臺灣博碩士論文加值系統

本文中使用實驗室生長的摻鉻鎂橄欖石晶體光纖以 520nm 綠光雷射泵浦產生放大自發輻射(Amplified spontaneous emission; ASE)作為Mirau-based 全域式光學同調斷層掃瞄系統所使用的光源，共使用兩顆 1-W 520nm 之雷射二極體泵浦摻鉻鎂橄欖石晶體光纖，對於沿 C 軸方向生長的摻鉻鎂橄欖石晶體光纖可以產生 1.4 mW ASE，中心波長 900 nm、頻寬 250 nm，可以使 OCT 系統上在活體組織中有 1.18 μm的縱向解析度能力；沿 B 軸方向生長的摻鉻鎂橄欖石晶體光纖可以產生3mW ASE，中心波長 900 nm、頻寬 200 nm，可使OCT 系統搭配 40X 物鏡下得到0.98μm 的橫向解析度能力，1.2 μm的縱向解析度能力。
皮膚切片是臨床上用來判斷皮膚疾病的準則，在皮膚切片上有分成鑽取活組織檢查(Punch biopsy)、活削活組織檢查(Shave biospy)、切口活組織檢查(Incisional biopsy)，皮膚切片檢查是屬於侵入式的檢測方式，這樣子的檢測方式會讓病患傷口流血並且可能留下疤痕，光學同調斷層掃描術(Optical coherence tomography; OCT)在生醫影像中佔有很重要的地位，其在量測時不需要特別做標記，能夠以非侵入的方式量出樣本3D立體影像結構。
本論文中針對Mirau干涉儀部分進行改良，藉由改變鍍膜設計，使得干涉效率由7.64%大幅上升至22.35%，可有效提升訊噪比(Signal noise ratio, SNR)與影像品質。

In this thesis, Cr:forsterite crystal fiber amplified spontaneous emission(ASE) light source was used to build a Mirau-based full-field optical coherence tomography system using two 520-nm laser diode to pump the different axis Cr:forsterite crystal fiber. The C-axis fiber can generate 3-mW ASE light centered at 900 nm with a bandwidth of 250 nm was generated. The B-axis fiber generated ASE light centered at 900nm with a bandwidth of 200um. The mirau-based full-firld OCT has an axial resolution of 1.2um and a lateral resolution of 0.98um.
Skin biopsy is the gold standard for doctor to diagnosis skin cancers. There are several ways to do the skin biopsy such as punch biopsy, shave biopsy, incisional biopsy, incisional biopsy. These methods are all invasive that make the patient bleed and leave scar. Optical coherence tomography is one of the techniques in the biomedical imaging system. It is a noninvasive, label-free and 3D imaging method.
In this system, we can acquire in-vivo skin image and get high-resolution 3D volume structure.
In this thesis, we especially improve the design of our Mirau device to make interference efficiency increase from 7.64% to 22.35% and effective increase the noise signal ratio and obviously improve the quality of image.

目錄
摘 要 ……………………………………………………… VI
Abstract ……………………………………………………… VII
致 謝 ……………………………………………………… VIII
目 錄 ……………………………………………………… Ｘ
圖目錄 ……………………………………………………… XIII
表目錄 ……………………………………………………… XⅥII
第一章 　　導論…………………………………………… 1
1.1
1.2
1.3 緒論……………………………………………
研究動機………………………………………
文獻回顧……………………………………… 1
3
3
第二章 　　Mirau全域式光學同調斷層掃描…………… 8
2.1
2.1.1
2.1.2
2.2
2.3
2.4
2.5
2.6 光學同調斷層掃描基本原理…………………
解析度…………………………………………
　　全域式光學同調斷層掃描術…………………
影像處理與運算………………………………
摻鉻鎂橄欖石晶體材料特性…………………
摻鉻鎂橄欖石晶體光學特性…………………
摻鉻鎂橄欖石晶體光纖傳輸膜態原理………
摻鉻鎂橄欖石晶體光纖之製備……………… 8
13
16
19
22
28
34
37
第三章 　　光學薄膜特性與電子槍蒸鍍系統…………… 43
3.1
3.1.1
3.1.2
3.1.3
3.2
3.2.1
3.2.2 　　光學薄膜………………………………………
　　光學薄膜特性分析與設計 …………………
　　薄膜材料特性…………………………………
　　薄膜設計模擬軟體……………………………
　　電子槍…………………………………………
電子槍蒸鍍系統基本原理……………………
電子槍蒸鍍系統監控原理…………………… 43
43
48
50
53
54
57
第四章 全域式光學同調斷層掃描設計與改良……… 60
4.1
4.2
4.2.1
4.2.2
4.2.3
4.2.4 　　摻鉻鎂橄欖石晶體光纖光源模組……………
Mirau干涉儀設計……………………………
Mirau物鏡……………………………………
干涉儀組件設計………………………………
Mirau物鏡元件………………………………
　　Mirau物鏡量測示意圖……………………… 60
62
63
65
68
72
第五章 　　Mirau干涉儀的新設計結果與討論………… 78
5.1

5.2
5.3
5.4
5.5 　　使用摻鉻鎂橄欖石晶體光纖光源之Mirau-　based………………………………………………
原黑點設計變更為銀點設計鍍膜……………
原設計與新設計下干涉效率之比較…………
鍍膜製程品質之改善…………………………
掃描樣本之結果………………………………
78
83
86
89
91
第六章 　　未來展望……………………………………… 94
參考文獻 ……………………………………………………… 96

 

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