跳到主要內容

臺灣博碩士論文加值系統

(216.73.216.106) 您好!臺灣時間:2026/04/05 02:02
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:顧祐瑞
研究生(外文):KU, YOE-RAY
論文名稱:中藥指標成分及摻加西藥成分之分析方法研究
論文名稱(外文):Analysis of marker constituents and synthetic therapeutic substances adulterated in traditional Chinese medicines
指導教授:張永勳張永勳引用關係何禮剛何禮剛引用關係溫國慶溫國慶引用關係
指導教授(外文):CHANG, YUAN-SHIUNHO, LI-KANGWEN, KUO-CHING
學位類別:博士
校院名稱:中國醫藥學院
系所名稱:中國藥學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2000
畢業學年度:88
語文別:中文
論文頁數:117
中文關鍵詞:中藥製劑指標成分中藥摻加西藥高效液相層析毛細管電泳固相萃取茶葉
外文關鍵詞:traditional Chinese medicinemarker constituentadulteranthigh-performance liquid chromatographycapillary electrophoresissolid-phase extractiontea
相關次數:
  • 被引用被引用:1
  • 點閱點閱:1023
  • 評分評分:
  • 下載下載:73
  • 收藏至我的研究室書目清單書目收藏:4
摘 要
中藥製劑中摻加西藥成分,若在不知情下而長期服用,對身體健康不無影響,另對毒、副作用較強之中藥,造成之危害恐更為顯著。因此行政院衛生署為保護國民之用藥安全,禁止於中藥製劑中摻加西藥成分。至於中藥材本身所含之化學成分很複雜,加上其基原、產地無法充分掌握之情況下,要建立其品質管制標準有其困難,特別是由多味藥材組成之方劑,更加困難。
本研究以固相萃取 (SPE) 及高效液相層析 (HPLC) 或毛細管電泳層析(HPCE),系統性地分析支氣管鬆弛劑 (包括caffeine, theophylline, theobromine, diprophylline及proxyphylline)、類固醇(betamethasone, cortisone acetate, dexamethasone, hydrocortisone acetate, methylprednisolone, prednisolone, prednisone及triamcinolone)、減肥藥 (clobenzorex, diethylpropion, fenfluramine, methamphetamine, phenylpropanolamine及phentermine) 及胃腸藥 (cimetidine, homatropine, metoclopramide, pirenzepine, ranitidine及scopolamine butylbromide) 等四類西藥成分。在中藥製劑方面,則應用SPE及HPLC分析含茶葉方劑 (川芎茶調散、三黃石膏湯、滋腎明目湯、辛夷散、蒼耳散及香芎散) 中之caffeine。
本研究建立了上述四類西藥成分摻加於中藥製劑及含茶葉方劑中之caffeine之前處理及分析方法,而這些方法均可用於實際檢體之分析。
ABSTRACT
The adulteration by synthetic therapeutic substances in traditional Chinese medicines (TCM) has been reported on many occasions and has been a public health concern in Taiwan over the past years. The term "adulteration" refers to TCM tested and found to contain chemical substances not prescribed or labeled as part of the intended use. The adulteration by synthetic therapeutic substances in TCM was banned for the reasons of public safety by the health authorities in Taiwan.
Four pharmacological categories of chemical drugs, xanthine bronchodilators: caffeine, diprophylline, proxyphylline, theobromine and theophylline; steroids: betamethasone, cortisone acetate, dexamethasone, hydrocortisone acetate, methylprednisolone, prednisolone, prednisone and triamcinolone; anorexics: clobenzorex, diethylpropion, fenfluramine, methamphetamine, phenylpropanolamine and phentermine and gastrointestinal drugs: cimetidine, homatropine, metoclopramide, pirenzepine, ranitidine and scopolamine butylbromide, adulterated in TCM were assayed by solid-phase extraction with high-performance liquid chromatography or high-performance capillary electrophoresis.
