臺灣博碩士論文加值系統

傳統式皮膚檢測儀適用於較淺層之二維皮膚檢測。光學同調斷層攝影術 (Optical coherence tomography, OCT) 是一種無損傷、非侵入性、高解析度生物醫學影像技術，使它成為熱門的醫學影像技術之一。其中，全景光學同調攝影術 (Full-field optical coherence tomography, FF-OCT) 為使用樣品平面的像素進行影像處理之二維成像裝置，適用於高速度的三維組織成像。
從 OCT 發展至今，大多使用低同調性紅外光源，使得大多數拍攝的影像皆為單彩影像。由於發光二極體 (Light emitting diode, LED) 具有寬波寬和壽命長等優點，在本論文中，我們提出將 RGB LED 應用於 OCT 系統中，可應用三原色色光的 LED 個別拍攝生物樣本，再將紅、藍、綠三彩影像疊合，使其影像顯示出組織真實顏色。在本論文的實驗結果中，將顯示孔雀魚皮膚黑色素層之全彩組織圖像、豬皮之三維真皮層組織圖像、以及人體臉部真皮層之三維組織圖像，顯示使用 RGB LED 的 FF-OCT 系統在醫學成像上的潛力。
本論文中所顯示的皮膚造影系統有潛力微小化為手持式的模型架構。由於具備非侵入性的特點、解析度可達 10 微米等級、且可以全彩或三維立體影像顯示，本造影系統可應用於皮膚科學、皮膚醫學及醫學美容等相關領域，造福愛美人士。

Conventional handheld skin cameras are suitable for two-dimensional (2D) inspection of shallow skin. With noninvasiveness and high resolution, optical coherence tomography (OCT) has become a popular medical imaging technology. Among OCT schemes, full-field optical coherence tomography (FF-OCT) is suitable for rapid three-dimensional (3D) imaging, as it uses a 2D imaging device for pixel processing of a sample plane.
Conventionally, the use of low-coherent infrared light sources in OCT resulted in monochromatic images. As light emitting diode (LED) has advantages of wide bandwidth and long lifetime, RGB LEDs were applied in an FF-OCT system in this study to establish full-color skin imaging system by overlapping the respective red (R), green (G) and blue (B) tissue images. In this thesis, the experiment results such as full-color melanin images of a guppy, 3D skin images of a hog, and 3D skin images of human face show the potential of RGB LED sources in FF-OCT applications for dermal tissue imaging.
The skin imaging system shown in the study could be miniaturized to a handheld model. Due to its non-invasiveness, high spatial resolution and the potential for full-color or 3D imaging, this imaging system can further be applied in the fields of skin science, dermatology and cosmetology.

第一章 緒論 1
1.1 前言 1
1.2 研究動機 2
1.3 文獻回顧 3
1.4 論文架構 4
第二章 全景光學同調斷層攝影術原理 5
2.1 光的干涉理論 5
2.2 低同調干涉術 7
2.3 系統的空間解析度 12
2.3.1 橫向解析度 12
2.3.2 縱向解析度 14
2.4光與生物組織的交互作用 16
2.4.1 生物體對光的吸收作用 16
2.4.2光在組織中的散射現象 18
2.5 斷層掃描的方式 20
2.6 時域式 OCT 與全景式 OCT 之比較 21
第三章 全景光學同調斷層掃描系統的建構與成像 25
3.1 FF-OCT 系統架構之建構 25
3.1.1 實驗系統架構之建構方法 25
3.1.2 光源模組之建構 28
3.2系統的三維掃描程序 30
3.2.1 三維掃描機構 30
3.2.2 三維掃描程序 32
3.3信號擷取與成像方法 33
3.4全彩影像之建構 35
3.5 三維影像之建構 37
3.6 系統造影範圍量測 38
3.7 對人臉造影用之臉部夾具設計 39
第四章 實驗結果與討論 40
4.1造影系統三色光源的特性 40
4.1.1光源的亮度特性 40
4.1.2光源的光譜特性 41
4.1.3光源的造影特性 43
4.2 孔雀魚皮膚組織黑色素的全彩影像 45
4.3 豬皮組織的三維影像 52
4.4 人體皮膚組織二維影像 58
4.4.1人體皮膚組織的膠原蛋白纖維及微血管影像 60
4.4.2 人臉皮膚組織的黑色素影像 62
4.4.3 人臉皮膚組織的毛囊影像 64
4.5 人體皮膚組織三維影像 65
4.6 討論 66
第五章 結論與未來展望 68
5.1 結論 68
5.2 未來展望 69
參考文獻 71

參考文獻 71

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