臺灣博碩士論文加值系統

本研究將嘗試利用具有生物活性的脂質(酪梨油、乳油木果脂)及界面活性劑D-α-維生素E聚乙二醇琥珀酸酯製備形成功能性奈米載體。利用穿透式電子顯微鏡觀察酪梨油/乳油木果脂奈米載體之結構，證實酪梨油/乳油木果脂奈米載體之形成。再藉由動態光散射儀及黏度計進行酪梨油/乳油木果脂奈米載體的物化特徵分析，接著利用流變儀量測酪梨油/乳油木果脂奈米載體添加增稠劑之流變行為。

In this study, solid lipids shea and the liquid lipid avocado oil were combined with a bioactive surfactant TPGS to form nanoscale drug carriers. A transmission electron microscope (TEM) shows formation of the nanoscale colloids by materials mentioned above directly. Physical characteristics of nanocarriers were investigated by viscosity measurement, and rheometer.

摘要 i
ABSTRACT ii
誌謝 iii
目錄 iv
表目錄 vi
圖目錄 vii
符號說明 xi
第一章 緒論 1
1-1 前言 1
1-2 研究動機與目的 2
第二章 文獻回顧 3
2-1 奈米載體 3
2-2 酪梨油 5
2-3 乳油木果脂 6
2-4 維生素E聚乙二醇琥珀酸脂 7
2-5 奈米載體凝膠 8
2-6 ZEN 8
2-7 黑米萃取物之活性成分 9
2-8 花青素的結構與特性 11
2-9 花青素的化學穩定性 12
第三章 材料與方法 15
3-1 實驗藥品 15
3-2 實驗設備與方法 16
3-2-1 酪梨油/乳油木果脂奈米載體配方設計 16
3-2-2 酪梨油/乳油木果脂奈米載體製備流程 17
3-2-3 粒徑與界面電位的分析 17
3-2-4 穿透式電子顯微鏡拍攝實驗 19
3-2-5 黏度的量測 20
3-2-6 酪梨油/乳油木果脂奈米載體混合Zen膠 20
3-2-7 黑米萃取活性成分 21
3-2-8 活性成分含量分析(HPLC) 22
3-2-9 奈米載體包覆(Bre)製備程序 22
第四章 結果與討論 30
4-1 酪梨油/乳油木果脂奈米載體 30
4-1-1 酪梨油/乳油木果脂奈米載體之粒徑、分布係數、界面電位與型態觀察 30
4-1-2 酪梨油/乳油木果脂奈米載體之黏度變化 31
4-2 酪梨油/乳油木果脂奈米載體添加Zen膠之流變行為 31
4-3 黑米萃取活性成分之化學穩定性分析 32
4-3-1 定性分析 32
第五章 結論 59
參考文獻 60

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