A high-performance liquid chromatographic method in combination with C18 reversed phase SPE was also developed for the determination of caffeine in traditional Chinese medicinal prescriptions which contain Theae Folium. Six frequently used prescriptions were studied by above methods. These prescriptions include Shin-Yi-San, Chuan-Chyong-Char-Tyau-San, Tsang-Eel-San, San-Hwang-Shyr-Gau-Tang, Tzy-Shenn-Ming-Mu-Tang and Shiang-Chyong-San.
封面

謝辭
附圖目錄
附表目錄
縮寫字表
中文摘要
第一章 前言
第二章 材料與方法
第一節 中藥製劑中摻加支氣管鬆弛劑之固相萃取與高效相層析分析
第二節 中藥製劑中摻加類固醇之固相萃取與高效液相層析分析
第三節 中藥製劑中摻加減肥藥之固相萃取與毛細管電泳層析分析
第四節 中藥製劑中摻加胃腸藥之毛細管電泳層析分析
第五節 含茶葉方劑中caffenie之固相萃取與高效液相層析分析
第三章 結果與討論
第一節 中藥製劑中摻加支氣管鬆弛劑之固相萃取與高效相層析分析
第二節 中藥製劑中摻加類固醇之固相萃取與高效液相層析分析
第三節 中藥製劑中摻加減肥藥之固相萃取與毛細管電泳層析分析
第四節 中藥製劑中摻加胃腸藥之毛細管電泳層析分析
第五節 含茶葉方劑中caffeine之固相萃取與高效液相層析分析
第四章 結論
參考文獻
英文摘要
榮譽
與本論文有關之論文發表
顧祐瑞發表著作一覽表
個人資料表
參 考 文 獻
1. Ueng TH, Kang JJ, Wang HW and Lin PC. An overview of toxicology of commonly used traditional Chinese medicine. Journal of Food and Drug Analysis 1997; 5: 241-263.
2. Yang HY and Chen CF. Subacute toxicity and bioactivity evaluation of commonly used Chinese drugs: Analgesic Chinese drugs. Journal of Chinese Medicine 1992; 3: 41-60.
3. Yang HY and Chen CF. Subacute toxicity of 15 commonly used Chinese drugs (II). Journal of Food and Drug Analysis 1997; 5: 355-379.
4. 鄭建詒、林麗令、陳本、蔡明哲、王昭昭、謝伯舟、劉宜祝、鄭守訓,中藥製劑摻加西藥之檢驗研究 (第一~六報),藥物食品檢驗局調查研究年報 1981; 1: 213-225。
5. 鄭建詒、鄭守訓、秦玲、蔡明哲,中藥製劑摻加西藥之檢驗研究 (第七報) 中藥降壓利尿類製劑摻加西藥成分之檢驗法,藥物食品檢驗局調查研究年報 1983; 3: 1-5。
6. 劉宜祝、林哲輝,中藥檢驗方法專輯 (四) 中藥製劑摻加西藥之檢驗,行政院衛生署藥物食品檢驗局,台北,1991: 1-64。
7. 溫國慶、蔡明哲、顧祐瑞、曾木全、林小華、陳本、林美智、揚禮安、蔡文惠,中藥檢驗方法專輯 (七) 中藥摻加西藥數據圖譜 (I),行政院衛生署藥物食品檢驗局,台北,1995: 1-166。
8. 溫國慶、蔡明哲、顧祐瑞、曾木全、林小華、陳本、林美智、揚禮安,中藥檢驗方法專輯 (十) 中藥摻加西藥數據圖譜 (II),行政院衛生署藥物食品檢驗局,台北,1996: 1-371。
9. 鄭守訓、陳婉淑、歐天賜、陳本、莊清堯、林哲輝,七十四年度台灣地區中醫診所及中藥房調製中藥製劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報 1984; 4: 33-42。
