, an anti-IL-5 mAb,
in hypereosinophilic syndromes and asthma." J Allergy Clin Immunol 125(4):
803-813.
Castro M. S., et al. (2012). "Preliminary studies on the prevention of the
ovalbumin-induced allergic response by Enterococcus faecalis CECT7121 in
mice." Int Arch Allergy Immunol 157(1): 11-20.
Chang L., et al. (1993). "Rapid flow cytometric assay for the assessment of natural killer
cell activity." J Immunol Methods 166(1): 45-54.
- 87 -
Chang W. H., et al. (2007). "Effect of purple sweet potato leaves consumption on the
modulation of the immune response in basketball players during the training
period." Asia Pac J Clin Nutr 16(4): 609-615.
Chen C. M., et al. (2005). "Consumption of purple sweet potato leaves modulates human
immune response: T-lymphocyte functions, lytic activity of natural killer cell and
antibody production." World J Gastroenterol 11(37): 5777-5781.
Chen C. M., et al. (2008). "Consumption of purple sweet potato leaves decreases lipid
peroxidation and DNA damage in humans." Asia Pac J Clin Nutr 17(3): 408-414.
Chen Y. Y., et al. (2013). "Sweet Potato [Ipomoea batatas (L.) Lam. "Tainong 57"]
Starch Improves Insulin Sensitivity in High-Fructose Diet-Fed Rats by
Ameliorating Adipocytokine Levels, Pro-Inflammatory Status, and Insulin
Signaling." J Nutr Sci Vitaminol (Tokyo) 59(4): 272-280.
Christensen L. P. (2009). "Galactolipids as potential health promoting compounds in
vegetable foods." Recent Pat Food Nutr Agric 1(1): 50-58.
Chu Y.-H., et al. (2000). "Flavonoid content of several vegetables and their antioxidant
activity." J Sci Food Agric 80(5): 561-566.
Chung H. S., et al. (2013). "A synthetic compound,
4-acetyl-3-methyl-6-(3,4,5-trimethoxyphenyl)pyrano[3,4-c]pyran-1,8-dione,
ameliorates ovalbumin-induced asthma." Bioorg Med Chem 21(21): 6359-6365.
Cockcroft D. W. and Davis B. E. (2006). "Mechanisms of airway hyperresponsiveness."
J Allergy Clin Immunol 118(3): 551-559; quiz 560-551.
Dinarello C. A. (2007). "Historical Review of Cytokines." Eur J Immunol 37(Suppl 1):
S34.
Elias J. A. (2000). "Airway remodeling in asthma. Unanswered questions." Am J Respir
Crit Care Med 161(3 Pt 2): S168-171.
Fairley K. J., et al. (2007). "Exposure to the immunosuppressant, perfluorooctanoic acid,
enhances the murine IgE and airway hyperreactivity response to ovalbumin."
Toxicol Sci 97(2): 375-383.
Fireman P. (2003). "Understanding asthma pathophysiology." Allergy Asthma Proc
24(2): 79-83.
Fischer A. H., et al. (2008). "Hematoxylin and eosin staining of tissue and cell sections."
Cold Spring Harbor Protocols 2008(5): pdb. prot4986.
- 88 -
Franchimont D., et al. (2000). "Inhibition of Th1 immune response by glucocorticoids:
dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T
lymphocytes." J Immunol 164(4): 1768-1774.
Fuchs A. C., et al. (1996). "Clinical, hematologic, and immunologic effects of
interleukin-10 in humans." J Clin Immunol 16(5): 291-303.
Gerlier D. and Thomasset N. (1986). "Use of MTT colorimetric assay to measure cell
activation." J Immunol Methods 94(1-2): 57-63.
Gilmour J. and Lavender P. (2008). "Control of IL-4 expression in T helper 1 and 2
cells." Immunology 124(4): 437-444.
Grunig G., et al. (1997). "Interleukin-10 is a natural suppressor of cytokine production
and inflammation in a murine model of allergic bronchopulmonary
aspergillosis." J Exp Med 185(6): 1089-1099.
Gu P. C., et al. (2011). "Effect of San'ao Decoction on the airway inflammation and
hyperresponsiveness in a murine model of lipopolysaccharide-enhanced asthma."
Chin J Integr Med 17(7): 537-541.
