臺灣博碩士論文加值系統

本研究利用反射吸收式紅外光譜法（infrared reflection-absorption spectroscopy, IRRAS），探討在添加不同莫耳分率之雙碳氫鏈二甲基溴化銨(dialkyldimethylammonium bromide, DXDAB)的情況下，氣／液界面上具不同碳氫鏈之離子對雙親分子（ion pair amphiphile, IPA）單分子層的穩定性及分子排列特性。本研究所使用的IPA是由十六烷基三甲基溴化銨(hexadecyltrimethylammonium bromide, HTMAB, CH3(CH2)15N(CH3)3Br)和十六烷基硫酸鈉(sodium hexadecylsulfate, SHS, CH3(CH2)15SO4Na )製備而成的HTMA-HS。結果並和HTMA-DS／DXDAB混合系統的結果比較。
實驗結果顯示，純HTMA-HS單分子層的穩定性比HTMA-DS單分子層佳，這可能是由於HTMA-HS分子的碳氫鏈較長也較對稱，使得分子與分子間的作用較強，分子自由度較小，因此可以規則排列並穩定存在於氣／液界面上。
添加DXDAB於HTMA-HS單分子層中，會使得HTMA-HS的HTMA+被DXDA+置換而形成新的IPA分子。而當DXDAB的比率上升會接近完全取代，取代後所形成的三碳鏈IPA分子結構較穩定，分子碳氫鏈的不匹配度也下降，降低了分子的自由度，因此在固定單分子層佔據面積的鬆弛過程中，添加DXDAB可提升IPA單分子層的穩定性。
將鬆弛結果與同系統之陰陽離子液胞粒徑的穩定性比較，發現當DXDAB的添加量上升時，液胞的粒徑穩定性也隨之提升，推測添加DXDAB分子除了使液胞表面帶電，降低彼此間碰撞頻率外，還能改善液胞雙層膜結構的穩定性。

In this study, infrared reflection-absorption spectroscopy technique is applied to obtain information on the molecular packing properties of mixed IPA/DXDAB monolayers at the air/water interface. The results show that, the HTMA-HS monolayer is stable at the air/water interface while the HTMA-DS monolayer is not. The reason is that the structure of HTMA-DS molecule is asymmetry, and thus the degree of freedom of the carbon tails will be high. For three kinds of DXDAB, the results show that the DODAB monolayer can be stable at the air/water interface and the others can not. It is because DODAB has the longest carbon tails, leading to the strongest molecule interaction. The results of monolayer relaxation experiments show that HTMA-HS and DODAB monolayers can be stable at the air/water interface, while HTMA-DS, DTDAB, and DHDAB monolayers can not. Compared these results with size stability of the vesicles, one can find that vesicles formed of HTMA-HS or DODAB have higher size stability. This suggests that the physical stability of vesicles is controlled by the symmetry structure and number of carbon chains. For the two-component systems, the results show that HTMA+ of IPA will be replaced by DXDA+.This phenomenon will reduce the degree of freedom of the carbon tails, and the mixed IPA/DXDAB monolayers are then stable at the air/water interface. Therefore, adding DXDAB will not only reduce the collision frequency of the vesicles, but also increase the bilayer stability of the vesicles.

中文摘要 i
Extended Abstract iii
誌謝 viii
總目錄 ix
表目錄 xii
圖目錄 xiii
符號說明 xix
第一章　緒論 1
1-1 前言 1
1-2 研究目的與動機 4
1-3 文獻回顧 5
1-3-1 Langmuir單分子層 5
1-3-2 研究Langmuir單分子層特性的方法 10
1-3-3　反射吸收式紅外光譜技術的應用 10
1-3-4單分子層的鬆弛 15
第二章　實驗 18
2-1 藥品 18
2-2　實驗儀器 18
2-3　實驗方法 25
2-3-1 藥品配製 25
2-3-2　反射吸收式紅外光譜的操作 25
2-3-2-1　壓縮等溫線的量測 27
2-3-2-2　鬆弛等溫線的量測 29
2-4 參數解讀 30
2-4-1 RA intensity 30
2-4-1 Wavenumber 31
第三章　結果與討論 33
3-1 單成分單分子層 33
3-1-1 IPA 單分子層 33
3-1-1-1　壓縮等溫線 33
3-1-1-2　鬆弛等溫線 41
3-1-2 DXDAB 單分子層 45
3-1-2-1　壓縮等溫線 45
3-1-2-2　鬆弛等溫線 48
3-2 雙成分單分子層 51
3-2-1 IPA／DTDAB混合單分子層 51
3-2-1-1 壓縮等溫線 51
3-2-1-2 鬆弛等溫線 59
3-2-2 IPA／DHDAB混合單分子層 65
3-2-2-1 壓縮等溫線 65
3-2-2-2 鬆弛等溫線 73
3-2-3 IPA／DODAB混合單分子層 78
3-2-3-1 壓縮等溫線 78
3-2-3-2 鬆弛等溫線 86
3-3 分子取代 92
3-3-1 分子取代的分析 92
3-3-2 分子取代的影響 104
第四章　結論 110
參考文獻 112

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