10. 劉宜祝、劉芳淑、莊清堯,七十四年度台灣地區市售風濕鎮痛類中藥製劑摻加西藥成分之調查研究,藥物食品檢驗局調查研究年報1984; 4: 43-44。
11. 秦玲、曾人和、林哲輝、曾千芳,市售中藥感冒糖漿摻加未經核准西藥成分之調查,藥物食品檢驗局調查研究年報1987; 5: 204-205。
12. 劉芳淑、劉宜祝、陳繼昌、計惠卿、林隆達、曾千芳,市售肝病類中藥製劑摻加未經核准西藥成分及微生物污染情形調查研究,藥物食品檢驗局調查研究年報 1987; 5: 208-209。
13. 蔡明哲、賈東明、陳繼昌、林哲輝、曾千芳, 市售消渴類中藥製劑摻加未經核准西藥成分及微生物污染情形調查研究,藥物食品檢驗局調查研究年報 1987; 5: 210-211。
14. 鄭守訓、劉宜祝、徐廷光、莊清堯,台灣地區市售中藥感冒糖漿劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報1988; 6: 135-136。
15. 劉宜祝、徐廷光、鄭守訓、謝伯舟、莊清堯,台灣地區中醫診所及中藥房調製中藥製劑摻加西藥成分之調查報告 (第二報) ,藥物食品檢驗局調查研究年報 1988; 6: 146-148。
16. 劉宜祝、徐廷光、莊清堯,七十五年度市售風濕鎮痛類中藥製劑摻加西藥成分之調查研究,藥物食品檢驗局調查研究年報 1988; 6: 150-151。
17. 方燕嬌、劉宜祝、徐廷光、孫慈悌,市售調經理帶類中藥製劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報1989; 7: 144-145。
18. 楊美華、劉宜祝、徐廷光、孫慈悌,七十六年度市售感冒鎮咳類中藥製劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報 1989; 7: 148-149。
19. 劉宜祝、徐廷光、孫慈悌,七十六年度市售風濕鎮痛類中藥製劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報 1989; 7: 197-199。
20. 楊美華、方燕嬌、徐廷光、張柏林,七十八年度台灣地區中醫診所及中藥房調製風濕鎮痛類中藥製劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報 1991; 9: 48-53。
21. 楊美華、劉宜祝、方燕嬌、邵清益、徐廷光、張柏林,七十九年度台灣地區中醫診所及中藥房自行調製之調經理帶類中藥製劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報 1991; 9: 56-59。
22. 曾木全、李佩瑜、劉宜祝、林哲輝、溫國慶、周秀冠、楊福麟、詹榮弘,八十年度台灣地區國術館販售風濕鎮痛及鎮喘類中藥製劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報1992; 10: 42-46。
23. 簡俊生、林春惠、孫慈悌,減肥製劑中含安非他命類藥物之調查,中華衛誌 1992; 11: 44-48。
24. 溫國慶、朱芳玉、楊玉美、陳玉儀,歷年來中藥檢出西藥成分及來源變遷分析,藥物食品檢驗局調查研究年報 1996; 14: 223-232。
25. 林美智、蔡明哲、溫國慶,八十五年度調製劑中藥檢出西藥情形之分析,藥物食品檢驗局調查研究年報 1997; 15: 90-98。
26. 林美智、蔡明哲、溫國慶、廖俊亨,八十六年度調製劑中藥檢出西藥情形之分析,藥物食品檢驗局調查研究年報 1998; 16: 43-50。
27. 林美智、蔡明哲、溫國慶、廖俊亨,八十七年度調製劑中藥檢出西藥情形之分析,藥物食品檢驗局調查研究年報 1999; 17: 114-122。
28. Huang WF, Wen KC and Hsiao ML. Adulteration by synthetic therapeutic substances of traditional Chinese medicines in Taiwan. Journal of Clinical Pharmacology 1997; 37: 344-350.
