臺灣博碩士論文加值系統

第一部分：提出一個反轉式醣鏈結方法，規劃在醣受體引入磺酸酯基團，醣予體的1號位置為羥基，藉由鹼性或酸性條件，催化轉換醣受體的磺酸酯基至醣予體，建構離去基團，隨後，進行鹼性或酸性催化的醣鏈結反應。

第二部分：嘗試利用簡單保護的單醣，在1號碳位置以二醇串接無取代的吡啶酮，選擇性的生成碳水化合物修飾的1-（取代烷基）-2（1H）吡啶酮，以利日後複雜吡啶酮與複雜醣類合成之基礎與研究模型。

Part 1: A reversal glycosylation method is proposed to introduce a sulfonate group at the sugar receptor and a hydroxyl group at the anomeric carbon of the saccharide. The sulfonic acid ester group of the sugar receptor is catalytically converted to the saccharide body by alkaline or acidic conditions, the leaving group is constructed, followed by a basic or acidic catalyzed glycosylation.

Part 2: Try to use monosaccharides with simple protection to connect with diol and unsubstituted pyridine at anomeric carbon, selectively generate carbohydrate- Modified 1- (Substituted alkyl)-2 (1H) Pyridones.

目 錄
目 錄 3
中文摘要 4
Abstract 5
第一部分：反轉式醣鏈結反應中醣受體的磺酸酯離去基之研究 6
緒論 7
本論文研究目標及動機 16
實驗結果與討論 17
實驗步驟及光譜數據 27
第二部分：設計與合成碳水化合物修飾的1-（取代烷基）-2（1H）吡啶酮 32
緒論 33
本論文研究目標及動機 38
實驗結果與討論 39
實驗步驟及光譜數據 55
參考文獻 69
附錄 75

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