Hanieh H., et al. (2010). "In vivo immunomodulatory effects of dietary purple sweet
potato after immunization in chicken." Anim Sci J 81(1): 116-121.
Hanieh H., et al. (2012). "Immunomodulatory effects of Alliums and Ipomoea batata
extracts on lymphocytes and macrophages functions in White Leghorn chickens:
in vitro study." Anim Sci J 83(1): 68-76.
Hawrylowicz C. M. and O'Garra A. (2005). "Potential role of interleukin-10-secreting
regulatory T cells in allergy and asthma." Nat Rev Immunol 5(4): 271-283.
Holgate S. T. (2008). "The airway epithelium is central to the pathogenesis of asthma."
Allergol Int 57(1): 1-10.
Holt P. G. (2000). "Antigen presentation in the lung." Am J Respir Crit Care Med 162(4
Pt 2): S151-156.
Hsieh C. S., et al. (1993). "Development of TH1 CD4+ T cells through IL-12 produced
by Listeria-induced macrophages." Science 260(5107): 547-549.
Hsu Y. J., et al. (2013). "Suppression of Allergic Reactions in Ovalbumin-Sensitized
Mice by Yam Storage Proteins Dioscorins." J Agric Food Chem.
Huang C. F., et al. (2013). "Effect of oral administration with pravastatin and
atorvastatin on airway hyperresponsiveness and allergic reactions in asthmatic
mice." Ann Allergy Asthma Immunol 110(1): 11-17.
- 89 -
Hwang C. Y., et al. (2010). "Prevalence of atopic dermatitis, allergic rhinitis and asthma
in Taiwan: a national study 2000 to 2007." Acta Derm Venereol 90(6): 589-594.
Hwang Y. P., et al. (2011). "Purple sweet potato anthocyanins attenuate hepatic lipid
accumulation through activating adenosine monophosphate–activated protein
kinase in human HepG2 cells and obese mice." Nutrition Research 31(12):
896-906.
Hwang Y. P., et al. (2011). "Anthocyanins from purple sweet potato attenuate
dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated
antioxidant enzymes and reducing COX-2 and iNOS expression." Food Chem
Toxicol 49(1): 93-99.
Innami S., et al. (1998). "Dried green leaf powders of Jew's mellow (Corchorus),
persimmon (Diosphyros kaki) and sweet potato (Ipomoea batatas poir) lower
hepatic cholesterol concentration and increase fecal bile acid excretion in rats fed
a cholesterol-free diet." Plant Foods Hum Nutr 52(1): 55-65.
Ishida H., et al. (2000). "Nutritive evaluation on chemical components of leaves, stalks
and stems of sweet potatoes (< i> Ipomoea batatas poir)." Food Chem 68(3):
359-367.
Ishikawa H., et al. (2012). "Mice with asthma are more resistant to influenza virus
infection and NK cells activated by the induction of asthma have potentially
protective effects." J Clin Immunol 32(2): 256-267.
Islam M. S., et al. (2002). "Anthocyanin compositions in sweetpotato (Ipomoea batatas
L.) leaves." Biosci Biotechnol Biochem 66(11): 2483-2486.
Islam M. S., et al. (2003). "Distribution and Physiological Functions of Caffeoylquinic
Acid Derivatives in Leaves of Sweetpotato Genotypes." J Food Sci 68(1): 111-116.
Iwamura C., et al. (2010). "Naringenin chalcone suppresses allergic asthma by
inhibiting the type-2 function of CD4 T cells." Allergol Int 59(1): 67-73.
Jaffer U., et al. (2010). "Cytokines in the systemic inflammatory response syndrome: a
review." HSR Proc Intensive Care Cardiovasc Anesth 2(3): 161-175.
Janeway C. A., et al. (2001). "Immunobiology."
Jin Y. R., et al. (2007). "Intake of vitamin A-rich foods and lung cancer risk in Taiwan:
with special reference to garland chrysanthemum and sweet potato leaf
consumption." Asia Pac J Clin Nutr 16(3): 477-488.
Johanna G., et al. (2013). "Immunoregulatory Impact Of Food Antioxidants." Curr
Pharm Des.
- 90 -
Johnson M. and Pace R. D. (2010). "Sweet potato leaves: properties and synergistic
interactions that promote health and prevent disease." Nutr Rev 68(10): 604-615.