29. 顧祐瑞、蔡明哲、溫國慶,利用高效液相層析法篩檢中藥製劑中摻加之風濕鎮痛類西藥成分,藥物食品分析 1995; 3: 51-56。
30. 顧祐瑞、蔡明哲、溫國慶,中藥摻加Sulfamethoxazole之定量探討,藥物食品分析 1995; 3: 115-119。
31. 顧祐瑞、蔡明哲、溫國慶,中藥製劑中摻加Aminitrozole,Metronidazole,Ornidazole及Tinidazole之高效液相層析分析,藥物食品分析 1996; 4: 141-148。
32. 顧祐瑞、蔡明哲、溫國慶,中藥製劑中摻加Nifedipine之高效液相層析定量之探討,臺灣臨床藥學雜誌 1996; 5: 16-21。
33. 顧祐瑞、蔡明哲、溫國慶,中藥製劑中摻加Fluoxymesterone, Methyltestosterone及Testosterone之高效液相層析法定量探討,藥物食品分析 1997; 5: 121-129。
34. Mc Laughlin GM, Nolan JA, Lindahl JL, Palmieri RH, Anderson KW, Morris SC, Morrison JA and Bronzert TJ. Pharmaceutical drug separations by HPCE: Practical guidelines. Journal of Liquid Chromatography 1992; 15: 961-1021.
35. Tagliaro F, Turrina S and Smith FP. Capillary electrophoresis: principles and applications in illicit drug analysis. Forsenic Science International 1996; 77: 211-229.
36. Beale SC. Capillary electrophoresis. Analtical Chemistry 1998; 70: 279R-300R.
37. 顧祐瑞、蔡明哲、溫國慶,毛細管電泳法定量風濕鎮痛類中藥製劑中摻加西藥成分之探討,藥物食品分析 1995; 3: 185-192。
38. Ku YR, Tsai MJ, Lin JH and Wen KC. Micellar electrokinetic capillary chromatography of clobenzorex HCl and diazepam adulterated in anorexiant traditional Chinese medicine, The Chinese Pharmaceutical Journal 1996; 48: 157-165.
39. Ries CA and Sahtud MA. Agranulocytosis caused by Chinese herbal medicines. JAMA 1975; 231: 352-355.
40. Goromaru T, Mihara M, Iguchi S, Mizushima Y. Detection of synthetic drugs in illegally enriched Chinese medicine. Iyakuhin Kenkyu 1977; 8: 212-217.
41. Hatanaka H and Hashimoto K. Addition of synthetic medicines in herbal medicines. Hyogo-ken Eisei Kenkyusho Kenkyu Hokoku 1984; 19: 106-108.
42. Hashimoto K and Hatanaka H. Determination of synthetic drugs illegally enriched to Chinese medicine. Yakugaku Zasshi 1984; 104: 287-292.
43. Yuen S and Lau-Cam CA. Thin-layer chromatographic screening procedure for undeclared synthetic drugs in Chinese herbal preparations. Journal of Chromatography 1985; 329: 107-112.
44. Bowron P and Lewis JH. Possible contamination of a herbal product with a prohibited substance. The Medical Journal Austral 1987; 146: 325.
45. Bury RW, Fullinfaw RO, Barraclough D, Muirden KD, Moulds RFW and Anghie T. Problems with herbal medicines. The Medical Journal Austral 1987; 146: 324-325.
46. Cairns T, Siegmund EG and Rader BR. Identification of prescription drugs in adulterated Chinese herbal medications. Pharmaceutical Research 1987; 4: 126-129.
47. By A, Ethier JC, Lauriault G, LcBelle M, Lodge BA, Savard C, Sy WW and Wilson WL. Traditional oriental medicines I. Black pearl: identification and chromatographic determination of some undeclared medicinal ingredients. Journal of Chromatography 1989; 469: 406-411.
48. Knoblauch A, Schafroth A, Paky A and Galeazzi RL. Amborum special F and ASFO: two glucocorticoid containing herbal remedies. Schweiz Med Wochenschr 1989; 119: 796-802.
