臺灣博碩士論文加值系統

Objective: Mandibular molar protraction for complete closure of an edentulous space is a time-consuming procedure and loses alveolar bone. The purpose of this retrospective and preliminary study was to evaluate the effects of platelet rich plasma (PRP) injection on mandibular molar protraction for closing an edentulous space.
Methods: Thirty-seven mandibular molars were protracted to close the edentulous spaces, of which 9 had submucosal PRP-injection (PRP-group) and another 28 had no PRP-injection (non-PRP-group) right before the protraction. The cone beam computer tomography images taken right before (T1) and after (T2) orthodontic treatment were used to analyze the alveolar bone loss, alveolar bone preserving ratio, root resorption, and rate of molar protraction. The intragroup and intergroup comparisons were analyzed statistically by the Wilcoxon singed-rank test and the Mann-Whitney U test respectively (p<0.05).
Results: The rate of mandibular molar protraction in the PRP-group was 1.73 times faster than that in the non-PRP-group. Both of the non-PRP-group and PRP-group were revealed having alveolar bone loss significantly (p<0.05) in almost all aspects of the protracted molars. However, the amount of alveolar bone loss was 36-40% less and the alveolar bone preserving ratio was elevated significantly at the lingual and mesial aspects of the protracted molars in the PRP-group (p<0.05). The root resorption was similar between the non-PRP-group and PRP-group.
Conclusion: Submucosal injection of PRP might accelerate mandibular molar protraction and reduce the alveolar bone loss in mandibular molar protraction for complete closure of an edentulous space

Recommendation Letter from the Thesis Advisor
Thesis/Dissertation Oral Defense Committee Certification
Acknowledgments…………………………………………………….iii
English Abstract………………………………………………………iv
Contents………………………………………………………………..v
List of Tables………………………………………………………...viii
List of Figures………………………………………………………….x
Chapter 1 INTRODUCTION………………………………………...1
1.1 Introduction……………………………………………………1
Chapter 2 SYSTEMATIC REVIEW………………………………...3
2.1 Systematic Review of mandibular molar protraction…………..3
2.1.1 Introduction………………………………………………..3
2.1.2 Methods……………………………………………………3
2.1.3 Results……………………………………………………..4
2.1.4 Discussion…………………………………………………8
2.1.5 Summary…………………………………………………..9
2.2 Systematic Review of Platelet Rich Plasma in Orthodontics….9
2.2.1 Introduction………………………………………………...9
2.2.2 Methods……………………………………………………10
2.2.3 Results……………………………………………………...10
2.2.4 Discussion………………………………………………….12
2.2.5 Summary…………………………………………………...12
Chapter 3 Objectives and Hypotheses………………………………..13
3.1 Objectives ……………………………………………………...13
3.2 Hypotheses……………………………………………………..13
Chapter 4 MATERIALS and METHODS …………………………..14
4.1 Study design……………………………………………………14
4.1.1. Patients…………………………………………………….14
4.1.2. 3D image reconstruction of the protracted molar and surrounding alveolar bone………………………………………..15
4.1.3. Measurement of alveolar bone volume surrounding the protracted molar………………………………………………….16
4.1.4. Measurement of alveolar bone preserving ratio (T2/T1)… 16
4.1.5. Measurement of the rate of mandibular molar protraction..17
4.2 The PRP preparation and clinical application…………………17
4.3 Statistical Analyses……………………………………………18
Chapter 5 RESULTS………………………………………………….19
5.1 Bone volume change and alveolar bone preserving ratio…....19
5.2 Root resorption and percentage of root resorption…………..19
5.3 Rate of mandibular molar protraction……………………….19
Chapter 6 DISCUSSION……………………………………………...20
Chapter 7 CONCLUSION……………………………………………25
REFERENCES………………………………………………………..26
TABLE 1-17…………………………………………………………...33
FIGURES 1-8………………………………………………………….60
APPENDIX (List of abbreviations)………………………………… 68

LIST OF TABLES
Table 1. The summary of systematic review articles (molar protraction)……………………………………………………………. 33
Table 2. The summary of systematic review articles
(PRP in Orthodontic)………………………………………………….. 38
Table 3. Descriptive data of patients…………………………………...40
Table 4. Intragroup comparisons of bone volume change and root resorption from T1 to T2 ………………………………………………41
Table 5. Intergroup comparison of change in bone volume, alveolar bone preserving ratio, root resorption and percentage of root resorption between the non-PRP and PRP-groups………………………………...42
Table 6. Intergroup comparison of treatment duration, distance of molar protraction, and rate of molar protraction……………………………...43
Table 7. Gender and Age of each subject in this study………………..44
Table 8. Bone volume in non-PRP group (Raw Data)………………. 45
Table 9. Bone volume in PRP-group (Raw Data)……………………. 47
Table 10. Bone volume change (T1-T2) in non-PRP-group (Raw Data) …………………………………………………………………………48
Table 11 Bone volume change (T1-T2) in PRP-group (Raw Data)….. 50
Table 12. Alveolar bone preserving Ratio (T2/T1) in non-PRP-group (Raw Data)…………………………………………………………… 51
Table 13. Alveolar bone preserving ratio (T2/T1) in PRP-group (Raw Data)……………………………………………………………..53
Table 14. Root volume, root resorption, percentage of root resorption in non- PRP-group (Raw Data)………………………………………... 54
Table 15. Root volume, root resorption, percentage of root resorption in PRP-group (Raw Data)………………………………………………... 56
Table 16. Distance, treatment duration and rate of molar protraction in non- PRP-group (Raw Data)…………………………………………... 57
Table 17. Distance, treatment duration and rate of molar protraction in PRP-group (Raw Data)………………………………………………... 59

LIST OF FIGURES

Figure 1. Diagram of systematic review process (molar protraction)… 60
Figure 2. Diagram of systematic review process (PRP & orthodontic). 61
Figure 3. Diagram of materials and methods…………………………..62
Figure 4. The borders of the region of interest (ROI)……………………. 63
Figure 5. The height of alveolar bone block…………………………...64
Figure 6. Mesial, distal, buccal and lingual component of alveolar bone block ……………………………………………………………………65
Figure 7. Alveolar bone loss in PRP and non-PRP-group……………...65
Figure 8. Root Resorption……………………………………………...67

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