Kang H., et al. (2009). "Leuconostoc citreum HJ-P4 (KACC 91035) regulates
immunoglobulin E in an ovalbumin-induced allergy model and induces
interleukin-12 through nuclear factor-kappa B and p38/c-Jun N-terminal kinases
signaling in macrophages." Microbiol Immunol 53(6): 331-339.
Kelly H. W. and Nelson H. S. (2003). "Potential adverse effects of the inhaled
corticosteroids." J Allergy Clin Immunol 112(3): 469-478; quiz 479.
Kennedy G. L., Jr. (1985). "Dermal toxicity of ammonium perfluorooctanoate." Toxicol
Appl Pharmacol 81(2): 348-355.
Kennedy G. L., Jr., et al. (1986). "Inhalation toxicity of ammonium
perfluorooctanoate." Food Chem Toxicol 24(12): 1325-1329.
Kim D. Y. and Yang W. M. (2011). "Panax ginseng ameliorates airway inflammation in
an ovalbumin-sensitized mouse allergic asthma model." J Ethnopharmacol
136(1): 230-235.
Kim J. J., et al. (2012). "Anti-inflammatory and anti-allergic effects of Agrimonia pilosa
Ledeb extract on murine cell lines and OVA-induced airway inflammation." J
Ethnopharmacol 140(2): 213-221.
Kim J. K., et al. (2011). "In vitro and in vivo immunomodulatory activity of sulfated
polysaccharides from Enteromorpha prolifera." Int J Biol Macromol 49(5):
1051-1058.
Kroesen B.-J., et al. (1992). "Direct visualisation and quantification of cellular
cytotoxicity using two colour fluorescence." Journal of immunological methods
156(1): 47-54.
Kusano S. and Abe H. (2000). "Antidiabetic activity of white skinned sweet potato
(Ipomoea batatas L.) in obese Zucker fatty rats." Biol Pharm Bull 23(1): 23-26.
Kusano S., et al. (2001). "Isolation of antidiabetic components from white-skinned sweet
potato (Ipomoea batatas L.)." Biosci Biotechnol Biochem 65(1): 109-114.
Lai C. K., et al. (2009). "Global variation in the prevalence and severity of asthma
symptoms: phase three of the International Study of Asthma and Allergies in
Childhood (ISAAC)." Thorax 64(6): 476-483.
Ludvik B., et al. (2008). "Improved metabolic control by Ipomoea batatas (Caiapo) is
associated with increased adiponectin and decreased fibrinogen levels in type 2
diabetic subjects." Diabetes Obes Metab 10(7): 586-592.
- 91 -
Ludvik B., et al. (2004). "Efficacy of Ipomoea batatas (Caiapo) on diabetes control in
type 2 diabetic subjects treated with diet." Diabetes Care 27(2): 436-440.
Ludvik B., et al. (2003). "Mode of action of ipomoea batatas (Caiapo) in type 2 diabetic
patients." Metabolism 52(7): 875-880.
Ludvik B. H., et al. (2002). "The effect of Ipomoea batatas (Caiapo) on glucose
metabolism and serum cholesterol in patients with type 2 diabetes: a randomized
study." Diabetes Care 25(1): 239-240.
Majdalawieh A. F., et al. (2010). "Nigella sativa modulates splenocyte proliferation,
Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity." J
Ethnopharmacol 131(2): 268-275.
Manetti R., et al. (1993). "Natural killer cell stimulatory factor (interleukin 12 [IL-12])
induces T helper type 1 (Th1)-specific immune responses and inhibits the
development of IL-4-producing Th cells." J Exp Med 177(4): 1199-1204.
Matsuse H., et al. (2013). "Differential effects of dexamethasone and itraconazole on
Aspergillus fumigatus-exacerbated allergic airway inflammation in a murine
model of mite-sensitized asthma." Respiration 85(5): 429-435.
Medzhitov R. and Janeway C. A., Jr. (1997). "Innate immunity: impact on the adaptive
immune response." Curr Opin Immunol 9(1): 4-9.
Medzhitov R. and Janeway C. A., Jr. (1999). "Innate immune induction of the adaptive
immune response." Cold Spring Harb Symp Quant Biol 64: 429-435.