49. Goldman JA. Chinese herbal medicine: Camouflaged prescription antiinflammatory drugs, corticosteroids, and lead. Arthritis and Rheumatism 1991; 34: 1207.
50. Parodi B, Caviglioli G, Bachi A, Cafaggi S and Romussi G. Herbal mixtures with claimed slimming activity: determination by TLC and HPLC of illegally added drugs. Pharmazie 1993; 48: 678-681.
51. Lai SJ, Binder SR, Essien H and Wen KC. Identification of western medicines as adulterants in Chinese herbal medicines using a broad-spectrum drug screening HPLC system. Journal of Liquid Chromatography 1995; 18: 2861-2875.
52. Gertner E, Marshall PS, Filandrinos D, Potek AS and Smith TM. Complications resulting from the use of Chinese herbal medications containing undeclared prescription drugs. Arthritis and Rheumatism 1995; 38: 614-617.
53. Fraser DB, Tomlinson J, Turner J and Satzger RD. Determination of undeclared prescription drugs in black pearl products. Journal of Food and Drug Analysis 1997; 5: 329-335.
54. 陳瓊雪、林慧玲、王韻嬿、潘賢隆,抗風濕痛類中藥摻加之苯丁唑酮 (Phenylbutazone) 及其分解物之分析研究,台灣藥學雜誌 1985; 37: 169-178
55. 曾木全、蔡明哲、溫國慶,一種固精補元氣中藥丸摻加Acetaminophen,Piroxicam,Ethoxybenzamide,Hydrochlorothiazide,Chlorzoxazone,Caffeine及Nicotinamide西藥成分之分析與定量研究,藥物食品分析 1996; 4: 49-56。
56. 曾木全、蔡明哲、溫國慶,治療心臟病與牌尿酸用之中藥丸摻加Caffeine,Diazepam,Chlorzoxazone,Ethoxybenzamide及Indomethacin西藥成分之分析與定量研究,藥物食品分析 1997; 5: 73-80。
57. Song Y, Her GR and Wen KC. Analysis of synthetic drugs in adulterated Chinese medicine by high performance liquid chromatography/electrospray mass spectrometry. Journal of Food and Drug Analysis 1997; 5: 295-301.
58. 林隆達、劉芳淑、盧芬鈴、黃坤森、廖幸淑,中藥檢驗方法專輯 (一),行政院衛生署藥物食品檢驗局,台北,1988: 1-88。
59. 蔡明哲、林秀珍、高麗華、林美智,中藥檢驗方法專輯 (二) 製劑薄層層析法,行政院衛生署藥物食品檢驗局,台北,1989: 1-222。
60. 蔡明哲、范純慧、林美智、謝王昭昭,中藥檢驗方法專輯 (三) 製劑薄層層析法,行政院衛生署藥物食品檢驗局,台北,1991: 1-241。
61. 蔡明哲、謝王昭昭、秦玲、黃坤森、盧芬鈴、楊慧美、曾人和,中藥檢驗方法專輯 (六) 製劑薄層層析法,行政院衛生署藥物食品檢驗局,台北,1994: 1-518。
62. 黃成禹、秦玲、黃坤森、盧芬鈴、楊慧美、曾人和、傅瓊慧,中藥檢驗方法專輯 (八) 製劑薄層層析法,行政院衛生署藥物食品檢驗局,台北,1995: 1-566。
63. 溫國慶、黃成禹、劉芳淑、黃坤森、盧芬鈴、秦玲、蔡文惠、林秀珍,中藥檢驗方法專輯 (九) 中藥濃縮製劑指標成分定量方法,行政院衛生署藥物食品檢驗局,台北,1996: 1-454。
64. 溫國慶、曾信雄、秦玲、黃坤森、盧芬鈴、劉芳淑、林秀珍、顧祐瑞、林雅姿,中藥檢驗方法專輯 (十一) 中藥濃縮製劑指標成分定量方法,行政院衛生署藥物食品檢驗局,台北,1999: 1-154。
65. Wen KC, Huang CY and Liu FS. Determination of cinnamic acid and paeoniflorin in traditional Chinese medicinal preparations by high-performance liquid chromatography. Journal of Chromatography 1992; 593: 191-199.
