臺灣博碩士論文加值系統

五蕊寄生（Dendrophthoe pentandra (L.) Miq.）及廣寄生(Taxillus chinensis (DC.) Danser)皆為桑寄生科(Loranthaceae)植物，分屬於五蕊寄生屬及鈍果寄生屬。
從新鮮五蕊寄生（367.75 g）總共分得15個化合物，其中11個化合物經光譜分析及文獻比對後，確認其結構為2,3-diaminopropionic acid (1)、gallic acid (3)、methyl gallate (4)、methylparaben (5)、phlorin (6)、(+)-catechin (10)、2-(3',4'-dihydroxyphenyl)-chroman-5,7-diol (11)、β-sitosterol (15)、β-sitosteryl-O-glucoside (16)、friedelin (18)與lupeol (20)，以上之化合物皆為本屬首次分離得到之化合物。
從新鮮廣寄生（336.28 g）總共分離得到24個化合物，其中16個經光譜分析及文獻比對後，確認其結構分別為2,4-dimethoxy-
benzaldehyde (2)、gallic acid (3)、methyl gallate (4)、methylparaben(5)、phlorin (6)、syringaldehyde (7)、methyl-21-hydroxy-(21R)-pheophorbide-a (8)、methyl pheophorbide-a (9)、(+)-catechin (10)、2-(3',4'-dihydroxy-phenyl)-chroman-5,7-diol (11)、kaempferol-3-O-α-L-rhamnoside (12)、quercetin-3-O-α-L-rhamnoside (13)、quercetin-3-O-β-D-glucoside(14)、β-amyrin acetate (17)、friedelin (18) 與 lupenyl acetate (19)。

Dendrophthoe pentandra (L.) Miq. and Taxillus chinensis (DC.)Danser are species of Loranthaceae.
Fifteen compounds were isolated from the fresh Dendrophthoepentandra (L.) Miq., and eleven compounds were determined by spectralanalysis. They included 2,3-diamino-propionic acid (1), gallic acid (3),methyl gallate (4), methylparaben (5), phlorin (6), (+)-catechin (10),2-(3',4'-dihydroxyphenyl)-chroman-5,7-diol (11), β-sitosterol (15),β-sitosteryl-O-glucoside (16), friedelin (18) and lupeol (20).
Twenty-four compounds were isolated from the fresh Taxilluschinensis (DC.) Danser, and sixteen compounds were determined byspectral analysis. They included 2,4-dimethoxy-benzaldehyde (2), gallicacid (3), methyl gallate (4), methylparaben (5), phlorin (6),syringaldehyde(7), methyl-21-hydroxy-(21R)-pheophorbide-a (8), methylpheophorbide-a (9), (+)-catechin (10), 2-(3',4'-dihydrophenyl)-chroman-5,7-diol (11), kaempferol-3-O-α-L-rhamnoside (12), quercetin-3-O-α-L-rhamnoside (13), quercetin-3-O-β-D-glucoside (14), β-amyrin acetate(17), friedelin (18) and lupenyl acetate (19).

指導教授推薦書
口試委員審定書
授權書............................................................iii
謝誌..............................................................iv
中文摘要...........................................................v
英文摘要...........................................................vi
目錄..............................................................vii

第一章 緒論......................................................1
第一節 前言...................................................1
第二節 五蕊寄生之植物分佈及其形態................................3
第三節 廣寄生之植物分佈及其形態..................................5

第二章 文獻回顧...................................................7
第一節 化學成分回顧.............................................7
第二節 藥理研究回顧.............................................18

第三章 抽取與分離..................................................21
第一節 五蕊寄生之抽取與分離......................................21
第二節 廣寄生之抽取與分離........................................24
第三節 純化所得之化合物..........................................26

第四章 化合物之構造研究..............................................32
第一節 2,4-Dimethoxy-benzaldehyde（2）之結構研究.................32
第二節 Phlorin（6）之結構研究....................................36
第三節 2-(3',4'-Dihydroxyphenyl)-chroman-5,7-diol（11）之結構研
究......................................................38
第四節 Friedelin（18）之結構研究.................................43
第五節 其他化合物................................................47

第五章 生物活性試驗.................................................48
第一節 DPPH自由基的清除作用......................................49
第二節 超氧自由基 (O2.-) 釋放之測定...............................51
第三節 Elastase 釋放之測定.......................................53

第六章 結論.........................................................55
第七章 實驗部分.....................................................56
第一節 本實驗所用之儀器與藥品.....................................56
第二節 五蕊寄生之分離與純化.......................................58
第三節 廣寄生之分離與純化.........................................59
第四節 生物活性試驗..............................................61
光譜數據............................................................63
參考文獻............................................................81

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