Miyazaki Y., et al. (2005). "Effects on immune response of antidiabetic ingredients from
white-skinned sweet potato (Ipomoea batatas L.)." Nutrition 21(3): 358-362.
Mizuno M. (2010). In Vitro and In Vivo immunomodulatory and anti-allergic effects of
Agaricus blazei Murill. Dietary Components and Immune Function, Springer:
387-394.
Mo J. H., et al. (2013). "Anti-allergic effects of So-Cheong-Ryong-Tang, a traditional
Korean herbal medicine, in an allergic rhinitis mouse model." Eur Arch
Otorhinolaryngol 270(3): 923-930.
Mosmann T. R. and Coffman R. L. (1989). "TH1 and TH2 cells: different patterns of
lymphokine secretion lead to different functional properties." Annu Rev
Immunol 7: 145-173.
Mosmann T. R. and Moore K. W. (1991). "The role of IL-10 in crossregulation of TH1
and TH2 responses." Immunol Today 12(3): A49-53.
- 92 -
Nagai M., et al. (2011). "Sweet potato (Ipomoea batatas L.) leaves suppressed oxidation
of low density lipoprotein (LDL) in vitro and in human subjects." J Clin Biochem
Nutr 48(3): 203-208.
Neis M. M., et al. (2006). "Enhanced expression levels of IL-31 correlate with IL-4 and
IL-13 in atopic and allergic contact dermatitis." J Allergy Clin Immunol 118(4):
930-937.
Nelson H. S. (2006). "Is there a problem with inhaled long-acting beta-adrenergic
agonists?" J Allergy Clin Immunol 117(1): 3-16; quiz 17.
Norman P. S. (1998). "Immunotherapy: past and present." J Allergy Clin Immunol
102(1): 1-10.
O'Connor R. A., et al. (2010). "Translational mini-review series on Th17 cells: CD4 T
helper cells: functional plasticity and differential sensitivity to regulatory T
cell-mediated regulation." Clin Exp Immunol 159(2): 137-147.
O'Garra A. and Vieira P. (2004). "Regulatory T cells and mechanisms of immune
system control." Nat Med 10(8): 801-805.
Oki N., et al. (2011). "The effects of an arabinogalactan-protein from the white-skinned
sweet potato (Ipomoea batatas L.) on blood glucose in spontaneous diabetic
mice." Biosci Biotechnol Biochem 75(3): 596-598.
Ozaki S., et al. (2010). "Structural characterization and hypoglycemic effects of
arabinogalactan-protein from the tuberous cortex of the white-skinned sweet
potato (Ipomoea batatas L.)." J Agric Food Chem 58(22): 11593-11599.
Parham P. and Janeway C. A. (2005). The immune system, Garland Science New York,
NY.
Pichavant M., et al. (2001). Animal Models of Airway Sensitization. Current Protocols in
Immunology, John Wiley & Sons, Inc.
Ple C., et al. (2010). "Natural killer cells accumulate in lung-draining lymph nodes and
regulate airway eosinophilia in a murine model of asthma." Scand J Immunol
72(2): 118-127.
Ravindran V., et al. (1995). "Biochemical and nutritional assessment of tubers from 16
cultivars of sweet potato (Ipomoea batatas L.)." J Agric Food Chem 43(10):
2646-2651.
Ren K., et al. (2012). "The effect of a sweet potato, footbath, and acupressure
intervention in preventing constipation in hospitalized patients with acute
coronary syndromes." Gastroenterol Nurs 35(4): 271-277.
- 93 -
Roh S. S., et al. (2008). "Effects of radix adenophorae and cyclosporine A on an
OVA-induced murine model of asthma by suppressing to T cells activity,
eosinophilia, and bronchial hyperresponsiveness." Mediators Inflamm 2008:
781425.
Roitt I., et al. (1994). "Immunology. 1998." Barcelona: Mosby 213.
Romagnani S. (1995). "Biology of human TH1 and TH2 cells." J Clin Immunol 15(3):
121-129.
Royhan A. and Susilowati R. (2011). "Effects of White-Skinned Sweet Potato (Ipomoea
batatas L.) on Pancreatic Beta Cells and Insulin Expression in Streptozotocin
Induced Diabetic Rats." Majalah Kesehatan Pharmamedika 1(2): 45-49.