66. Wen KC, Huang CY, and Lu FL. Determination of baicalin and puerarin in traditional Chinese medicinal preparations by high-performance liquid chromatography. Journal of Chromatography 1993; 631: 241-250.
67. Lee YC, Huang CY, Wen KC and Suen TT. Determination of paeoniflorin, ferulic acid and baicalin in the traditional Chinese medicinal preparation Dang-Guei-San by high-performance liquid chromatography. Journal of Chromatography A 1994; 660: 299-306.
68. Lee YC, Huang CY, Wen KC and Suen TT. Determination of liquiritin, glycyrrhizin, hesperidin, cinnamic acid, cinnamaldehyde, honokiol and magnolol in the traditional Chinese medicinal preparation Wuu-Ji-San by high-performance liquid chromatography. Journal of Chromatography A 1995; 692: 137-145.
69. Lin SJ, Tseng HH, Wen KC and Suen TT. Determination of gentiopicroside, mangiferin, palmatine, berberine, baicalin, wogonin and glycyrrhizin in the traditional Chinese medicinal preparation Sann-Joong-Kuey-Jian-Tang by high-performance liquid chromatography. Journal of Chromatography A 1996; 730: 17-23.
70. 顧祐瑞、劉宜祝、郝景平、溫國慶、林哲輝、黃文鴻,天麻藥材中指標成分Parishin, Parishin B及C之高效液相層析定量法之探討,藥物食品分析 1995; 3: 287-293。
71. Ku YR, Lin YT, Wen KC, Lin JH and Liao CH. Determination of parishin, parishins B and C in traditional Chinese medicinal preparations by high performance liquid chromatography, Journal of Liquid Chromatography and Related Technologies 1996; 19: 3265-3277.
72. 林哲輝、顧祐瑞、黃韻笙、顏芳玫、溫國慶、黃文鴻,玄參藥材中高極性成分之分離及高效液相層析定量研究,藥物食品分析 1996; 4: 131-139。
73. Lin JH, Ku YR, Huang YS, Wen KC and Liao CH. Determination of polar constituents of Scrophulariae Radix in traditional Chinese medicinal preparations by high performance liquid chromatography. Journal of Liquid Chromatography and Related Technologies 1997; 20: 1617-1632.
74. 林哲輝、顧祐瑞、邱怡寧、溫國慶、廖俊亨,Determination of anthraquinones in Knoxiae Radix by high performance liquid chromatography,中國藥學會八十七年度年會暨藥學學術研討會 (台大醫學院,台北),1998。
75. Ku YR, Lin YT, Wen KC, Lin JH and Liao CH. Analysis of parishin, parishin B and parishin C in Gastrodiae Rhizoma by micellar electrokinetic capillary chromatography, Journal of Chromatography A 1998; 805: 330-336.
76. Ku YR, Lin YT, Lin JH, Wen KC, Liao CH. Determination of parishin, parishin B and parishin C in traditional Chinese medicinal formulas by micellar electrokinetic capillary chromatography Journal of Chromatography A. 1998; 805: 301-308.
77. Ku YR, Lin JH, Wen KC and Liao CH. Determination of polar constituents in Scrophulariae Radix by micellar electrokinetic capillary chromatography. Journal of Food and Drug Analysis 1998; 6: 413-422.
78. Ku YR, Chou FC, Wen KC, Lin JH and Liao CH. Determination of polar constituents of Scrophulariae Radix in Bai-He-Gu-Jin-Tang by micellar electrokinetic capillary chromatography, The Chinese Pharmaceutical Journal 1998; 50: 157-165.
79. 林哲輝、顧祐瑞、鄧書芳、溫國慶、廖俊亨,甘遂藥材中Triterpenoid成分之分離及氣相層析質譜儀定量研究,第五屆海峽兩岸及香港中藥研討會暨第十四屆天然藥物研討會 (國立中國醫藥研究所,台北),1999。
80. 黃寶慧、李茂榮,固相萃取技術,化學 1996; 56: 319-326。
81. Gillespie AM, Daly SL, Gilvydis DM, Sehneider F and Walters SM. Mutlicolumn solid-phase extraction cleanup of organophosphorus and organochlorine pesticide residues in vegetable oils and butterfat. Journal of AOAC International 1995; 78: 431-437.
82. Liska I. On-line versus off-line solid-phase extraction in the determination of organic contaminants in water. Journal of Chromatography A 1993; 655: 163-176.
83. Tyler VE. Herbs of Choice--The therapeutic use of phytomedicinals. Pharmaceutical Products Press. New York. 1994; p 87
84. Covington TR, Dipalma JR, Hussar DA, Kunkel FE, Lasagna L, Tatro DS and Whitsett TL. Drug facts and comparisons. Lippincott Co. St. Louis. 1992.
85. Paterson N. High-performance liquid chromatographic method for the determination of diprophylline in human serum. Journal of Chromatography B 1982; 232: 450-455.
86. Scott NR, Chakraborty J, Marks V. Determination of the urinary metabolites of caffeine and theophylline by high-performance Liquid chromatography: A comparative study of a direct injection and ion-pair extraction procedure. Journal of Chromatography B 1986; 375: 321-329.
87. Zhang ZY, Fasco MJ and Kaminsky LS. Determination of theophylline and its metabolites in rat liver microsomes and human urine by capillary electrophoresis. Journal of Chromatography B 1995; 665: 201-208.
88. Papadoyannis IN, Samanidou VF and Georga KA. Solid-phase extraction study and photodiode array RP-HPLC analysis of xanthine derivatives in human biological fluids. Journal of Liquid Chromatography and Relative Technology 1996; 19: 2559-2578.
89. Lee MR, Yu SC, Lin CL, Yeh YC, Chen YL and Hu SH. Solid-phase extraction in amphetamine and methamphetamine analysis of urine. Journal of Analytical Toxicology 1997; 21: 278-282.
90. Sadeghipour F, Varesio E, Giroud C, Rivier L and Veuthey JL. Analysis of amphetamines by capillary electrophoresis and liquid chromatography: application to drug seizures and cross-validation. Forensic Science International 1997; 86: 1-13.
91. Gross AS, Phillips AC, Boutagy J and Shenfield GM. Determination of dexfenfluramine and nordexfenfluramine in urine by high-performance liquid chromatography using ultraviolet detection. Journal of Chromatography Biomedical Applications 1993; 621: 115-120.
92. Krogh M, Brekke S, Tonnesen F and Rasmussen KE. Analysis of drug seizures of heroin and amphetamine by capillary electrophoresis. Journal of Chromatography A 1994; 674: 235-240.
93. Russel FGM, Creemers MCW, Tan Y, Riel PLC and Gribnau FWJ. Ion-pair solid-phase extraction of cimetidine from plasma and subsequent analysis by high-performance liquid chromatography. Journal of Chromatography B 1994; 661: 173-177.
94. Catlow JT, Barton RD, Clemens M, Gillespie TA, Goodwin M and Swanson SP. Analysis of olanzapine in human plasma utilizing reversed-phase high-performance liquid chromatography with electrochemical detection. Journal of Chromatography B 1995; 668: 85-90.
95. Ascalone V, Ripamonti M and Malavasi B. Stereospecific determination of amisulpride, a new benzamide deterivative, in human plasma and urine by automated solid-phase extraction and liquid chromatography on a chiral column: Application to pharmacokinetics. Journal of Chromatography B 1996; 676: 95-105.