Sato Y., et al. (2010). "Dietary carotenoids inhibit oral sensitization and the development
of food allergy." J Agric Food Chem 58(12): 7180-7186.
Schnare M., et al. (2001). "Toll-like receptors control activation of adaptive immune
responses." Nat Immunol 2(10): 947-950.
Schoenborn J. R. and Wilson C. B. (2007). "Regulation of interferon-gamma during
innate and adaptive immune responses." Adv Immunol 96: 41-101.
Selgrade M. K., et al. (2008). "Assessing the health effects and risks associated with
children's inhalation exposures--asthma and allergy." J Toxicol Environ Health
A 71(3): 196-207.
Shan Q., et al. (2009). "Purple sweet potato color ameliorates cognition deficits and
attenuates oxidative damage and inflammation in aging mouse brain induced by
d-galactose." J Biomed Biotechnol 2009: 564-737.
Shefrin A. E. and Goldman R. D. (2009). "Use of dexamethasone and prednisone in
acute asthma exacerbations in pediatric patients." Can Fam Physician 55(7):
704-706.
Sherman M. A. (2001). "The role of STAT6 in mast cell IL-4 production." Immunol Rev
179: 48-56.
Shevach E. M. (2002). "CD4+ CD25+ suppressor T cells: more questions than answers."
Nat Rev Immunol 2(6): 389-400.
Smith K. A. (1980). "T-cell growth factor." Immunol Rev 51: 337-357.
Standen M. D., et al. (2006). "Natural killer cell activity and lymphocyte activation:
Investigating the effects of a selection of essential oils and components in vitro."
International Journal of Aromatherapy 16(3–4): 133-139.
- 94 -
Suzuki K., et al. (2007). "Intestinal IgA synthesis: a primitive form of adaptive
immunity that regulates microbial communities in the gut." Semin Immunol
19(2): 127-135.
Sy L. B., et al. (2006). "Propolis extracts exhibit an immunoregulatory activity in an
OVA-sensitized airway inflammatory animal model." Int Immunopharmacol
6(7): 1053-1060.
Takanaski S., et al. (1994). "Interleukin 10 inhibits lipopolysaccharide-induced survival
and cytokine production by human peripheral blood eosinophils." J Exp Med
180(2): 711-715.
Takatsu K., et al. (2009). "Interleukin 5 in the link between the innate and acquired
immune response." Adv Immunol 101: 191-236.
Takatsu K. and Nakajima H. (2008). "IL-5 and eosinophilia." Curr Opin Immunol 20(3):
288-294.
Tiron A. and Vasilescu C. (2008). "[Role of the spleen in immunity. Immunologic
consequences of splenectomy]." Chirurgia (Bucur) 103(3): 255-263.
To T., et al. (2012). "Global asthma prevalence in adults: findings from the
cross-sectional world health survey." BMC Public Health 12: 204.
Truong V. D., et al. (2007). "Phenolic acid content and composition in leaves and roots
of common commercial sweetpotato (Ipomea batatas L.) cultivars in the United
States." J Food Sci 72(6): C343-349.
Tsuji M., et al. (2008). "Dynamic interactions between bacteria and immune cells
leading to intestinal IgA synthesis." Semin Immunol 20(1): 59-66.
Turner H. and Kinet J. P. (1999). "Signalling through the high-affinity IgE receptor Fc
epsilonRI." Nature 402(6760 Suppl): B24-30.
Venge P. (2004). "Monitoring the allergic inflammation." Allergy 59(1): 26-32.
Venge P., et al. (1999). "Eosinophil cationic protein (ECP): molecular and biological
properties and the use of ECP as a marker of eosinophil activation in disease."
Clin Exp Allergy 29(9): 1172-1186.
Wang J., et al. (2009). "The effects of anti-asthma drugs on the phagocytic clearance of
apoptotic eosinophils by A549 cells." Respir Med 103(11): 1693-1699.
Wang Y. J., et al. (2010). "Purple sweet potato color suppresses
lipopolysaccharide-induced acute inflammatory response in mouse brain."
Neurochem Int 56(3): 424-430.
- 95 -
Wershil B. K., et al. (1995). "Dexamethasone and cyclosporin A suppress mast
cell-leukocyte cytokine cascades by multiple mechanisms." Int Arch Allergy
Immunol 107(1-3): 323-324.