96. Farthing D, Brouwer KLR, Fakhry I and Sica D. Solid-phase extraction and determination of ranitidine in human plasma by a high-performance liquid chromatographic method utilizing midbore chromatography. Journal of Chromatography B 1997; 688: 350-353.
97. Keys JD. Chinese herbs-their botany, chemistry, and pharmacodynamics, Charles E. Tuttle Company, Tokyo, 1976; p. 189.
98. Dulitzky M, Teja EDL and Lewis HF. Determination of caffeine in tea by high-performance liquid chromatography and a modified digestion procedure. Journal of Chromatography 1984; 317: 403-405.
99. Finger A, Kuhr S and Engelhardt UH. Chromatography of tea constituents. Journal of Chromatography 1992; 624: 293-315.
100. Hsu HY and Hsu CS. Commonly used Chinese herb formulas with illustrations. Oriental Health Arts Institute. Taipei. 1980; pp. 26, 86, 130-131, 490-491.
101. Hara M. Proper usage of Chinese medicinal preparations--bronchial asthma. Journal of Practical Pharmacy 1997; 48: 33-35.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
1. 26. 林美智、蔡明哲、溫國慶、廖俊亨,八十六年度調製劑中藥檢出西藥情形之分析,藥物食品檢驗局調查研究年報 1998; 16: 43-50。
2. 25. 林美智、蔡明哲、溫國慶,八十五年度調製劑中藥檢出西藥情形之分析,藥物食品檢驗局調查研究年報 1997; 15: 90-98。
3. 24. 溫國慶、朱芳玉、楊玉美、陳玉儀,歷年來中藥檢出西藥成分及來源變遷分析,藥物食品檢驗局調查研究年報 1996; 14: 223-232。
4. 21. 楊美華、劉宜祝、方燕嬌、邵清益、徐廷光、張柏林,七十九年度台灣地區中醫診所及中藥房自行調製之調經理帶類中藥製劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報 1991; 9: 56-59。
5. 20. 楊美華、方燕嬌、徐廷光、張柏林,七十八年度台灣地區中醫診所及中藥房調製風濕鎮痛類中藥製劑摻加西藥成分之調查,藥物食品檢驗局調查研究年報 1991; 9: 48-53。
6. 7. 郁凱衡 (1999) 酚類抗氧化劑(上)-合成類,食品資訊157:p34-38。
7. 17. 錢明賽,(1998),蔬果中之抗氧化物質,食品工業月刊,30(8):p21-33。
8. 9. 陳其潮,(1998),飲料中的有益物質。食品資訊,148:p28-33。
9. 6. 郁凱衡 (1999) 酚類抗氧化劑(下)-天然類,食品資訊158:p18-27。
10. 4. 林松洲,(1996),蜂膠的成分及藥理作用,生藥資訊,4:p20-24。
11. 2. 王進崑、孫璐西,(1993),檳榔嚼塊中酚類化合物之分析。中國農業化學會誌,31(5):p623-632。
12. 27. 林美智、蔡明哲、溫國慶、廖俊亨,八十七年度調製劑中藥檢出西藥情形之分析,藥物食品檢驗局調查研究年報 1999; 17: 114-122。
13. 29. 顧祐瑞、蔡明哲、溫國慶,利用高效液相層析法篩檢中藥製劑中摻加之風濕鎮痛類西藥成分,藥物食品分析 1995; 3: 51-56。
14. 30. 顧祐瑞、蔡明哲、溫國慶,中藥摻加Sulfamethoxazole之定量探討,藥物食品分析 1995; 3: 115-119。
15. 31. 顧祐瑞、蔡明哲、溫國慶,中藥製劑中摻加Aminitrozole,Metronidazole,Ornidazole及Tinidazole之高效液相層析分析,藥物食品分析 1996; 4: 141-148。