Woolfe J. A. (1992). Sweet potato: An untapped food resource, Cambridge University
Press.
Wu D. M., et al. (2008). "Purple sweet potato color repairs d-galactose-induced spatial
learning and memory impairment by regulating the expression of synaptic
proteins." Neurobiol Learn Mem 90(1): 19-27.
Wynn T. A., et al. (1997). "Analysis of granuloma formation in double cytokine-deficient
mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T
helper cell 2-type cytokine responses in vivo." J Immunol 159(10): 5014-5023.
Yi Y., et al. (2011). "Immunomodulatory activity of polysaccharide-protein complex of
longan (Dimocarpus longan Lour.) pulp." Molecules 16(12): 10324-10336.
Yoshikawa K., et al. (2010). "Ipomotaosides A-D, resin glycosides from the aerial parts
of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2." J
Nat Prod 73(11): 1763-1766.
Yuk J. E., et al. (2011). "Effects of astilbic acid on airway hyperresponsiveness and
inflammation in a mouse model of allergic asthma." Int Immunopharmacol 11(2):
266-273.
Zhang K., et al. (1997). "Inhibition of glutathione reductase by plant polyphenols."
Biochem Pharmacol 54(9): 1047-1053.
Zhao G., et al. (2005). "Characterization and immunostimulatory activity of an
(1-->6)-a-D-glucan from the root of Ipomoea batatas." Int Immunopharmacol
5(9): 1436-1445.
Zhao H., et al. (2012). "Antitumor and immunostimulatory activity of a
polysaccharide-protein complex from Scolopendra subspinipes mutilans L. Koch
in tumor-bearing mice." Food Chem Toxicol 50(8): 2648-2655.
Zhao R., et al. (2007). "Antidiabetic activity of flavone from Ipomoea Batatas leaf in non
‐ insulin dependent diabetic rats." International journal of food science &
technology 42(1): 80-85.
Zhao Y. T., et al. (2012). "[Effects of Chinese herbal medicine Pingchuan Formula on
airway inflammation, interferon-gamma and interleukin-4 in mice with
asthma]." Zhong Xi Yi Jie He Xue Bao 10(7): 807-813.
- 96 -
二、 中文文獻
杜維耶 (2009),甘藷 (Ipomoea batatas Lam.) 之抗氧化研究。屏東科技大學熱帶農業暨
國際合作系所學位論文,屏東,台灣。
台灣省農業試驗所,嘉義農業試驗分所 (1993)。食用甘藷品種。嘉義農業試驗分所,嘉
義,台灣。
李時珍 (1990),本草綱目。大台北出版社,新台市,台灣。
林雅玲 (2003),談討台灣鄉土蔬菜─紅甘藷葉中多酚類之生體可利用率對人體抗氧化狀
態之影響。台北醫學大學保健營養學系碩士論文,台北,台灣。
徐明麗 (1997),薏仁抗過敏及抗腫瘤之研究。國立台灣大學食品科技研究所碩士論文,
台北,台灣。
張文心 (2004),台灣鄉土蔬菜-紅甘藷葉對運動期之籃球選手其抗氧化力與免疫狀態的
調節。台北醫學大學保健營養學系碩士論文,台北,台灣。
張立德 (2010),免疫學。華格納出版社,台中,台灣。
湯貞淑 (2000),台灣紅色鄉土蔬菜萃取物之抗氧化效力研究。中國文化大學生活應用科
學研究所碩士論文,台北,台灣。
劉雨田、汪蕙蘭等 (2001),新編微生物學。永大書局,台北,台灣。
薛聰賢、楊宗愈 (2000),台灣蔬果實用百科。台灣普綠出版,彰化,台灣。
羅淑芳、賴永昌 (2012),甘藷健康管理技術暨操作手冊。行政院農業委員會農業試驗所,
台中,台灣。
李鴻奇 (2006),白番薯的神奇療效。世茂出版社,新北,台灣。
華希新、鄔景禹、王胜武、李蕾 (1988),藥用甘藷 “希蒙一號”的生物學特性及栽培技
- 97 -
術研究。中國甘藷,2:51-56。
行政院衛生署編著 (1999),台灣地區食品營養成分資料庫。行政院衛生署,台灣。
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